Alyssa H. Hasty

Department of Molecular Physiology and Biophysics, Vanderbilt University School of Medicine

Affiliated withVanderbilt University School of Medicine

Research Area

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JoVE Journal Publications

ArticleTotal : 1	Year
Publication title Cited by 75	2013

Other Publications

Article	Year
Dual regulation of mouse Delta(5)- and Delta(6)-desaturase gene expression by SREBP-1 and PPARalpha. Journal of lipid research\| PubMed ID: 11792729	2002
Absence of sterol regulatory element-binding protein-1 (SREBP-1) ameliorates fatty livers but not obesity or insulin resistance in Lep(ob)/Lep(ob) mice. The Journal of biological chemistry\| PubMed ID: 11923308	2002
Cloning and characterization of a mammalian fatty acyl-CoA elongase as a lipogenic enzyme regulated by SREBPs. Journal of lipid research\| PubMed ID: 12032166	2002
Transcriptional activities of nuclear SREBP-1a, -1c, and -2 to different target promoters of lipogenic and cholesterogenic genes. Journal of lipid research\| PubMed ID: 12177166	2002
Physiological expression of macrophage apoE in the artery wall reduces atherosclerosis in severely hyperlipidemic mice. Journal of lipid research\| PubMed ID: 12364544	2002
The recycling of apolipoprotein E in primary cultures of mouse hepatocytes. Evidence for a physiologic connection to high density lipoprotein metabolism. The Journal of biological chemistry\| PubMed ID: 12524433	2003
Hepatocyte-derived ApoE is more effective than non-hepatocyte-derived ApoE in remnant lipoprotein clearance. The Journal of biological chemistry\| PubMed ID: 12551940	2003
Cross-talk between peroxisome proliferator-activated receptor (PPAR) alpha and liver X receptor (LXR) in nutritional regulation of fatty acid metabolism. I. PPARs suppress sterol regulatory ... Molecular endocrinology (Baltimore, Md.)\| PubMed ID: 12730331	2003
Macrophage apolipoprotein A-I expression protects against atherosclerosis in ApoE-deficient mice and up-regulates ABC transporters. Molecular therapy : the journal of the American Society of Gene Therapy\| PubMed ID: 14529830	2003
The recycling of apolipoprotein E in macrophages: influence of HDL and apolipoprotein A-I. Journal of lipid research\| PubMed ID: 15805547	2005
Reduced ABCA1-mediated cholesterol efflux and accelerated atherosclerosis in apolipoprotein E-deficient mice lacking macrophage-derived ACAT1. Circulation\| PubMed ID: 15851589	2005
Recombinant leptin promotes atherosclerosis and thrombosis in apolipoprotein E-deficient mice. Arteriosclerosis, thrombosis, and vascular biology\| PubMed ID: 15947243	2005
Persistence of high density lipoprotein particles in obese mice lacking apolipoprotein A-I. Journal of lipid research\| PubMed ID: 15995171	2005
Plasma insulin levels predict atherosclerotic lesion burden in obese hyperlipidemic mice. Atherosclerosis\| PubMed ID: 16102772	2006
Plasminogen activator inhibitor-1 modulates adipocyte differentiation. American journal of physiology. Endocrinology and metabolism\| PubMed ID: 16144810	2006
Physiological relevance of apolipoprotein E recycling: studies in primary mouse hepatocytes. Metabolism: clinical and experimental\| PubMed ID: 16154429	2005
TFE3 transcriptionally activates hepatic IRS-2, participates in insulin signaling and ameliorates diabetes. Nature medicine\| PubMed ID: 16327801	2006
Intracellular trafficking of recycling apolipoprotein E in Chinese hamster ovary cells. Journal of lipid research\| PubMed ID: 16534141	2006
Quantitation and cellular localization of 11beta-HSD1 expression in murine thymus. The Journal of steroid biochemistry and molecular biology\| PubMed ID: 16621520	2006
The role of lipolysis in mediating the proinflammatory effects of very low density lipoproteins in mouse peritoneal macrophages. Journal of lipid research\| PubMed ID: 16639077	2006
Effects of vitamin E on oxidative stress and atherosclerosis in an obese hyperlipidemic mouse model. The Journal of nutritional biochemistry\| PubMed ID: 16781857	2007
Granuphilin is activated by SREBP-1c and involved in impaired insulin secretion in diabetic mice. Cell metabolism\| PubMed ID: 16890542	2006
Deletion of the gene encoding the ubiquitously expressed glucose-6-phosphatase catalytic subunit-related protein (UGRP)/glucose-6-phosphatase catalytic subunit-beta results in lowered plasma... The Journal of biological chemistry\| PubMed ID: 17023421	2006
Diet-induced increases in adiposity, but not plasma lipids, promote macrophage infiltration into white adipose tissue. Diabetes\| PubMed ID: 17327423	2007
Obesity causes very low density lipoprotein clearance defects in low-density lipoprotein receptor-deficient mice. The Journal of nutritional biochemistry\| PubMed ID: 17418556	2007
Obesity potentiates development of fatty liver and insulin resistance, but not atherosclerosis, in high-fat diet-fed agouti LDLR-deficient mice. American journal of physiology. Endocrinology and metabolism\| PubMed ID: 17566116	2007
Direct effect of cholesterol on insulin secretion: a novel mechanism for pancreatic beta-cell dysfunction. Diabetes\| PubMed ID: 17575085	2007
Fish oil increases cholesterol storage in white adipose tissue with concomitant decreases in inflammation, hepatic steatosis, and atherosclerosis in mice. The Journal of nutrition\| PubMed ID: 17585030	2007
Leptin requires canonical migratory signaling pathways for induction of monocyte and macrophage chemotaxis. American journal of physiology. Cell physiology\| PubMed ID: 17728393	2007
Carbenoxolone treatment attenuates symptoms of metabolic syndrome and atherogenesis in obese, hyperlipidemic mice. American journal of physiology. Endocrinology and metabolism\| PubMed ID: 17878220	2007
Crucial role of a long-chain fatty acid elongase, Elovl6, in obesity-induced insulin resistance. Nature medicine\| PubMed ID: 17906635	2007
Macrophage-derived apolipoprotein E ameliorates dyslipidemia and atherosclerosis in obese apolipoprotein E-deficient mice. American journal of physiology. Endocrinology and metabolism\| PubMed ID: 18029445	2008
The role of macrophage leptin receptor in aortic root lesion formation. American journal of physiology. Endocrinology and metabolism\| PubMed ID: 18182468	2008
Atherosclerotic lesion formation and triglyceride storage in obese apolipoprotein AI-deficient mice. The Journal of nutritional biochemistry\| PubMed ID: 18280133	2008
Central nervous system neuropeptide Y signaling modulates VLDL triglyceride secretion. Diabetes\| PubMed ID: 18332095	2008
Cyclin-dependent kinase inhibitor, p21WAF1/CIP1, is involved in adipocyte differentiation and hypertrophy, linking to obesity, and insulin resistance. The Journal of biological chemistry\| PubMed ID: 18445590	2008
Palmitate impairs and eicosapentaenoate restores insulin secretion through regulation of SREBP-1c in pancreatic islets. Diabetes\| PubMed ID: 18458149	2008
Macrophage infiltration into adipose tissue: initiation, propagation and remodeling. Future lipidology\| PubMed ID: 18978945	2008
Lipid and phospholipid profiling of biological samples using MALDI Fourier transform mass spectrometry. Lipids\| PubMed ID: 19005715	2009
Impact of increased adipose tissue mass on inflammation, insulin resistance, and dyslipidemia. Current diabetes reports\| PubMed ID: 19192421	2009
Loss of ovarian function in the VCD mouse-model of menopause leads to insulin resistance and a rapid progression into the metabolic syndrome. American journal of physiology. Regulatory, integrative and comparative physiology\| PubMed ID: 19439618	2009
Inhibition of long-chain acyl coenzyme A synthetases during fatty acid loading induces lipotoxicity in macrophages. Arteriosclerosis, thrombosis, and vascular biology\| PubMed ID: 19679826	2009
Defective phagocytosis of apoptotic cells by macrophages in atherosclerotic lesions of ob/ob mice and reversal by a fish oil diet. Circulation research\| PubMed ID: 19834009	2009
Dietary fish oil exerts hypolipidemic effects in lean and insulin sensitizing effects in obese LDLR-/- mice. The Journal of nutrition\| PubMed ID: 19864403	2009
The role of chemokines in recruitment of immune cells to the artery wall and adipose tissue. Vascular pharmacology\| PubMed ID: 20026286	2010
Nitro-fatty acids reduce atherosclerosis in apolipoprotein E-deficient mice. Arteriosclerosis, thrombosis, and vascular biology\| PubMed ID: 20167658	2010
Mouse models of the metabolic syndrome. Disease models & mechanisms\| PubMed ID: 20212084	2010
Adipose tissue recruitment of leukocytes. Current opinion in lipidology\| PubMed ID: 20410821	2010
Absence of macrophage inflammatory protein-1{alpha} does not impact macrophage accumulation in adipose tissue of diet-induced obese mice. American journal of physiology. Endocrinology and metabolism\| PubMed ID: 20551286	2010
The role of adipose tissue in mediating the beneficial effects of dietary fish oil. The Journal of nutritional biochemistry\| PubMed ID: 21145721	2011
Aberrant accumulation of undifferentiated myeloid cells in the adipose tissue of CCR2-deficient mice delays improvements in insulin sensitivity. Diabetes\| PubMed ID: 21926275	2011
Haematopoietic leptin receptor deficiency does not affect macrophage accumulation in adipose tissue or systemic insulin sensitivity. The Journal of endocrinology\| PubMed ID: 22194312	2012
Impact of macrophage inflammatory protein-1Î± deficiency on atherosclerotic lesion formation, hepatic steatosis, and adipose tissue expansion. PloS one\| PubMed ID: 22359597	2012
Stearic acid accumulation in macrophages induces toll-like receptor 4/2-independent inflammation leading to endoplasmic reticulum stress-mediated apoptosis. Arteriosclerosis, thrombosis, and vascular biology\| PubMed ID: 22556332	2012
Toll-like receptor 4 deficiency promotes the alternative activation of adipose tissue macrophages. Diabetes\| PubMed ID: 22751700	2012
Endoplasmic reticulum stress and hypertension - a new paradigm? The Journal of clinical investigation\| PubMed ID: 23064369	2012