Alfred E. Chang

Publications

• OK-432 Synergizes with IFN-γ to Confer Dendritic Cells with Enhanced Antitumor Immunity
  Immunology and Cell Biology. Dec, 2013  |   Pubmed ID: 24296809
• Cancer Immunotherapy: Current Status and Future Directions
  Surgical Oncology Clinics of North America. Oct, 2013  |   Pubmed ID: 24012398
• IL-17A Promotes Immune Cell Recruitment in Human Esophageal Cancers and the Infiltrating Dendritic Cells Represent a Positive Prognostic Marker for Patient Survival
  Journal of Immunotherapy (Hagerstown, Md. : 1997). Oct, 2013  |   Pubmed ID: 23994890
• Cytokine-induced Killer (CIK) Cells Bound with Anti-CD3/anti-CD133 Bispecific Antibodies Target CD133(high) Cancer Stem Cells in Vitro and in Vivo
  Clinical Immunology (Orlando, Fla.). Oct, 2013  |   Pubmed ID: 23994769
• Effects of Tumor Irradiation on Host T-regulatory Cells and Systemic Immunity in the Context of Adoptive T-cell Therapy in Mice
  Journal of Immunotherapy (Hagerstown, Md. : 1997). Feb, 2013  |   Pubmed ID: 23377667
• Targeting Cancer Stem Cells Via Dendritic-cell Vaccination
  Oncoimmunology. Nov, 2012  |   Pubmed ID: 23243607
• Interleukin-6 Inhibits Regulatory T Cells and Improves the Proliferation and Cytotoxic Activity of Cytokine-induced Killer Cells
  Journal of Immunotherapy (Hagerstown, Md. : 1997). May, 2012  |   Pubmed ID: 22495391
• Cancer Stem Cell Vaccination Confers Significant Antitumor Immunity
  Cancer Research. Apr, 2012  |   Pubmed ID: 22473314
• Characterization of Bridging Integrator 1 (BIN1) As a Potential Tumor Suppressor and Prognostic Marker in Hepatocellular Carcinoma
  Molecular Medicine (Cambridge, Mass.). 2012  |   Pubmed ID: 22281836
• Is Duct Excision Still Necessary for All Cases of Suspicious Nipple Discharge?
  The Breast Journal. Mar-Apr, 2012  |   Pubmed ID: 22211878
• B Lymphocytes As Effector Cells in the Immunotherapy of Cancer
  Journal of Surgical Oncology. Mar, 2012  |   Pubmed ID: 21898417
• Is a Level III Dissection Necessary for a Positive Sentinel Lymph Node in Melanoma?
  Journal of Surgical Oncology. Mar, 2012  |   Pubmed ID: 21882199
• Validation of Statistical Predictive Models Meant to Select Melanoma Patients for Sentinel Lymph Node Biopsy
  Annals of Surgical Oncology. Jan, 2012  |   Pubmed ID: 21822550
• Defining the Critical Hurdles in Cancer Immunotherapy
  Journal of Translational Medicine. 2011  |   Pubmed ID: 22168571
• Long-term Cultured Human Neural Stem Cells Undergo Spontaneous Transformation to Tumor-initiating Cells
  International Journal of Biological Sciences. 2011  |   Pubmed ID: 21814484
• Adoptive Transfer of Tumor Reactive B Cells Confers Host T-cell Immunity and Tumor Regression
  Clinical Cancer Research : an Official Journal of the American Association for Cancer Research. Aug, 2011  |   Pubmed ID: 21690573
• Surgical Options for Localized and Advanced Gastrointestinal Stromal Tumors
  Journal of Surgical Oncology. Dec, 2011  |   Pubmed ID: 21381037
• Intratumoral Expression of IL-17 and Its Prognostic Role in Gastric Adenocarcinoma Patients
  International Journal of Biological Sciences. 2011  |   Pubmed ID: 21234303
• From the Guest Editors: Introduction to Local Therapies in the Treatment of Liver Cancer
  Cancer Journal (Sudbury, Mass.). Mar-Apr, 2010  |   Pubmed ID: 20404604
• Rate of Freeze Alters the Immunologic Response After Cryoablation of Breast Cancer
  Annals of Surgical Oncology. Apr, 2010  |   Pubmed ID: 20033323
• Intratumoral Delivery of Encapsulated IL-12, IL-18 and TNF-alpha in a Model of Metastatic Breast Cancer
  Breast Cancer Research and Treatment. Jul, 2010  |   Pubmed ID: 19802695
• Is There a Benefit to Sentinel Lymph Node Biopsy in Patients with T4 Melanoma?
  Cancer. Dec, 2009  |   Pubmed ID: 19827151
• Prognostic Significance of a Positive Nonsentinel Lymph Node in Cutaneous Melanoma
  Annals of Surgical Oncology. Nov, 2009  |   Pubmed ID: 19711133
• In Vivo Sensitized and in Vitro Activated B Cells Mediate Tumor Regression in Cancer Adoptive Immunotherapy
  Journal of Immunology (Baltimore, Md. : 1950). Sep, 2009  |   Pubmed ID: 19667089
• Radiotherapy Combined with Intratumoral Dendritic Cell Vaccination Enhances the Therapeutic Efficacy of Adoptive T-cell Transfer
  Journal of Immunotherapy (Hagerstown, Md. : 1997). Jul-Aug, 2009  |   Pubmed ID: 19483649
• Gemcitabine-based Combination Chemotherapy Followed by Radiation with Capecitabine As Adjuvant Therapy for Resected Pancreas Cancer
  International Journal of Radiation Oncology, Biology, Physics. Dec, 2009  |   Pubmed ID: 19409732
• Antitumor Activity of T Cells Generated from Lymph Nodes Draining the SEA-expressing Murine B16 Melanoma and Secondarily Activated with Dendritic Cells
  International Journal of Biological Sciences. 2009  |   Pubmed ID: 19173035
• Determinants of Breast Conservation Rates: Reasons for Mastectomy at a Comprehensive Cancer Center
  The Breast Journal. Jan-Feb, 2009  |   Pubmed ID: 19141132
• Residual Disease After Re-excision Lumpectomy for Close Margins
  Journal of Surgical Oncology. Feb, 2009  |   Pubmed ID: 19065638
• Dendritic Cells Pulsed with Keyhole Limpet Hemocyanin and Cryopreserved Maintain Anti-tumor Activity in a Murine Melanoma Model
  Clinical Immunology (Orlando, Fla.). Dec, 2008  |   Pubmed ID: 18845485
• Intratumoral Dendritic Cells and Chemoradiation for the Treatment of Murine Squamous Cell Carcinoma
  Journal of Immunotherapy (Hagerstown, Md. : 1997). Nov-Dec, 2008  |   Pubmed ID: 18832999
• Axillary Staging Prior to Neoadjuvant Chemotherapy for Breast Cancer: Predictors of Recurrence
  Annals of Surgical Oncology. Nov, 2008  |   Pubmed ID: 18784961
• Do Micromorphometric Features of Metastatic Deposits Within Sentinel Nodes Predict Nonsentinel Lymph Node Involvement in Melanoma?
  Annals of Surgical Oncology. Sep, 2008  |   Pubmed ID: 18626721
• Tumor-induced Immune Suppression of in Vivo Effector T-cell Priming is Mediated by the B7-H1/PD-1 Axis and Transforming Growth Factor Beta
  Cancer Research. Jul, 2008  |   Pubmed ID: 18593946
• Phase Ib Trial Assessing Autologous, Tumor-pulsed Dendritic Cells As a Vaccine Administered with or Without IL-2 in Patients with Metastatic Melanoma
  Journal of Immunotherapy (Hagerstown, Md. : 1997). Jul-Aug, 2008  |   Pubmed ID: 18528294
• Interleukin-21 Augments the Efficacy of T-cell Therapy by Eliciting Concurrent Cellular and Humoral Responses
  Cancer Research. Jun, 2008  |   Pubmed ID: 18519706
• Mechanisms Involved in Radiation Enhancement of Intratumoral Dendritic Cell Therapy
  Journal of Immunotherapy (Hagerstown, Md. : 1997). May, 2008  |   Pubmed ID: 18391761
• Adjuvant Effect of Anti-4-1BB MAb Administration in Adoptive T Cell Therapy of Cancer
  International Journal of Biological Sciences. 2007  |   Pubmed ID: 18071585
• Generation of a Tumor-specific Systemic Response After Intratumoral Injection of IL-12 and IL-18-loaded Polylactic Acid Microspheres
  Journal of Immunotherapy (Hagerstown, Md. : 1997). Nov-Dec, 2007  |   Pubmed ID: 18049332
• Synergistic Effect of Intratumoral IL-12 and TNF-alpha Microspheres: Systemic Anti-tumor Immunity is Mediated by Both CD8+ CTL and NK Cells
  Surgery. Nov, 2007  |   Pubmed ID: 17981196
• The Registry Case Finding Engine: an Automated Tool to Identify Cancer Cases from Unstructured, Free-text Pathology Reports and Clinical Notes
  Journal of the American College of Surgeons. Nov, 2007  |   Pubmed ID: 17964445
• Phase I Study of Oxaliplatin, Full-dose Gemcitabine, and Concurrent Radiation Therapy in Pancreatic Cancer
  Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology. Oct, 2007  |   Pubmed ID: 17925553
• CCL19 and CXCL13 Synergistically Regulate Interaction Between B Cell Acute Lymphocytic Leukemia CD23+CD5+ B Cells and CD8+ T Cells
  Journal of Immunology (Baltimore, Md. : 1950). Sep, 2007  |   Pubmed ID: 17709502
• Sentinel Lymph Node Biopsy for Breast Cancer: How Many Nodes Are Enough?
  Journal of Surgical Oncology. Dec, 2007  |   Pubmed ID: 17685432
• Inguinal Node Dissection for Melanoma in the Era of Sentinel Lymph Node Biopsy
  Surgery. Jun, 2007  |   Pubmed ID: 17560249
• Sentinel Lymph Node Biopsy Performed After Neoadjuvant Chemotherapy is Accurate in Patients with Documented Node-positive Breast Cancer at Presentation
  Annals of Surgical Oncology. Oct, 2007  |   Pubmed ID: 17514407
• 4-1BB Costimulation of Effector T Cells for Adoptive Immunotherapy of Cancer: Involvement of Bcl Gene Family Members
  Journal of Immunotherapy (Hagerstown, Md. : 1997). May-Jun, 2007  |   Pubmed ID: 17457215
• Radiation-induced Apoptosis Along with Local and Systemic Cytokine Elaboration is Associated with DC Plus Radiotherapy-mediated Renal Cell Tumor Regression
  Clinical Immunology (Orlando, Fla.). Jun, 2007  |   Pubmed ID: 17449328
• What is a Sentinel Node? Re-evaluating the 10% Rule for Sentinel Lymph Node Biopsy in Melanoma
  Journal of Surgical Oncology. Jun, 2007  |   Pubmed ID: 17345610
• Improving Surgical Outcomes for Cancer in the United States
  Journal of Surgical Oncology. Feb, 2007  |   Pubmed ID: 17262738
• The Impact of Factors Beyond Breslow Depth on Predicting Sentinel Lymph Node Positivity in Melanoma
  Cancer. Jan, 2007  |   Pubmed ID: 17146784
• CXC Chemokine Ligand 13 and CC Chemokine Ligand 19 Cooperatively Render Resistance to Apoptosis in B Cell Lineage Acute and Chronic Lymphocytic Leukemia CD23+CD5+ B Cells
  Journal of Immunology (Baltimore, Md. : 1950). Nov, 2006  |   Pubmed ID: 17082584
• Changes in Surgical Management Resulting from Case Review at a Breast Cancer Multidisciplinary Tumor Board
  Cancer. Nov, 2006  |   Pubmed ID: 16998942
• Adoptive Immunotherapy of Breast Cancer with Lymph Node Cells Primed by Cryoablation of the Primary Tumor
  Cryobiology. Dec, 2006  |   Pubmed ID: 16973145
• Neoadjuvant Intratumoral Cytokine-loaded Microspheres Are Superior to Postoperative Autologous Cellular Vaccines in Generating Systemic Anti-tumor Immunity
  Journal of Surgical Oncology. Oct, 2006  |   Pubmed ID: 16967445
• Significance of Multiple Lymphatic Basin Drainage in Truncal Melanoma Patients Undergoing Sentinel Lymph Node Biopsy
  Annals of Surgical Oncology. Sep, 2006  |   Pubmed ID: 16952026
• Ex Vivo Culture with Interleukin (IL)-12 Improves CD8(+) T-cell Adoptive Immunotherapy for Murine Leukemia Independent of IL-18 or IFN-gamma but Requires Perforin
  Cancer Research. May, 2006  |   Pubmed ID: 16651448
• Does the Method of Biopsy Affect the Incidence of Sentinel Lymph Node Metastases?
  The Breast Journal. Jan-Feb, 2006  |   Pubmed ID: 16409587
• Clinicopathologic Features Associated with Having Four or More Metastatic Axillary Nodes in Breast Cancer Patients with a Positive Sentinel Lymph Node
  Annals of Surgical Oncology. Jan, 2006  |   Pubmed ID: 16378156
• Lymphatic Mapping and Sentinel Lymph Node Biopsy for Patients with Local Recurrence After Breast-conservation Therapy
  Annals of Surgical Oncology. Jan, 2006  |   Pubmed ID: 16372155
• Wide Excision Without Radiation for Desmoplastic Melanoma
  Cancer. Oct, 2005  |   Pubmed ID: 16080180
• Comprehensive Axillary Evaluation in Neoadjuvant Chemotherapy Patients with Ultrasonography and Sentinel Lymph Node Biopsy
  Annals of Surgical Oncology. Sep, 2005  |   Pubmed ID: 16079956
• Is Blue Dye Indicated for Sentinel Lymph Node Biopsy in Breast Cancer Patients with a Positive Lymphoscintigram?
  Annals of Surgical Oncology. Sep, 2005  |   Pubmed ID: 16079955
• Simultaneous Targeting of CD3 on T Cells and CD40 on B or Dendritic Cells Augments the Antitumor Reactivity of Tumor-primed Lymph Node Cells
  Journal of Immunology (Baltimore, Md. : 1950). Aug, 2005  |   Pubmed ID: 16034078
• Capecitabine and Radiation Therapy Preceded and Followed by Combination Chemotherapy in Advanced Pancreatic Cancer
  International Journal of Radiation Oncology, Biology, Physics. Dec, 2005  |   Pubmed ID: 15993549
• Predictors of Nonsentinel Lymph Node Positivity in Patients with a Positive Sentinel Node for Melanoma
  Journal of the American College of Surgeons. Jul, 2005  |   Pubmed ID: 15978442
• Immunologic Response to Cryoablation of Breast Cancer
  Breast Cancer Research and Treatment. Mar, 2005  |   Pubmed ID: 15770533
• Synergistic Effects of IL-12 and IL-18 in Skewing Tumor-reactive T-cell Responses Towards a Type 1 Pattern
  Cancer Research. Feb, 2005  |   Pubmed ID: 15705908
• Anti-CD137 Monoclonal Antibody Administration Augments the Antitumor Efficacy of Dendritic Cell-based Vaccines
  Cancer Research. Nov, 2004  |   Pubmed ID: 15548712
• An Academic Health Center Cost Analysis of Screening Mammography: Creating a Financially Viable Service
  Cancer. Sep, 2004  |   Pubmed ID: 15329914
• Mastectomy and Concomitant Sentinel Lymph Node Biopsy for Invasive Breast Cancer
  American Journal of Surgery. Jun, 2004  |   Pubmed ID: 15191855
• Efficacy of Sentinel Lymph Node Biopsy in Male Breast Cancer
  Journal of Surgical Oncology. May, 2004  |   Pubmed ID: 15112248
• Donor Cell Cycling, Trafficking, and Accumulation During Adoptive Immunotherapy for Murine Lung Metastases
  Cancer Research. Mar, 2004  |   Pubmed ID: 15026361
• Mitotic Rate and Younger Age Are Predictors of Sentinel Lymph Node Positivity: Lessons Learned from the Generation of a Probabilistic Model
  Annals of Surgical Oncology. Mar, 2004  |   Pubmed ID: 14993019
• Exaggerated Pigmented Granulomatous Reaction to the Artificial Joint Implant Mimics Metastatic Melanoma
  Diagnostic Cytopathology. Mar, 2004  |   Pubmed ID: 14986302
• Intratumoral IL-12 and TNF-alpha-loaded Microspheres Lead to Regression of Breast Cancer and Systemic Antitumor Immunity
  Annals of Surgical Oncology. Feb, 2004  |   Pubmed ID: 14761917
• Radiotherapy Potentiates the Therapeutic Efficacy of Intratumoral Dendritic Cell Administration
  Cancer Research. Dec, 2003  |   Pubmed ID: 14679011
• Clinicopathologic Features of Metastasis in Nonsentinel Lymph Nodes of Breast Carcinoma Patients
  Cancer. Dec, 2003  |   Pubmed ID: 14635063
• Sentinel Node Biopsy Prior to Neoadjuvant Chemotherapy
  American Journal of Surgery. Aug, 2003  |   Pubmed ID: 12885598
• Antitumor Reactivity of Anti-CD3/anti-CD28 Bead-activated Lymphoid Cells: Implications for Cell Therapy in a Murine Model
  Journal of Immunotherapy (Hagerstown, Md. : 1997). May-Jun, 2003  |   Pubmed ID: 12806276
• Polarization Effects of 4-1BB During CD28 Costimulation in Generating Tumor-reactive T Cells for Cancer Immunotherapy
  Cancer Research. May, 2003  |   Pubmed ID: 12750278
• Phase II Trial of Autologous Tumor Vaccination, Anti-CD3-activated Vaccine-primed Lymphocytes, and Interleukin-2 in Stage IV Renal Cell Cancer
  Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology. Mar, 2003  |   Pubmed ID: 12610189
• Generation of Vaccine-primed Lymphocytes for the Treatment of Head and Neck Cancer
  Head & Neck. Mar, 2003  |   Pubmed ID: 12599287
• Comparison of Attenuation-corrected and Non-corrected FDG-PET Images for Axillary Nodal Staging in Newly Diagnosed Breast Cancer
  Molecular Imaging and Biology : MIB : the Official Publication of the Academy of Molecular Imaging. Mar, 2002  |   Pubmed ID: 14537139
• Applications of Gene Transfer to Cellular Immunotherapy
  Surgical Oncology Clinics of North America. Jul, 2002  |   Pubmed ID: 12487059
• Melanoma and Human Leukocyte Antigen Status: the Missing Link?
  Annals of Surgical Oncology. Oct, 2002  |   Pubmed ID: 12374654
• Hepatic Artery Chemotherapy for Colorectal Liver Metastases: Technical Considerations and Review of Clinical Trials
  Surgical Oncology. Nov, 2002  |   Pubmed ID: 12356508
• Therapeutic Effects of Tumor Reactive CD4+ Cells Generated from Tumor-primed Lymph Nodes Using Anti-CD3/anti-CD28 Monoclonal Antibodies
  Journal of Immunotherapy (Hagerstown, Md. : 1997). Jul-Aug, 2002  |   Pubmed ID: 12142553
• Mammographic Screening of TRAM Flap Breast Reconstructions for Detection of Nonpalpable Recurrent Cancer
  Radiology. Jul, 2002  |   Pubmed ID: 12091685
• Resection of Liver Tumors: Technical Aspects
  Surgical Oncology. May, 2002  |   Pubmed ID: 12020669
• A Phase I Trial of Tumor Lysate-pulsed Dendritic Cells in the Treatment of Advanced Cancer
  Clinical Cancer Research : an Official Journal of the American Association for Cancer Research. Apr, 2002  |   Pubmed ID: 11948109