David P. Speert

Department of Pediatrics, University of British Columbia

Affiliated withUniversity of British Columbia

Research Area

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JoVE Journal Publications

ArticleTotal : 1	Year
Publication title Cited by 2	2013

Other Publications

Article	Year
Antibiotic resistance in Pseudomonas aeruginosa: mechanisms and impact on treatment. Drug resistance updates : reviews and commentaries in antimicrobial and anticancer chemotherapy\| PubMed ID: 11498392	2000
Epidemiology of Burkholderia cepacia complex in patients with cystic fibrosis, Canada. Emerging infectious diseases\| PubMed ID: 11897071	2002
Differential persistence among genomovars of the Burkholderia cepacia complex in a murine model of pulmonary infection. Infection and immunity\| PubMed ID: 11953418	2002
Burkholderia anthina sp. nov. and Burkholderia pyrrocinia, two additional Burkholderia cepacia complex bacteria, may confound results of new molecular diagnostic tools. FEMS immunology and medical microbiology\| PubMed ID: 12052570	2002
Multidrug efflux systems play an important role in the invasiveness of Pseudomonas aeruginosa. The Journal of experimental medicine\| PubMed ID: 12093875	2002
Effect of Burkholderia cepacia infection in the clinical course of patients with cystic fibrosis: a pilot study in a Sydney clinic. Respirology (Carlton, Vic.)\| PubMed ID: 12153690	2002
Molecular epidemiology of Pseudomonas aeruginosa. Frontiers in bioscience : a journal and virtual library\| PubMed ID: 12165481	2002
Biofilm formation and acyl homoserine lactone production in the Burkholderia cepacia complex. Journal of bacteriology\| PubMed ID: 12270826	2002
Evaluation of a diagnostic polymerase chain reaction assay for Neisseria meningitidis in North America and field experience during an outbreak. Archives of pathology & laboratory medicine\| PubMed ID: 12296761	2002
Epidemiology of Pseudomonas aeruginosa in cystic fibrosis in British Columbia, Canada. American journal of respiratory and critical care medicine\| PubMed ID: 12359659	2002
Colonial morphology of Burkholderia cepacia complex genomovar III: implications in exopolysaccharide production, pilus expression, and persistence in the mouse. Infection and immunity\| PubMed ID: 12540572	2003
The cationic antimicrobial peptide LL-37 modulates dendritic cell differentiation and dendritic cell-induced T cell polarization. Journal of immunology (Baltimore, Md. : 1950)\| PubMed ID: 14707090	2004
The human cationic peptide LL-37 induces activation of the extracellular signal-regulated kinase and p38 kinase pathways in primary human monocytes. Journal of immunology (Baltimore, Md. : 1950)\| PubMed ID: 15004180	2004
Primary immunodeficiency to pneumococcal infection due to a defect in Toll-like receptor signaling. The Journal of pediatrics\| PubMed ID: 15069402	2004
Detection and genotyping of varicella-zoster virus by TaqMan allelic discrimination real-time PCR. Journal of clinical microbiology\| PubMed ID: 15070981	2004
Differential post-transcriptional activation of human phagocytes by different Pseudomonas aeruginosa isolates. Cellular microbiology\| PubMed ID: 15186400	2004
Burkholderia cepacia complex and cystic fibrosis: in search of the smoking gun. American journal of respiratory and critical care medicine\| PubMed ID: 15220120	2004
Production of exopolysaccharide by Burkholderia cenocepacia results in altered cell-surface interactions and altered bacterial clearance in mice. The Journal of infectious diseases\| PubMed ID: 15295701	2004
Persistence of Burkholderia multivorans within the pulmonary macrophage in the murine lung. Infection and immunity\| PubMed ID: 15385520	2004
Burkholderia phenoliruptrix sp. nov., to accommodate the 2,4,5-trichlorophenoxyacetic acid and halophenol-degrading strain AC1100. Systematic and applied microbiology\| PubMed ID: 15612618	2004
Burkholderia cenocepacia induces neutrophil necrosis in chronic granulomatous disease. Journal of immunology (Baltimore, Md. : 1950)\| PubMed ID: 15749893	2005
Identification of DNA markers for a transmissible Pseudomonas aeruginosa cystic fibrosis strain. American journal of respiratory cell and molecular biology\| PubMed ID: 15834046	2005
Viridans streptococci bacteremia in children with malignancy: relevance of species identification and penicillin susceptibility. The Pediatric infectious disease journal\| PubMed ID: 15933573	2005
Pseudomonas aeruginosa: role in the pathogenesis of the CF lung lesion. Seminars in respiratory and critical care medicine\| PubMed ID: 16088583	2003
Chronic granulomatous disease: from genetic defect to clinical presentation. Advances in experimental medicine and biology\| PubMed ID: 16107066	2005
Primary immune deficiencies presenting in adults: seven years of experience from Iran. Journal of clinical immunology\| PubMed ID: 16133995	2005
Multilocus sequence typing scheme that provides both species and strain differentiation for the Burkholderia cepacia complex. Journal of clinical microbiology\| PubMed ID: 16145124	2005
Exopolysaccharides from Burkholderia cenocepacia inhibit neutrophil chemotaxis and scavenge reactive oxygen species. The Journal of biological chemistry\| PubMed ID: 16316987	2006
Persistent bacteremia and severe thrombocytopenia caused by coagulase-negative Staphylococcus in a neonatal intensive care unit. Pediatrics\| PubMed ID: 16452352	2006
Genetic adaptation by Pseudomonas aeruginosa to the airways of cystic fibrosis patients. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 16687478	2006
IRAK-4 mutation (Q293X): rapid detection and characterization of defective post-transcriptional TLR/IL-1R responses in human myeloid and non-myeloid cells. Journal of immunology (Baltimore, Md. : 1950)\| PubMed ID: 17114497	2006
Reliability of multilocus sequence typing of the Burkholderia cepacia complex in cystic fibrosis. Journal of cystic fibrosis : official journal of the European Cystic Fibrosis Society\| PubMed ID: 17141579	2007
Proteomic identification and characterization of bacterial factors associated with Burkholderia cenocepacia survival in a murine host. Microbiology (Reading, England)\| PubMed ID: 17185549	2007
Bacterial infections of the lung in normal and immunodeficient patients. Novartis Foundation symposium\| PubMed ID: 17278384	2006
Enhanced inflammatory responses of chronic granulomatous disease leukocytes involve ROS-independent activation of NF-kappa B. European journal of immunology\| PubMed ID: 17330823	2007
Environmental Burkholderia cepacia complex isolates in human infections. Emerging infectious diseases\| PubMed ID: 17552100	2007
Unique lipid a modifications in Pseudomonas aeruginosa isolated from the airways of patients with cystic fibrosis. The Journal of infectious diseases\| PubMed ID: 17763333	2007
Recurrent systemic pneumococcal disease and IRAK4 deficiency. The Pediatric infectious disease journal\| PubMed ID: 17984826	2007
Elucidating global epidemiology of Burkholderia multivorans in cases of cystic fibrosis by multilocus sequence typing. Journal of clinical microbiology\| PubMed ID: 18032622	2008
Differential mucoid exopolysaccharide production by members of the Burkholderia cepacia complex. Journal of clinical microbiology\| PubMed ID: 18256220	2008
Differential modulation of innate immune cell functions by the Burkholderia cepacia complex: Burkholderia cenocepacia but not Burkholderia multivorans disrupts maturation and induces necrosi... Cellular microbiology\| PubMed ID: 18624797	2008
ROS-deficient monocytes have aberrant gene expression that correlates with inflammatory disorders of chronic granulomatous disease. Clinical immunology (Orlando, Fla.)\| PubMed ID: 18676204	2008
Taxon K, a complex within the Burkholderia cepacia complex, comprises at least two novel species, Burkholderia contaminans sp. nov. and Burkholderia lata sp. nov. International journal of systematic and evolutionary microbiology\| PubMed ID: 19126732	2009
Mycobacterium tuberculosis Cpn60.2 and DnaK are located on the bacterial surface, where Cpn60.2 facilitates efficient bacterial association with macrophages. Infection and immunity\| PubMed ID: 19470749	2009
Robust TLR4-induced gene expression patterns are not an accurate indicator of human immunity. Journal of translational medicine\| PubMed ID: 20105294	2010
Mycobacterium tuberculosis employs Cpn60.2 as an adhesin that binds CD43 on the macrophage surface. Cellular microbiology\| PubMed ID: 20633027	2010
The role of mucoidy in virulence of bacteria from the Burkholderia cepacia complex: a systematic proteomic and transcriptomic analysis. The Journal of infectious diseases\| PubMed ID: 20670172	2010
Mucoid and nonmucoid Burkholderia cepacia complex bacteria in cystic fibrosis infections. American journal of respiratory and critical care medicine\| PubMed ID: 20709823	2011
Toll-like receptor gene polymorphisms and preeclampsia risk: a case-control study and data synthesis. Hypertension in pregnancy : official journal of the International Society for the Study of Hypertension in Pregnancy\| PubMed ID: 20818954	2010
Parallel evolution in Pseudomonas aeruginosa over 39,000 generations in vivo. mBio\| PubMed ID: 20856824	2010
Profound lack of interleukin (IL)-12/IL-23p40 in neonates born early in gestation is associated with an increased risk of sepsis. The Journal of infectious diseases\| PubMed ID: 20977341	2010
Clinical features and outcome of patients with IRAK-4 and MyD88 deficiency. Medicine\| PubMed ID: 21057262	2010
In vitro susceptibility of Burkholderia vietnamiensis to aminoglycosides. Antimicrobial agents and chemotherapy\| PubMed ID: 21321142	2011
In vivo-transmigrated human neutrophils are resistant to antiapoptotic stimulation. Journal of leukocyte biology\| PubMed ID: 21697259	2011
Mucoid morphotype variation of Burkholderia multivorans during chronic cystic fibrosis lung infection is correlated with changes in metabolism, motility, biofilm formation and virulence. Microbiology (Reading, England)\| PubMed ID: 21835880	2011
Identification of hopanoid biosynthesis genes involved in polymyxin resistance in Burkholderia multivorans. Antimicrobial agents and chemotherapy\| PubMed ID: 22006009	2012
Identification of differentially expressed proteins from Burkholderia pseudomallei isolated during primary and relapsing melioidosis. Microbes and infection / Institut Pasteur\| PubMed ID: 22172334	2012
Influence of common non-synonymous Toll-like receptor 4 polymorphisms on bronchopulmonary dysplasia and prematurity in human infants. PloS one\| PubMed ID: 22348075	2012
Serum susceptibility in clinical isolates of Burkholderia cepacia complex bacteria: development of a growth-based assay for high throughput determination. Frontiers in cellular and infection microbiology\| PubMed ID: 22919658	2012
Ontogeny of Toll-like receptor mediated cytokine responses of South African infants throughout the first year of life. PloS one\| PubMed ID: 23028609	2012
Antibody responses to vaccination among South African HIV-exposed and unexposed uninfected infants during the first 2 years of life. Clinical and vaccine immunology : CVI\| PubMed ID: 23114697	2013
Recurrent subacute post-viral onset of ataxia associated with a PRF1 mutation. European journal of human genetics : EJHG\| PubMed ID: 23443029	2013