Charalabos Pothoulakis Vatche and Tamar Manoukian Division of Digestive Diseases, Department of Medicine University of California, Los Angeles Biography Publications Institution JoVE Articles Charalabos Pothoulakis has not added a biography. If you are Charalabos Pothoulakis and would like to personalize this page please email our Author Liaison for assistance. Publications Antimicrobial Peptides and Colitis Current Pharmaceutical Design. Aug, 2012 | Pubmed ID: 22950497 The Antimicrobial Peptide Cathelicidin Modulates Clostridium Difficile-associated Colitis and Toxin A-mediated Enteritis in Mice Gut. Jul, 2012 | Pubmed ID: 22760006 Elevated Lipopolysaccharide in the Colon Evokes Intestinal Inflammation, Aggravated in Immune Modulator-impaired Mice American Journal of Physiology. Gastrointestinal and Liver Physiology. Aug, 2012 | Pubmed ID: 22723263 Efficacy and Safety of the Probiotic Saccharomyces Boulardii for the Prevention and Therapy of Gastrointestinal Disorders Therapeutic Advances in Gastroenterology. Mar, 2012 | Pubmed ID: 22423260 Neurotensin-induced Proinflammatory Signaling in Human Colonocytes is Regulated by β-arrestins and Endothelin-converting Enzyme-1-dependent Endocytosis and Resensitization of Neurotensin Receptor 1 The Journal of Biological Chemistry. Apr, 2012 | Pubmed ID: 22416137 Adipose Tissue and Inflammatory Bowel Disease Pathogenesis Inflammatory Bowel Diseases. Aug, 2012 | Pubmed ID: 22407798 Clostridial Toxins: Sensing a Target in a Hostile Gut Environment Gut Microbes. Jan-Feb, 2012 | Pubmed ID: 22356854 Serum and Colonic Mucosal Immune Markers in Irritable Bowel Syndrome The American Journal of Gastroenterology. Feb, 2012 | Pubmed ID: 22158028 Constitutive TL1A Expression Under Colitogenic Conditions Modulates the Severity and Location of Gut Mucosal Inflammation and Induces Fibrostenosis The American Journal of Pathology. Feb, 2012 | Pubmed ID: 22138299 The Neurotensin Receptor-1 Promotes Tumor Development in a Sporadic but Not an Inflammation-associated Mouse Model of Colon Cancer International Journal of Cancer. Journal International Du Cancer. Apr, 2012 | Pubmed ID: 21630261 Lin28A and Lin28B Inhibit Let-7 MicroRNA Biogenesis by Distinct Mechanisms Cell. Nov, 2011 | Pubmed ID: 22118463 Role of Substance P in the Regulation of Glucose Metabolism Via Insulin Signaling-associated Pathways Endocrinology. Dec, 2011 | Pubmed ID: 22009727 Substance P Induces CCN1 Expression Via Histone Deacetylase Activity in Human Colonic Epithelial Cells The American Journal of Pathology. Nov, 2011 | Pubmed ID: 21945803 The Effects of Acute and Chronic Psychological Stress on Bladder Function in a Rodent Model Urology. Oct, 2011 | Pubmed ID: 21868072 Host S-nitrosylation Inhibits Clostridial Small Molecule-activated Glucosylating Toxins Nature Medicine. Sep, 2011 | Pubmed ID: 21857653 The Insect Peptide Coprisin Prevents Clostridium Difficile-mediated Acute Inflammation and Mucosal Damage Through Selective Antimicrobial Activity Antimicrobial Agents and Chemotherapy. Oct, 2011 | Pubmed ID: 21807975 Neurotensin Signaling Activates MicroRNAs-21 and -155 and Akt, Promotes Tumor Growth in Mice, and is Increased in Human Colon Tumors Gastroenterology. Nov, 2011 | Pubmed ID: 21806946 Cathelicidin Signaling Via the Toll-like Receptor Protects Against Colitis in Mice Gastroenterology. Nov, 2011 | Pubmed ID: 21762664 Role of Astrocytes and Altered Regulation of Spinal Glutamatergic Neurotransmission in Stress-induced Visceral Hyperalgesia in Rats American Journal of Physiology. Gastrointestinal and Liver Physiology. Sep, 2011 | Pubmed ID: 21719739 Neuropeptide - Adipose Tissue Communication and Intestinal Pathophysiology Current Pharmaceutical Design. 2011 | Pubmed ID: 21548874 Substance P (SP)-neurokinin-1 Receptor (NK-1R) Alters Adipose Tissue Responses to High-fat Diet and Insulin Action Endocrinology. Jun, 2011 | Pubmed ID: 21467195 Activation of Corticotropin-releasing Factor Receptor 2 Mediates the Colonic Motor Coping Response to Acute Stress in Rodents Gastroenterology. May, 2011 | Pubmed ID: 21277852 Constitutive TL1A (TNFSF15) Expression on Lymphoid or Myeloid Cells Leads to Mild Intestinal Inflammation and Fibrosis PloS One. 2011 | Pubmed ID: 21264313 Insulin-like Growth Factor-1 Receptor Transactivation Modulates the Inflammatory and Proliferative Responses of Neurotensin in Human Colonic Epithelial Cells The Journal of Biological Chemistry. Feb, 2011 | Pubmed ID: 21212273 Substance P Modulates Colitis-associated Fibrosis The American Journal of Pathology. Nov, 2010 | Pubmed ID: 20889569 TRIF Mediates Toll-like Receptor 5-induced Signaling in Intestinal Epithelial Cells The Journal of Biological Chemistry. Nov, 2010 | Pubmed ID: 20855887 Corticotropin-releasing Factor Regulates TLR4 Expression in the Colon and Protects Mice from Colitis Gastroenterology. Dec, 2010 | Pubmed ID: 20732324 Clostridium Difficile Toxin A Decreases Acetylation of Tubulin, Leading to Microtubule Depolymerization Through Activation of Histone Deacetylase 6, and This Mediates Acute Inflammation The Journal of Biological Chemistry. Oct, 2010 | Pubmed ID: 20696758 TRIF Modulates TLR5-dependent Responses by Inducing Proteolytic Degradation of TLR5 The Journal of Biological Chemistry. Jul, 2010 | Pubmed ID: 20452988 Corticotropin-releasing Hormone Family of Peptides Regulates Intestinal Angiogenesis Gastroenterology. Jun, 2010 | Pubmed ID: 20206175 The Anticancer Effect of Probiotic Bacillus Polyfermenticus on Human Colon Cancer Cells is Mediated Through ErbB2 and ErbB3 Inhibition International Journal of Cancer. Journal International Du Cancer. Aug, 2010 | Pubmed ID: 19876926 The Angiogenic Effect of Probiotic Bacillus Polyfermenticus on Human Intestinal Microvascular Endothelial Cells is Mediated by IL-8 American Journal of Physiology. Gastrointestinal and Liver Physiology. Nov, 2009 | Pubmed ID: 20501448 Serotonin Has a Critical Role in the Pathogenesis of Experimental Colitis Gastroenterology. Nov, 2009 | Pubmed ID: 19789088 Bacillus Polyfermenticus Ameliorates Colonic Inflammation by Promoting Cytoprotective Effects in Colitic Mice The Journal of Nutrition. Oct, 2009 | Pubmed ID: 19675103 Activation of Phosphatidylinositol 3-kinase/protein Kinase B by Corticotropin-releasing Factor in Human Monocytes Endocrinology. Oct, 2009 | Pubmed ID: 19628576 Saccharomyces Boulardii Inhibits EGF Receptor Signaling and Intestinal Tumor Growth in Apc(min) Mice Gastroenterology. Sep, 2009 | Pubmed ID: 19482027 Clostridium Difficile Toxin A Binds Colonocyte Src Causing Dephosphorylation of Focal Adhesion Kinase and Paxillin Experimental Cell Research. Nov, 2009 | Pubmed ID: 19481075 Neurotensin Induces IL-6 Secretion in Mouse Preadipocytes and Adipose Tissues During 2,4,6,-trinitrobenzensulphonic Acid-induced Colitis Proceedings of the National Academy of Sciences of the United States of America. May, 2009 | Pubmed ID: 19443690 Principles and Clinical Implications of the Brain-gut-enteric Microbiota Axis Nature Reviews. Gastroenterology & Hepatology. May, 2009 | Pubmed ID: 19404271 Substance P Promotes Expansion of Human Mesenteric Preadipocytes Through Proliferative and Antiapoptotic Pathways American Journal of Physiology. Gastrointestinal and Liver Physiology. May, 2009 | Pubmed ID: 19282377 Role of Spinal Microglia in Visceral Hyperalgesia and NK1R Up-regulation in a Rat Model of Chronic Stress Gastroenterology. Apr, 2009 | Pubmed ID: 19249394 Substance P, Obesity, and Gut Inflammation Current Opinion in Endocrinology, Diabetes, and Obesity. Feb, 2009 | Pubmed ID: 19104238 Neuropeptides, Mesenteric Fat, and Intestinal Inflammation Annals of the New York Academy of Sciences. Nov, 2008 | Pubmed ID: 19076372 Melanin-concentrating Hormone As a Mediator of Intestinal Inflammation Proceedings of the National Academy of Sciences of the United States of America. Jul, 2008 | Pubmed ID: 18650383 Substance P-mediated Expression of the Pro-angiogenic Factor CCN1 Modulates the Course of Colitis The American Journal of Pathology. Aug, 2008 | Pubmed ID: 18599605 Toll-like Receptor 5 Engagement Modulates Tumor Development and Growth in a Mouse Xenograft Model of Human Colon Cancer Gastroenterology. Aug, 2008 | Pubmed ID: 18538140 Gp96 is a Human Colonocyte Plasma Membrane Binding Protein for Clostridium Difficile Toxin A Infection and Immunity. Jul, 2008 | Pubmed ID: 18411291 Corticotropin-releasing Hormone Deficiency is Associated with Reduced Local Inflammation in a Mouse Model of Experimental Colitis Endocrinology. Jul, 2008 | Pubmed ID: 18403481 Gastrin-mediated Interleukin-8 and Cyclooxygenase-2 Gene Expression: Differential Transcriptional and Posttranscriptional Mechanisms Gastroenterology. Apr, 2008 | Pubmed ID: 18395088 Substance P As a Novel Anti-obesity Target Gastroenterology. Mar, 2008 | Pubmed ID: 18325388 Comparative Efficacies of Rifaximin and Vancomycin for Treatment of Clostridium Difficile-associated Diarrhea and Prevention of Disease Recurrence in Hamsters Antimicrobial Agents and Chemotherapy. Mar, 2008 | Pubmed ID: 18195066 Obesity, Innate Immunity and Gut Inflammation Current Opinion in Gastroenterology. Nov, 2007 | Pubmed ID: 17906444 Inflammation and Apoptosis in Clostridium Difficile Enteritis is Mediated by PGE2 Up-regulation of Fas Ligand Gastroenterology. Sep, 2007 | Pubmed ID: 17854595 Protease-activated Receptor 2, Dipeptidyl Peptidase I, and Proteases Mediate Clostridium Difficile Toxin A Enteritis Gastroenterology. Jun, 2007 | Pubmed ID: 17570216 Functional Consequences of Alteration of N-linked Glycosylation Sites on the Neurokinin 1 Receptor Proceedings of the National Academy of Sciences of the United States of America. Jun, 2007 | Pubmed ID: 17563389 Urocortin II Mediates Pro-inflammatory Effects in Human Colonocytes Via Corticotropin-releasing Hormone Receptor 2alpha Gut. Sep, 2007 | Pubmed ID: 17412781 Enteric Glia Regulate Intestinal Barrier Function and Inflammation Via Release of S-nitrosoglutathione Gastroenterology. Apr, 2007 | Pubmed ID: 17408650 Role of Neuropeptides in Inflammatory Bowel Disease Inflammatory Bowel Diseases. Jul, 2007 | Pubmed ID: 17343284 Substance P Mediates Antiapoptotic Responses in Human Colonocytes by Akt Activation Proceedings of the National Academy of Sciences of the United States of America. Feb, 2007 | Pubmed ID: 17264209 Neurotensin Stimulates Expression of Early Growth Response Gene-1 and EGF Receptor Through MAP Kinase Activation in Human Colonic Epithelial Cells International Journal of Cancer. Journal International Du Cancer. Apr, 2007 | Pubmed ID: 17230532 Identification of Depot-specific Human Fat Cell Progenitors Through Distinct Expression Profiles and Developmental Gene Patterns American Journal of Physiology. Endocrinology and Metabolism. Jan, 2007 | Pubmed ID: 16985259 Immunomodulatory Properties of Substance P: the Gastrointestinal System As a Model Annals of the New York Academy of Sciences. Nov, 2006 | Pubmed ID: 17192554 Interleukin-6 Genetic Ablation Protects from Trinitrobenzene Sulfonic Acid-induced Colitis in Mice. Putative Effect of Antiinflammatory Cytokines Neuroimmunomodulation. 2006 | Pubmed ID: 17077645 Corticotropin-releasing Hormone Receptor 2-deficient Mice Have Reduced Intestinal Inflammatory Responses Journal of Immunology (Baltimore, Md. : 1950). Sep, 2006 | Pubmed ID: 16920976 Effects of NT on Gastrointestinal Motility and Secretion, and Role in Intestinal Inflammation Peptides. Oct, 2006 | Pubmed ID: 16872719 Epithelial Cell I Kappa B-kinase Beta Has an Important Protective Role in Clostridium Difficile Toxin A-induced Mucosal Injury Journal of Immunology (Baltimore, Md. : 1950). Jul, 2006 | Pubmed ID: 16818780 Saccharomyces Boulardii Inhibits ERK1/2 Mitogen-activated Protein Kinase Activation Both in Vitro and in Vivo and Protects Against Clostridium Difficile Toxin A-induced Enteritis The Journal of Biological Chemistry. Aug, 2006 | Pubmed ID: 16816386 The Role of Neurokinin 1 Receptors in the Maintenance of Visceral Hyperalgesia Induced by Repeated Stress in Rats Gastroenterology. May, 2006 | Pubmed ID: 16697737 Role of MyD88 in Phosphatidylinositol 3-kinase Activation by Flagellin/toll-like Receptor 5 Engagement in Colonic Epithelial Cells The Journal of Biological Chemistry. Jul, 2006 | Pubmed ID: 16644730 Substance P Stimulates Cyclooxygenase-2 and Prostaglandin E2 Expression Through JAK-STAT Activation in Human Colonic Epithelial Cells Journal of Immunology (Baltimore, Md. : 1950). Apr, 2006 | Pubmed ID: 16585602 Ghrelin Stimulates Interleukin-8 Gene Expression Through Protein Kinase C-mediated NF-kappaB Pathway in Human Colonic Epithelial Cells Journal of Cellular Biochemistry. Apr, 2006 | Pubmed ID: 16552751 Induction of Colitis Causes Inflammatory Responses in Fat Depots: Evidence for Substance P Pathways in Human Mesenteric Preadipocytes Proceedings of the National Academy of Sciences of the United States of America. Mar, 2006 | Pubmed ID: 16549770 Saccharomyces Boulardii Produces a Soluble Anti-inflammatory Factor That Inhibits NF-kappaB-mediated IL-8 Gene Expression Biochemical and Biophysical Research Communications. Apr, 2006 | Pubmed ID: 16529714 Clostridium Difficile Toxin A-induced Colonocyte Apoptosis Involves P53-dependent P21(WAF1/CIP1) Induction Via P38 Mitogen-activated Protein Kinase Gastroenterology. Dec, 2005 | Pubmed ID: 16344056 Pathophysiological Role of Toll-like Receptor 5 Engagement by Bacterial Flagellin in Colonic Inflammation Proceedings of the National Academy of Sciences of the United States of America. Sep, 2005 | Pubmed ID: 16157881 Substance P-stimulated Interleukin-8 Expression in Human Colonic Epithelial Cells Involves Protein Kinase Cdelta Activation The Journal of Pharmacology and Experimental Therapeutics. Sep, 2005 | Pubmed ID: 15917399 Clostridium Difficile Toxin B Activates the EGF Receptor and the ERK/MAP Kinase Pathway in Human Colonocytes Gastroenterology. Apr, 2005 | Pubmed ID: 15825081 Clostridium Difficile Toxin A Regulates Inducible Cyclooxygenase-2 and Prostaglandin E2 Synthesis in Colonocytes Via Reactive Oxygen Species and Activation of P38 MAPK The Journal of Biological Chemistry. Jun, 2005 | Pubmed ID: 15767259 Clostridium Difficile Toxoid Vaccine in Recurrent C. Difficile-associated Diarrhea Gastroenterology. Mar, 2005 | Pubmed ID: 15765411 Neurotensin Stimulates Interleukin-8 Expression Through Modulation of I Kappa B Alpha Phosphorylation and P65 Transcriptional Activity: Involvement of Protein Kinase C Alpha Molecular Pharmacology. Jun, 2005 | Pubmed ID: 15755906 Repeated Exposure to Water Avoidance Stress in Rats: a New Model for Sustained Visceral Hyperalgesia American Journal of Physiology. Gastrointestinal and Liver Physiology. Jul, 2005 | Pubmed ID: 15746211 Rifalazil Treats and Prevents Relapse of Clostridium Difficile-associated Diarrhea in Hamsters Antimicrobial Agents and Chemotherapy. Oct, 2004 | Pubmed ID: 15388461 Metalloproteinases and Transforming Growth Factor-alpha Mediate Substance P-induced Mitogen-activated Protein Kinase Activation and Proliferation in Human Colonocytes The Journal of Biological Chemistry. Oct, 2004 | Pubmed ID: 15319441 Metalloproteinase-dependent Transforming Growth Factor-alpha Release Mediates Neurotensin-stimulated MAP Kinase Activation in Human Colonic Epithelial Cells The Journal of Biological Chemistry. Oct, 2004 | Pubmed ID: 15247267 Corticotropin-releasing Hormone (CRH) Requirement in Clostridium Difficile Toxin A-mediated Intestinal Inflammation Proceedings of the National Academy of Sciences of the United States of America. Jun, 2004 | Pubmed ID: 15159534 MEK is a Key Modulator for TLR5-induced Interleukin-8 and MIP3alpha Gene Expression in Non-transformed Human Colonic Epithelial Cells The Journal of Biological Chemistry. Jun, 2004 | Pubmed ID: 15069060 Bacterial Infections: Small Intestine and Colon Current Opinion in Gastroenterology. Jan, 2003 | Pubmed ID: 15699889 Rho GTPases As Therapeutic Targets for the Treatment of Inflammatory Diseases Expert Opinion on Therapeutic Targets. Oct, 2003 | Pubmed ID: 14498821 A Neurokinin 1 Receptor Antagonist Reduces an Ongoing Ileal Pouch Inflammation and the Response to a Subsequent Inflammatory Stimulus American Journal of Physiology. Gastrointestinal and Liver Physiology. Dec, 2003 | Pubmed ID: 12893626 Clostridium Difficile Toxin B is an Inflammatory Enterotoxin in Human Intestine Gastroenterology. Aug, 2003 | Pubmed ID: 12891543 Development of Microbial-human Enterocyte Interaction: Cholera Toxin Pediatric Research. Aug, 2003 | Pubmed ID: 12736381 Leptin Mediates Clostridium Difficile Toxin A-induced Enteritis in Mice Gastroenterology. Mar, 2003 | Pubmed ID: 12612907 Regulation of the NK-1 Receptor Gene Expression in Human Macrophage Cells Via an NF-kappa B Site on Its Promoter Proceedings of the National Academy of Sciences of the United States of America. Mar, 2003 | Pubmed ID: 12594338 Neurotensin Stimulates IL-8 Expression in Human Colonic Epithelial Cells Through Rho GTPase-mediated NF-kappa B Pathways American Journal of Physiology. Cell Physiology. Jun, 2003 | Pubmed ID: 12584113 Protective Role of HSP72 Against Clostridium Difficile Toxin A-induced Intestinal Epithelial Cell Dysfunction American Journal of Physiology. Cell Physiology. Apr, 2003 | Pubmed ID: 12490434 Substance P-stimulated Interleukin-8 Expression in Human Colonic Epithelial Cells Involves Rho Family Small GTPases The Biochemical Journal. Dec, 2002 | Pubmed ID: 12169092 Corticotropin-releasing Hormone Antagonists Possess Anti-inflammatory Effects in the Mouse Ileum Gastroenterology. Aug, 2002 | Pubmed ID: 12145804 Clostridium Difficile Toxin A Triggers Human Colonocyte IL-8 Release Via Mitochondrial Oxygen Radical Generation Gastroenterology. Apr, 2002 | Pubmed ID: 11910356 Mechanism of Lovastatin-induced Apoptosis in Intestinal Epithelial Cells Carcinogenesis. Mar, 2002 | Pubmed ID: 11895868 Genetic Deficiency in the Chemokine Receptor CCR1 Protects Against Acute Clostridium Difficile Toxin A Enteritis in Mice Gastroenterology. Mar, 2002 | Pubmed ID: 11875005 Protein Kinase C Signaling Regulates ZO-1 Translocation and Increased Paracellular Flux of T84 Colonocytes Exposed to Clostridium Difficile Toxin A The Journal of Biological Chemistry. Feb, 2002 | Pubmed ID: 11729192 Nerves and Intestinal Mast Cells Modulate Responses to Enterotoxins News in Physiological Sciences : an International Journal of Physiology Produced Jointly by the International Union of Physiological Sciences and the American Physiological Society. Apr, 1998 | Pubmed ID: 11390763 Overexpressing الكشف فضله منذ فترة طويلة باستخدام الجينات-تفعيل كريسبر Carl Robert Rankin1, Janet Treger1, Emmanuelle Faure-Kumar2, Jihane Benhammou1, Deborah Anisman-Posner3, Alex Edward Bollinger3, Charalabos Pothoulakis1, David Miguel Padua1 1Vatche and Tamar Manoukian Division of Digestive Diseases, Department of Medicine, University of California, Los Angeles, 2Vatche and Tamar Manoukian Division of Digestive Diseases, Integrated Molecular Technologies (IMT) Core, Department of Medicine, University of California, Los Angeles, 3Division of Hematology and Oncology, Department of Medicine, University of California, Los Angeles JoVE 59233 Genetics التفريق الأدوار الوظيفية في التعبير الجيني من الخلايا المناعية وغير المناعية في التهاب القولون الماوس عن طريق زرع نخاع العظم Hon Wai Koon1, Samantha Ho1, Michelle Cheng1, Ryan Ichikawa1, Charalabos Pothoulakis1 1Center for Inflammatory Bowel Diseases, Division of Digestive Diseases, David Geffen School of Medicine, The University of California Los Angeles, Los Angeles JoVE 4208 Immunology and Infection
Overexpressing الكشف فضله منذ فترة طويلة باستخدام الجينات-تفعيل كريسبر Carl Robert Rankin1, Janet Treger1, Emmanuelle Faure-Kumar2, Jihane Benhammou1, Deborah Anisman-Posner3, Alex Edward Bollinger3, Charalabos Pothoulakis1, David Miguel Padua1 1Vatche and Tamar Manoukian Division of Digestive Diseases, Department of Medicine, University of California, Los Angeles, 2Vatche and Tamar Manoukian Division of Digestive Diseases, Integrated Molecular Technologies (IMT) Core, Department of Medicine, University of California, Los Angeles, 3Division of Hematology and Oncology, Department of Medicine, University of California, Los Angeles JoVE 59233 Genetics
التفريق الأدوار الوظيفية في التعبير الجيني من الخلايا المناعية وغير المناعية في التهاب القولون الماوس عن طريق زرع نخاع العظم Hon Wai Koon1, Samantha Ho1, Michelle Cheng1, Ryan Ichikawa1, Charalabos Pothoulakis1 1Center for Inflammatory Bowel Diseases, Division of Digestive Diseases, David Geffen School of Medicine, The University of California Los Angeles, Los Angeles JoVE 4208 Immunology and Infection
