Anumantha G. Kanthasamy Biomedical Sciences & Iowa Center for Advanced Neurotoxicology Iowa State University Biography Publications Institution JoVE Articles Anumantha G. Kanthasamy has not added a biography. If you are Anumantha G. Kanthasamy and would like to personalize this page please email our Author Liaison for assistance. Publications Molecular Mechanisms Underlying Protective Effects of Quercetin Against Mitochondrial Dysfunction and Progressive Dopaminergic Neurodegeneration in Cell Culture and MitoPark Transgenic Mouse Models of Parkinson's Disease Journal of Neurochemistry. Apr, 2017 | Pubmed ID: 28376279 Mito-Apocynin Prevents Mitochondrial Dysfunction, Microglial Activation, Oxidative Damage, and Progressive Neurodegeneration in MitoPark Transgenic Mice Antioxidants & Redox Signaling. Apr, 2017 | Pubmed ID: 28375739 Role of Protein Kinase C in Metabolic Regulation of the Cardiac Na(+) Channel Heart Rhythm. Mar, 2017 | Pubmed ID: 27989687 P73 Gene in Dopaminergic Neurons is Highly Susceptible to Manganese Neurotoxicity Neurotoxicology. Mar, 2017 | Pubmed ID: 27107493 Role of Neurotoxicants and Traumatic Brain Injury in α-synuclein Protein Misfolding and Aggregation Brain Research Bulletin. Dec, 2016 | Pubmed ID: 27993598 Neuronal Protection Against Oxidative Insult by Polyanhydride Nanoparticle-based Mitochondria-targeted Antioxidant Therapy Nanomedicine : Nanotechnology, Biology, and Medicine. Oct, 2016 | Pubmed ID: 27771430 Prokineticin-2 Upregulation During Neuronal Injury Mediates a Compensatory Protective Response Against Dopaminergic Neuronal Degeneration Nature Communications. Oct, 2016 | Pubmed ID: 27703142 Differential Arousal Regulation by Prokineticin 2 Signaling in the Nocturnal Mouse and the Diurnal Monkey Molecular Brain. Aug, 2016 | Pubmed ID: 27535380 Hepcidin Plays a Key Role in 6-OHDA Induced Iron Overload and Apoptotic Cell Death in a Cell Culture Model of Parkinson's Disease Parkinson's Disease. 2016 | Pubmed ID: 27298749 Protein Kinase Cδ Upregulation in Microglia Drives Neuroinflammatory Responses and Dopaminergic Neurodegeneration in Experimental Models of Parkinson's Disease Neurobiology of Disease. Sep, 2016 | Pubmed ID: 27151770 Mitoapocynin Treatment Protects Against Neuroinflammation and Dopaminergic Neurodegeneration in a Preclinical Animal Model of Parkinson's Disease Journal of Neuroimmune Pharmacology : the Official Journal of the Society on NeuroImmune Pharmacology. Jun, 2016 | Pubmed ID: 26838361 Guidelines for the Use and Interpretation of Assays for Monitoring Autophagy (3rd Edition) Autophagy. Jan, 2016 | Pubmed ID: 26799652 Alterations in Mitochondrial Dynamics Induced by Tebufenpyrad and Pyridaben in a Dopaminergic Neuronal Cell Culture Model Neurotoxicology. Mar, 2016 | Pubmed ID: 26141520 EGCG Protects Against 6-OHDA-Induced Neurotoxicity in a Cell Culture Model Parkinson's Disease. 2015 | Pubmed ID: 26770869 Nano-enabled Delivery of Diverse Payloads Across Complex Biological Barriers Journal of Controlled Release : Official Journal of the Controlled Release Society. Dec, 2015 | Pubmed ID: 26315817 Molecular Cloning, Epigenetic Regulation, and Functional Characterization of Prkd1 Gene Promoter in Dopaminergic Cell Culture Models of Parkinson's Disease Journal of Neurochemistry. Oct, 2015 | Pubmed ID: 26230914 Fyn Kinase Regulates Microglial Neuroinflammatory Responses in Cell Culture and Animal Models of Parkinson's Disease The Journal of Neuroscience : the Official Journal of the Society for Neuroscience. Jul, 2015 | Pubmed ID: 26157004 Nanoneuromedicines for Degenerative, Inflammatory, and Infectious Nervous System Diseases Nanomedicine : Nanotechnology, Biology, and Medicine. Apr, 2015 | Pubmed ID: 25645958 α-Synuclein Protects Against Manganese Neurotoxic Insult During the Early Stages of Exposure in a Dopaminergic Cell Model of Parkinson's Disease Toxicological Sciences : an Official Journal of the Society of Toxicology. Feb, 2015 | Pubmed ID: 25416158 In Vitro Amplification of Scrapie and Chronic Wasting Disease PrP(res) Using Baculovirus-expressed Recombinant PrP As Substrate Prion. 2014 | Pubmed ID: 25495764 Histone Hyperacetylation Up-regulates Protein Kinase Cδ in Dopaminergic Neurons to Induce Cell Death: Relevance to Epigenetic Mechanisms of Neurodegeneration in Parkinson Disease The Journal of Biological Chemistry. Dec, 2014 | Pubmed ID: 25342743 A Novel Mitochondrially-targeted Apocynin Derivative Prevents Hyposmia and Loss of Motor Function in the Leucine-rich Repeat Kinase 2 (LRRK2(R1441G)) Transgenic Mouse Model of Parkinson's Disease Neuroscience Letters. Nov, 2014 | Pubmed ID: 25263790 Protein Kinase D1 (PKD1) Phosphorylation Promotes Dopaminergic Neuronal Survival During 6-OHDA-induced Oxidative Stress PloS One. 2014 | Pubmed ID: 24806360 Role of Proteolytic Activation of Protein Kinase Cδ in the Pathogenesis of Prion Disease Prion. Jan-Feb, 2014 | Pubmed ID: 24576946 Vanadium Exposure Induces Olfactory Dysfunction in an Animal Model of Metal Neurotoxicity Neurotoxicology. Jul, 2014 | Pubmed ID: 24362016 Mitochondria-targeted Antioxidants for Treatment of Parkinson's Disease: Preclinical and Clinical Outcomes Biochimica Et Biophysica Acta. Aug, 2014 | Pubmed ID: 24060637 The Peptidyl-prolyl Isomerase Pin1 Up-regulation and Proapoptotic Function in Dopaminergic Neurons: Relevance to the Pathogenesis of Parkinson Disease The Journal of Biological Chemistry. Jul, 2013 | Pubmed ID: 23754278 Diapocynin Prevents Early Parkinson's Disease Symptoms in the Leucine-rich Repeat Kinase 2 (LRRK2R¹⁴⁴¹G) Transgenic Mouse Neuroscience Letters. Aug, 2013 | Pubmed ID: 23721786 Anti-inflammatory and Neuroprotective Effects of an Orally Active Apocynin Derivative in Pre-clinical Models of Parkinson's Disease Journal of Neuroinflammation. Oct, 2012 | Pubmed ID: 23092448 Guidelines for the Use and Interpretation of Assays for Monitoring Autophagy Autophagy. Apr, 2012 | Pubmed ID: 22966490 Alterations in Bioenergetic Function Induced by Parkinson's Disease Mimetic Compounds: Lack of Correlation with Superoxide Generation Journal of Neurochemistry. Sep, 2012 | Pubmed ID: 22708893 Proteolytic Activation of Proapoptotic Kinase Protein Kinase Cδ by Tumor Necrosis Factor α Death Receptor Signaling in Dopaminergic Neurons During Neuroinflammation Journal of Neuroinflammation. Apr, 2012 | Pubmed ID: 22540228 Role of Oxidative Stress in Methamphetamine-induced Dopaminergic Toxicity Mediated by Protein Kinase Cδ Behavioural Brain Research. Jun, 2012 | Pubmed ID: 22512859 Neuroprotective Effect of Resveratrol Against Methamphetamine-induced Dopaminergic Apoptotic Cell Death in a Cell Culture Model of Neurotoxicity Current Neuropharmacology. Mar, 2011 | Pubmed ID: 21886561 Infectious Prion Protein Alters Manganese Transport and Neurotoxicity in a Cell Culture Model of Prion Disease Neurotoxicology. Oct, 2011 | Pubmed ID: 21871919 Manganese Nanoparticle Activates Mitochondrial Dependent Apoptotic Signaling and Autophagy in Dopaminergic Neuronal Cells Toxicology and Applied Pharmacology. Nov, 2011 | Pubmed ID: 21856324 Measurement of Proteasomal Dysfunction in Cell Models of Dopaminergic Degeneration Methods in Molecular Biology (Clifton, N.J.). 2011 | Pubmed ID: 21815074 Environmental Neurotoxic Pesticide Dieldrin Activates a Non Receptor Tyrosine Kinase to Promote PKCδ-mediated Dopaminergic Apoptosis in a Dopaminergic Neuronal Cell Model Neurotoxicology. Oct, 2011 | Pubmed ID: 21801747 Protein Kinase D1 (PKD1) Activation Mediates a Compensatory Protective Response During Early Stages of Oxidative Stress-induced Neuronal Degeneration Molecular Neurodegeneration. Jun, 2011 | Pubmed ID: 21696630 PKCδ Inhibition Enhances Tyrosine Hydroxylase Phosphorylation in Mice After Methamphetamine Treatment Neurochemistry International. Aug, 2011 | Pubmed ID: 21672585 Transcriptional Regulation of Pro-apoptotic Protein Kinase Cdelta: Implications for Oxidative Stress-induced Neuronal Cell Death The Journal of Biological Chemistry. Jun, 2011 | Pubmed ID: 21467032 Phytic Acid Protects Against 6-Hydroxydopamine-Induced Dopaminergic Neuron Apoptosis in Normal and Iron Excess Conditions in a Cell Culture Model Parkinson's Disease. Feb, 2011 | Pubmed ID: 21331377 α-Synuclein Negatively Regulates Protein Kinase Cδ Expression to Suppress Apoptosis in Dopaminergic Neurons by Reducing P300 Histone Acetyltransferase Activity The Journal of Neuroscience : the Official Journal of the Society for Neuroscience. Feb, 2011 | Pubmed ID: 21307242 A Simple Magnetic Separation Method for High-yield Isolation of Pure Primary Microglia Journal of Neuroscience Methods. Jan, 2011 | Pubmed ID: 21074565 Manganese Upregulates Cellular Prion Protein and Contributes to Altered Stabilization and Proteolysis: Relevance to Role of Metals in Pathogenesis of Prion Disease Toxicological Sciences : an Official Journal of the Society of Toxicology. Jun, 2010 | Pubmed ID: 20176619 Curcumin Enhances Paraquat-induced Apoptosis of N27 Mesencephalic Cells Via the Generation of Reactive Oxygen Species Neurotoxicology. Nov, 2009 | Pubmed ID: 19660496 Vanadium Induces Dopaminergic Neurotoxicity Via Protein Kinase Cdelta Dependent Oxidative Signaling Mechanisms: Relevance to Etiopathogenesis of Parkinson's Disease Toxicology and Applied Pharmacology. Oct, 2009 | Pubmed ID: 19646462 Mitochondrial Accumulation of Polyubiquitinated Proteins and Differential Regulation of Apoptosis by Polyubiquitination Sites Lys-48 and -63 Journal of Cellular and Molecular Medicine. Aug, 2009 | Pubmed ID: 19432818 Environmental Neurotoxin Dieldrin Induces Apoptosis Via Caspase-3-dependent Proteolytic Activation of Protein Kinase C Delta (PKCdelta): Implications for Neurodegeneration in Parkinson's Disease Molecular Brain. 2008 | Pubmed ID: 18945348 Opposing Roles of Prion Protein in Oxidative Stress- and ER Stress-induced Apoptotic Signaling Free Radical Biology & Medicine. Dec, 2008 | Pubmed ID: 18835352 Proteasome Inhibitor-induced Apoptosis is Mediated by Positive Feedback Amplification of PKCdelta Proteolytic Activation and Mitochondrial Translocation Journal of Cellular and Molecular Medicine. Dec, 2008 | Pubmed ID: 18298651 Neuroprotective Effect of the Natural Iron Chelator, Phytic Acid in a Cell Culture Model of Parkinson's Disease Toxicology. Mar, 2008 | Pubmed ID: 18255213 Pharmacological Inhibition of Neuronal NADPH Oxidase Protects Against 1-methyl-4-phenylpyridinium (MPP+)-induced Oxidative Stress and Apoptosis in Mesencephalic Dopaminergic Neuronal Cells Neurotoxicology. Sep, 2007 | Pubmed ID: 17904225 Neuroprotective Effect of Protein Kinase C Delta Inhibitor Rottlerin in Cell Culture and Animal Models of Parkinson's Disease The Journal of Pharmacology and Experimental Therapeutics. Sep, 2007 | Pubmed ID: 17565007 Environmental Neurotoxic Chemicals-induced Ubiquitin Proteasome System Dysfunction in the Pathogenesis and Progression of Parkinson's Disease Pharmacology & Therapeutics. Jun, 2007 | Pubmed ID: 17521740 Normal Cellular Prion Protein Protects Against Manganese-induced Oxidative Stress and Apoptotic Cell Death Toxicological Sciences : an Official Journal of the Society of Toxicology. Aug, 2007 | Pubmed ID: 17483122 Microarray Analysis of Oxidative Stress Regulated Genes in Mesencephalic Dopaminergic Neuronal Cells: Relevance to Oxidative Damage in Parkinson's Disease Neurochemistry International. May, 2007 | Pubmed ID: 17397968 A Novel Peptide Inhibitor Targeted to Caspase-3 Cleavage Site of a Proapoptotic Kinase Protein Kinase C Delta (PKCdelta) Protects Against Dopaminergic Neuronal Degeneration in Parkinson's Disease Models Free Radical Biology & Medicine. Nov, 2006 | Pubmed ID: 17045926 Proteasome Inhibitor MG-132 Induces Dopaminergic Degeneration in Cell Culture and Animal Models Neurotoxicology. Sep, 2006 | Pubmed ID: 16870259 Interaction of Metals with Prion Protein: Possible Role of Divalent Cations in the Pathogenesis of Prion Diseases Neurotoxicology. Sep, 2006 | Pubmed ID: 16860868 Dieldrin-induced Neurotoxicity: Relevance to Parkinson's Disease Pathogenesis Neurotoxicology. Aug, 2005 | Pubmed ID: 16112328 Dieldrin Induces Ubiquitin-proteasome Dysfunction in Alpha-synuclein Overexpressing Dopaminergic Neuronal Cells and Enhances Susceptibility to Apoptotic Cell Death The Journal of Pharmacology and Experimental Therapeutics. Oct, 2005 | Pubmed ID: 15987830 Wild-type Alpha-synuclein Interacts with Pro-apoptotic Proteins PKCdelta and BAD to Protect Dopaminergic Neuronal Cells Against MPP+-induced Apoptotic Cell Death Brain Research. Molecular Brain Research. Sep, 2005 | Pubmed ID: 15978696 Tyrosine Phosphorylation Regulates the Proteolytic Activation of Protein Kinase Cdelta in Dopaminergic Neuronal Cells The Journal of Biological Chemistry. Aug, 2005 | Pubmed ID: 15961393 Blood Lipid and Oxidative Stress Responses to Soy Protein with Isoflavones and Phytic Acid in Postmenopausal Women The American Journal of Clinical Nutrition. Mar, 2005 | Pubmed ID: 15755827 Protein Kinase Cdelta is a Key Downstream Mediator of Manganese-induced Apoptosis in Dopaminergic Neuronal Cells The Journal of Pharmacology and Experimental Therapeutics. Apr, 2005 | Pubmed ID: 15608081 Activation of Protein Kinase C Delta by Proteolytic Cleavage Contributes to Manganese-induced Apoptosis in Dopaminergic Cells: Protective Role of Bcl-2 Biochemical Pharmacology. Jan, 2005 | Pubmed ID: 15588722 Dieldrin Promotes Proteolytic Cleavage of Poly(ADP-ribose) Polymerase and Apoptosis in Dopaminergic Cells: Protective Effect of Mitochondrial Anti-apoptotic Protein Bcl-2 Neurotoxicology. Jun, 2004 | Pubmed ID: 15183012 Suppression of Caspase-3-dependent Proteolytic Activation of Protein Kinase C Delta by Small Interfering RNA Prevents MPP+-induced Dopaminergic Degeneration Molecular and Cellular Neurosciences. Mar, 2004 | Pubmed ID: 15033169 Role of Proteolytic Activation of Protein Kinase Cdelta in Oxidative Stress-induced Apoptosis Antioxidants & Redox Signaling. Oct, 2003 | Pubmed ID: 14580317 Caspase-3 Dependent Proteolytic Activation of Protein Kinase C Delta Mediates and Regulates 1-methyl-4-phenylpyridinium (MPP+)-induced Apoptotic Cell Death in Dopaminergic Cells: Relevance to Oxidative Stress in Dopaminergic Degeneration The European Journal of Neuroscience. Sep, 2003 | Pubmed ID: 14511319 5-hydroxytryptamine 1A Receptor Activation Protects Against N-methyl-D-aspartate-induced Apoptotic Cell Death in Striatal and Mesencephalic Cultures The Journal of Pharmacology and Experimental Therapeutics. Mar, 2003 | Pubmed ID: 12604665 Oxidative Stress and Mitochondrial-mediated Apoptosis in Dopaminergic Cells Exposed to Methylcyclopentadienyl Manganese Tricarbonyl The Journal of Pharmacology and Experimental Therapeutics. Jul, 2002 | Pubmed ID: 12065696 Caspase-3-dependent Proteolytic Cleavage of Protein Kinase Cdelta is Essential for Oxidative Stress-mediated Dopaminergic Cell Death After Exposure to Methylcyclopentadienyl Manganese Tricarbonyl The Journal of Neuroscience : the Official Journal of the Society for Neuroscience. Mar, 2002 | Pubmed ID: 11880503 Antimyoclonic and Neuroprotective Effects of Lamotrigine in an Animal Model of Cardiac Arrest Restorative Neurology and Neuroscience. 1999 | Pubmed ID: 12671243 בידוד ראפיד ומעודן CD11b מגנטי של Microglia הראשי עם טוהר משופר רבגוני Souvarish Sarkar*1, Emir Malovic*1, Brandon Plante1, Gary Zenitsky1, Huajun Jin1, Vellareddy Anantharam1, Arthi Kanthasamy1, Anumantha G. Kanthasamy1 1Biomedical Sciences & Iowa Center for Advanced Neurotoxicology, Iowa State University JoVE 55364 Neuroscience
בידוד ראפיד ומעודן CD11b מגנטי של Microglia הראשי עם טוהר משופר רבגוני Souvarish Sarkar*1, Emir Malovic*1, Brandon Plante1, Gary Zenitsky1, Huajun Jin1, Vellareddy Anantharam1, Arthi Kanthasamy1, Anumantha G. Kanthasamy1 1Biomedical Sciences & Iowa Center for Advanced Neurotoxicology, Iowa State University JoVE 55364 Neuroscience