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- Stem Strategier Cell Transplantation för Restaurering av kognitiv dysfunktion orsakad av Kraniell Strålbehandling
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Articles by Dante E. Roa in JoVE
Stem Strategier Cell Transplantation för Restaurering av kognitiv dysfunktion orsakad av Kraniell Strålbehandling
Munjal M. Acharya*, Dante E. Roa*, Omar Bosch, Mary L. Lan*, Charles L. Limoli
Department of Radiation Oncology, University of California Irvine
Hjärntumör patienter genomgår rutinmässigt kraniell strålbehandling, och medan välgörande, denna behandling leder ofta till invalidiserande kognitiv dysfunktion. Denna allvarliga olösta problem har för närvarande inga kliniska användningen, och har drivit arbetet med att utforma stamcellsbaserade behandlingar för återvinning av strålningsinducerad kognitiva minskningar.
Other articles by Dante E. Roa on PubMed
Medical Physics. May, 2004 | Pubmed ID: 15191319
Measurements were performed on the 30, 40, and 60 mm 90Sr/Y beta-emitter source trains used in the Novoste Beta-Cath system to determine their dosimetric characteristics at submillimeter distances and provide the necessary TG-60 parameters for mapping their dose distributions. These measurements were carried out in a Solid Water phantom where MD55-2 Gafchromic films were placed in direct contact with a 5 French (F) catheter used for the 30 and 60 mm source trains and a 3.5F catheter used for thinner 30 and 40 mm source trains. A data set consisted of three pieces of Gafchromic film irradiated for periods of 1.5, 5, and 10 minutes, respectively. This 3-film irradiation technique provided reliable dose data at short, intermediate and long distances from a source train. Three data sets per source train were collected in this study. For the 30 mm source train with a 5F catheter, data were collected with the source axis at proximal (0.41 mm) and distal (1.19 mm) positions to the film surface in order to investigate dosimetric effects due to the off centering of the source train lumen within the catheter. Absolute doses were determined by calibrating the Gafchromic film in a high-energy electron beam from a radiotherapy accelerator. The absolute dose rates at a distance of 2 mm along the source trains transverse axis were found to be within 13.7% of the values provided by Novoste. Radial dose functions were within 13% compared to 90Sr/Y source train data constructed from Soares' 90Sr/Y single seed data and within 17% and 25% compared to Monte Carlo data by Ye et al., and Wang et al., respectively. Discrepancies of 33% and 19% were observed at short radial distances (< or = 1 mm) between the Novoste Monte Carlo and the 3.5F and 5F catheter measured data, respectively. The source off centering data showed higher dose contribution from the source train at its distal rather than proximal position. Radial dose function comparisons between the Novoste Monte Carlo and the measured data, calculated as a function of radial distance from the catheter's center showed good agreement (< or = 10%).