Carlos J. Orihuela Department of Microbiology and Immunology The University of Texas Health Science Center at San Antonio Biography Publications Institution JoVE Articles Carlos J. Orihuela has not added a biography. If you are Carlos J. Orihuela and would like to personalize this page please email our Author Liaison for assistance. Publications Cardiotoxicity During Invasive Pneumococcal Disease American Journal of Respiratory and Critical Care Medicine. Apr, 2015 | Pubmed ID: 25629643 Senescent Cells Contribute to the Physiological Remodeling of Aged Lungs The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences. Jan, 2015 | Pubmed ID: 25568097 Requirement for Serratia Marcescens Cytolysin in a Murine Model of Hemorrhagic Pneumonia Infection and Immunity. Feb, 2015 | Pubmed ID: 25422267 Pneumococci in Biofilms Are Non-invasive: Implications on Nasopharyngeal Colonization Frontiers in Cellular and Infection Microbiology. 2014 | Pubmed ID: 25414838 Streptococcus Pneumoniae Translocates into the Myocardium and Forms Unique Microlesions That Disrupt Cardiac Function PLoS Pathogens. Sep, 2014 | Pubmed ID: 25232870 Elevated A20 Contributes to Age-dependent Macrophage Dysfunction in the Lungs Experimental Gerontology. Jun, 2014 | Pubmed ID: 24440463 Streptococcus Pneumoniae Biofilm Formation is Strain Dependent, Multifactorial, and Associated with Reduced Invasiveness and Immunoreactivity During Colonization MBio. 2013 | Pubmed ID: 24129258 Interactions Between Blood-borne Streptococcus Pneumoniae and the Blood-brain Barrier Preceding Meningitis PloS One. 2013 | Pubmed ID: 23874613 Enteric-delivered Rapamycin Enhances Resistance of Aged Mice to Pneumococcal Pneumonia Through Reduced Cellular Senescence Experimental Gerontology. Dec, 2012 | Pubmed ID: 22981852 Prevalence and Clonal Distribution of PcpA, PsrP and Pilus-1 Among Pediatric Isolates of Streptococcus Pneumoniae PloS One. 2012 | Pubmed ID: 22848535 Impact of Oral Simvastatin Therapy on Acute Lung Injury in Mice During Pneumococcal Pneumonia BMC Microbiology. 2012 | Pubmed ID: 22587610 Age-related Defects in TLR2 Signaling Diminish the Cytokine Response by Alveolar Macrophages During Murine Pneumococcal Pneumonia Experimental Gerontology. Jul, 2012 | Pubmed ID: 22548913 Future Perspective on Host-pathogen Interactions During Bacterial Biofilm Formation Within the Nasopharynx Future Microbiology. Feb, 2012 | Pubmed ID: 22324992 Pneumococcal Gene Complex Involved in Resistance to Extracellular Oxidative Stress Infection and Immunity. Mar, 2012 | Pubmed ID: 22215735 Dysregulated Inflammation As a Risk Factor for Pneumonia in the Elderly Aging and Disease. Dec, 2011 | Pubmed ID: 22288022 Streptococcus Pneumoniae in Biofilms Are Unable to Cause Invasive Disease Due to Altered Virulence Determinant Production PloS One. 2011 | Pubmed ID: 22174882 Biofilm and Planktonic Pneumococci Demonstrate Disparate Immunoreactivity to Human Convalescent Sera BMC Microbiology. 2011 | Pubmed ID: 22047041 Changes in Capsular Serotype Alter the Surface Exposure of Pneumococcal Adhesins and Impact Virulence PloS One. 2011 | Pubmed ID: 22028914 Cellular Senescence Increases Expression of Bacterial Ligands in the Lungs and is Positively Correlated with Increased Susceptibility to Pneumococcal Pneumonia Aging Cell. Oct, 2011 | Pubmed ID: 21615674 Incidence of Cardiovascular Events After Hospital Admission for Pneumonia The American Journal of Medicine. Mar, 2011 | Pubmed ID: 21396508 Rapamycin, but Not Resveratrol or Simvastatin, Extends Life Span of Genetically Heterogeneous Mice The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences. Feb, 2011 | Pubmed ID: 20974732 PsrP, a Protective Pneumococcal Antigen, is Highly Prevalent in Children with Pneumonia and is Strongly Associated with Clonal Type Clinical and Vaccine Immunology : CVI. Nov, 2010 | Pubmed ID: 20861332 The Pneumococcal Serine-rich Repeat Protein is an Intra-species Bacterial Adhesin That Promotes Bacterial Aggregation in Vivo and in Biofilms PLoS Pathogens. 2010 | Pubmed ID: 20714350 Pneumococci: Immunology of the Innate Host Response Respirology (Carlton, Vic.). Oct, 2010 | Pubmed ID: 20646240 Pneumococcal Microbial Surface Components Recognizing Adhesive Matrix Molecules Targeting of the Extracellular Matrix Molecular Microbiology. Jul, 2010 | Pubmed ID: 20444102 Early Biofilm Formation on Microtiter Plates is Not Correlated with the Invasive Disease Potential of Streptococcus Pneumoniae Microbial Pathogenesis. Mar-Apr, 2010 | Pubmed ID: 20096771 Statins Protect Against Fulminant Pneumococcal Infection and Cytolysin Toxicity in a Mouse Model of Sickle Cell Disease The Journal of Clinical Investigation. Feb, 2010 | Pubmed ID: 20093777 Role Played by PsrP-secY2A2 (accessory Region 34) in the Invasive Disease Potential of Streptococcus Pneumoniae The Journal of Infectious Diseases. Oct, 2009 | Pubmed ID: 19723013 Emu-BCL10 Mice Exhibit Constitutive Activation of Both Canonical and Noncanonical NF-kappaB Pathways Generating Marginal Zone (MZ) B-cell Expansion As a Precursor to Splenic MZ Lymphoma Blood. Nov, 2009 | Pubmed ID: 19696203 The Streptococcus Pneumoniae Adhesin PsrP Binds to Keratin 10 on Lung Cells Molecular Microbiology. Aug, 2009 | Pubmed ID: 19627498 Age-associated Inflammation and Toll-like Receptor Dysfunction Prime the Lungs for Pneumococcal Pneumonia The Journal of Infectious Diseases. Aug, 2009 | Pubmed ID: 19586419 Laminin Receptor Initiates Bacterial Contact with the Blood Brain Barrier in Experimental Meningitis Models The Journal of Clinical Investigation. Jun, 2009 | Pubmed ID: 19436113 Antibodies Against PsrP, a Novel Streptococcus Pneumoniae Adhesin, Block Adhesion and Protect Mice Against Pneumococcal Challenge The Journal of Infectious Diseases. Aug, 2008 | Pubmed ID: 18507531 Assessment of Molecular Typing Methods to Determine Invasiveness and to Differentiate Clones of Streptococcus Pneumoniae Infection, Genetics and Evolution : Journal of Molecular Epidemiology and Evolutionary Genetics in Infectious Diseases. Dec, 2007 | Pubmed ID: 17768094 Regions of Diversity 8, 9 and 13 Contribute to Streptococcus Pneumoniae Virulence BMC Microbiology. 2007 | Pubmed ID: 17723151 Induction of Pro- and Anti-inflammatory Molecules in a Mouse Model of Pneumococcal Pneumonia After Influenza Comparative Medicine. Feb, 2007 | Pubmed ID: 17348295 Platelet-activating Factor Receptor and Innate Immunity: Uptake of Gram-positive Bacterial Cell Wall into Host Cells and Cell-specific Pathophysiology Journal of Immunology (Baltimore, Md. : 1950). Nov, 2006 | Pubmed ID: 17056547 Identification of a Candidate Streptococcus Pneumoniae Core Genome and Regions of Diversity Correlated with Invasive Pneumococcal Disease Infection and Immunity. Aug, 2006 | Pubmed ID: 16861665 Cell Wall-mediated Neuronal Damage in Early Sepsis Infection and Immunity. Jul, 2006 | Pubmed ID: 16790750 Beta-Arrestin 1 Participates in Platelet-activating Factor Receptor-mediated Endocytosis of Streptococcus Pneumoniae Infection and Immunity. Dec, 2005 | Pubmed ID: 16299272 Virulence in Mice of Pneumococcal Clonal Types with Known Invasive Disease Potential in Humans The Journal of Infectious Diseases. Sep, 2005 | Pubmed ID: 16088828 Tissue-specific Contributions of Pneumococcal Virulence Factors to Pathogenesis The Journal of Infectious Diseases. Nov, 2004 | Pubmed ID: 15478073 Microarray Analysis of Pneumococcal Gene Expression During Invasive Disease Infection and Immunity. Oct, 2004 | Pubmed ID: 15385455 Organ-specific Models of Streptococcus Pneumoniae Disease Scandinavian Journal of Infectious Diseases. 2003 | Pubmed ID: 14620149 Visualization of Streptococcus pneumoniae within Cardiac Microlesions and Subsequent Cardiac Remodeling Armand O. Brown1, Carlos J. Orihuela1 1Department of Microbiology and Immunology, The University of Texas Health Science Center at San Antonio JoVE 52590 Medicine
Visualization of Streptococcus pneumoniae within Cardiac Microlesions and Subsequent Cardiac Remodeling Armand O. Brown1, Carlos J. Orihuela1 1Department of Microbiology and Immunology, The University of Texas Health Science Center at San Antonio JoVE 52590 Medicine