cloud-based-phrase-mining-analysis-user-defined-phrase-category

Cloud-Based Phrase Mining and Analysis of User-Defined Phrase-Category Association in Biomedical Publications

The rapid accumulation of biomedical textual data has far exceeded the human capacity of manual curation and analysis, necessitating novel text-mining ...

a-knowledge-graph-approach-to-elucidate-role-organellar-pathways

A Knowledge Graph Approach to Elucidate the Role of Organellar Pathways in Disease <em>via</em> Biomedical Reports

The rapidly increasing and vast quantities of biomedical reports, each containing numerous entities and rich information, represent a rich resource for ...

University of California, Los Angeles

UCLA School of Medicine

During cardiovascular disease progression, molecular systems of myocardium (e.g., a proteome) undergo diverse and distinct changes. Dynamic, temporally-regulated alterations of individual molecules underlie the collective response of the heart to pathological drivers and the ultimate development of pathogenesis. Advances in high-throughput omics technologies have enabled cost-effective, temporal profiling of targeted systems in animal models of human diseases. However, computational analysis of temporal patterns from omics data remains challenging. In particular, bioinformatic pipelines involving unsupervised statistical approaches to support cardiovascular investigations are lacking, which hinders one's ability to extract biomedical insights from these complex datasets.

Identifying temporal molecular signatures underlying cardiovascular diseases: A data science platform.

The search for new strategies for better understanding cardiovascular (CV) disease is a constant one, spanning multitudinous types of observations and studies. A comprehensive characterization of each disease state and its biomolecular underpinnings relies upon insights gleaned from extensive information collection of various types of data. Researchers and clinicians in CV biomedicine repeatedly face questions regarding which types of data may best answer their questions, how to integrate information from multiple datasets of various types, and how to adapt emerging advances in machine learning and/or artificial intelligence to their needs in data processing. Frequently lauded as a field with great practical and translational potential, the interface between biomedical informatics and CV medicine is challenged with staggeringly massive datasets. Successful application of computational approaches to decode these complex and gigantic amounts of information becomes an essential step toward realizing the desired benefits. In this review, we examine recent efforts to adapt informatics strategies to CV biomedical research: automated information extraction and unification of multifaceted -omics data. We discuss how and why this interdisciplinary space of CV Informatics is particularly relevant to and supportive of current experimental and clinical research. We describe in detail how open data sources and methods can drive discovery while demanding few initial resources, an advantage afforded by widespread availability of cloud computing-driven platforms. Subsequently, we provide examples of how interoperable computational systems facilitate exploration of data from multiple sources, including both consistently formatted structured data and unstructured data. Taken together, these approaches for achieving data harmony enable molecular phenotyping of CV diseases and unification of CV knowledge.

Cardiovascular informatics: building a bridge to data harmony.

We present a deep-learning-based platform, MIND-S, for protein post-translational modification (PTM) predictions. MIND-S employs a multi-head attention and graph neural network and assembles a 15-fold ensemble model in a multi-label strategy to enable simultaneous prediction of multiple PTMs with high performance and computation efficiency. MIND-S also features an interpretation module, which provides the relevance of each amino acid for making the predictions and is validated with known motifs. The interpretation module also captures PTM patterns without any supervision. Furthermore, MIND-S enables examination of mutation effects on PTMs. We document a workflow, its applications to 26 types of PTMs of two datasets consisting of ∼50,000 proteins, and an example of MIND-S identifying a PTM-interrupting SNP with validation from biological data. We also include use case analyses of targeted proteins. Taken together, we have demonstrated that MIND-S is accurate, interpretable, and efficient to elucidate PTM-relevant biological processes in health and diseases.

ArticleTotal : 2	Year
Publication title Cited by 8	2019
Publication title Cited by 2	2023

Article	Year
Identifying temporal molecular signatures underlying cardiovascular diseases: A data science platform. Journal of molecular and cellular cardiology\| PubMed ID: 32504647	2020
Cardiovascular informatics: building a bridge to data harmony. Cardiovascular research\| PubMed ID: 33751044	2022
MIND-S is a deep-learning prediction model for elucidating protein post-translational modifications in human diseases. Cell reports methods\| PubMed ID: 37056379	2023

Dibakar Sigdel

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