Carlos J. Orihuela

Department of Microbiology and Immunology, The University of Texas Health Science Center at San Antonio

Affiliated withThe University of Texas Health Science Center at San Antonio

Research Area

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JoVE Journal Publications

ArticleTotal : 1	Year
Publication title Cited by 11	2015

Other Publications

Article	Year
Organ-specific models of Streptococcus pneumoniae disease. Scandinavian journal of infectious diseases\| PubMed ID: 14620149	2003
Microarray analysis of pneumococcal gene expression during invasive disease. Infection and immunity\| PubMed ID: 15385455	2004
Tissue-specific contributions of pneumococcal virulence factors to pathogenesis. The Journal of infectious diseases\| PubMed ID: 15478073	2004
Virulence in mice of pneumococcal clonal types with known invasive disease potential in humans. The Journal of infectious diseases\| PubMed ID: 16088828	2005
beta-Arrestin 1 participates in platelet-activating factor receptor-mediated endocytosis of Streptococcus pneumoniae. Infection and immunity\| PubMed ID: 16299272	2005
Cell wall-mediated neuronal damage in early sepsis. Infection and immunity\| PubMed ID: 16790750	2006
Identification of a Candidate Streptococcus pneumoniae core genome and regions of diversity correlated with invasive pneumococcal disease. Infection and immunity\| PubMed ID: 16861665	2006
Platelet-activating factor receptor and innate immunity: uptake of gram-positive bacterial cell wall into host cells and cell-specific pathophysiology. Journal of immunology (Baltimore, Md. : 1950)\| PubMed ID: 17056547	2006
Induction of pro- and anti-inflammatory molecules in a mouse model of pneumococcal pneumonia after influenza. Comparative medicine\| PubMed ID: 17348295	2007
Regions of Diversity 8, 9 and 13 contribute to Streptococcus pneumoniae virulence. BMC microbiology\| PubMed ID: 17723151	2007
Assessment of molecular typing methods to determine invasiveness and to differentiate clones of Streptococcus pneumoniae. Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases\| PubMed ID: 17768094	2007
Antibodies against PsrP, a novel Streptococcus pneumoniae adhesin, block adhesion and protect mice against pneumococcal challenge. The Journal of infectious diseases\| PubMed ID: 18507531	2008
Laminin receptor initiates bacterial contact with the blood brain barrier in experimental meningitis models. The Journal of clinical investigation\| PubMed ID: 19436113	2009
Age-associated inflammation and toll-like receptor dysfunction prime the lungs for pneumococcal pneumonia. The Journal of infectious diseases\| PubMed ID: 19586419	2009
The Streptococcus pneumoniae adhesin PsrP binds to Keratin 10 on lung cells. Molecular microbiology\| PubMed ID: 19627498	2009
Emu-BCL10 mice exhibit constitutive activation of both canonical and noncanonical NF-kappaB pathways generating marginal zone (MZ) B-cell expansion as a precursor to splenic MZ lymphoma. Blood\| PubMed ID: 19696203	2009
Role played by psrP-secY2A2 (accessory region 34) in the invasive disease potential of Streptococcus pneumoniae. The Journal of infectious diseases\| PubMed ID: 19723013	2009
Statins protect against fulminant pneumococcal infection and cytolysin toxicity in a mouse model of sickle cell disease. The Journal of clinical investigation\| PubMed ID: 20093777	2010
Early biofilm formation on microtiter plates is not correlated with the invasive disease potential of Streptococcus pneumoniae. Microbial pathogenesis\| PubMed ID: 20096771	2010
Pneumococcal microbial surface components recognizing adhesive matrix molecules targeting of the extracellular matrix. Molecular microbiology\| PubMed ID: 20444102	2010
Pneumococci: immunology of the innate host response. Respirology (Carlton, Vic.)\| PubMed ID: 20646240	2010
The pneumococcal serine-rich repeat protein is an intra-species bacterial adhesin that promotes bacterial aggregation in vivo and in biofilms. PLoS pathogens\| PubMed ID: 20714350	2010
PsrP, a protective pneumococcal antigen, is highly prevalent in children with pneumonia and is strongly associated with clonal type. Clinical and vaccine immunology : CVI\| PubMed ID: 20861332	2010
Rapamycin, but not resveratrol or simvastatin, extends life span of genetically heterogeneous mice. The journals of gerontology. Series A, Biological sciences and medical sciences\| PubMed ID: 20974732	2011
Incidence of cardiovascular events after hospital admission for pneumonia. The American journal of medicine\| PubMed ID: 21396508	2011
Cellular senescence increases expression of bacterial ligands in the lungs and is positively correlated with increased susceptibility to pneumococcal pneumonia. Aging cell\| PubMed ID: 21615674	2011
Changes in capsular serotype alter the surface exposure of pneumococcal adhesins and impact virulence. PloS one\| PubMed ID: 22028914	2011
Biofilm and planktonic pneumococci demonstrate disparate immunoreactivity to human convalescent sera. BMC microbiology\| PubMed ID: 22047041	2011
Streptococcus pneumoniae in biofilms are unable to cause invasive disease due to altered virulence determinant production. PloS one\| PubMed ID: 22174882	2011
Pneumococcal gene complex involved in resistance to extracellular oxidative stress. Infection and immunity\| PubMed ID: 22215735	2012
Dysregulated inflammation as a risk factor for pneumonia in the elderly. Aging and disease\| PubMed ID: 22288022	2011
Future perspective on host-pathogen interactions during bacterial biofilm formation within the nasopharynx. Future microbiology\| PubMed ID: 22324992	2012
Age-related defects in TLR2 signaling diminish the cytokine response by alveolar macrophages during murine pneumococcal pneumonia. Experimental gerontology\| PubMed ID: 22548913	2012
Impact of oral simvastatin therapy on acute lung injury in mice during pneumococcal pneumonia. BMC microbiology\| PubMed ID: 22587610	2012
Prevalence and clonal distribution of pcpA, psrP and Pilus-1 among pediatric isolates of Streptococcus pneumoniae. PloS one\| PubMed ID: 22848535	2012
Enteric-delivered rapamycin enhances resistance of aged mice to pneumococcal pneumonia through reduced cellular senescence. Experimental gerontology\| PubMed ID: 22981852	2012
Interactions between blood-borne Streptococcus pneumoniae and the blood-brain barrier preceding meningitis. PloS one\| PubMed ID: 23874613	2013
Streptococcus pneumoniae biofilm formation is strain dependent, multifactorial, and associated with reduced invasiveness and immunoreactivity during colonization. mBio\| PubMed ID: 24129258	2013
Elevated A20 contributes to age-dependent macrophage dysfunction in the lungs. Experimental gerontology\| PubMed ID: 24440463	2014
Streptococcus pneumoniae translocates into the myocardium and forms unique microlesions that disrupt cardiac function. PLoS pathogens\| PubMed ID: 25232870	2014
Pneumococci in biofilms are non-invasive: implications on nasopharyngeal colonization. Frontiers in cellular and infection microbiology\| PubMed ID: 25414838	2014
Requirement for Serratia marcescens cytolysin in a murine model of hemorrhagic pneumonia. Infection and immunity\| PubMed ID: 25422267	2015
Senescent Cells Contribute to the Physiological Remodeling of Aged Lungs. The journals of gerontology. Series A, Biological sciences and medical sciences\| PubMed ID: 25568097	2015
Cardiotoxicity during Invasive Pneumococcal Disease. American journal of respiratory and critical care medicine\| PubMed ID: 25629643	2015