David G. Nicholls

Buck Institute for Age Research, Novato, CA

Affiliated withNovato, CA

Research Area

Biography

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JoVE Journal Publications

ArticleTotal : 1	Year
Publication title Cited by 190	2010

Other Publications

Article	Year
Mitochondrial function and dysfunction in the cell: its relevance to aging and aging-related disease. The international journal of biochemistry & cell biology\| PubMed ID: 12200032	2002
Barbiturates induce mitochondrial depolarization and potentiate excitotoxic neuronal death. The Journal of neuroscience : the official journal of the Society for Neuroscience\| PubMed ID: 12417645	2002
The relationship between free and total calcium concentrations in the matrix of liver and brain mitochondria. The Journal of biological chemistry\| PubMed ID: 12660243	2003
Interactions between mitochondrial bioenergetics and cytoplasmic calcium in cultured cerebellar granule cells. Cell calcium\| PubMed ID: 12909085	2003
Oxidative alpha-ketoglutarate dehydrogenase inhibition via subtle elevations in monoamine oxidase B levels results in loss of spare respiratory capacity: implications for Parkinson's disease... The Journal of biological chemistry\| PubMed ID: 12963742	2003
Bioenergetics and transmitter release in the isolated nerve terminal. Neurochemical research\| PubMed ID: 14570388	2003
Mitochondrial membrane potential and aging. Aging cell\| PubMed ID: 14965354	2004
In situ respiration and bioenergetic status of mitochondria in primary cerebellar granule neuronal cultures exposed continuously to glutamate. The Journal of biological chemistry\| PubMed ID: 15166243	2004
Relationships between superoxide levels and delayed calcium deregulation in cultured cerebellar granule cells exposed continuously to glutamate. Journal of neurochemistry\| PubMed ID: 15255947	2004
The integration of mitochondrial calcium transport and storage. Journal of bioenergetics and biomembranes\| PubMed ID: 15377857	2004
Calpain I induces cleavage and release of apoptosis-inducing factor from isolated mitochondria. The Journal of biological chemistry\| PubMed ID: 15590628	2005
Mitochondria and calcium signaling. Cell calcium\| PubMed ID: 16087232	2005
Acute glutathione depletion restricts mitochondrial ATP export in cerebellar granule neurons. The Journal of biological chemistry\| PubMed ID: 16172117	2005
Commentary on: 'old and new data, new issues: the mitochondrial Deltapsi' by H. Tedeschi. Biochimica et biophysica acta\| PubMed ID: 16242663	2005
Simultaneous monitoring of ionophore- and inhibitor-mediated plasma and mitochondrial membrane potential changes in cultured neurons. The Journal of biological chemistry\| PubMed ID: 16551630	2006
The physiological regulation of uncoupling proteins. Biochimica et biophysica acta\| PubMed ID: 16725104	2006
Mitochondrial-dependent Ca2+ handling in Huntington's disease striatal cells: effect of histone deacetylase inhibitors. The Journal of neuroscience : the official journal of the Society for Neuroscience\| PubMed ID: 17065457	2006
Mitochondrial dysfunction in Huntington's disease: the bioenergetics of isolated and in situ mitochondria from transgenic mice. Journal of neurochemistry\| PubMed ID: 17394466	2007
Bioenergetics of mitochondria in cultured neurons and their role in glutamate excitotoxicity. Journal of neuroscience research\| PubMed ID: 17455297	2007
Spare respiratory capacity rather than oxidative stress regulates glutamate excitotoxicity after partial respiratory inhibition of mitochondrial complex I with rotenone. The Journal of neuroscience : the official journal of the Society for Neuroscience\| PubMed ID: 17611283	2007
Mitochondrial and plasma membrane potential of cultured cerebellar neurons during glutamate-induced necrosis, apoptosis, and tolerance. The Journal of neuroscience : the official journal of the Society for Neuroscience\| PubMed ID: 17670970	2007
Inducible alterations of glutathione levels in adult dopaminergic midbrain neurons result in nigrostriatal degeneration. The Journal of neuroscience : the official journal of the Society for Neuroscience\| PubMed ID: 18094238	2007
Experimental assessment of bioenergetic differences caused by the common European mitochondrial DNA haplogroups H and T. Gene\| PubMed ID: 18280061	2008
MAO-B elevation in mouse brain astrocytes results in Parkinson's pathology. PloS one\| PubMed ID: 18286173	2008
Forty years of Mitchell's proton circuit: From little grey books to little grey cells. Biochimica et biophysica acta\| PubMed ID: 18423395	2008
Effects of neuroglobin overexpression on mitochondrial function and oxidative stress following hypoxia/reoxygenation in cultured neurons. Journal of neuroscience research\| PubMed ID: 18711728	2009
Measurement of instantaneous velocity vectors of organelle transport: mitochondrial transport and bioenergetics in hippocampal neurons. Biophysical journal\| PubMed ID: 18757564	2008
UCPs--unlikely calcium porters. Nature cell biology\| PubMed ID: 18978830	2008
Oxidative stress and energy crises in neuronal dysfunction. Annals of the New York Academy of Sciences\| PubMed ID: 19076430	2008
Reactive oxygen species regulation by AIF- and complex I-depleted brain mitochondria. Free radical biology & medicine\| PubMed ID: 19280713	2009
Mitochondrial calcium function and dysfunction in the central nervous system. Biochimica et biophysica acta\| PubMed ID: 19298790	2009
Real-time visualization of cytoplasmic calpain activation and calcium deregulation in acute glutamate excitotoxicity. Journal of neurochemistry\| PubMed ID: 19493161	2009
Bioenergetic analysis of isolated cerebrocortical nerve terminals on a microgram scale: spare respiratory capacity and stochastic mitochondrial failure. Journal of neurochemistry\| PubMed ID: 19519782	2009
Metabolic control analysis in a cellular model of elevated MAO-B: relevance to Parkinson's disease. Neurotoxicity research\| PubMed ID: 19526285	2009
Quantitative microplate-based respirometry with correction for oxygen diffusion. Analytical chemistry\| PubMed ID: 19555051	2009
Tight coupling between glucose and mitochondrial metabolism in clonal beta-cells is required for robust insulin secretion. The Journal of biological chemistry\| PubMed ID: 19797055	2009
Spare respiratory capacity, oxidative stress and excitotoxicity. Biochemical Society transactions\| PubMed ID: 19909281	2009
Stochastic aspects of transmitter release and bioenergetic dysfunction in isolated nerve terminals. Biochemical Society transactions\| PubMed ID: 20298202	2010
Mitochondrial ion circuits. Essays in biochemistry\| PubMed ID: 20533898	2010
Intrinsic bioenergetic properties and stress sensitivity of dopaminergic synaptosomes. The Journal of neuroscience : the official journal of the Society for Neuroscience\| PubMed ID: 21430153	2011
Assessing mitochondrial dysfunction in cells. The Biochemical journal\| PubMed ID: 21726199	2011
Fluorescence measurement of mitochondrial membrane potential changes in cultured cells. Methods in molecular biology (Clifton, N.J.)\| PubMed ID: 22057564	2012