Anton Wellstein

Lombardi Comprehensive Cancer Center, Georgetown University

Affiliated withGeorgetown University Georgetown University Medical Center

Research Area

Biography

I am a tenured Professor and Associate Director for Basic Research at the Lombardi Comprehensive Cancer Center, Georgetown University. I trained as an MD/PhD at the Gutenberg University in Mainz and Goethe Uiversity in Frankfurt, Germany joined NIH USA to study growth factor signaling. I was recruited to Georgetown University Medical School where I run a research lab and teach in the Medical and Graduate School. My research has focused on tumor / stromal interaction with a particular emphasis on invasion and metastasis, crosstalk with the immune system and uncovering driver pathways suitable for drug targeting.

JoVE Journal Publications

ArticleTotal : 4	Year
Publication title Cited by 112	2015
Publication title Cited by 19	2016
Publication title Cited by 24	2020
Publication title Cited by 1	2022

Other Publications

Article	Year
Distinct Response of Circulating microRNAs to the Treatment of Pancreatic Cancer Xenografts with FGFR and ALK Kinase Inhibitors. Cancers\| PubMed ID: 35326668	2022
Melanoma angiogenesis and metastasis modulated by ribozyme targeting of the secreted growth factor pleiotrophin. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 8962127	1996
Human trophoblast and choriocarcinoma expression of the growth factor pleiotrophin attributable to germ-line insertion of an endogenous retrovirus. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 8962128	1996
Structure and phylogenetic analysis of an endogenous retrovirus inserted into the human growth factor gene pleiotrophin. Journal of virology\| PubMed ID: 9621070	1998
Pleiotrophin signaling through anaplastic lymphoma kinase is rate-limiting for glioblastoma growth. The Journal of biological chemistry\| PubMed ID: 11809760	2002
Immunolocalization of an FGF-binding protein reveals a widespread expression pattern during different stages of mouse embryo development. Histochemistry and cell biology\| PubMed ID: 11819092	2002
Significance of the expression of the growth factor pleiotrophin in pancreatic cancer patients. Clinical cancer research : an official journal of the American Association for Cancer Research\| PubMed ID: 11895915	2002
Anti-apoptotic signaling of pleiotrophin through its receptor, anaplastic lymphoma kinase. The Journal of biological chemistry\| PubMed ID: 12107166	2002
Midkine binds to anaplastic lymphoma kinase (ALK) and acts as a growth factor for different cell types. The Journal of biological chemistry\| PubMed ID: 12122009	2002
A role for TGF-beta in estrogen and retinoid mediated regulation of the nuclear receptor coactivator AIB1 in MCF-7 breast cancer cells. Oncogene\| PubMed ID: 12370804	2002
Estradiol rapidly activates Akt via the ErbB2 signaling pathway. Molecular endocrinology (Baltimore, Md.)\| PubMed ID: 12554767	2003
Complex regulation of the fibroblast growth factor-binding protein in MDA- MB-468 breast cancer cells by CCAAT/enhancer-binding protein beta. Cancer research\| PubMed ID: 12670924	2003
Heregulin-beta1 regulates the estrogen receptor-alpha gene expression and activity via the ErbB2/PI 3-K/Akt pathway. Oncogene\| PubMed ID: 12687010	2003
Effect of estradiol on estrogen receptor-alpha gene expression and activity can be modulated by the ErbB2/PI 3-K/Akt pathway. Oncogene\| PubMed ID: 12970748	2003
Up-regulation of fibroblast growth factor-binding protein, by beta-catenin during colon carcinogenesis. Cancer research\| PubMed ID: 14678957	2003
Impact of the nuclear receptor coactivator AIB1 isoform AIB1-Delta3 on estrogenic ligands with different intrinsic activity. Oncogene\| PubMed ID: 14691461	2004
Systemic morphine administration suppresses genes involved in antigen presentation. Molecular pharmacology\| PubMed ID: 14742686	2004
Altered Rho GTPase signaling pathways in breast cancer cells. Breast cancer research and treatment\| PubMed ID: 14999153	2004
Overexpression of the nuclear receptor coactivator AIB1 (SRC-3) during progression of pancreatic adenocarcinoma. Clinical cancer research : an official journal of the American Association for Cancer Research\| PubMed ID: 15448000	2004
Differential regulation of a fibroblast growth factor-binding protein during skin carcinogenesis and wound healing. Neoplasia (New York, N.Y.)\| PubMed ID: 15548369	2004
The nuclear receptor coactivator AIB1 mediates insulin-like growth factor I-induced phenotypic changes in human breast cancer cells. Cancer research\| PubMed ID: 15548698	2004
Heregulin-beta1 regulates the estrogen receptor-alpha gene expression and activity via the ErbB2/PI 3-K/Akt pathway. Oncogene\| PubMed ID: 15759010	2005
Vascular leakage in chick embryos after expression of a secreted binding protein for fibroblast growth factors. Laboratory investigation; a journal of technical methods and pathology\| PubMed ID: 15806140	2005
Identification of the fibroblast growth factor (FGF)-interacting domain in a secreted FGF-binding protein by phage display. The Journal of biological chemistry\| PubMed ID: 16257968	2006
Role of fibroblast growth factor-binding protein in the pathogenesis of HIV-associated hemolytic uremic syndrome. American journal of physiology. Regulatory, integrative and comparative physiology\| PubMed ID: 16352855	2006
RNA silencing in vivo reveals role of p22phox in rat angiotensin slow pressor response. Hypertension\| PubMed ID: 16391171	2006
Expression of a fibroblast growth factor-binding protein during the development of adenocarcinoma of the pancreas and colon. Cancer research\| PubMed ID: 16424058	2006
Expression analysis of mRNA in formalin-fixed, paraffin-embedded archival tissues by mRNA in situ hybridization. Methods (San Diego, Calif.)\| PubMed ID: 16513366	2006
E6AP mediates regulated proteasomal degradation of the nuclear receptor coactivator amplified in breast cancer 1 in immortalized cells. Cancer research\| PubMed ID: 16951183	2006
The angiogenic switch molecule, secreted FGF-binding protein, an indicator of early stages of pancreatic and colorectal adenocarcinoma. Seminars in oncology\| PubMed ID: 17178288	2006
Effects on neurite outgrowth and cell survival of a secreted fibroblast growth factor binding protein upregulated during spinal cord injury. American journal of physiology. Regulatory, integrative and comparative physiology\| PubMed ID: 17553847	2007
Epidermal growth factor receptor tyrosine phosphorylation and signaling controlled by a nuclear receptor coactivator, amplified in breast cancer 1. Cancer research\| PubMed ID: 17671194	2007
The nuclear receptor coactivator amplified in breast cancer-1 is required for Neu (ErbB2/HER2) activation, signaling, and mammary tumorigenesis in mice. Cancer research\| PubMed ID: 18483252	2008
Effect of FGF-binding protein 3 on vascular permeability. The Journal of biological chemistry\| PubMed ID: 18669637	2008
Chronic antidepressant treatments increase basic fibroblast growth factor and fibroblast growth factor-binding protein in neurons. Neuropharmacology\| PubMed ID: 18682257	2008
Tyrosine phosphorylation of the nuclear receptor coactivator AIB1/SRC-3 is enhanced by Abl kinase and is required for its activity in cancer cells. Molecular and cellular biology\| PubMed ID: 18765637	2008
The role and regulation of the nuclear receptor co-activator AIB1 in breast cancer. Breast cancer research and treatment\| PubMed ID: 19418218	2009
A distinct role for secreted fibroblast growth factor-binding proteins in development. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 19433791	2009
Tumor angiogenesis: initiation and targeting - therapeutic targeting of an FGF-binding protein, an angiogenic switch molecule, and indicator of early stages of gastrointestinal adenocarcinom... Cancer research and treatment : official journal of Korean Cancer Association\| PubMed ID: 19771241	2006
Omics-based molecular target and biomarker identification. Methods in molecular biology (Clifton, N.J.)\| PubMed ID: 21370102	2011
Hunting ALK to feed targeted cancer therapy. Nature medicine\| PubMed ID: 21383740	2011
Role of the nuclear receptor coactivator AIB1-Delta4 splice variant in the control of gene transcription. The Journal of biological chemistry\| PubMed ID: 21636853	2011
Proteomic analysis of pathways involved in estrogen-induced growth and apoptosis of breast cancer cells. PloS one\| PubMed ID: 21738574	2011
Tissue and serum microRNAs in the Kras(G12D) transgenic animal model and in patients with pancreatic cancer. PloS one\| PubMed ID: 21738581	2011
Superoxide modulates myogenic contractions of mouse afferent arterioles. Hypertension\| PubMed ID: 21859962	2011
Impact of fibroblast growth factor-binding protein-1 expression on angiogenesis and wound healing. The American journal of pathology\| PubMed ID: 21945411	2011
p47(phox) is required for afferent arteriolar contractile responses to angiotensin II and perfusion pressure in mice. Hypertension\| PubMed ID: 22184329	2012
Role of the nuclear receptor coactivator AIB1/SRC-3 in angiogenesis and wound healing. The American journal of pathology\| PubMed ID: 22342158	2012
Effects of the antioxidant drug tempol on renal oxygenation in mice with reduced renal mass. American journal of physiology. Renal physiology\| PubMed ID: 22492941	2012
Pleiotrophin (PTN) expression and function and in the mouse mammary gland and mammary epithelial cells. PloS one\| PubMed ID: 23077670	2012
The mitochondrial citrate transporter, CIC, is essential for mitochondrial homeostasis. Oncotarget\| PubMed ID: 23100451	2012
Dietary downregulation of mutant p53 levels via glucose restriction: mechanisms and implications for tumor therapy. Cell cycle (Georgetown, Tex.)\| PubMed ID: 23151455	2012
ALK receptor activation, ligands and therapeutic targeting in glioblastoma and in other cancers. Frontiers in oncology\| PubMed ID: 23267434	2012
Transcriptional repression of AIB1 by FoxG1 leads to apoptosis in breast cancer cells. Molecular endocrinology (Baltimore, Md.)\| PubMed ID: 23660594	2013
Late failure of a split-thickness skin graft in the setting of homozygous factor V Leiden mutation: a case report and correlative animal model from the Wound Etiology and Healing (WE-HEAL) s... International wound journal\| PubMed ID: 24028566	2013
Utility of a human-mouse xenograft model and in vivo near-infrared fluorescent imaging for studying wound healing. International wound journal\| PubMed ID: 24373153	2015
Recurrence of early stage colon cancer predicted by expression pattern of circulating microRNAs. PloS one\| PubMed ID: 24400111	2014
Regulation of HER2 oncogene transcription by a multifunctional coactivator/corepressor complex. Molecular endocrinology (Baltimore, Md.)\| PubMed ID: 24678732	2014
SLC25A1, or CIC, is a novel transcriptional target of mutant p53 and a negative tumor prognostic marker. Oncotarget\| PubMed ID: 24681808	2014
Downstream of mutant KRAS, the transcription regulator YAP is essential for neoplastic progression to pancreatic ductal adenocarcinoma. Science signaling\| PubMed ID: 24803537	2014
Conditionally reprogrammed normal and transformed mouse mammary epithelial cells display a progenitor-cell-like phenotype. PloS one\| PubMed ID: 24831228	2014
Expression of a Secreted Fibroblast Growth Factor Binding Protein-1 (FGFBP1) in Angioproliferative Kaposi Sarcoma. Journal of AIDS & clinical research\| PubMed ID: 25429350	2014
Thromboxane prostanoid receptors enhance contractions, endothelin-1, and oxidative stress in microvessels from mice with chronic kidney disease. Hypertension\| PubMed ID: 25733239	2015
Cell growth density modulates cancer cell vascular invasion via Hippo pathway activity and CXCR2 signaling. Oncogene\| PubMed ID: 25772246	2015
Distinct serum metabolomics profiles associated with malignant progression in the KrasG12D mouse model of pancreatic ductal adenocarcinoma. BMC genomics\| PubMed ID: 25923219	2015
Circulating DNA and Micro-RNA in Patients with Pancreatic Cancer. Pancreatic disorders & therapy\| PubMed ID: 26161297	2015
Cell density regulates cancer metastasis via the Hippo pathway. Future oncology (London, England)\| PubMed ID: 26561730	2015
Increased Pleiotrophin Concentrations in Papillary Thyroid Cancer. PloS one\| PubMed ID: 26914549	2016
Circulating microRNA profile predicts disease progression in patients receiving second-line treatment of lapatinib and capecitabine for metastatic pancreatic cancer. Oncology letters\| PubMed ID: 26998056	2016
Differential effects of superoxide and hydrogen peroxide on myogenic signaling, membrane potential, and contractions of mouse renal afferent arterioles. American journal of physiology. Renal physiology\| PubMed ID: 27053691	2016
Midkine and Pleiotrophin Concentrations in Amniotic Fluid in Healthy and Complicated Pregnancies. PloS one\| PubMed ID: 27089523	2016
Circulating biomarkers to monitor cancer progression and treatment. Computational and structural biotechnology journal\| PubMed ID: 27358717	2016
Keratin-associated protein 5-5 controls cytoskeletal function and cancer cell vascular invasion. Oncogene\| PubMed ID: 27375028	2017
Superoxide and hydrogen peroxide counterregulate myogenic contractions in renal afferent arterioles from a mouse model of chronic kidney disease. Kidney international\| PubMed ID: 28396118	2017
Conditional cell reprogramming involves non-canonical β-catenin activation and mTOR-mediated inactivation of Akt. PloS one\| PubMed ID: 28700668	2017
The Role of Fibroblast Growth Factor-Binding Protein 1 in Skin Carcinogenesis and Inflammation. The Journal of investigative dermatology\| PubMed ID: 28864076	2018
Midkine and pleiotrophin concentrations in needle biopsies of breast and lung masses. Cancer biomarkers : section A of Disease markers\| PubMed ID: 28946562	2017
Circulating microRNAs in patients with hormone receptor-positive, metastatic breast cancer treated with dovitinib. Clinical and translational medicine\| PubMed ID: 28980224	2017
Circulating cell-free DNA mutation patterns in early and late stage colon and pancreatic cancer. Cancer genetics\| PubMed ID: 29153095	2017
Blood Pressure Control by a Secreted FGFBP1 (Fibroblast Growth Factor-Binding Protein). Hypertension (Dallas, Tex. : 1979)\| PubMed ID: 29158353	2018
NRF2 prevents hypertension, increased ADMA, microvascular oxidative stress, and dysfunction in mice with two weeks of ANG II infusion. American journal of physiology. Regulatory, integrative and comparative physiology\| PubMed ID: 29167164	2018
The PPARγ agonist efatutazone delays invasive progression and induces differentiation of ductal carcinoma in situ. Breast cancer research and treatment\| PubMed ID: 29350308	2018
Left Ventricular Dysfunction in Cancer Treatment: Is it Relevant? JACC. Heart failure\| PubMed ID: 29413379	2018
Fenofibrate improves vascular endothelial function and contractility in diabetic mice. Redox biology\| PubMed ID: 30296701	2019
High Salt Enhances Reactive Oxygen Species and Angiotensin II Contractions of Glomerular Afferent Arterioles From Mice With Reduced Renal Mass. Hypertension (Dallas, Tex. : 1979)\| PubMed ID: 30354808	2018
Fibroblast Growth Factor Binding Protein 3 (FGFBP3) impacts carbohydrate and lipid metabolism. Scientific reports\| PubMed ID: 30374109	2018
Reprint of: Circulating cell-free DNA mutation patterns in early and late stage colon and pancreatic cancer. Cancer genetics\| PubMed ID: 30447903	2018
Single-Molecule Real-Time (SMRT) Full-Length RNA-Sequencing Reveals Novel and Distinct mRNA Isoforms in Human Bone Marrow Cell Subpopulations. Genes\| PubMed ID: 30934798	2019
Short- and Long-Term Effects of CDK4/6 Inhibition on Early-Stage Breast Cancer. Molecular cancer therapeutics\| PubMed ID: 31451564	2019
Loss of ANCO1 repression at AIB1/YAP targets drives breast cancer progression. EMBO reports\| PubMed ID: 31788936	2020
Cadherin 11 Promotes Immunosuppression and Extracellular Matrix Deposition to Support Growth of Pancreatic Tumors and Resistance to Gemcitabine in Mice. Gastroenterology\| PubMed ID: 33307028	2021
An AIB1 Isoform Alters Enhancer Access and Enables Progression of Early-Stage Triple-Negative Breast Cancer. Cancer research\| PubMed ID: 34135000	2021