Brett Nixon

Priority Research Centre for Reproductive Science, University of Newcastle

Affiliated withUniversity of Newcastle Hunter Medical Research Institute

Research Area

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JoVE Journal Publications

ArticleTotal : 1	Year
Publication title Cited by 14	2018

Other Publications

Article	Year
Rabbit epididymal secretory proteins. I. Characterization and hormonal regulation. Biology of reproduction\| PubMed ID: 12080009	2002
Identification of RARhoGAP, a novel putative RhoGAP gene expressed in male germ cells. Genomics\| PubMed ID: 15234003	2004
Tyrosine phosphorylation activates surface chaperones facilitating sperm-zona recognition. Journal of cell science\| PubMed ID: 15252132	2004
Localization and significance of molecular chaperones, heat shock protein 1, and tumor rejection antigen gp96 in the male reproductive tract and during capacitation and acrosome reaction. Biology of reproduction\| PubMed ID: 15456702	2005
The role of molecular chaperones in mouse sperm-egg interactions. Molecular and cellular endocrinology\| PubMed ID: 16043280	2005
Evidence for the involvement of PECAM-1 in a receptor mediated signal-transduction pathway regulating capacitation-associated tyrosine phosphorylation in human spermatozoa. Journal of cell science\| PubMed ID: 16219692	2005
The identification of mouse sperm-surface-associated proteins and characterization of their ability to act as decapacitation factors. Biology of reproduction\| PubMed ID: 16221991	2006
Role of the epididymis in sperm competition. Asian journal of andrology\| PubMed ID: 17589786	2007
Proteomic changes in mammalian spermatozoa during epididymal maturation. Asian journal of andrology\| PubMed ID: 17589795	2007
Molecular and functional characterization of the rabbit epididymal secretory protein 52, REP52. Biology of reproduction\| PubMed ID: 18199886	2008
Investigation of the role of SRC in capacitation-associated tyrosine phosphorylation of human spermatozoa. Molecular human reproduction\| PubMed ID: 18245108	2008
Identification of the molecular chaperone, heat shock protein 1 (chaperonin 10), in the reproductive tract and in capacitating spermatozoa in the male mouse. Biology of reproduction\| PubMed ID: 18276932	2008
Genome analysis of the platypus reveals unique signatures of evolution. Nature\| PubMed ID: 18464734	2008
Composition and significance of detergent resistant membranes in mouse spermatozoa. Journal of cellular physiology\| PubMed ID: 18726997	2009
DNA damage in human spermatozoa is highly correlated with the efficiency of chromatin remodeling and the formation of 8-hydroxy-2'-deoxyguanosine, a marker of oxidative stress. Biology of reproduction\| PubMed ID: 19494251	2009
The biological significance of detergent-resistant membranes in spermatozoa. Journal of reproductive immunology\| PubMed ID: 19857901	2009
Elucidation of the signaling pathways that underpin capacitation-associated surface phosphotyrosine expression in mouse spermatozoa. Journal of cellular physiology\| PubMed ID: 20232304	2010
New insights into sperm physiology and pathology. Handbook of experimental pharmacology\| PubMed ID: 20839089	2010
Sperm-zona pellucida interaction: molecular mechanisms and the potential for contraceptive intervention. Handbook of experimental pharmacology\| PubMed ID: 20839091	2010
Cellular mechanisms regulating sperm-zona pellucida interaction. Asian journal of andrology\| PubMed ID: 21042304	2011
Monotremes provide a key to understanding the evolutionary significance of epididymal sperm maturation. Journal of andrology\| PubMed ID: 21441429	2011
Involvement of multimeric protein complexes in mediating the capacitation-dependent binding of human spermatozoa to homologous zonae pellucidae. Developmental biology\| PubMed ID: 21672535	2011
Proteomic and functional analysis of human sperm detergent resistant membranes. Journal of cellular physiology\| PubMed ID: 21792924	2011
The chaperonin containing TCP1 complex (CCT/TRiC) is involved in mediating sperm-oocyte interaction. The Journal of biological chemistry\| PubMed ID: 21880732	2011
Staying alive: PI3K pathway promotes primordial follicle activation and survival in response to 3MC-induced ovotoxicity. Toxicological sciences : an official journal of the Society of Toxicology\| PubMed ID: 22505044	2012
The role of molecular chaperones in spermatogenesis and the post-testicular maturation of mammalian spermatozoa. Human reproduction update\| PubMed ID: 22523110	2012
A unique combination of male germ cell miRNAs coordinates gonocyte differentiation. PloS one\| PubMed ID: 22536405	2012
Chronic exposure to acrylamide induces DNA damage in male germ cells of mice. Toxicological sciences : an official journal of the Society of Toxicology\| PubMed ID: 22610608	2012
Proteomic insights into the maturation and capacitation of mammalian spermatozoa. Systems biology in reproductive medicine\| PubMed ID: 22788533	2012
Dynamin regulates specific membrane fusion events necessary for acrosomal exocytosis in mouse spermatozoa. The Journal of biological chemistry\| PubMed ID: 22977254	2012
The function of chaperone proteins in the assemblage of protein complexes involved in gamete adhesion and fusion processes. Reproduction (Cambridge, England)\| PubMed ID: 23166368	2013
The molecular chaperone HSPA2 plays a key role in regulating the expression of sperm surface receptors that mediate sperm-egg recognition. PloS one\| PubMed ID: 23209833	2012
Investigation of the mechanisms by which the molecular chaperone HSPA2 regulates the expression of sperm surface receptors involved in human sperm-oocyte recognition. Molecular human reproduction\| PubMed ID: 23247813	2013
Melatonin prevents postovulatory oocyte aging in the mouse and extends the window for optimal fertilization in vitro. Biology of reproduction\| PubMed ID: 23365415	2013
Sperm capacitation: a distant landscape glimpsed but unexplored. Molecular human reproduction\| PubMed ID: 24071444	2013
Capacitation in the presence of methyl-β-cyclodextrin results in enhanced zona pellucida-binding ability of stallion spermatozoa. Reproduction (Cambridge, England)\| PubMed ID: 24194571	2014
Post-testicular sperm maturation and identification of an epididymal protein in the Japanese quail (Coturnix coturnix japonica). Reproduction (Cambridge, England)\| PubMed ID: 24298048	2014
The rise of testicular germ cell tumours: the search for causes, risk factors and novel therapeutic targets. F1000Research\| PubMed ID: 24555040	2013
Mouse spermatocytes express CYP2E1 and respond to acrylamide exposure. PloS one\| PubMed ID: 24788432	2014
Glycogen synthase kinase 3 regulates acrosomal exocytosis in mouse spermatozoa via dynamin phosphorylation. FASEB journal : official publication of the Federation of American Societies for Experimental Biology\| PubMed ID: 25808536	2015
The role of the molecular chaperone heat shock protein A2 (HSPA2) in regulating human sperm-egg recognition. Asian journal of andrology\| PubMed ID: 25865850	2015
The 12 (th) International Symposium on Spermatology. Asian journal of andrology\| PubMed ID: 25994646	2015
Are sperm capacitation and apoptosis the opposite ends of a continuum driven by oxidative stress? Asian journal of andrology\| PubMed ID: 25999358	2015
Novel characterization of the HSPA2-stabilizing protein BAG6 in human spermatozoa. Molecular human reproduction\| PubMed ID: 26153132	2015
Next Generation Sequencing Analysis Reveals Segmental Patterns of microRNA Expression in Mouse Epididymal Epithelial Cells. PloS one\| PubMed ID: 26270822	2015
The microRNA signature of mouse spermatozoa is substantially modified during epididymal maturation. Biology of reproduction\| PubMed ID: 26333995	2015
The impact of oxidative stress on chaperone-mediated human sperm-egg interaction. Human reproduction (Oxford, England)\| PubMed ID: 26345691	2015
Heat Shock Protein member A2 forms a stable complex with angiotensin converting enzyme and protein disulfide isomerase A6 in human spermatozoa. Molecular human reproduction\| PubMed ID: 26676989	2016
Assessment of microRNA expression in mouse epididymal epithelial cells and spermatozoa by next generation sequencing. Genomics data\| PubMed ID: 26697376	2015
A novel germ cell protein, SPIF (sperm PKA interacting factor), is essential for the formation of a PKA/TCP11 complex that undergoes conformational and phosphorylation changes upon capacitat... FASEB journal : official publication of the Federation of American Societies for Experimental Biology\| PubMed ID: 27105888	2016
The Australian saltwater crocodile (Crocodylus porosus) provides evidence that the capacitation of spermatozoa may extend beyond the mammalian lineage. Proceedings. Biological sciences\| PubMed ID: 27147099	2016
Chronic acrylamide exposure in male mice induces DNA damage to spermatozoa; Potential for amelioration by resveratrol. Reproductive toxicology (Elmsford, N.Y.)\| PubMed ID: 27174446	2016
Identification of a key role for permeability glycoprotein in enhancing the cellular defense mechanisms of fertilized oocytes. Developmental biology\| PubMed ID: 27397031	2016
Data on the concentrations of etoposide, PSC833, BAPTA-AM, and cycloheximide that do not compromise the vitality of mature mouse oocytes, parthenogencially activated and fertilized embryos. Data in brief\| PubMed ID: 27547800	2016
Characterisation of mouse epididymosomes reveals a complex profile of microRNAs and a potential mechanism for modification of the sperm epigenome. Scientific reports\| PubMed ID: 27549865	2016
Formation and Dissociation of Sperm Bundles in Monotremes. Biology of reproduction\| PubMed ID: 27557648	2016
Biochemical alterations in the oocyte in support of early embryonic development. Cellular and molecular life sciences : CMLS\| PubMed ID: 27604868	2017
Non-surgical sterilisation methods may offer a sustainable solution to feral horse (Equus caballus) overpopulation. Reproduction, fertility, and development\| PubMed ID: 27700983	2017
Dynamin 2 is essential for mammalian spermatogenesis. Scientific reports\| PubMed ID: 27725702	2016
Proteolytic degradation of heat shock protein A2 occurs in response to oxidative stress in male germ cells of the mouse. Molecular human reproduction\| PubMed ID: 27932549	2017
Inhibition of arachidonate 15-lipoxygenase prevents 4-hydroxynonenal-induced protein damage in male germ cells. Biology of reproduction\| PubMed ID: 28339608	2017
Epididymal CYP2E1 plays a critical role in acrylamide-induced DNA damage in spermatozoa and paternally mediated embryonic resorptions†. Biology of reproduction\| PubMed ID: 28379345	2017
Heat Shock Protein A2 (HSPA2): Regulatory Roles in Germ Cell Development and Sperm Function. Advances in anatomy, embryology, and cell biology\| PubMed ID: 28389751	2017
Developmental expression of the dynamin family of mechanoenzymes in the mouse epididymis. Biology of reproduction\| PubMed ID: 28395327	2017
Electrophilic aldehyde products of lipid peroxidation selectively adduct to heat shock protein 90 and arylsulfatase A in stallion spermatozoa. Biology of reproduction\| PubMed ID: 28395341	2017
The lipid peroxidation product 4-hydroxynonenal contributes to oxidative stress-mediated deterioration of the ageing oocyte. Scientific reports\| PubMed ID: 28740075	2017
Analysis of the small non-protein-coding RNA profile of mouse spermatozoa reveals specific enrichment of piRNAs within mature spermatozoa. RNA biology\| PubMed ID: 28816603	2017
Characterization of a novel role for the dynamin mechanoenzymes in the regulation of human sperm acrosomal exocytosis. Molecular human reproduction\| PubMed ID: 29044420	2017
Molecular Mechanisms Responsible for Increased Vulnerability of the Ageing Oocyte to Oxidative Damage. Oxidative medicine and cellular longevity\| PubMed ID: 29312475	2017
Heat exposure induces oxidative stress and DNA damage in the male germ line. Biology of reproduction\| PubMed ID: 29351587	2018
Characteristics of the Epididymal Luminal Environment Responsible for Sperm Maturation and Storage. Frontiers in endocrinology\| PubMed ID: 29541061	2018
Pharmacological inhibition of arachidonate 15-lipoxygenase protects human spermatozoa against oxidative stress. Biology of reproduction\| PubMed ID: 29546268	2018
Improved methods of DNA extraction from human spermatozoa that mitigate experimentally-induced oxidative DNA damage. PloS one\| PubMed ID: 29579126	2018
Mouse quiescin sulfhydryl oxidases exhibit distinct epididymal luminal distribution with Segment-Specific sperm surface associations. Biology of reproduction\| PubMed ID: 29800099	2018
Double Strand Break DNA Repair occurs via Non-Homologous End-Joining in Mouse MII Oocytes. Scientific reports\| PubMed ID: 29946146	2018
Proteomic profiling of crocodile spermatozoa refutes the tenet that post-testicular maturation is restricted to mammals. Molecular & cellular proteomics : MCP\| PubMed ID: 30072580	2018