Clayton E. Mathews Department of Pathology, Immunology, and Laboratory Medicine University of Florida Biography Publications Institution JoVE Articles Clayton E. Mathews has not added a biography. If you are Clayton E. Mathews and would like to personalize this page please email our Author Liaison for assistance. Publications Islet Sympathetic Innervation and Islet Neuropathology in Patients with Type 1 Diabetes Scientific Reports. Mar, 2021 | Pubmed ID: 33753784 Influence of Allotypes on Innate and Adaptive Immune Function in Health and Disease Frontiers in Immunology. 2021 | Pubmed ID: 33717184 Low-dose ATG/GCSF in Established Type 1 Diabetes: A Five-Year Follow-up Report Diabetes. Feb, 2021 | Pubmed ID: 33632742 Mitochondrial Haplogroup G is Associated with Nonalcoholic Fatty Liver Disease, While Haplogroup A Mitigates the Effects of PNPLA3 Endocrinology, Diabetes & Metabolism. Jan, 2021 | Pubmed ID: 33532620 Branched Chain Amino Acids and Carbohydrate Restriction Exacerbate Ketogenesis and Hepatic Mitochondrial Oxidative Dysfunction During NAFLD FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology. Nov, 2020 | Pubmed ID: 32918763 Comparing Beta Cell Preservation Across Clinical Trials in Recent-Onset Type 1 Diabetes Diabetes Technology & Therapeutics. 12, 2020 | Pubmed ID: 32833543 Lipid Mediators and Biomarkers Associated with Type 1 Diabetes Development JCI Insight. 08, 2020 | Pubmed ID: 32814707 NKG2D Signaling Within the Pancreatic Islets Reduces NOD Diabetes and Increases Protective Central Memory CD8 T-Cell Numbers Diabetes. 08, 2020 | Pubmed ID: 32535552 Disruption of Hepatic One-carbon Metabolism Impairs Mitochondrial Function and Enhances Macrophage Activity in Methionine-choline-deficient Mice The Journal of Nutritional Biochemistry. 07, 2020 | Pubmed ID: 32422424 Innate Inflammation Drives NK Cell Activation to Impair Treg Activity Journal of Autoimmunity. 03, 2020 | Pubmed ID: 32035746 Neutrophil Cytosolic Factor 1 in Dendritic Cells Promotes Autoreactive CD8 T Cell Activation Via Cross-Presentation in Type 1 Diabetes Frontiers in Immunology. 2019 | Pubmed ID: 31118934 Boosting to Amplify Signal with Isobaric Labeling (BASIL) Strategy for Comprehensive Quantitative Phosphoproteomic Characterization of Small Populations of Cells Analytical Chemistry. May, 2019 | Pubmed ID: 30843680 Sixteen Diverse Laboratory Mouse Reference Genomes Define Strain-specific Haplotypes and Novel Functional Loci Nature Genetics. 11, 2018 | Pubmed ID: 30275530 Nanowell-mediated Two-dimensional Liquid Chromatography Enables Deep Proteome Profiling of <1000 Mammalian Cells Chemical Science. Sep, 2018 | Pubmed ID: 30210768 Correction To: Metabolic Abnormalities in the Pathogenesis of Type 1 Diabetes Current Diabetes Reports. 09, 2018 | Pubmed ID: 30173405 Protective Role of Myeloid Cells Expressing a G-CSF Receptor Polymorphism in an Induced Model of Lupus Frontiers in Immunology. 2018 | Pubmed ID: 29868014 Abnormal Islet Sphingolipid Metabolism in Type 1 Diabetes Diabetologia. 07, 2018 | Pubmed ID: 29671030 The Role of NOD Mice in Type 1 Diabetes Research: Lessons from the Past and Recommendations for the Future Frontiers in Endocrinology. 2018 | Pubmed ID: 29527189 Nanodroplet Processing Platform for Deep and Quantitative Proteome Profiling of 10-100 Mammalian Cells Nature Communications. 02, 2018 | Pubmed ID: 29491378 Loss of B-Cell Anergy in Type 1 Diabetes Is Associated With High-Risk HLA and Non-HLA Disease Susceptibility Alleles Diabetes. 04, 2018 | Pubmed ID: 29343548 Mitochondrial Reactive Oxygen Species and Type 1 Diabetes Antioxidants & Redox Signaling. 11, 2018 | Pubmed ID: 29295631 Avidity and Bystander Suppressive Capacity of Human Regulatory T Cells Expressing Autoreactive T-Cell Receptors in Type 1 Diabetes Frontiers in Immunology. 2017 | Pubmed ID: 29123516 The Type 1 Diabetes-Resistance Locus Controls Trafficking of Autoreactive CTLs into the Pancreatic Islets of NOD Mice Journal of Immunology (Baltimore, Md. : 1950). 12, 2017 | Pubmed ID: 29109122 Type I Interferon Is a Catastrophic Feature of the Diabetic Islet Microenvironment Frontiers in Endocrinology. 2017 | Pubmed ID: 28959234 T Cells Display Mitochondria Hyperpolarization in Human Type 1 Diabetes Scientific Reports. 09, 2017 | Pubmed ID: 28883439 Type 1 Interferons Potentiate Human CD8 T-Cell Cytotoxicity Through a STAT4- and Granzyme B-Dependent Pathway Diabetes. 12, 2017 | Pubmed ID: 28877912 Mitochondrial ATP Transporter Depletion Protects Mice Against Liver Steatosis and Insulin Resistance Nature Communications. 02, 2017 | Pubmed ID: 28205519 Interferon-γ Limits Diabetogenic CD8 T-Cell Effector Responses in Type 1 Diabetes Diabetes. 03, 2017 | Pubmed ID: 27920091 Human Pancreatic Cancer Cells Induce a MyD88-Dependent Stromal Response to Promote a Tumor-Tolerant Immune Microenvironment Cancer Research. 02, 2017 | Pubmed ID: 27864347 Genetic Risk Analysis of a Patient with Fulminant Autoimmune Type 1 Diabetes Mellitus Secondary to Combination Ipilimumab and Nivolumab Immunotherapy Journal for Immunotherapy of Cancer. 2016 | Pubmed ID: 28031819 Islet-derived CD4 T-cells Targeting Proinsulin in Human Autoimmune Diabetes Diabetes. Dec, 2016 | Pubmed ID: 27920090 Antithymocyte Globulin Plus G-CSF Combination Therapy Leads to Sustained Immunomodulatory and Metabolic Effects in a Subset of Responders With Established Type 1 Diabetes Diabetes. Dec, 2016 | Pubmed ID: 27669730 Islet Cell Hyperexpression of HLA Class I Antigens: a Defining Feature in Type 1 Diabetes Diabetologia. 11, 2016 | Pubmed ID: 27506584 Liquid Chromatography-Mass Spectrometry Metabolic and Lipidomic Sample Preparation Workflow for Suspension-Cultured Mammalian Cells Using Jurkat T Lymphocyte Cells Journal of Proteomics & Bioinformatics. Jun, 2015 | Pubmed ID: 26401069 Respiration and Substrate Transport Rates As Well As Reactive Oxygen Species Production Distinguish Mitochondria from Brain and Liver BMC Biochemistry. Sep, 2015 | Pubmed ID: 26358560 Loss of NOX-Derived Superoxide Exacerbates Diabetogenic CD4 T-Cell Effector Responses in Type 1 Diabetes Diabetes. Dec, 2015 | Pubmed ID: 26269022 Acute Versus Progressive Onset of Diabetes in NOD Mice: Potential Implications for Therapeutic Interventions in Type 1 Diabetes Diabetes. Nov, 2015 | Pubmed ID: 26216853 Combination Therapy Reverses Hyperglycemia in NOD Mice With Established Type 1 Diabetes Diabetes. Nov, 2015 | Pubmed ID: 26185279 Distinct Differences in the Responses of the Human Pancreatic β-cell Line EndoC-βH1 and Human Islets to Proinflammatory Cytokines American Journal of Physiology. Regulatory, Integrative and Comparative Physiology. Sep, 2015 | Pubmed ID: 26084699 Reply to Gurgul-Convey and Lenzen: Cytokines, Nitric Oxide, and β-cells The Journal of Biological Chemistry. Apr, 2015 | Pubmed ID: 26065037 How the Location of Superoxide Generation Influences the β-cell Response to Nitric Oxide The Journal of Biological Chemistry. Mar, 2015 | Pubmed ID: 25648890 TRIF-dependent Innate Immune Activation is Critical for Survival to Neonatal Gram-negative Sepsis Journal of Immunology (Baltimore, Md. : 1950). Feb, 2015 | Pubmed ID: 25548220 Association of the Mt-ND2 5178A/C Polymorphism with Parkinson's Disease Neuroscience Letters. Feb, 2015 | Pubmed ID: 25511548 Anti-thymocyte Globulin/G-CSF Treatment Preserves β Cell Function in Patients with Established Type 1 Diabetes The Journal of Clinical Investigation. Jan, 2015 | Pubmed ID: 25500887 Mechanisms of Tumor Necrosis Factor α Antagonist-induced Lupus in a Murine Model Arthritis & Rheumatology (Hoboken, N.J.). Jan, 2015 | Pubmed ID: 25252121 Metabolic Abnormalities in the Pathogenesis of Type 1 Diabetes Current Diabetes Reports. 2014 | Pubmed ID: 25023213 In Search of a Surrogate: Engineering Human Beta Cell Lines for Therapy Trends in Endocrinology and Metabolism: TEM. Aug, 2014 | Pubmed ID: 24958526 Use of Chemical Probes to Detect Mitochondrial ROS by Flow Cytometry and Spectrofluorometry Methods in Enzymology. 2014 | Pubmed ID: 24862269 Do β-cells Generate Peroxynitrite in Response to Cytokine Treatment? The Journal of Biological Chemistry. Dec, 2013 | Pubmed ID: 24194521 Comparative Genetics: Synergizing Human and NOD Mouse Studies for Identifying Genetic Causation of Type 1 Diabetes The Review of Diabetic Studies : RDS. 2012 | Pubmed ID: 23804259 Oxidative Stress and Beta Cell Dysfunction Methods in Molecular Biology (Clifton, N.J.). 2012 | Pubmed ID: 22933078 Immune-mediated β-cell Death in Type 1 Diabetes: Lessons from Human β-cell Lines European Journal of Clinical Investigation. Nov, 2012 | Pubmed ID: 22924552 Inherited β-cell Dysfunction in Lean Individuals with Type 2 Diabetes Diabetes. Jul, 2012 | Pubmed ID: 22723272 Pleiotropic IFN-dependent and -independent Effects of IRF5 on the Pathogenesis of Experimental Lupus Journal of Immunology (Baltimore, Md. : 1950). Apr, 2012 | Pubmed ID: 22422888 L'uso Di Leptina Come Trattamento Per Il Diabete Mellito Di Tipo 1: Contrappunto Pediatric Diabetes. Feb, 2012 | Pubmed ID: 21884562 Ruolo Della Genetica Nella Resistenza Al Diabete Di Tipo 1 Diabetes/metabolism Research and Reviews. Nov, 2011 | Pubmed ID: 22069272 Superossido Aumentato Accumulo Di Fibroblasti Carente Complesso Piruvato Deidrogenasi Molecular Genetics and Metabolism. Nov, 2011 | Pubmed ID: 21846590 Lo Sviluppo Di Diabete Nei Topi Ncb5or Null Magri è Associato a Manifestazioni Del Reticolo Endoplasmatico E Stress Ossidativo Nelle Cellule Beta Biochimica Et Biophysica Acta. Nov, 2011 | Pubmed ID: 21839170 Ruolo Dei Mitocondri Nella Morte Apoptotic Immuno-mediata Del β Del Pancreas Umano Cella Linea βLox5 PloS One. 2011 | Pubmed ID: 21738580 Produzione Di Superossido Da Macrofagi E Cellule T è Un Fattore Critico Per L'induzione Di Autoreactivity E Diabete Di Tipo 1 Diabetes. Aug, 2011 | Pubmed ID: 21715554 Mobilitazione Dei Neutrofili Dal Midollo Osseo Durante Sepsi Etiologico è Dipendente CXCL12 Segnalazione Journal of Immunology (Baltimore, Md. : 1950). Jul, 2011 | Pubmed ID: 21690321 Progressiva Erosione Della Funzione β-cellula Precede L'insorgenza Di Iperglicemia Nel Modello Del Mouse Di Cenno Del Diabete Di Tipo 1 Diabetes. Aug, 2011 | Pubmed ID: 21659497 Ruolo Critico Di CXC Ligando Recettore CXC/10 3 Segnalazione in Risposta a Sepsi Neonatale Murina Infection and Immunity. Jul, 2011 | Pubmed ID: 21518789 Sepsi Induce Alterazioni Precoce Nell'immunità Innata Che Influiscono Sulla Mortalità Per Infezione Secondaria Journal of Immunology (Baltimore, Md. : 1950). Jan, 2011 | Pubmed ID: 21106855 Mt-Nd2(a) Consente Di Modificare La Resistenza Contro Il Diabete Autoimmune Di Tipo 1 Nei Topi NOD Al Livello Della β-cellula Pancreatica Diabetes. Jan, 2011 | Pubmed ID: 20980458 Carenza Di NADPH Ossidasi Regola Impegno Lignaggio Th E Modula L'autoimmunità Journal of Immunology (Baltimore, Md. : 1950). Nov, 2010 | Pubmed ID: 20881184 Uso Di Topi Diabetici Nonobese Capire Umano Diabete Di Tipo 1 Endocrinology and Metabolism Clinics of North America. Sep, 2010 | Pubmed ID: 20723819 Esaurimento Immunitario Con Mobilizzazione Cellulare Conferisce Immunoregolazione E Inverte Il Diabete Autoimmune in Nonobese Topi Diabetici Diabetes. Oct, 2009 | Pubmed ID: 19628781 Valutazione Di Protocolli Per La Differenziazione Delle Cellule Staminali Embrionali in Cellule Beta Che Secernono Insulina Utilizzando Insulina II-GFP Come Reporter Specifico E Non Invasivo Cloning and Stem Cells. Jun, 2009 | Pubmed ID: 19508115 Ruolo Di SREBP-1 Nello Sviluppo Della Disfunzione Parasimpatico Nei Cuori Dei Topi Akita Diabetici Di Tipo 1 Circulation Research. Jul, 2009 | Pubmed ID: 19423844 Capitolo 24 Specificità Tessuto, Localizzazione E Quantificazione Della Produzione Di Specie Ossigeno Reattive Mitocondriale Del Mouse Methods in Enzymology. 2009 | Pubmed ID: 19348903 MerTK Regola La Selezione Timica Di T Autoreattivi Cellule Proceedings of the National Academy of Sciences of the United States of America. Mar, 2009 | Pubmed ID: 19251650 Ruolo Del Maggiore Dissipazione Di ROS Nella Prevenzione Del T1D Annals of the New York Academy of Sciences. Dec, 2008 | Pubmed ID: 19120287 Comunanze Di Resistenza Genetica Alla Spontanea Autoimmune E Radicali Liberi - Mediata Da Diabete Free Radical Biology & Medicine. Nov, 2008 | Pubmed ID: 18718526 MT-Nd2a Sopprime La Produzione Di Specie Reattive Dell'ossigeno Mitocondriale Complessi I E III The Journal of Biological Chemistry. Apr, 2008 | Pubmed ID: 18281288 MerTK è Richiesto Per La Tolleranza Di Apoptotic Cell-indotta Delle Cellule T The Journal of Experimental Medicine. Jan, 2008 | Pubmed ID: 18195070 Le Risposte Delle Cellule T Autoreattivi: Nuova Tecnologia Nel Perseguimento Di Una Vecchia Nemesi Pediatric Diabetes. Oct, 2007 | Pubmed ID: 17850466 Interazione Nucleare E Mitocondriale Coinvolgendo Mt-Nd2 Conduce Alla Produzione Di Specie Di Ossigeno Reattivo Mitocondriale Aumentata The Journal of Biological Chemistry. Feb, 2007 | Pubmed ID: 17189252 Le Cellule Apoptotic Inducono Blocco Mer Tirosina Chinasi Dipendente Dalla Attivazione Di NF-kappaB in Cellule Dendritiche Blood. Jan, 2007 | Pubmed ID: 17008547 Modulatrice Ruolo Delle Risposte T-cellula CD4 DR4 E DQ8 Limitato E Suscettibilità Di Diabete Di Tipo 1 Diabetes. Dec, 2006 | Pubmed ID: 17130492 HLA-A * 0201-limitato Di Cellule T Da Topi NOD Umanizzati Riconoscono Autoantigeni Di Potenziale Rilevanza Clinica Di Diabete Di Tipo 1 Journal of Immunology (Baltimore, Md. : 1950). Mar, 2006 | Pubmed ID: 16493087 Utilità Dei Modelli Murini Per Lo Studio Della Spontanea Autoimmune Diabete Di Tipo 1 Pediatric Diabetes. Sep, 2005 | Pubmed ID: 16109074 Meccanismi Sottostanti Resistenza Di Isole Pancreatiche Da Topi ALR/Lt a Distruzione Indotta Da Citochine Journal of Immunology (Baltimore, Md. : 1950). Jul, 2005 | Pubmed ID: 16002729 Maggiore Suscettibilità Diabete Collegato Complesso Di Istocompatibilità in Topi NOD/Lt: Analisi Subcongenic Localizza Un Componente Di Idd16 Alla Fine Del Diabetogenic H2(g7) Complesso H2-D Diabetes. May, 2005 | Pubmed ID: 15855353 L'inibizione Del Proteasoma Altera La Secrezione Di Insulina (pro) Glucosio Stimolato E Fatturato Nel Pancreas {beta}-cellule The Journal of Biological Chemistry. Apr, 2005 | Pubmed ID: 15705591 ALS/Lt: Un Nuovo Modello Di Mouse Diabete Di Tipo 2 Associato Basso Free Radical Scavenging Potenziale Diabetes. Feb, 2004 | Pubmed ID: 14749277 Analisi Genetica Della Resistenza Al Diabete Di Tipo 1 Nei Topi ALR/Lt, Un Ceppo Di NOD Con Difese Contro Lo Stress Diabetogenic Autoimmune-mediata Immunogenetics. Oct, 2003 | Pubmed ID: 14513297 Rodent Models for the Study of Type 2 Diabetes in Children (juvenile Diabesity) Pediatric Diabetes. Sep, 2002 | Pubmed ID: 15016157 Nuovo Modello Di Mouse Per Studiare Il Trapianto Isolotto in Mellitus Del Diabete Insulino - Dipendente Transplantation. Apr, 2002 | Pubmed ID: 11981430 Controllo Genetico Della Produzione Di Superossido Neutrofili Nel Diabete Resistenti Topi ALR/Lt Free Radical Biology & Medicine. Apr, 2002 | Pubmed ID: 11937300 Osservare la funzione delle isole e le interazioni isolo-cellule immunitarie nelle fette di tessuto pancreatico vivo Mollie K. Huber1, Denise M. Drotar2,3,4, Helmut Hiller1, Maria L. Beery1, Paul Joseph1, Irina Kusmartseva1, Stephan Speier2,3,4, Mark A. Atkinson1, Clayton E. Mathews1, Edward A. Phelps5 1Department of Pathology, Immunology, and Laboratory Medicine, University of Florida, 2Paul Langerhans Institute Dresden (PLID) of the Helmholtz Zentrum München at the University Clinic Carl Gustav Carus of Technische Universität Dresden, 3Institute of Physiology, Faculty of Medicine, Technische Universität Dresden, 4German Center for Diabetes Research (DZD), 5J. Crayton Pruitt Family Department of Biomedical Engineering, University of Florida JoVE 62207 Immunology and Infection Metodi per valutare la morte delle cellule beta Mediata da linfociti T citotossici Jing Chen1, Scott Grieshaber1, Clayton E. Mathews1 1Departments of Pathology, Immunology and Laboratory Medicine, College of Medicine, University of Florida JoVE 2724 Immunology and Infection
Osservare la funzione delle isole e le interazioni isolo-cellule immunitarie nelle fette di tessuto pancreatico vivo Mollie K. Huber1, Denise M. Drotar2,3,4, Helmut Hiller1, Maria L. Beery1, Paul Joseph1, Irina Kusmartseva1, Stephan Speier2,3,4, Mark A. Atkinson1, Clayton E. Mathews1, Edward A. Phelps5 1Department of Pathology, Immunology, and Laboratory Medicine, University of Florida, 2Paul Langerhans Institute Dresden (PLID) of the Helmholtz Zentrum München at the University Clinic Carl Gustav Carus of Technische Universität Dresden, 3Institute of Physiology, Faculty of Medicine, Technische Universität Dresden, 4German Center for Diabetes Research (DZD), 5J. Crayton Pruitt Family Department of Biomedical Engineering, University of Florida JoVE 62207 Immunology and Infection
Metodi per valutare la morte delle cellule beta Mediata da linfociti T citotossici Jing Chen1, Scott Grieshaber1, Clayton E. Mathews1 1Departments of Pathology, Immunology and Laboratory Medicine, College of Medicine, University of Florida JoVE 2724 Immunology and Infection