Carol M. Troy Department of Pathology & Cell Biology; Vagelos College of Physicians and Surgeons Columbia University Biography Publications Institution JoVE Articles Carol M. Troy has not added a biography. If you are Carol M. Troy and would like to personalize this page please email our Author Liaison for assistance. Publications Caspase-9: A Multimodal Therapeutic Target With Diverse Cellular Expression in Human Disease Frontiers in Pharmacology. 2021 | Pubmed ID: 34305609 Author Correction: Endothelial Activation of Caspase-9 Promotes Neurovascular Injury in Retinal Vein Occlusion Nature Communications. 07, 2020 | Pubmed ID: 32647109 Endothelial Activation of Caspase-9 Promotes Neurovascular Injury in Retinal Vein Occlusion Nature Communications. 06, 2020 | Pubmed ID: 32576823 Proneurotrophins Induce Apoptotic Neuronal Death After Controlled Cortical Impact Injury in Adult Mice ASN Neuro. Jan-Dec, 2020 | Pubmed ID: 32493127 Caspase-2 and Tau-a Toxic Partnership? Nature Medicine. 11, 2016 | Pubmed ID: 27824824 Mutations in CRADD Result in Reduced Caspase-2-Mediated Neuronal Apoptosis and Cause Megalencephaly with a Rare Lissencephaly Variant American Journal of Human Genetics. Nov, 2016 | Pubmed ID: 27773430 Caspases: Therapeutic Targets in Neurologic Disease Neurotherapeutics : the Journal of the American Society for Experimental NeuroTherapeutics. Jan, 2015 | Pubmed ID: 25339539 Caspase-9 Mediates Photoreceptor Death After Blunt Ocular Trauma Investigative Ophthalmology & Visual Science. Oct, 2014 | Pubmed ID: 25190658 Axonally Synthesized ATF4 Transmits a Neurodegenerative Signal Across Brain Regions Cell. Aug, 2014 | Pubmed ID: 25171414 Combined Suppression of CASP2 and CASP6 Protects Retinal Ganglion Cells from Apoptosis and Promotes Axon Regeneration Through CNTF-mediated JAK/STAT Signalling Brain : a Journal of Neurology. Jun, 2014 | Pubmed ID: 24727569 Caspase-2 is Essential for C-Jun Transcriptional Activation and Bim Induction in Neuron Death The Biochemical Journal. Oct, 2013 | Pubmed ID: 23815625 Caspase-2 is Required for Dendritic Spine and Behavioural Alterations in J20 APP Transgenic Mice Nature Communications. 2013 | Pubmed ID: 23748737 Caspase Inhibitors: Prospective Therapies for Stroke The Neuroscientist : a Review Journal Bringing Neurobiology, Neurology and Psychiatry. Apr, 2013 | Pubmed ID: 22645109 Caspase-9 Mediates Synaptic Plasticity and Memory Deficits of Danish Dementia Knock-in Mice: Caspase-9 Inhibition Provides Therapeutic Protection Molecular Neurodegeneration. 2012 | Pubmed ID: 23217200 Neuronal Caspase 2 Activity and Function Requires RAIDD, but Not PIDD The Biochemical Journal. Jun, 2012 | Pubmed ID: 22515271 Intranasal Delivery of Caspase-9 Inhibitor Reduces Caspase-6-dependent Axon/neuron Loss and Improves Neurological Function After Stroke The Journal of Neuroscience : the Official Journal of the Society for Neuroscience. Jun, 2011 | Pubmed ID: 21677173 Endogenous Amyloid-β is Necessary for Hippocampal Synaptic Plasticity and Memory Annals of Neurology. May, 2011 | Pubmed ID: 21472769 Regulation of Caspases in the Nervous System Implications for Functions in Health and Disease Progress in Molecular Biology and Translational Science. 2011 | Pubmed ID: 21238939 Cystatin C Protects Neuronal Cells from Amyloid-beta-induced Toxicity Journal of Alzheimer's Disease : JAD. 2010 | Pubmed ID: 20157244 Selective Inhibition of Hypoxia-inducible Factor (HIF) Prolyl-hydroxylase 1 Mediates Neuroprotection Against Normoxic Oxidative Death Via HIF- and CREB-independent Pathways The Journal of Neuroscience : the Official Journal of the Society for Neuroscience. Jul, 2009 | Pubmed ID: 19587290 The Parkinson Disease Protein Leucine-rich Repeat Kinase 2 Transduces Death Signals Via Fas-associated Protein with Death Domain and Caspase-8 in a Cellular Model of Neurodegeneration The Journal of Neuroscience : the Official Journal of the Society for Neuroscience. Jan, 2009 | Pubmed ID: 19176810 Caspase-2: Vestigial Remnant or Master Regulator? Science Signaling. 2008 | Pubmed ID: 18812565 Mechanisms of Neuronal Death in Disease: Defining the Models and the Players The Biochemical Journal. Oct, 2008 | Pubmed ID: 18800967 Bim is Elevated in Alzheimer's Disease Neurons and is Required for Beta-amyloid-induced Neuronal Apoptosis The Journal of Neuroscience : the Official Journal of the Society for Neuroscience. Jan, 2007 | Pubmed ID: 17251431 Cell Cycle Molecules Define a Pathway Required for Neuron Death in Development and Disease Biochimica Et Biophysica Acta. Apr, 2007 | Pubmed ID: 17229557 Caspase Function in Neuronal Death: Delineation of the Role of Caspases in Ischemia Current Drug Targets. CNS and Neurological Disorders. Feb, 2005 | Pubmed ID: 15723613 Highly Efficient Small Interfering RNA Delivery to Primary Mammalian Neurons Induces MicroRNA-like Effects Before MRNA Degradation The Journal of Neuroscience : the Official Journal of the Society for Neuroscience. Nov, 2004 | Pubmed ID: 15537872 Balancing Neuronal Death Journal of Neuroscience Research. Oct, 2004 | Pubmed ID: 15372573 Divergence of the Apoptotic Pathways Induced by 4-hydroxynonenal and Amyloid Beta-protein Neurobiology of Aging. Sep, 2004 | Pubmed ID: 15212831 Caspases on the Brain Journal of Neuroscience Research. Jul, 2002 | Pubmed ID: 12111795 Mechanisms of P75-mediated Death of Hippocampal Neurons. Role of Caspases The Journal of Biological Chemistry. Sep, 2002 | Pubmed ID: 12097334 Death in the Balance: Alternative Participation of the Caspase-2 and -9 Pathways in Neuronal Death Induced by Nerve Growth Factor Deprivation The Journal of Neuroscience : the Official Journal of the Society for Neuroscience. Jul, 2001 | Pubmed ID: 11438576 Caspase-2 Mediates Neuronal Cell Death Induced by Beta-amyloid The Journal of Neuroscience : the Official Journal of the Society for Neuroscience. Feb, 2000 | Pubmed ID: 10662829 Caspase-2 (Nedd-2) Processing and Death of Trophic Factor-deprived PC12 Cells and Sympathetic Neurons Occur Independently of Caspase-3 (CPP32)-like Activity The Journal of Neuroscience : the Official Journal of the Society for Neuroscience. Nov, 1998 | Pubmed ID: 9801360 Multiple Pathways of Neuronal Death Induced by DNA-damaging Agents, NGF Deprivation, and Oxidative Stress The Journal of Neuroscience : the Official Journal of the Society for Neuroscience. Feb, 1998 | Pubmed ID: 9437005 Nedd2 is Required for Apoptosis After Trophic Factor Withdrawal, but Not Superoxide Dismutase (SOD1) Downregulation, in Sympathetic Neurons and PC12 Cells The Journal of Neuroscience : the Official Journal of the Society for Neuroscience. Mar, 1997 | Pubmed ID: 9045720 Optimalisering av musemodellen for retinal veneokklusjon for å begrense variabiliteten Crystal Colón Ortiz*1, Anna Potenski*2, Jaqueline M. Lawson1, Jade Smart1, Carol M. Troy1,3,4 1Department of Pathology & Cell Biology; Vagelos College of Physicians and Surgeons, Columbia University, 2Department of Molecular Pharmacology and Therapeutics; Vagelos College of Physicians and Surgeons, Columbia University, 3Department of Neurology; Vagelos College of Physicians and Surgeons, Columbia University, 4The Taub Institute for Research on Alzheimer’s Disease and the Aging Brain; Vagelos College of Physicians and Surgeons, Columbia University JoVE 62980 Neuroscience Stereotaksisk Infusjon av Oligomeric amyloid-beta i musen Hippocampus Ying Y. Jean1, Jimena Baleriola2, Mauro Fà2, Ulrich Hengst1,2, Carol M. Troy1,2,3 1Department of Pathology and Cell Biology, Columbia University Medical Center, 2The Taub Institute for Research on Alzheimer's Disease and the Aging Brain, Columbia University Medical Center, 3Department of Neurology, Columbia University Medical Center Neuroscience
Optimalisering av musemodellen for retinal veneokklusjon for å begrense variabiliteten Crystal Colón Ortiz*1, Anna Potenski*2, Jaqueline M. Lawson1, Jade Smart1, Carol M. Troy1,3,4 1Department of Pathology & Cell Biology; Vagelos College of Physicians and Surgeons, Columbia University, 2Department of Molecular Pharmacology and Therapeutics; Vagelos College of Physicians and Surgeons, Columbia University, 3Department of Neurology; Vagelos College of Physicians and Surgeons, Columbia University, 4The Taub Institute for Research on Alzheimer’s Disease and the Aging Brain; Vagelos College of Physicians and Surgeons, Columbia University JoVE 62980 Neuroscience
Stereotaksisk Infusjon av Oligomeric amyloid-beta i musen Hippocampus Ying Y. Jean1, Jimena Baleriola2, Mauro Fà2, Ulrich Hengst1,2, Carol M. Troy1,2,3 1Department of Pathology and Cell Biology, Columbia University Medical Center, 2The Taub Institute for Research on Alzheimer's Disease and the Aging Brain, Columbia University Medical Center, 3Department of Neurology, Columbia University Medical Center Neuroscience
