Christopher C. W. Hughes Molecular Biology and Biochemistry University of California, Irvine Biography Publications Institution JoVE Articles Christopher C. W. Hughes has not added a biography. If you are Christopher C. W. Hughes and would like to personalize this page please email our Author Liaison for assistance. Publications A Human Vascularized Microtumor Model of Patient-derived Colorectal Cancer Recapitulates Clinical Disease Translational Research : the Journal of Laboratory and Clinical Medicine. May, 2023 | Pubmed ID: 36481562 Organotypic Stromal Cells Impact Endothelial Cell Transcriptome in 3D Microvessel Networks Scientific Reports. Nov, 2022 | Pubmed ID: 36443378 Adoptive T-Cell Therapy in Advanced Colorectal Cancer: A Systematic Review The Oncologist. Mar, 2022 | Pubmed ID: 35274719 Correction: The Vascular Niche in Next Generation Microphysiological Systems Lab on a Chip. Sep, 2021 | Pubmed ID: 34472547 The Vascular Niche in Next Generation Microphysiological Systems Lab on a Chip. Sep, 2021 | Pubmed ID: 34396383 An in Vitro Vascularized Micro-tumor Model of Human Colorectal Cancer Recapitulates in Vivo Responses to Standard-of-care Therapy Lab on a Chip. Apr, 2021 | Pubmed ID: 33605955 Slug Regulates the Dll4-Notch-VEGFR2 Axis to Control Endothelial Cell Activation and Angiogenesis Nature Communications. Oct, 2020 | Pubmed ID: 33106502 Induction of Mesoderm and Neural Crest-Derived Pericytes from Human Pluripotent Stem Cells to Study Blood-Brain Barrier Interactions Stem Cell Reports. Mar, 2019 | Pubmed ID: 30745035 Pazopanib May Reduce Bleeding in Hereditary Hemorrhagic Telangiectasia Angiogenesis. Feb, 2019 | Pubmed ID: 30191360 Executive Summary of the 12th HHT International Scientific Conference Angiogenesis. Feb, 2018 | Pubmed ID: 29147802 3D Anastomosed Microvascular Network Model with Living Capillary Networks and Endothelial Cell-Lined Microfluidic Channels Methods in Molecular Biology (Clifton, N.J.). 2017 | Pubmed ID: 28634954 A Vascularized and Perfused Organ-on-a-chip Platform for Large-scale Drug Screening Applications Lab on a Chip. Jan, 2017 | Pubmed ID: 28092382 Recapitulating the Human Tumor Microenvironment: Colon Tumor-derived Extracellular Matrix Promotes Angiogenesis and Tumor Cell Growth Biomaterials. Feb, 2017 | Pubmed ID: 27914984 MTORC2 Mediates CXCL12-induced Angiogenesis Angiogenesis. Jul, 2016 | Pubmed ID: 27106789 Engineering Anastomosis Between Living Capillary Networks and Endothelial Cell-lined Microfluidic Channels Lab on a Chip. Jan, 2016 | Pubmed ID: 26616908 Executive Summary of the 11th HHT International Scientific Conference Angiogenesis. Oct, 2015 | Pubmed ID: 26391603 A Role for Partial Endothelial-mesenchymal Transitions in Angiogenesis? Arteriosclerosis, Thrombosis, and Vascular Biology. Feb, 2015 | Pubmed ID: 25425619 Interferon-induced Transmembrane Protein 1 Regulates Endothelial Lumen Formation During Angiogenesis Arteriosclerosis, Thrombosis, and Vascular Biology. May, 2014 | Pubmed ID: 24603679 Angiogenic Sprouting is Regulated by Endothelial Cell Expression of Slug Journal of Cell Science. May, 2014 | Pubmed ID: 24554431 Analysis of Stromal Cell Secretomes Reveals a Critical Role for Stromal Cell-derived Hepatocyte Growth Factor and Fibronectin in Angiogenesis Arteriosclerosis, Thrombosis, and Vascular Biology. Mar, 2013 | Pubmed ID: 23288153 Macrophages and Angiogenesis: a Role for Wnt Signaling Vascular Cell. 2012 | Pubmed ID: 22938389 BMP9 Induces EphrinB2 Expression in Endothelial Cells Through an Alk1-BMPRII/ActRII-ID1/ID3-dependent Pathway: Implications for Hereditary Hemorrhagic Telangiectasia Type II Angiogenesis. Sep, 2012 | Pubmed ID: 22622516 整合素信号通过适配器分子 Grb2 与 β-连环素-依赖 Wnt 通路的集成。 PloS One. 2009 | Pubmed ID: 19924227 NFkappaB 依赖于肿瘤坏死因子诱导的锯齿状 1 内皮细胞。 Gene. Apr, 2009 | Pubmed ID: 19393188 Prevascularization 基于纤维蛋白的组织构造的加速功能吻合与宿主血管的形成。 Tissue Engineering. Part A. Jun, 2009 | Pubmed ID: 18976155 优化三维体外模型分析中的血管生成。 Methods in Enzymology. 2008 | Pubmed ID: 18772011 在血管的内皮-间质相互作用。 Current Opinion in Hematology. May, 2008 | Pubmed ID: 18391786 Wnt 信号诱导基质金属蛋白酶表达及调节 T 细胞轮回。 Immunity. Feb, 2007 | Pubmed ID: 17306568 骨髓间充质干细胞增强通过早期的基质金属蛋白酶上调机械可行 Prevascularized 组织中的血管生成。 Tissue Engineering. Oct, 2006 | Pubmed ID: 17518656 HESR1/CHF2 取消 VEGFR2 转录到 E 框绑定的独立。 Biochemical and Biophysical Research Communications. Aug, 2006 | Pubmed ID: 16782059 细胞自主 Notch 信号规管分支血管内皮细胞和血管 Tubulogenesis 期间扩散。 FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology. Jun, 2005 | Pubmed ID: 15774577 VEGF(121) 和 VEGF(165) 调节血管直径,通过血管内皮生长因子受体 2 在体外血管生成模型。 Laboratory Investigation; a Journal of Technical Methods and Pathology. Dec, 2003 | Pubmed ID: 14691306 体外血管内皮细胞网络形成过程中的槽口活化的目标基本 HLH 转录因子 HESR-1 和病毒生长因子受体-2/kdr 基因的表达。 Microvascular Research. Nov, 2002 | Pubmed ID: 12453432 Creating Human Vascularized Micro-Tumors as Models for Translational Cancer Research (Video) | JoVE Stephanie J. Hachey1, Daniela Gaebler1, Christopher C. W. Hughes1,2 1Molecular Biology and Biochemistry, University of California, Irvine, 2Biomedical Engineering, University of California, Irvine JoVE 65865 Cancer Research
Creating Human Vascularized Micro-Tumors as Models for Translational Cancer Research (Video) | JoVE Stephanie J. Hachey1, Daniela Gaebler1, Christopher C. W. Hughes1,2 1Molecular Biology and Biochemistry, University of California, Irvine, 2Biomedical Engineering, University of California, Irvine JoVE 65865 Cancer Research