Clayton E. Mathews Department of Pathology, Immunology, and Laboratory Medicine University of Florida Biography Publications Institution JoVE Articles Clayton E. Mathews has not added a biography. If you are Clayton E. Mathews and would like to personalize this page please email our Author Liaison for assistance. Publications Islet Sympathetic Innervation and Islet Neuropathology in Patients with Type 1 Diabetes Scientific Reports. Mar, 2021 | Pubmed ID: 33753784 Influence of Allotypes on Innate and Adaptive Immune Function in Health and Disease Frontiers in Immunology. 2021 | Pubmed ID: 33717184 Low-dose ATG/GCSF in Established Type 1 Diabetes: A Five-Year Follow-up Report Diabetes. Feb, 2021 | Pubmed ID: 33632742 Mitochondrial Haplogroup G is Associated with Nonalcoholic Fatty Liver Disease, While Haplogroup A Mitigates the Effects of PNPLA3 Endocrinology, Diabetes & Metabolism. Jan, 2021 | Pubmed ID: 33532620 Branched Chain Amino Acids and Carbohydrate Restriction Exacerbate Ketogenesis and Hepatic Mitochondrial Oxidative Dysfunction During NAFLD FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology. Nov, 2020 | Pubmed ID: 32918763 Comparing Beta Cell Preservation Across Clinical Trials in Recent-Onset Type 1 Diabetes Diabetes Technology & Therapeutics. 12, 2020 | Pubmed ID: 32833543 Lipid Mediators and Biomarkers Associated with Type 1 Diabetes Development JCI Insight. 08, 2020 | Pubmed ID: 32814707 NKG2D Signaling Within the Pancreatic Islets Reduces NOD Diabetes and Increases Protective Central Memory CD8 T-Cell Numbers Diabetes. 08, 2020 | Pubmed ID: 32535552 Disruption of Hepatic One-carbon Metabolism Impairs Mitochondrial Function and Enhances Macrophage Activity in Methionine-choline-deficient Mice The Journal of Nutritional Biochemistry. 07, 2020 | Pubmed ID: 32422424 Innate Inflammation Drives NK Cell Activation to Impair Treg Activity Journal of Autoimmunity. 03, 2020 | Pubmed ID: 32035746 Neutrophil Cytosolic Factor 1 in Dendritic Cells Promotes Autoreactive CD8 T Cell Activation Via Cross-Presentation in Type 1 Diabetes Frontiers in Immunology. 2019 | Pubmed ID: 31118934 Boosting to Amplify Signal with Isobaric Labeling (BASIL) Strategy for Comprehensive Quantitative Phosphoproteomic Characterization of Small Populations of Cells Analytical Chemistry. May, 2019 | Pubmed ID: 30843680 Sixteen Diverse Laboratory Mouse Reference Genomes Define Strain-specific Haplotypes and Novel Functional Loci Nature Genetics. 11, 2018 | Pubmed ID: 30275530 Nanowell-mediated Two-dimensional Liquid Chromatography Enables Deep Proteome Profiling of <1000 Mammalian Cells Chemical Science. Sep, 2018 | Pubmed ID: 30210768 Correction To: Metabolic Abnormalities in the Pathogenesis of Type 1 Diabetes Current Diabetes Reports. 09, 2018 | Pubmed ID: 30173405 Protective Role of Myeloid Cells Expressing a G-CSF Receptor Polymorphism in an Induced Model of Lupus Frontiers in Immunology. 2018 | Pubmed ID: 29868014 Abnormal Islet Sphingolipid Metabolism in Type 1 Diabetes Diabetologia. 07, 2018 | Pubmed ID: 29671030 The Role of NOD Mice in Type 1 Diabetes Research: Lessons from the Past and Recommendations for the Future Frontiers in Endocrinology. 2018 | Pubmed ID: 29527189 Nanodroplet Processing Platform for Deep and Quantitative Proteome Profiling of 10-100 Mammalian Cells Nature Communications. 02, 2018 | Pubmed ID: 29491378 Loss of B-Cell Anergy in Type 1 Diabetes Is Associated With High-Risk HLA and Non-HLA Disease Susceptibility Alleles Diabetes. 04, 2018 | Pubmed ID: 29343548 Mitochondrial Reactive Oxygen Species and Type 1 Diabetes Antioxidants & Redox Signaling. 11, 2018 | Pubmed ID: 29295631 Avidity and Bystander Suppressive Capacity of Human Regulatory T Cells Expressing Autoreactive T-Cell Receptors in Type 1 Diabetes Frontiers in Immunology. 2017 | Pubmed ID: 29123516 The Type 1 Diabetes-Resistance Locus Controls Trafficking of Autoreactive CTLs into the Pancreatic Islets of NOD Mice Journal of Immunology (Baltimore, Md. : 1950). 12, 2017 | Pubmed ID: 29109122 Type I Interferon Is a Catastrophic Feature of the Diabetic Islet Microenvironment Frontiers in Endocrinology. 2017 | Pubmed ID: 28959234 T Cells Display Mitochondria Hyperpolarization in Human Type 1 Diabetes Scientific Reports. 09, 2017 | Pubmed ID: 28883439 Type 1 Interferons Potentiate Human CD8 T-Cell Cytotoxicity Through a STAT4- and Granzyme B-Dependent Pathway Diabetes. 12, 2017 | Pubmed ID: 28877912 Mitochondrial ATP Transporter Depletion Protects Mice Against Liver Steatosis and Insulin Resistance Nature Communications. 02, 2017 | Pubmed ID: 28205519 Interferon-γ Limits Diabetogenic CD8 T-Cell Effector Responses in Type 1 Diabetes Diabetes. 03, 2017 | Pubmed ID: 27920091 Human Pancreatic Cancer Cells Induce a MyD88-Dependent Stromal Response to Promote a Tumor-Tolerant Immune Microenvironment Cancer Research. 02, 2017 | Pubmed ID: 27864347 Genetic Risk Analysis of a Patient with Fulminant Autoimmune Type 1 Diabetes Mellitus Secondary to Combination Ipilimumab and Nivolumab Immunotherapy Journal for Immunotherapy of Cancer. 2016 | Pubmed ID: 28031819 Islet-derived CD4 T-cells Targeting Proinsulin in Human Autoimmune Diabetes Diabetes. Dec, 2016 | Pubmed ID: 27920090 Antithymocyte Globulin Plus G-CSF Combination Therapy Leads to Sustained Immunomodulatory and Metabolic Effects in a Subset of Responders With Established Type 1 Diabetes Diabetes. Dec, 2016 | Pubmed ID: 27669730 Islet Cell Hyperexpression of HLA Class I Antigens: a Defining Feature in Type 1 Diabetes Diabetologia. 11, 2016 | Pubmed ID: 27506584 Liquid Chromatography-Mass Spectrometry Metabolic and Lipidomic Sample Preparation Workflow for Suspension-Cultured Mammalian Cells Using Jurkat T Lymphocyte Cells Journal of Proteomics & Bioinformatics. Jun, 2015 | Pubmed ID: 26401069 Respiration and Substrate Transport Rates As Well As Reactive Oxygen Species Production Distinguish Mitochondria from Brain and Liver BMC Biochemistry. Sep, 2015 | Pubmed ID: 26358560 Loss of NOX-Derived Superoxide Exacerbates Diabetogenic CD4 T-Cell Effector Responses in Type 1 Diabetes Diabetes. Dec, 2015 | Pubmed ID: 26269022 Acute Versus Progressive Onset of Diabetes in NOD Mice: Potential Implications for Therapeutic Interventions in Type 1 Diabetes Diabetes. Nov, 2015 | Pubmed ID: 26216853 Combination Therapy Reverses Hyperglycemia in NOD Mice With Established Type 1 Diabetes Diabetes. Nov, 2015 | Pubmed ID: 26185279 Distinct Differences in the Responses of the Human Pancreatic β-cell Line EndoC-βH1 and Human Islets to Proinflammatory Cytokines American Journal of Physiology. Regulatory, Integrative and Comparative Physiology. Sep, 2015 | Pubmed ID: 26084699 Reply to Gurgul-Convey and Lenzen: Cytokines, Nitric Oxide, and β-cells The Journal of Biological Chemistry. Apr, 2015 | Pubmed ID: 26065037 How the Location of Superoxide Generation Influences the β-cell Response to Nitric Oxide The Journal of Biological Chemistry. Mar, 2015 | Pubmed ID: 25648890 TRIF-dependent Innate Immune Activation is Critical for Survival to Neonatal Gram-negative Sepsis Journal of Immunology (Baltimore, Md. : 1950). Feb, 2015 | Pubmed ID: 25548220 Association of the Mt-ND2 5178A/C Polymorphism with Parkinson's Disease Neuroscience Letters. Feb, 2015 | Pubmed ID: 25511548 Anti-thymocyte Globulin/G-CSF Treatment Preserves β Cell Function in Patients with Established Type 1 Diabetes The Journal of Clinical Investigation. Jan, 2015 | Pubmed ID: 25500887 Mechanisms of Tumor Necrosis Factor α Antagonist-induced Lupus in a Murine Model Arthritis & Rheumatology (Hoboken, N.J.). Jan, 2015 | Pubmed ID: 25252121 Metabolic Abnormalities in the Pathogenesis of Type 1 Diabetes Current Diabetes Reports. 2014 | Pubmed ID: 25023213 In Search of a Surrogate: Engineering Human Beta Cell Lines for Therapy Trends in Endocrinology and Metabolism: TEM. Aug, 2014 | Pubmed ID: 24958526 Use of Chemical Probes to Detect Mitochondrial ROS by Flow Cytometry and Spectrofluorometry Methods in Enzymology. 2014 | Pubmed ID: 24862269 Do β-cells Generate Peroxynitrite in Response to Cytokine Treatment? The Journal of Biological Chemistry. Dec, 2013 | Pubmed ID: 24194521 Comparative Genetics: Synergizing Human and NOD Mouse Studies for Identifying Genetic Causation of Type 1 Diabetes The Review of Diabetic Studies : RDS. 2012 | Pubmed ID: 23804259 Oxidative Stress and Beta Cell Dysfunction Methods in Molecular Biology (Clifton, N.J.). 2012 | Pubmed ID: 22933078 Immune-mediated β-cell Death in Type 1 Diabetes: Lessons from Human β-cell Lines European Journal of Clinical Investigation. Nov, 2012 | Pubmed ID: 22924552 Inherited β-cell Dysfunction in Lean Individuals with Type 2 Diabetes Diabetes. Jul, 2012 | Pubmed ID: 22723272 Pleiotropic IFN-dependent and -independent Effects of IRF5 on the Pathogenesis of Experimental Lupus Journal of Immunology (Baltimore, Md. : 1950). Apr, 2012 | Pubmed ID: 22422888 1型糖尿病の治療としてのレプチンの使用:カウンター Pediatric Diabetes. Feb, 2012 | Pubmed ID: 21884562 1型糖尿病に抵抗性の遺伝学の役割 Diabetes/metabolism Research and Reviews. Nov, 2011 | Pubmed ID: 22069272 ピルビン酸脱水素酵素複合体欠損線維芽細胞における増加した活性酸素の蓄積 Molecular Genetics and Metabolism. Nov, 2011 | Pubmed ID: 21846590 リーンNcb5orがnullマウスにおける糖尿病の開発がベータ細胞の小胞体および酸化ストレスの症状に関係している Biochimica Et Biophysica Acta. Nov, 2011 | Pubmed ID: 21839170 ヒト膵β細胞株βLox5の免疫介在性アポトーシスにおけるミトコンドリアの役割 PloS One. 2011 | Pubmed ID: 21738580 マクロファージとT細胞によるスーパーオキシドの生産は、自己反応性と1型糖尿病の誘導に重要である Diabetes. Aug, 2011 | Pubmed ID: 21715554 複数菌による敗血症時の骨髄からの好中球の動員は、CXCL12シグナル伝達に依存しています Journal of Immunology (Baltimore, Md. : 1950). Jul, 2011 | Pubmed ID: 21690321 β細胞機能の進行性の侵食は1型糖尿病のNODマウスモデルにおける高血糖の発症の前に置きます Diabetes. Aug, 2011 | Pubmed ID: 21659497 敗血症のマウス新生児応答におけるCXCリガンド10/CXC受容体3シグナリングのための重要な役割 Infection and Immunity. Jul, 2011 | Pubmed ID: 21518789 敗血症は、自然免疫での早期の変化を誘導することが二次感染への影響の死亡率 Journal of Immunology (Baltimore, Md. : 1950). Jan, 2011 | Pubmed ID: 21106855 MT-ND2(a)は、膵β細胞のレベルでNODマウスにおける自己免疫性1型糖尿病に対する抵抗性を修正 Diabetes. Jan, 2011 | Pubmed ID: 20980458 NADPHオキシダーゼ欠損症はTh系統コミットメントを調節し、自己免疫を調節する Journal of Immunology (Baltimore, Md. : 1950). Nov, 2010 | Pubmed ID: 20881184 1型糖尿病人間のタイプを理解する非肥満糖尿病マウスの使用 Endocrinology and Metabolism Clinics of North America. Sep, 2010 | Pubmed ID: 20723819 携帯電話の動員による免疫枯渇が免疫調節を与え、非肥満糖尿病マウスにおける自己免疫性糖尿病を逆に Diabetes. Oct, 2009 | Pubmed ID: 19628781 具体的と非侵襲的レポーターとしてインスリンII-GFPを用いたインスリン分泌β細胞に胚性幹細胞の分化のためのプロトコルを評価する Cloning and Stem Cells. Jun, 2009 | Pubmed ID: 19508115 1型糖尿病秋田マウスの心臓における副交感神経機能障害の開発におけるSREBP-1の役割 Circulation Research. Jul, 2009 | Pubmed ID: 19423844 第24章定量化、ローカライゼーション、およびマウスミトコンドリア活性酸素種産生の組織特異性 Methods in Enzymology. 2009 | Pubmed ID: 19348903 MerTKは、自己反応性T細胞の胸腺選択を調節する Proceedings of the National Academy of Sciences of the United States of America. Mar, 2009 | Pubmed ID: 19251650 T1Dの予防の増加ROS損失の役割 Annals of the New York Academy of Sciences. Dec, 2008 | Pubmed ID: 19120287 を介した糖尿病 - 自発的な自己免疫疾患とフリーラジカルへの遺伝的抵抗性の共通点 Free Radical Biology & Medicine. Nov, 2008 | Pubmed ID: 18718526 MT-Nd2aは、ミトコンドリア複合体IとIIIによる活性酸素種の産生を抑制 The Journal of Biological Chemistry. Apr, 2008 | Pubmed ID: 18281288 MerTKは、アポトーシス細胞誘導性T細胞寛容が必要です The Journal of Experimental Medicine. Jan, 2008 | Pubmed ID: 18195070 自己反応性T細胞の応答:古いネメシスの追求で新技術 Pediatric Diabetes. Oct, 2007 | Pubmed ID: 17850466 MT-ND2を伴う核およびミトコンドリアの相互作用が増加したミトコンドリア活性酸素種産生に導く The Journal of Biological Chemistry. Feb, 2007 | Pubmed ID: 17189252 アポトーシス細胞は、樹状細胞におけるNF-κB活性化のMerのチロシンキナーゼ依存性の封鎖を誘導する Blood. Jan, 2007 | Pubmed ID: 17008547 DR4-DQ8に制限されたCD4 T細胞応答と1型糖尿病感受性の調節の役割 Diabetes. Dec, 2006 | Pubmed ID: 17130492 HLA-AヒトNODマウスからA * 0201拘束性T細胞は1型糖尿病に潜在的な臨床関連性の自己抗原を認識する Journal of Immunology (Baltimore, Md. : 1950). Mar, 2006 | Pubmed ID: 16493087 自発的な自己免疫性1型糖尿病の研究のためのマウスモデルの有用性 Pediatric Diabetes. Sep, 2005 | Pubmed ID: 16109074 サイトカイン誘導破壊にALR /中尉マウスから膵島の抵抗のメカニズム Journal of Immunology (Baltimore, Md. : 1950). Jul, 2005 | Pubmed ID: 16002729 NOD /中尉マウスの主要組織適合遺伝子複合体にリンクされた糖尿病感受性:Subcongenic分析は、複雑な糖尿病H2のH2-Dエンド(G7)でIdd16のコンポーネントのローカライズ Diabetes. May, 2005 | Pubmed ID: 15855353 プロテアソーム阻害を変化させるグルコース刺激(プロ)インスリン分泌と膵臓における売上高{ベータ} - 細胞 The Journal of Biological Chemistry. Apr, 2005 | Pubmed ID: 15705591 ALS / LT:ローフリーラジカル消去の可能性に関連付けられている新しい2型糖尿病モデルマウス Diabetes. Feb, 2004 | Pubmed ID: 14749277 ALR /中尉マウスにおける1型糖尿病、自己免疫介在性糖尿病ストレスに対する防御とNOD関連のひずみに対する抵抗性の遺伝様式の解析 Immunogenetics. Oct, 2003 | Pubmed ID: 14513297 Rodent Models for the Study of Type 2 Diabetes in Children (juvenile Diabesity) Pediatric Diabetes. Sep, 2002 | Pubmed ID: 15016157 インスリン依存型糖尿病で膵島移植を研究するための新しいマウスモデル Transplantation. Apr, 2002 | Pubmed ID: 11981430 糖尿病性ALR /中尉マウスにおける好中球活性酸素産生能の遺伝的制御 Free Radical Biology & Medicine. Apr, 2002 | Pubmed ID: 11937300 膵臓の生きた組織スライスにおける膵島機能と膵島免疫細胞相互作用の観察 Mollie K. Huber1, Denise M. Drotar2,3,4, Helmut Hiller1, Maria L. Beery1, Paul Joseph1, Irina Kusmartseva1, Stephan Speier2,3,4, Mark A. Atkinson1, Clayton E. Mathews1, Edward A. Phelps5 1Department of Pathology, Immunology, and Laboratory Medicine, University of Florida, 2Paul Langerhans Institute Dresden (PLID) of the Helmholtz Zentrum München at the University Clinic Carl Gustav Carus of Technische Universität Dresden, 3Institute of Physiology, Faculty of Medicine, Technische Universität Dresden, 4German Center for Diabetes Research (DZD), 5J. Crayton Pruitt Family Department of Biomedical Engineering, University of Florida JoVE 62207 Immunology and Infection 傷害性Tリンパ球によって媒介ベータ細胞死を評価するための方法 Jing Chen1, Scott Grieshaber1, Clayton E. Mathews1 1Departments of Pathology, Immunology and Laboratory Medicine, College of Medicine, University of Florida JoVE 2724 Immunology and Infection
膵臓の生きた組織スライスにおける膵島機能と膵島免疫細胞相互作用の観察 Mollie K. Huber1, Denise M. Drotar2,3,4, Helmut Hiller1, Maria L. Beery1, Paul Joseph1, Irina Kusmartseva1, Stephan Speier2,3,4, Mark A. Atkinson1, Clayton E. Mathews1, Edward A. Phelps5 1Department of Pathology, Immunology, and Laboratory Medicine, University of Florida, 2Paul Langerhans Institute Dresden (PLID) of the Helmholtz Zentrum München at the University Clinic Carl Gustav Carus of Technische Universität Dresden, 3Institute of Physiology, Faculty of Medicine, Technische Universität Dresden, 4German Center for Diabetes Research (DZD), 5J. Crayton Pruitt Family Department of Biomedical Engineering, University of Florida JoVE 62207 Immunology and Infection
傷害性Tリンパ球によって媒介ベータ細胞死を評価するための方法 Jing Chen1, Scott Grieshaber1, Clayton E. Mathews1 1Departments of Pathology, Immunology and Laboratory Medicine, College of Medicine, University of Florida JoVE 2724 Immunology and Infection