Minimizing Stress in Mouse and Rat Handling

Mouse and rat handling can create stress, even when the procedure is brief. Cage changing and other noninvasive tasks can raise heart rate, blood pressure, and serum corticosterone levels. These changes may last for several hours.

Restraint for injections and blood withdrawal can also affect the ...

Rodents are widely used model organisms to investigate diverse scientific questions, and it has been demonstrated that handling can be stressful for these animals. 
Handling for simple tasks such as cage changing may cause an increase in heart rate, blood pressure, and serum corticosterone levels, and these effects can persist for several...