Denis Wirtz

Department of Chemical and Biomolecular Engineering, Johns Hopkins University

Affiliated withJohns Hopkins University Johns Hopkins University School of Medicine

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JoVE Journal Publications

ArticleTotal : 1	Year
Publication title Cited by 5	2017

Other Publications

Article	Year
Shape anisotropy of a single random-walk polymer. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 10984514	2000
The nonhelical tail domain of keratin 14 promotes filament bundling and enhances the mechanical properties of keratin intermediate filaments in vitro. The Journal of cell biology\| PubMed ID: 11724817	2001
Pairwise assembly determines the intrinsic potential for self-organization and mechanical properties of keratin filaments. Molecular biology of the cell\| PubMed ID: 11809846	2002
Microheterogeneity controls the rate of gelation of actin filament networks. The Journal of biological chemistry\| PubMed ID: 11889122	2002
Functional synergy of actin filament cross-linking proteins. The Journal of biological chemistry\| PubMed ID: 12006593	2002
Micromechanical coupling between cell surface receptors and RGD peptides. Biochemical and biophysical research communications\| PubMed ID: 12176050	2002
Effect of length, topology, and concentration on the microviscosity and microheterogeneity of DNA solutions. Journal of molecular biology\| PubMed ID: 12381315	2002
Micromechanical mapping of live cells by multiple-particle-tracking microrheology. Biophysical journal\| PubMed ID: 12496086	2002
Single molecule characterization of P-selectin/ligand binding. The Journal of biological chemistry\| PubMed ID: 12522146	2003
A mechanism of coupling RCC1 mobility to RanGTP production on the chromatin in vivo. The Journal of cell biology\| PubMed ID: 12604592	2003
Efficient active transport of gene nanocarriers to the cell nucleus. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 12644705	2003
The mechanical properties of simple epithelial keratins 8 and 18: discriminating between interfacial and bulk elasticities. Journal of structural biology\| PubMed ID: 12892725	2003
Receptor-ligand binding: 'catch' bonds finally caught. Current biology : CB\| PubMed ID: 12906816	2003
Enhanced viscoelasticity of human cystic fibrotic sputum correlates with increasing microheterogeneity in particle transport. The Journal of biological chemistry\| PubMed ID: 13679362	2003
The bimodal role of filamin in controlling the architecture and mechanics of F-actin networks. The Journal of biological chemistry\| PubMed ID: 14594947	2004
Real-time intracellular transport of gene nanocarriers studied by multiple particle tracking. Biotechnology progress\| PubMed ID: 15059007	2004
Micro-organization and visco-elasticity of the interphase nucleus revealed by particle nanotracking. Journal of cell science\| PubMed ID: 15090601	2004
Rho kinase regulates the intracellular micromechanical response of adherent cells to rho activation. Molecular biology of the cell\| PubMed ID: 15146061	2004
Distinct kinetic and mechanical properties govern selectin-leukocyte interactions. Journal of cell science\| PubMed ID: 15159451	2004
Transport of polymeric nanoparticle gene carriers in gastric mucus. Biotechnology progress\| PubMed ID: 15176891	2004
Nuclear envelope breakdown requires overcoming the mechanical integrity of the nuclear lamina. The Journal of biological chemistry\| PubMed ID: 15292200	2004
Intracellular mechanics of migrating fibroblasts. Molecular biology of the cell\| PubMed ID: 15483053	2005
The assembly of MreB, a prokaryotic homolog of actin. The Journal of biological chemistry\| PubMed ID: 15548516	2005
Cdc42 mediates nucleus movement and MTOC polarization in Swiss 3T3 fibroblasts under mechanical shear stress. Molecular biology of the cell\| PubMed ID: 15548602	2005
Structure-function relationship of biological gels revealed by multiple-particle tracking and differential interference contrast microscopy: the case of human lamin networks. Physical review. E, Statistical, nonlinear, and soft matter physics\| PubMed ID: 15600434	2004
Intracellular microrheology as a tool for the measurement of the local mechanical properties of live cells. Methods in cell biology\| PubMed ID: 15646615	2004
Dendritic branching and homogenization of actin networks mediated by arp2/3 complex. Physical review letters\| PubMed ID: 15697951	2004
Cell migration without a lamellipodium: translation of actin dynamics into cell movement mediated by tropomyosin. The Journal of cell biology\| PubMed ID: 15716379	2005
The rapid onset of elasticity during the assembly of the bacterial cell-division protein FtsZ. Biochemical and biophysical research communications\| PubMed ID: 15950938	2005
How actin crosslinking and bundling proteins cooperate to generate an enhanced cell mechanical response. Biochemical and biophysical research communications\| PubMed ID: 15992772	2005
Morphology of the lamellipodium and organization of actin filaments at the leading edge of crawling cells. Biophysical journal\| PubMed ID: 16085776	2005
Mechanical shear can accelerate the gelation of actin filament networks. Physical review letters\| PubMed ID: 16090845	2005
Mechanics and dynamics of actin-driven thin membrane protrusions. Biophysical journal\| PubMed ID: 16214866	2006
Single-molecule analysis of human immunodeficiency virus type 1 gp120-receptor interactions in living cells. Journal of virology\| PubMed ID: 16282475	2005
Mechanics of enveloped virus entry into host cells. Biophysical journal\| PubMed ID: 16284274	2006
Single-molecule analysis of cadherin-mediated cell-cell adhesion. Journal of cell science\| PubMed ID: 16371651	2006
GTPase activity, structure, and mechanical properties of filaments assembled from bacterial cytoskeleton protein MreB. Journal of bacteriology\| PubMed ID: 16428401	2006
Probing intercellular interactions between vascular endothelial cadherin pairs at single-molecule resolution and in living cells. Journal of molecular biology\| PubMed ID: 16540120	2006
Probing single-cell micromechanics in vivo: the microrheology of C. elegans developing embryos. Biophysical journal\| PubMed ID: 16581841	2006
Ballistic intracellular nanorheology reveals ROCK-hard cytoplasmic stiffening response to fluid flow. Journal of cell science\| PubMed ID: 16636071	2006
Microrheology and ROCK signaling of human endothelial cells embedded in a 3D matrix. Biophysical journal\| PubMed ID: 16891369	2006
A direct interaction between actin and vimentin filaments mediated by the tail domain of vimentin. The Journal of biological chemistry\| PubMed ID: 16901892	2006
Probing cellular mechanical responses to stimuli using ballistic intracellular nanorheology. Methods in cell biology\| PubMed ID: 17613307	2007
Nuclear lamin A/C deficiency induces defects in cell mechanics, polarization, and migration. Biophysical journal\| PubMed ID: 17631533	2007
MinC spatially controls bacterial cytokinesis by antagonizing the scaffolding function of FtsZ. Current biology : CB\| PubMed ID: 18291654	2008
Structural requirements for the assembly of LINC complexes and their function in cellular mechanical stiffness. Experimental cell research\| PubMed ID: 18396275	2008
Fibronectin fibrillogenesis regulates three-dimensional neovessel formation. Genes & development\| PubMed ID: 18451110	2008
Monitoring early fusion dynamics of human immunodeficiency virus type 1 at single-molecule resolution. Journal of virology\| PubMed ID: 18480458	2008
Polymerization and bundling kinetics of FtsZ filaments. Biophysical journal\| PubMed ID: 18621825	2008
Mapping local matrix remodeling induced by a migrating tumor cell using three-dimensional multiple-particle tracking. Biophysical journal\| PubMed ID: 18641063	2008
Dysfunctional connections between the nucleus and the actin and microtubule networks in laminopathic models. Biophysical journal\| PubMed ID: 18790843	2008
The filamentous actin cross-linking/bundling activity of mammalian formins. Journal of molecular biology\| PubMed ID: 18835565	2008
{alpha}-Catenin mediates initial E-cadherin-dependent cell-cell recognition and subsequent bond strengthening. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 19017792	2008
Condensation of FtsZ filaments can drive bacterial cell division. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 19116281	2009
Chapter 15: Live-cell single-molecule force spectroscopy. Methods in cell biology\| PubMed ID: 19118684	2008
Chapter 18: Sensing cytoskeletal mechanics by ballistic intracellular nanorheology (BIN) coupled with cell transfection. Methods in cell biology\| PubMed ID: 19118687	2008
Micro- and macrorheology of mucus. Advanced drug delivery reviews\| PubMed ID: 19166889	2009
Altering mucus rheology to "solidify" human mucus at the nanoscale. PloS one\| PubMed ID: 19173002	2009
Programmed subcellular release for studying the dynamics of cell detachment. Nature methods\| PubMed ID: 19182793	2009
Alpha-actinin and filamin cooperatively enhance the stiffness of actin filament networks. PloS one\| PubMed ID: 19198659	2009
Asymmetric enrichment of PIE-1 in the Caenorhabditis elegans zygote mediated by binary counterdiffusion. The Journal of cell biology\| PubMed ID: 19221192	2009
Magnetic tweezers measurement of single molecule torque. Nano letters\| PubMed ID: 19301859	2009
Particle-tracking microrheology of living cells: principles and applications. Annual review of biophysics\| PubMed ID: 19416071	2009
Loss of alpha-catenin decreases the strength of single E-cadherin bonds between human cancer cells. The Journal of biological chemistry\| PubMed ID: 19458087	2009
Resolving the role of actoymyosin contractility in cell microrheology. PloS one\| PubMed ID: 19756147	2009
A perinuclear actin cap regulates nuclear shape. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 19850871	2009
Dynamics of the bacterial intermediate filament crescentin in vitro and in vivo. PloS one\| PubMed ID: 20140233	2010
A distinctive role for focal adhesion proteins in three-dimensional cell motility. Nature cell biology\| PubMed ID: 20473295	2010
Triggering cell detachment from patterned electrode arrays by programmed subcellular release. Nature protocols\| PubMed ID: 20595956	2010
MEX-5 enrichment in the C. elegans early embryo mediated by differential diffusion. Development (Cambridge, England)\| PubMed ID: 20627961	2010
Organization of cellular receptors into a nanoscale junction during HIV-1 adhesion. PLoS computational biology\| PubMed ID: 20657663	2010
PEG-based hydrogels with collagen mimetic peptide-mediated and tunable physical cross-links. Biomacromolecules\| PubMed ID: 20715762	2010
Cross-linking FtsZ polymers into coherent Z rings. Molecular microbiology\| PubMed ID: 20969647	2010
Torsional mechanics of DNA are regulated by small-molecule intercalation. The journal of physical chemistry. B\| PubMed ID: 21090816	2010
Interplay of RhoA and motility in the programmed spreading of daughter cells postmitosis. Biophysical journal\| PubMed ID: 21112276	2010
Differences in the microrheology of human embryonic stem cells and human induced pluripotent stem cells. Biophysical journal\| PubMed ID: 21112280	2010
Biophysics of selectin-ligand interactions in inflammation and cancer. Physical biology\| PubMed ID: 21301059	2011
The perinuclear actin cap in health and disease. Nucleus (Austin, Tex.)\| PubMed ID: 21327082	2010
Recapitulating cancer cell invasion in vitro. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 21490296	2011
Single-molecule binding of CD44 to fibrin versus P-selectin predicts their distinct shear-dependent interactions in cancer. Journal of cell science\| PubMed ID: 21558419	2011
The physics of cancer: the role of physical interactions and mechanical forces in metastasis. Nature reviews. Cancer\| PubMed ID: 21701513	2011
Hypoxia-inducible factor 1 is a master regulator of breast cancer metastatic niche formation. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 21911388	2011
Magnetic manipulation of nanorods in the nucleus of living cells. Biophysical journal\| PubMed ID: 22004741	2011
SMRT analysis of MTOC and nuclear positioning reveals the role of EB1 and LIC1 in single-cell polarization. Journal of cell science\| PubMed ID: 22193958	2011
Nucleation and decay initiation are the stiffness-sensitive phases of focal adhesion maturation. Biophysical journal\| PubMed ID: 22208190	2011
High-throughput ballistic injection nanorheology to measure cell mechanics. Nature protocols\| PubMed ID: 22222790	2012
Dimensional and temporal controls of three-dimensional cell migration by zyxin and binding partners. Nature communications\| PubMed ID: 22395610	2012
Divergent roles of CD44 and carcinoembryonic antigen in colon cancer metastasis. FASEB journal : official publication of the Federation of American Societies for Experimental Biology\| PubMed ID: 22415308	2012
The differential formation of the LINC-mediated perinuclear actin cap in pluripotent and somatic cells. PloS one\| PubMed ID: 22574215	2012
Mismatch in mechanical and adhesive properties induces pulsating cancer cell migration in epithelial monolayer. Biophysical journal\| PubMed ID: 22735523	2012
NAC1 is an actin-binding protein that is essential for effective cytokinesis in cancer cells. Cancer research\| PubMed ID: 22761335	2012
The distinct roles of the nucleus and nucleus-cytoskeleton connections in three-dimensional cell migration. Scientific reports\| PubMed ID: 22761994	2012
Effect of modifying quantum dot surface charge on airway epithelial cell uptake in vitro. Nanotoxicology\| PubMed ID: 22783847	2013
Actin cap associated focal adhesions and their distinct role in cellular mechanosensing. Scientific reports\| PubMed ID: 22870384	2012
Distinct kinetic and molecular requirements govern CD44 binding to hyaluronan versus fibrin(ogen). Biophysical journal\| PubMed ID: 22947857	2012
Focal adhesion size uniquely predicts cell migration. FASEB journal : official publication of the Federation of American Societies for Experimental Biology\| PubMed ID: 23254340	2013
Functional interplay between the cell cycle and cell phenotypes. Integrative biology : quantitative biosciences from nano to macro\| PubMed ID: 23319145	2013
The LINC-anchored actin cap connects the extracellular milieu to the nucleus for ultrafast mechanotransduction. Scientific reports\| PubMed ID: 23336069	2013
High-throughput secretomic analysis of single cells to assess functional cellular heterogeneity. Analytical chemistry\| PubMed ID: 23339603	2013
Procollagen lysyl hydroxylase 2 is essential for hypoxia-induced breast cancer metastasis. Molecular cancer research : MCR\| PubMed ID: 23378577	2013
Hypoxia-inducible factor 1 (HIF-1) promotes extracellular matrix remodeling under hypoxic conditions by inducing P4HA1, P4HA2, and PLOD2 expression in fibroblasts. The Journal of biological chemistry\| PubMed ID: 23423382	2013
Dimensional control of cancer cell migration. Biophysical journal\| PubMed ID: 23442847	2013
Interstitial friction greatly impacts membrane mechanics. Biophysical journal\| PubMed ID: 23528079	2013
Simultaneously defining cell phenotypes, cell cycle, and chromatin modifications at single-cell resolution. FASEB journal : official publication of the Federation of American Societies for Experimental Biology\| PubMed ID: 23538711	2013
Collagen prolyl hydroxylases are essential for breast cancer metastasis. Cancer research\| PubMed ID: 23539444	2013
Predicting how cells spread and migrate: focal adhesion size does matter. Cell adhesion & migration\| PubMed ID: 23628962	2013
Age-dependent stochastic models for understanding population fluctuations in continuously cultured cells. Journal of the Royal Society, Interface\| PubMed ID: 23760298	2013
The Arp2/3 complex mediates multigeneration dendritic protrusions for efficient 3-dimensional cancer cell migration. FASEB journal : official publication of the Federation of American Societies for Experimental Biology\| PubMed ID: 23796785	2013
The multi-faceted role of the actin cap in cellular mechanosensation and mechanotransduction. Soft matter\| PubMed ID: 23930135	2013
Morphological effects on expression of growth differentiation factor 15 (GDF15), a marker of metastasis. Journal of cellular physiology\| PubMed ID: 23996089	2014
Modulation of keratocyte phenotype by collagen fibril nanoarchitecture in membranes for corneal repair. Biomaterials\| PubMed ID: 24041426	2013
Adhesion and fusion efficiencies of human immunodeficiency virus type 1 (HIV-1) surface proteins. Scientific reports\| PubMed ID: 24145278	2013
Form-finding model shows how cytoskeleton network stiffness is realized. PloS one\| PubMed ID: 24146992	2013
β-Catenin serves as a clutch between low and high intercellular E-cadherin bond strengths. Biophysical journal\| PubMed ID: 24268141	2013
Hypoxia-inducible factors mediate coordinated RhoA-ROCK1 expression and signaling in breast cancer cells. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 24324133	2014
Nuclear envelope in nuclear positioning and cell migration. Advances in experimental medicine and biology\| PubMed ID: 24563361	2014
Three-dimensional cell migration does not follow a random walk. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 24594603	2014
Tight coupling between nucleus and cell migration through the perinuclear actin cap. Journal of cell science\| PubMed ID: 24639463	2014
Local mechanical response of cells to the controlled rotation of magnetic nanorods. Journal of biomedical materials research. Part B, Applied biomaterials\| PubMed ID: 24700696	2014
Water permeation drives tumor cell migration in confined microenvironments. Cell\| PubMed ID: 24726433	2014
Hypoxia and the extracellular matrix: drivers of tumour metastasis. Nature reviews. Cancer\| PubMed ID: 24827502	2014
Switching from protease-independent to protease-dependent cancer cell invasion. Biophysical journal\| PubMed ID: 25468324	2014
Cytoskeletal tension induces the polarized architecture of the nucleus. Biomaterials\| PubMed ID: 25701041	2015
COX-2 dependent regulation of mechanotransduction in human breast cancer cells. Cancer biology & therapy\| PubMed ID: 25701047	2015
Statistical analysis of cell migration in 3D using the anisotropic persistent random walk model. Nature protocols\| PubMed ID: 25719270	2015
Inhibition of Spleen Tyrosine Kinase Potentiates Paclitaxel-Induced Cytotoxicity in Ovarian Cancer Cells by Stabilizing Microtubules. Cancer cell\| PubMed ID: 26096845	2015
Multiple scale model for cell migration in monolayers: Elastic mismatch between cells enhances motility. Scientific reports\| PubMed ID: 26134134	2015
Volume regulation and shape bifurcation in the cell nucleus. Journal of cell science\| PubMed ID: 26243474	2015
Distinct kinetic and mechanical properties govern mucin 16- and podocalyxin-mediated tumor cell adhesion to E- and L-selectin in shear flow. Oncotarget\| PubMed ID: 26329844	2015
Normal mammary epithelial cells promote carcinoma basement membrane invasion by inducing microtubule-rich protrusions. Oncotarget\| PubMed ID: 26334095	2015
Three-dimensional matrix fiber alignment modulates cell migration and MT1-MMP utility by spatially and temporally directing protrusions. Scientific reports\| PubMed ID: 26423227	2015
Senescent stromal cells induce cancer cell migration via inhibition of RhoA/ROCK/myosin-based cell contractility. Oncotarget\| PubMed ID: 26483365	2015
Local 3D matrix confinement determines division axis through cell shape. Oncotarget\| PubMed ID: 26515603	2016
Collective cancer cell invasion induced by coordinated contractile stresses. Oncotarget\| PubMed ID: 26528856	2015
The Mechanobiology of Aging. Annual review of biomedical engineering\| PubMed ID: 26643020	2015
Evolution of cellular morpho-phenotypes in cancer metastasis. Scientific reports\| PubMed ID: 26675084	2015
A robust nonlinear tissue-component discrimination method for computational pathology. Laboratory investigation; a journal of technical methods and pathology\| PubMed ID: 26779829	2016
Differential vesicular sorting of AMPA and GABAA receptors. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 26839408	2016
Biophysical changes reduce energetic demand in growth factor-deprived lymphocytes. The Journal of cell biology\| PubMed ID: 26880201	2016
Confinement Sensing and Signal Optimization via Piezo1/PKA and Myosin II Pathways. Cell reports\| PubMed ID: 27160899	2016
Engineered Models of Confined Cell Migration. Annual review of biomedical engineering\| PubMed ID: 27420571	2016
Transient Opening of the Mitochondrial Permeability Transition Pore Induces Microdomain Calcium Transients in Astrocyte Processes. Neuron\| PubMed ID: 28132831	2017
Modeling the two-way feedback between contractility and matrix realignment reveals a nonlinear mode of cancer cell invasion. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 28196892	2017
Hypoxia Selectively Enhances Integrin α5β1 Receptor Expression in Breast Cancer to Promote Metastasis. Molecular cancer research : MCR\| PubMed ID: 28213554	2017
Affine and non-affine deformations quantified in cytoskeletal networks through three-dimensional form-finding model. Journal of the mechanical behavior of biomedical materials\| PubMed ID: 28448922	2017
Synergistic IL-6 and IL-8 paracrine signalling pathway infers a strategy to inhibit tumour cell migration. Nature communications\| PubMed ID: 28548090	2017
Pluri-IQ: Quantification of Embryonic Stem Cell Pluripotency through an Image-Based Analysis Software. Stem cell reports\| PubMed ID: 28712847	2017
Loss of giant obscurins alters breast epithelial cell mechanosensing of matrix stiffness. Oncotarget\| PubMed ID: 28903319	2017
EB1 and cytoplasmic dynein mediate protrusion dynamics for efficient 3-dimensional cell migration. FASEB journal : official publication of the Federation of American Societies for Experimental Biology\| PubMed ID: 29097501	2017