Christopher C. W. Hughes Molecular Biology and Biochemistry University of California, Irvine Biography Publications Institution JoVE Articles Christopher C. W. Hughes has not added a biography. If you are Christopher C. W. Hughes and would like to personalize this page please email our Author Liaison for assistance. Publications A Human Vascularized Microtumor Model of Patient-derived Colorectal Cancer Recapitulates Clinical Disease Translational Research : the Journal of Laboratory and Clinical Medicine. May, 2023 | Pubmed ID: 36481562 Organotypic Stromal Cells Impact Endothelial Cell Transcriptome in 3D Microvessel Networks Scientific Reports. Nov, 2022 | Pubmed ID: 36443378 Adoptive T-Cell Therapy in Advanced Colorectal Cancer: A Systematic Review The Oncologist. Mar, 2022 | Pubmed ID: 35274719 Correction: The Vascular Niche in Next Generation Microphysiological Systems Lab on a Chip. Sep, 2021 | Pubmed ID: 34472547 The Vascular Niche in Next Generation Microphysiological Systems Lab on a Chip. Sep, 2021 | Pubmed ID: 34396383 An in Vitro Vascularized Micro-tumor Model of Human Colorectal Cancer Recapitulates in Vivo Responses to Standard-of-care Therapy Lab on a Chip. Apr, 2021 | Pubmed ID: 33605955 Slug Regulates the Dll4-Notch-VEGFR2 Axis to Control Endothelial Cell Activation and Angiogenesis Nature Communications. Oct, 2020 | Pubmed ID: 33106502 Induction of Mesoderm and Neural Crest-Derived Pericytes from Human Pluripotent Stem Cells to Study Blood-Brain Barrier Interactions Stem Cell Reports. Mar, 2019 | Pubmed ID: 30745035 Pazopanib May Reduce Bleeding in Hereditary Hemorrhagic Telangiectasia Angiogenesis. Feb, 2019 | Pubmed ID: 30191360 Executive Summary of the 12th HHT International Scientific Conference Angiogenesis. Feb, 2018 | Pubmed ID: 29147802 3D Anastomosed Microvascular Network Model with Living Capillary Networks and Endothelial Cell-Lined Microfluidic Channels Methods in Molecular Biology (Clifton, N.J.). 2017 | Pubmed ID: 28634954 A Vascularized and Perfused Organ-on-a-chip Platform for Large-scale Drug Screening Applications Lab on a Chip. Jan, 2017 | Pubmed ID: 28092382 Recapitulating the Human Tumor Microenvironment: Colon Tumor-derived Extracellular Matrix Promotes Angiogenesis and Tumor Cell Growth Biomaterials. Feb, 2017 | Pubmed ID: 27914984 MTORC2 Mediates CXCL12-induced Angiogenesis Angiogenesis. Jul, 2016 | Pubmed ID: 27106789 Engineering Anastomosis Between Living Capillary Networks and Endothelial Cell-lined Microfluidic Channels Lab on a Chip. Jan, 2016 | Pubmed ID: 26616908 Executive Summary of the 11th HHT International Scientific Conference Angiogenesis. Oct, 2015 | Pubmed ID: 26391603 A Role for Partial Endothelial-mesenchymal Transitions in Angiogenesis? Arteriosclerosis, Thrombosis, and Vascular Biology. Feb, 2015 | Pubmed ID: 25425619 Interferon-induced Transmembrane Protein 1 Regulates Endothelial Lumen Formation During Angiogenesis Arteriosclerosis, Thrombosis, and Vascular Biology. May, 2014 | Pubmed ID: 24603679 Angiogenic Sprouting is Regulated by Endothelial Cell Expression of Slug Journal of Cell Science. May, 2014 | Pubmed ID: 24554431 Analysis of Stromal Cell Secretomes Reveals a Critical Role for Stromal Cell-derived Hepatocyte Growth Factor and Fibronectin in Angiogenesis Arteriosclerosis, Thrombosis, and Vascular Biology. Mar, 2013 | Pubmed ID: 23288153 Macrophages and Angiogenesis: a Role for Wnt Signaling Vascular Cell. 2012 | Pubmed ID: 22938389 BMP9 Induces EphrinB2 Expression in Endothelial Cells Through an Alk1-BMPRII/ActRII-ID1/ID3-dependent Pathway: Implications for Hereditary Hemorrhagic Telangiectasia Type II Angiogenesis. Sep, 2012 | Pubmed ID: 22622516 Intégration De La Voie Bêta-caténine-dépendante Wnt Avec L'intégrine De Signalisation à Travers La Molécule Adaptateur Grb2 PloS One. 2009 | Pubmed ID: 19924227 Induction Du TNF Jagged-1 Dans Les Cellules Endothéliales Est NFkappaB-dépendante Gene. Apr, 2009 | Pubmed ID: 19393188 Prevascularization D'une Construction Tissulaire à Base De Fibrine Accélère La Formation De Vaisseaux Sanguins Anastomose Fonctionnelle Avec L'hôte Tissue Engineering. Part A. Jun, 2009 | Pubmed ID: 18976155 Un Optimisée En Trois Dimensions Dans Le Modèle in Vitro Pour L'analyse De L'angiogenèse Methods in Enzymology. 2008 | Pubmed ID: 18772011 Endothelial-stromales Interactions Dans L'angiogenèse Current Opinion in Hematology. May, 2008 | Pubmed ID: 18391786 Signalisation Wnt Induit L'expression De Métalloprotéinase De La Matrice Et Réglemente La Transmigration Des Lymphocytes T Immunity. Feb, 2007 | Pubmed ID: 17306568 Cellules Souches Mésenchymateuses Améliorer Angiogenèse Dans Les Tissus Prevascularized Mécaniquement Viables Via Régulation à La Hausse Matrice Métalloprotéinase Précoce Tissue Engineering. Oct, 2006 | Pubmed ID: 17518656 HESR1/CHF2 Supprime VEGFR2 Transcription Indépendant De Se Lier à E-boîtes Biochemical and Biophysical Research Communications. Aug, 2006 | Pubmed ID: 16782059 Signalisation Notch Des Cellules Autonomes Réglemente Cellules Endothéliales Des Branches Et Des Cours De Prolifération Vasculaire Tubulogenèse FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology. Jun, 2005 | Pubmed ID: 15774577 VEGF (121) Et Le VEGF (165) Réglementer Diamètre Du Vaisseau Sanguin Grâce Vasculaire Endothéliale Growth Factor Receptor 2 Dans Un Modèle D'angiogenèse in Vitro Laboratory Investigation; a Journal of Technical Methods and Pathology. Dec, 2003 | Pubmed ID: 14691306 Activation De Notch Cours De La Formation Du Réseau De Cellules Endothéliales in Vitro Cible Le Facteur De Transcription De Base HLH HESR-1 Et Régule Négativement L'expression VEGFR-2/KDR Microvascular Research. Nov, 2002 | Pubmed ID: 12453432 Creating Human Vascularized Micro-Tumors as Models for Translational Cancer Research (Video) | JoVE Stephanie J. Hachey1, Daniela Gaebler1, Christopher C. W. Hughes1,2 1Molecular Biology and Biochemistry, University of California, Irvine, 2Biomedical Engineering, University of California, Irvine JoVE 65865 Cancer Research
Creating Human Vascularized Micro-Tumors as Models for Translational Cancer Research (Video) | JoVE Stephanie J. Hachey1, Daniela Gaebler1, Christopher C. W. Hughes1,2 1Molecular Biology and Biochemistry, University of California, Irvine, 2Biomedical Engineering, University of California, Irvine JoVE 65865 Cancer Research