Arthi Kanthasamy

Biomedical Sciences & Iowa Center for Advanced Neurotoxicology, Iowa State University

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JoVE Journal Publications

ArticleTotal : 1	Year
Publication title Cited by 22	2017

Other Publications

Article	Year
Caspase-3 dependent proteolytic activation of protein kinase C delta mediates and regulates 1-methyl-4-phenylpyridinium (MPP+)-induced apoptotic cell death in dopaminergic cells: relevance t... The European journal of neuroscience\| PubMed ID: 14511319	2003
Role of proteolytic activation of protein kinase Cdelta in oxidative stress-induced apoptosis. Antioxidants & redox signaling\| PubMed ID: 14580317	2003
Dieldrin promotes proteolytic cleavage of poly(ADP-ribose) polymerase and apoptosis in dopaminergic cells: protective effect of mitochondrial anti-apoptotic protein Bcl-2. Neurotoxicology\| PubMed ID: 15183012	2004
Activation of protein kinase C delta by proteolytic cleavage contributes to manganese-induced apoptosis in dopaminergic cells: protective role of Bcl-2. Biochemical pharmacology\| PubMed ID: 15588722	2005
Protein kinase Cdelta is a key downstream mediator of manganese-induced apoptosis in dopaminergic neuronal cells. The Journal of pharmacology and experimental therapeutics\| PubMed ID: 15608081	2005
Tyrosine phosphorylation regulates the proteolytic activation of protein kinase Cdelta in dopaminergic neuronal cells. The Journal of biological chemistry\| PubMed ID: 15961393	2005
Wild-type alpha-synuclein interacts with pro-apoptotic proteins PKCdelta and BAD to protect dopaminergic neuronal cells against MPP+-induced apoptotic cell death. Brain research. Molecular brain research\| PubMed ID: 15978696	2005
Dieldrin induces ubiquitin-proteasome dysfunction in alpha-synuclein overexpressing dopaminergic neuronal cells and enhances susceptibility to apoptotic cell death. The Journal of pharmacology and experimental therapeutics\| PubMed ID: 15987830	2005
Dieldrin-induced neurotoxicity: relevance to Parkinson's disease pathogenesis. Neurotoxicology\| PubMed ID: 16112328	2005
Interaction of metals with prion protein: possible role of divalent cations in the pathogenesis of prion diseases. Neurotoxicology\| PubMed ID: 16860868	2006
Proteasome inhibitor MG-132 induces dopaminergic degeneration in cell culture and animal models. Neurotoxicology\| PubMed ID: 16870259	2006
A novel peptide inhibitor targeted to caspase-3 cleavage site of a proapoptotic kinase protein kinase C delta (PKCdelta) protects against dopaminergic neuronal degeneration in Parkinson's di... Free radical biology & medicine\| PubMed ID: 17045926	2006
Methamphetamine induces autophagy and apoptosis in a mesencephalic dopaminergic neuronal culture model: role of cathepsin-D in methamphetamine-induced apoptotic cell death. Annals of the New York Academy of Sciences\| PubMed ID: 17105920	2006
Microarray analysis of oxidative stress regulated genes in mesencephalic dopaminergic neuronal cells: relevance to oxidative damage in Parkinson's disease. Neurochemistry international\| PubMed ID: 17397968	2007
Normal cellular prion protein protects against manganese-induced oxidative stress and apoptotic cell death. Toxicological sciences : an official journal of the Society of Toxicology\| PubMed ID: 17483122	2007
Protein kinase C delta negatively regulates tyrosine hydroxylase activity and dopamine synthesis by enhancing protein phosphatase-2A activity in dopaminergic neurons. The Journal of neuroscience : the official journal of the Society for Neuroscience\| PubMed ID: 17507557	2007
Environmental neurotoxic chemicals-induced ubiquitin proteasome system dysfunction in the pathogenesis and progression of Parkinson's disease. Pharmacology & therapeutics\| PubMed ID: 17521740	2007
Neuroprotective effect of protein kinase C delta inhibitor rottlerin in cell culture and animal models of Parkinson's disease. The Journal of pharmacology and experimental therapeutics\| PubMed ID: 17565007	2007
Pharmacological inhibition of neuronal NADPH oxidase protects against 1-methyl-4-phenylpyridinium (MPP+)-induced oxidative stress and apoptosis in mesencephalic dopaminergic neuronal cells. Neurotoxicology\| PubMed ID: 17904225	2007
Proteasome inhibitor-induced apoptosis is mediated by positive feedback amplification of PKCdelta proteolytic activation and mitochondrial translocation. Journal of cellular and molecular medicine\| PubMed ID: 18298651	2008
Opposing roles of prion protein in oxidative stress- and ER stress-induced apoptotic signaling. Free radical biology & medicine\| PubMed ID: 18835352	2008
Environmental neurotoxin dieldrin induces apoptosis via caspase-3-dependent proteolytic activation of protein kinase C delta (PKCdelta): Implications for neurodegeneration in Parkinson's dis... Molecular brain\| PubMed ID: 18945348	2008
Chronic low-dose oxidative stress induces caspase-3-dependent PKCdelta proteolytic activation and apoptosis in a cell culture model of dopaminergic neurodegeneration. Annals of the New York Academy of Sciences\| PubMed ID: 18991865	2008
Mitochondrial accumulation of polyubiquitinated proteins and differential regulation of apoptosis by polyubiquitination sites Lys-48 and -63. Journal of cellular and molecular medicine\| PubMed ID: 19432818	2009
Vanadium induces dopaminergic neurotoxicity via protein kinase Cdelta dependent oxidative signaling mechanisms: relevance to etiopathogenesis of Parkinson's disease. Toxicology and applied pharmacology\| PubMed ID: 19646462	2009
Novel cell death signaling pathways in neurotoxicity models of dopaminergic degeneration: relevance to oxidative stress and neuroinflammation in Parkinson's disease. Neurotoxicology\| PubMed ID: 20005250	2010
Manganese upregulates cellular prion protein and contributes to altered stabilization and proteolysis: relevance to role of metals in pathogenesis of prion disease. Toxicological sciences : an official journal of the Society of Toxicology\| PubMed ID: 20176619	2010
Neuroprotection by a mitochondria-targeted drug in a Parkinson's disease model. Free radical biology & medicine\| PubMed ID: 20828611	2010
A simple magnetic separation method for high-yield isolation of pure primary microglia. Journal of neuroscience methods\| PubMed ID: 21074565	2011
Î±-Synuclein negatively regulates protein kinase CÎ´ expression to suppress apoptosis in dopaminergic neurons by reducing p300 histone acetyltransferase activity. The Journal of neuroscience : the official journal of the Society for Neuroscience\| PubMed ID: 21307242	2011
Effects of manganese on tyrosine hydroxylase (TH) activity and TH-phosphorylation in a dopaminergic neural cell line. Toxicology and applied pharmacology\| PubMed ID: 21310168	2011
Transcriptional regulation of pro-apoptotic protein kinase Cdelta: implications for oxidative stress-induced neuronal cell death. The Journal of biological chemistry\| PubMed ID: 21467032	2011
Protein kinase D1 (PKD1) activation mediates a compensatory protective response during early stages of oxidative stress-induced neuronal degeneration. Molecular neurodegeneration\| PubMed ID: 21696630	2011
Environmental neurotoxic pesticide dieldrin activates a non receptor tyrosine kinase to promote PKCδ-mediated dopaminergic apoptosis in a dopaminergic neuronal cell model. Neurotoxicology\| PubMed ID: 21801747	2011
Measurement of proteasomal dysfunction in cell models of dopaminergic degeneration. Methods in molecular biology (Clifton, N.J.)\| PubMed ID: 21815074	2011
Dopaminergic neurotoxicant 6-OHDA induces oxidative damage through proteolytic activation of PKCδ in cell culture and animal models of Parkinson's disease. Toxicology and applied pharmacology\| PubMed ID: 21846476	2011
Manganese nanoparticle activates mitochondrial dependent apoptotic signaling and autophagy in dopaminergic neuronal cells. Toxicology and applied pharmacology\| PubMed ID: 21856324	2011
Infectious prion protein alters manganese transport and neurotoxicity in a cell culture model of prion disease. Neurotoxicology\| PubMed ID: 21871919	2011
Neuroprotective effect of resveratrol against methamphetamine-induced dopaminergic apoptotic cell death in a cell culture model of neurotoxicity. Current neuropharmacology\| PubMed ID: 21886561	2011
Emerging neurotoxic mechanisms in environmental factors-induced neurodegeneration. Neurotoxicology\| PubMed ID: 22342404	2012
Proteolytic activation of proapoptotic kinase protein kinase Cδ by tumor necrosis factor α death receptor signaling in dopaminergic neurons during neuroinflammation. Journal of neuroinflammation\| PubMed ID: 22540228	2012
Guidelines for the use and interpretation of assays for monitoring autophagy. Autophagy\| PubMed ID: 22966490	2012
N-Acetyl Cysteine Protects against Methamphetamine-Induced Dopaminergic Neurodegeneration via Modulation of Redox Status and Autophagy in Dopaminergic Cells. Parkinson's disease\| PubMed ID: 23056996	2012
Anti-inflammatory and neuroprotective effects of an orally active apocynin derivative in pre-clinical models of Parkinson's disease. Journal of neuroinflammation\| PubMed ID: 23092448	2012
The peptidyl-prolyl isomerase Pin1 up-regulation and proapoptotic function in dopaminergic neurons: relevance to the pathogenesis of Parkinson disease. The Journal of biological chemistry\| PubMed ID: 23754278	2013
Mitochondria-targeted antioxidants for treatment of Parkinson's disease: preclinical and clinical outcomes. Biochimica et biophysica acta\| PubMed ID: 24060637	2014
Vanadium exposure induces olfactory dysfunction in an animal model of metal neurotoxicity. Neurotoxicology\| PubMed ID: 24362016	2014
Role of proteolytic activation of protein kinase Cδ in the pathogenesis of prion disease. Prion\| PubMed ID: 24576946	2014
Protein kinase D1 (PKD1) phosphorylation promotes dopaminergic neuronal survival during 6-OHDA-induced oxidative stress. PloS one\| PubMed ID: 24806360	2014
Histone hyperacetylation up-regulates protein kinase Cδ in dopaminergic neurons to induce cell death: relevance to epigenetic mechanisms of neurodegeneration in Parkinson disease. The Journal of biological chemistry\| PubMed ID: 25342743	2014
α-Synuclein protects against manganese neurotoxic insult during the early stages of exposure in a dopaminergic cell model of Parkinson's disease. Toxicological sciences : an official journal of the Society of Toxicology\| PubMed ID: 25416158	2015
Targeted toxicants to dopaminergic neuronal cell death. Methods in molecular biology (Clifton, N.J.)\| PubMed ID: 25431070	2015
Alterations in mitochondrial dynamics induced by tebufenpyrad and pyridaben in a dopaminergic neuronal cell culture model. Neurotoxicology\| PubMed ID: 26141520	2016
Fyn Kinase Regulates Microglial Neuroinflammatory Responses in Cell Culture and Animal Models of Parkinson's Disease. The Journal of neuroscience : the official journal of the Society for Neuroscience\| PubMed ID: 26157004	2015
Molecular cloning, epigenetic regulation, and functional characterization of Prkd1 gene promoter in dopaminergic cell culture models of Parkinson's disease. Journal of neurochemistry\| PubMed ID: 26230914	2015
Mitoapocynin Treatment Protects Against Neuroinflammation and Dopaminergic Neurodegeneration in a Preclinical Animal Model of Parkinson's Disease. Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology\| PubMed ID: 26838361	2016
p73 gene in dopaminergic neurons is highly susceptible to manganese neurotoxicity. Neurotoxicology\| PubMed ID: 27107493	2017
Protein kinase Cδ upregulation in microglia drives neuroinflammatory responses and dopaminergic neurodegeneration in experimental models of Parkinson's disease. Neurobiology of disease\| PubMed ID: 27151770	2016
Acute hydrogen sulfide-induced neuropathology and neurological sequelae: challenges for translational neuroprotective research. Annals of the New York Academy of Sciences\| PubMed ID: 27442775	2016
Prokineticin-2 upregulation during neuronal injury mediates a compensatory protective response against dopaminergic neuronal degeneration. Nature communications\| PubMed ID: 27703142	2016
Role of neurotoxicants and traumatic brain injury in α-synuclein protein misfolding and aggregation. Brain research bulletin\| PubMed ID: 27993598	2016
Integrated Organotypic Slice Cultures and RT-QuIC (OSCAR) Assay: Implications for Translational Discovery in Protein Misfolding Diseases. Scientific reports\| PubMed ID: 28233859	2017
Mito-Apocynin Prevents Mitochondrial Dysfunction, Microglial Activation, Oxidative Damage, and Progressive Neurodegeneration in MitoPark Transgenic Mice. Antioxidants & redox signaling\| PubMed ID: 28375739	2017
Molecular Mechanisms Underlying Protective Effects of Quercetin Against Mitochondrial Dysfunction and Progressive Dopaminergic Neurodegeneration in Cell Culture and MitoPark Transgenic Mouse... Journal of neurochemistry\| PubMed ID: 28376279	2017