Technical University Dresden 1 article published in JoVE Neuroscience Recording and Analyzing Multimodal Large-Scale Neuronal Ensemble Dynamics on CMOS-Integrated High-Density Microelectrode Array Brett Addison Emery*1, Shahrukh Khanzada*1, Xin Hu*1, Diana Klütsch1, Hayder Amin1,2,3 1Group of "Biohybrid Neuroelectronics (BIONICS)", German Center for Neurodegenerative Diseases (DZNE), 2Faculty of Medicine Carl Gustav Carus, Technical University Dresden, 3Dresden Center for Intelligent Materials (DCIM), Technical University Dresden Here, we employ HD-MEA to delve into computational dynamics of large-scale neuronal ensembles, particularly in hippocampal, olfactory bulb circuits, and human neuronal networks. Capturing spatiotemporal activity, combined with computational tools, provides insights into neuronal ensemble complexity. The method enhances understanding of brain functions, potentially identifying biomarkers and treatments for neurological disorders.
