Endo and Exo Products in Diels–Alder Reactions

Diels–Alder reactions can form bridged bicyclic products when a cyclic diene is locked in the s-cis configuration. This arrangement lets the diene react with a dienophile to build the bicyclic ring system.

The stereochemistry of the product depends on the dienophile. When the dienophile has one o...

While Diels–Alder reactions between an acyclic diene and a dienophile give cyclic products, cyclic dienes form bridged bicyclic compounds.

Unlike the open-chain dienes, cyclic analogs are locked in an s-cis conformation, leading to rapid Diels–Alder reactions.

Reactions between cyclic dienes and substituted dienophiles giv...