Donald E. Ingber

Vascular Biology Program, Boston Children's Hospital and Harvard Medical School

Affiliated withBoston Children's Hospital and Harvard Medical School Harvard University Harvard School of Engineering and Applied Sciences

Research Area

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JoVE Journal Publications

ArticleTotal : 3	Year
Publication title Cited by 36	2013
Publication title Cited by 68	2016
Publication title Cited by 6	2024

Other Publications

Article	Year
Intact vinculin protein is required for control of cell shape, cell mechanics, and rac-dependent lamellipodia formation. Biochemical and biophysical research communications\| PubMed ID: 11785963	2002
Mechanotransduction: all signals point to cytoskeleton, matrix, and integrins. Science's STKE : signal transduction knowledge environment\| PubMed ID: 11842240	2002
A discrete cell cycle checkpoint in late G(1) that is cytoskeleton-dependent and MAP kinase (Erk)-independent. Experimental cell research\| PubMed ID: 11969294	2002
Control of embryonic lung branching morphogenesis by the Rho activator, cytotoxic necrotizing factor 1. The Journal of surgical research\| PubMed ID: 12020126	2002
Micropatterning tractional forces in living cells. Cell motility and the cytoskeleton\| PubMed ID: 12112152	2002
Sequential involvement of Cdk1, mTOR and p53 in apoptosis induced by the HIV-1 envelope. The EMBO journal\| PubMed ID: 12145207	2002
Directional control of lamellipodia extension by constraining cell shape and orienting cell tractional forces. FASEB journal : official publication of the Federation of American Societies for Experimental Biology\| PubMed ID: 12153987	2002
Mechanical signaling and the cellular response to extracellular matrix in angiogenesis and cardiovascular physiology. Circulation research\| PubMed ID: 12433832	2002
Cancer as a disease of epithelial-mesenchymal interactions and extracellular matrix regulation. Differentiation; research in biological diversity\| PubMed ID: 12492496	2002
Polycystins 1 and 2 mediate mechanosensation in the primary cilium of kidney cells. Nature genetics\| PubMed ID: 12514735	2003
Mechanosensation through integrins: cells act locally but think globally. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 12578965	2003
Tensegrity I. Cell structure and hierarchical systems biology. Journal of cell science\| PubMed ID: 12615960	2003
Selective chemical treatment of cellular microdomains using multiple laminar streams. Chemistry & biology\| PubMed ID: 12618184	2003
Tensegrity II. How structural networks influence cellular information processing networks. Journal of cell science\| PubMed ID: 12640025	2003
Intracellular stress tomography reveals stress focusing and structural anisotropy in cytoskeleton of living cells. American journal of physiology. Cell physiology\| PubMed ID: 12839836	2003
Identification of a distinct class of cytoskeleton-associated mRNAs using microarray technology. BMC cell biology\| PubMed ID: 12848903	2003
Cell shape provides global control of focal adhesion assembly. Biochemical and biophysical research communications\| PubMed ID: 12859964	2003
Caldesmon-dependent switching between capillary endothelial cell growth and apoptosis through modulation of cell shape and contractility. Angiogenesis\| PubMed ID: 14517405	2003
Gene Expression Dynamics Inspector (GEDI): for integrative analysis of expression profiles. Bioinformatics (Oxford, England)\| PubMed ID: 14630665	2003
Geometric determinants of directional cell motility revealed using microcontact printing. Langmuir : the ACS journal of surfaces and colloids\| PubMed ID: 14674434	2003
Mechanical properties of individual focal adhesions probed with a magnetic microneedle. Biochemical and biophysical research communications\| PubMed ID: 14697256	2004
Mechanobiology and diseases of mechanotransduction. Annals of medicine\| PubMed ID: 14708967	2003
Extracellular matrix controls myosin light chain phosphorylation and cell contractility through modulation of cell shape and cytoskeletal prestress. American journal of physiology. Cell physiology\| PubMed ID: 14761883	2004
Role of RhoA, mDia, and ROCK in cell shape-dependent control of the Skp2-p27kip1 pathway and the G1/S transition. The Journal of biological chemistry\| PubMed ID: 15096506	2004
A computational tensegrity model predicts dynamic rheological behaviors in living cells. Annals of biomedical engineering\| PubMed ID: 15117025	2004
Global cytoskeletal control of mechanotransduction in kidney epithelial cells. Experimental cell research\| PubMed ID: 15501441	2004
Control of basement membrane remodeling and epithelial branching morphogenesis in embryonic lung by Rho and cytoskeletal tension. Developmental dynamics : an official publication of the American Association of Anatomists\| PubMed ID: 15614768	2005
Inhibition of endothelial cell migration by thrombospondin-1 type-1 repeats is mediated by beta1 integrins. The Journal of cell biology\| PubMed ID: 15716381	2005
Cell fates as high-dimensional attractor states of a complex gene regulatory network. Physical review letters\| PubMed ID: 15903968	2005
High-betweenness proteins in the yeast protein interaction network. Journal of biomedicine & biotechnology\| PubMed ID: 16046814	2005
Mechanical control of tissue growth: function follows form. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 16091458	2005
Cell tension, matrix mechanics, and cancer development. Cancer cell\| PubMed ID: 16169461	2005
Integrins beta1, alpha6, and alpha3 contribute to mechanical strain-induced differentiation of fetal lung type II epithelial cells via distinct mechanisms. American journal of physiology. Lung cellular and molecular physiology\| PubMed ID: 16169900	2006
A mathematical model to determine molecular kinetic rate constants under non-steady state conditions using fluorescence recovery after photobleaching (FRAP). Biophysical chemistry\| PubMed ID: 16271824	2006
Mechanical forces alter zyxin unbinding kinetics within focal adhesions of living cells. Journal of cellular physiology\| PubMed ID: 16288479	2006
Alpha4beta1-dependent adhesion strengthening under mechanical strain is regulated by paxillin association with the alpha4-cytoplasmic domain. The Journal of cell biology\| PubMed ID: 16365170	2005
Evidence by molecular profiling for a placental origin of infantile hemangioma. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 16365311	2005
Force meets chemistry: analysis of mechanochemical conversion in focal adhesions using fluorescence recovery after photobleaching. Journal of cellular biochemistry\| PubMed ID: 16408278	2006
Cellular adaptation to mechanical stress: role of integrins, Rho, cytoskeletal tension and mechanosensitive ion channels. Journal of cell science\| PubMed ID: 16443749	2006
Mechanical control of tissue morphogenesis during embryological development. The International journal of developmental biology\| PubMed ID: 16479493	2006
Viscoelastic retraction of single living stress fibers and its impact on cell shape, cytoskeletal organization, and extracellular matrix mechanics. Biophysical journal\| PubMed ID: 16500961	2006
Multistable and multistep dynamics in neutrophil differentiation. BMC cell biology\| PubMed ID: 16507101	2006
Loss of polycystin-1 in human cyst-lining epithelia leads to ciliary dysfunction. Journal of the American Society of Nephrology : JASN\| PubMed ID: 16565258	2006
Cellular mechanotransduction: putting all the pieces together again. FASEB journal : official publication of the Federation of American Societies for Experimental Biology\| PubMed ID: 16675838	2006
Novel dynamic rheological behavior of individual focal adhesions measured within single cells using electromagnetic pulling cytometry. Acta biomaterialia\| PubMed ID: 16701808	2005
Ablation of cytoskeletal filaments and mitochondria in live cells using a femtosecond laser nanoscissor. Mechanics & chemistry of biosystems : MCB\| PubMed ID: 16708469	2005
Microtubules can bear enhanced compressive loads in living cells because of lateral reinforcement. The Journal of cell biology\| PubMed ID: 16754957	2006
An improved mathematical approach for determination of molecular kinetics in living cells with FRAP. Mechanics & chemistry of biosystems : MCB\| PubMed ID: 16783931	2004
Methods for measuring rates of protein binding to insoluble scaffolds in living cells: histone H1-chromatin interactions. Journal of cellular biochemistry\| PubMed ID: 16795044	2006
l-Caldesmon regulates proliferation and migration of vascular smooth muscle cells and inhibits neointimal formation after angioplasty. Arteriosclerosis, thrombosis, and vascular biology\| PubMed ID: 16888241	2006
Estrogen-receptor-alpha exchange and chromatin dynamics are ligand- and domain-dependent. Journal of cell science\| PubMed ID: 16968748	2006
Combined microfluidic-micromagnetic separation of living cells in continuous flow. Biomedical microdevices\| PubMed ID: 17003962	2006
Alpha-actinin-4 is required for normal podocyte adhesion. The Journal of biological chemistry\| PubMed ID: 17082197	2007
Filamin links cell shape and cytoskeletal structure to Rho regulation by controlling accumulation of p190RhoGAP in lipid rafts. Journal of cell science\| PubMed ID: 17227794	2007
Nanostructured magnetizable materials that switch cells between life and death. Biomaterials\| PubMed ID: 17339050	2007
A non-genetic basis for cancer progression and metastasis: self-organizing attractors in cell regulatory networks. Breast disease\| PubMed ID: 17473364	2006-2007
Towards a holistic, yet gene-centered analysis of gene expression profiles: a case study of human lung cancers. Journal of biomedicine & biotechnology\| PubMed ID: 17489018	2006
Magnetically-guided self-assembly of fibrin matrices with ordered nano-scale structure for tissue engineering. Tissue engineering\| PubMed ID: 17518638	2006
Tissue engineering and developmental biology: going biomimetic. Tissue engineering\| PubMed ID: 17518669	2006
What lies at the interface of regenerative medicine and developmental biology? Development (Cambridge, England)\| PubMed ID: 17553905	2007
Angiopoietin-1 requires p190 RhoGAP to protect against vascular leakage in vivo. The Journal of biological chemistry\| PubMed ID: 17562701	2007
Extracellular matrix, mechanotransduction and structural hierarchies in heart tissue engineering. Philosophical transactions of the Royal Society of London. Series B, Biological sciences\| PubMed ID: 17588874	2007
Tools to study cell mechanics and mechanotransduction. Methods in cell biology\| PubMed ID: 17613320	2007
Rheological behavior of living cells is timescale-dependent. Biophysical journal\| PubMed ID: 17693464	2007
Micromechanical control of cell and tissue development: implications for tissue engineering. Advanced drug delivery reviews\| PubMed ID: 17920155	2007
Tensile forces stimulate vascular remodeling and epidermal cell proliferation in living skin. Annals of surgery\| PubMed ID: 17968184	2007
Synaptic reorganization in scaled networks of controlled size. The Journal of neuroscience : the official journal of the Society for Neuroscience\| PubMed ID: 18077670	2007
Directional control of cell motility through focal adhesion positioning and spatial control of Rac activation. FASEB journal : official publication of the Federation of American Societies for Experimental Biology\| PubMed ID: 18180334	2008
Endothelial cilia are fluid shear sensors that regulate calcium signaling and nitric oxide production through polycystin-1. Circulation\| PubMed ID: 18285569	2008
Investigating complexity of protein-protein interactions in focal adhesions. Biochemical and biophysical research communications\| PubMed ID: 18331831	2008
Absence of cyclooxygenase-2 exacerbates hypoxia-induced pulmonary hypertension and enhances contractility of vascular smooth muscle cells. Circulation\| PubMed ID: 18391113	2008
Rho signaling and mechanical control of vascular development. Current opinion in hematology\| PubMed ID: 18391790	2008
Tensegrity-based mechanosensing from macro to micro. Progress in biophysics and molecular biology\| PubMed ID: 18406455	2008
Can cancer be reversed by engineering the tumor microenvironment? Seminars in cancer biology\| PubMed ID: 18472275	2008
Transcriptome-wide noise controls lineage choice in mammalian progenitor cells. Nature\| PubMed ID: 18497826	2008
A multi-modular tensegrity model of an actin stress fiber. Journal of biomechanics\| PubMed ID: 18632107	2008
Nanomagnetic actuation of receptor-mediated signal transduction. Nature nanotechnology\| PubMed ID: 18654448	2008
ABL2/ARG tyrosine kinase mediates SEMA3F-induced RhoA inactivation and cytoskeleton collapse in human glioma cells. The Journal of biological chemistry\| PubMed ID: 18660502	2008
Tumor-derived endothelial cells exhibit aberrant Rho-mediated mechanosensing and abnormal angiogenesis in vitro. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 18685096	2008
Noise-driven stem cell and progenitor population dynamics. PloS one\| PubMed ID: 18698344	2008
Methods for studying mechanical control of angiogenesis by the cytoskeleton and extracellular matrix. Methods in enzymology\| PubMed ID: 18772019	2008
Fibronectin unfolding revisited: modeling cell traction-mediated unfolding of the tenth type-III repeat. PloS one\| PubMed ID: 19020673	2008
Tensegrity and mechanotransduction. Journal of bodywork and movement therapies\| PubMed ID: 19083675	2008
Mechanical control of cAMP signaling through integrins is mediated by the heterotrimeric Galphas protein. Journal of cellular biochemistry\| PubMed ID: 19170051	2009
Mechanotransduction at a distance: mechanically coupling the extracellular matrix with the nucleus. Nature reviews. Molecular cell biology\| PubMed ID: 19197334	2009
A mechanosensitive transcriptional mechanism that controls angiogenesis. Nature\| PubMed ID: 19242469	2009
Using self-assembled monolayers to pattern ECM proteins and cells on substrates. Methods in molecular biology (Clifton, N.J.)\| PubMed ID: 19247618	2009
TRPV4 channels mediate cyclic strain-induced endothelial cell reorientation through integrin-to-integrin signaling. Circulation research\| PubMed ID: 19359599	2009
Micromagnetic-microfluidic blood cleansing device. Lab on a chip\| PubMed ID: 19370233	2009
Discovery of potent and practical antiangiogenic agents inspired by cortistatin A. Journal of the American Chemical Society\| PubMed ID: 19469509	2009
Cytoskeletal control of growth and cell fate switching. Current opinion in cell biology\| PubMed ID: 19740640	2009
Paper-supported 3D cell culture for tissue-based bioassays. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 19846768	2009
Tumor growth and angiogenesis are dependent on the presence of immature dendritic cells. FASEB journal : official publication of the Federation of American Societies for Experimental Biology\| PubMed ID: 20008545	2010
Carbon metabolism-mediated myogenic differentiation. Nature chemical biology\| PubMed ID: 20081855	2010
From cellular mechanotransduction to biologically inspired engineering: 2009 Pritzker Award Lecture, BMES Annual Meeting October 10, 2009. Annals of biomedical engineering\| PubMed ID: 20140519	2010
Mechanical control of tissue and organ development. Development (Cambridge, England)\| PubMed ID: 20388652	2010
Self-assembly of three-dimensional prestressed tensegrity structures from DNA. Nature nanotechnology\| PubMed ID: 20562873	2010
Reconstituting organ-level lung functions on a chip. Science (New York, N.Y.)\| PubMed ID: 20576885	2010
Ultra-rapid activation of TRPV4 ion channels by mechanical forces applied to cell surface beta1 integrins. Integrative biology : quantitative biosciences from nano to macro\| PubMed ID: 20725677	2010
Filamin A regulates focal adhesion disassembly and suppresses breast cancer cell migration and invasion. The Journal of experimental medicine\| PubMed ID: 20937704	2010
Multizone paper platform for 3D cell cultures. PloS one\| PubMed ID: 21573103	2011
The Wyss Institute at Harvard University. IEEE pulse\| PubMed ID: 21791399	2011
Mechanochemical control of mesenchymal condensation and embryonic tooth organ formation. Developmental cell\| PubMed ID: 21924961	2011
From 3D cell culture to organs-on-chips. Trends in cell biology\| PubMed ID: 22033488	2011
Unexpected strength and toughness in chitosan-fibroin laminates inspired by insect cuticle. Advanced materials (Deerfield Beach, Fla.)\| PubMed ID: 22162193	2012
Epoxyeicosanoids stimulate multiorgan metastasis and tumor dormancy escape in mice. The Journal of clinical investigation\| PubMed ID: 22182838	2012
Forty-year journey of angiogenesis translational research. Science translational medicine\| PubMed ID: 22190240	2011
Paxillin mediates sensing of physical cues and regulates directional cell motility by controlling lamellipodia positioning. PloS one\| PubMed ID: 22194823	2011
Polymeric nanomaterials for islet targeting and immunotherapeutic delivery. Nano letters\| PubMed ID: 22196766	2012
A Wnt-bmp feedback circuit controls intertissue signaling dynamics in tooth organogenesis. Science signaling\| PubMed ID: 22234613	2012
Human gut-on-a-chip inhabited by microbial flora that experiences intestinal peristalsis-like motions and flow. Lab on a chip\| PubMed ID: 22434367	2012
A combined micromagnetic-microfluidic device for rapid capture and culture of rare circulating tumor cells. Lab on a chip\| PubMed ID: 22453808	2012
Inhibition of mammary tumor growth using lysyl oxidase-targeting nanoparticles to modify extracellular matrix. Nano letters\| PubMed ID: 22554317	2012
Microengineered physiological biomimicry: organs-on-chips. Lab on a chip\| PubMed ID: 22555377	2012
Lab on a chip: United States of America. Lab on a chip\| PubMed ID: 22588356	2012
Shear-activated nanotherapeutics for drug targeting to obstructed blood vessels. Science (New York, N.Y.)\| PubMed ID: 22767894	2012
Mechanosensitive mechanisms in transcriptional regulation. Journal of cell science\| PubMed ID: 22797927	2012
LRP5 regulates development of lung microvessels and alveoli through the angiopoietin-Tie2 pathway. PloS one\| PubMed ID: 22848540	2012
A mini-microscope for in situ monitoring of cells. Lab on a chip\| PubMed ID: 22911426	2012
Paxillin controls directional cell motility in response to physical cues. Cell adhesion & migration\| PubMed ID: 23076140	2012
Magnetic Cellular Switches. IEEE transactions on magnetics\| PubMed ID: 23097592	2004
A human disease model of drug toxicity-induced pulmonary edema in a lung-on-a-chip microdevice. Science translational medicine\| PubMed ID: 23136042	2012
Control of lung vascular permeability and endotoxin-induced pulmonary oedema by changes in extracellular matrix mechanics. Nature communications\| PubMed ID: 23612300	2013
Nogo-A is a negative regulator of CNS angiogenesis. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 23625008	2013
Human kidney proximal tubule-on-a-chip for drug transport and nephrotoxicity assessment. Integrative biology : quantitative biosciences from nano to macro\| PubMed ID: 23644926	2013
Low urine vascular endothelial growth factor levels are associated with mechanical ventilation, bronchopulmonary dysplasia and retinopathy of prematurity. Neonatology\| PubMed ID: 23711562	2013
SLLISWD sequence in the 10FNIII domain initiates fibronectin fibrillogenesis. The Journal of biological chemistry\| PubMed ID: 23740248	2013
Breast cancer normalization induced by embryonic mesenchyme is mediated by extracellular matrix biglycan. Integrative biology : quantitative biosciences from nano to macro\| PubMed ID: 23817524	2013
Gut-on-a-Chip microenvironment induces human intestinal cells to undergo villus differentiation. Integrative biology : quantitative biosciences from nano to macro\| PubMed ID: 23817533	2013
Epoxyeicosanoids promote organ and tissue regeneration. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 23898174	2013
Organs on chips 2013. Lab on a chip\| PubMed ID: 23918086	2013
Platform for High-Throughput Testing of the Effect of Soluble Compounds on 3D Cell Cultures. Analytical chemistry\| PubMed ID: 23952342	2013
Clear castable polyurethane elastomer for fabrication of microfluidic devices. Lab on a chip\| PubMed ID: 23954953	2013
Patterned deposition of cells and proteins onto surfaces by using three-dimensional microfluidic systems. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 10681460	2000
How changes in extracellular matrix mechanics and gene expression variability might combine to drive cancer progression. PloS one\| PubMed ID: 24098430	2013
Microfabrication of human organs-on-chips. Nature protocols\| PubMed ID: 24113786	2013
A microdevice for rapid optical detection of magnetically captured rare blood pathogens. Lab on a chip\| PubMed ID: 24169822	2014
Quantifying cell-generated mechanical forces within living embryonic tissues. Nature methods\| PubMed ID: 24317254	2014
Silencing HoxA1 by intraductal injection of siRNA lipidoid nanoparticles prevents mammary tumor progression in mice. Science translational medicine\| PubMed ID: 24382894	2014
A combinatorial cell-laden gel microarray for inducing osteogenic differentiation of human mesenchymal stem cells. Scientific reports\| PubMed ID: 24473466	2014
Paxillin controls endothelial cell migration and tumor angiogenesis by altering neuropilin 2 expression. Journal of cell science\| PubMed ID: 24522185	2014
Developmentally-inspired shrink-wrap polymers for mechanical induction of tissue differentiation. Advanced materials (Deerfield Beach, Fla.)\| PubMed ID: 24550068	2014
Mechanotransduction of fluid stresses governs 3D cell migration. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 24550267	2014
Tensegrity, cellular biophysics, and the mechanics of living systems. Reports on progress in physics. Physical Society (Great Britain)\| PubMed ID: 24695087	2014
Bone marrow-on-a-chip replicates hematopoietic niche physiology in vitro. Nature methods\| PubMed ID: 24793454	2014
Nanoparticle targeting of anti-cancer drugs that alter intracellular signaling or influence the tumor microenvironment. Advanced drug delivery reviews\| PubMed ID: 24819216	2014
Mononuclear cells from dedifferentiation of mouse myotubes display remarkable regenerative capability. Stem cells (Dayton, Ohio)\| PubMed ID: 24916688	2014
Stationary nanoliter droplet array with a substrate of choice for single adherent/nonadherent cell incubation and analysis. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 25053808	2014
Developing microphysiological systems for use as regulatory tools--challenges and opportunities. ALTEX\| PubMed ID: 25061900	2014
Microfluidic organs-on-chips. Nature biotechnology\| PubMed ID: 25093883	2014
A bioinspired omniphobic surface coating on medical devices prevents thrombosis and biofouling. Nature biotechnology\| PubMed ID: 25306244	2014
Targeted drug delivery to flow-obstructed blood vessels using mechanically activated nanotherapeutics. JAMA neurology\| PubMed ID: 25365638	2015
Engineered in vitro disease models. Annual review of pathology\| PubMed ID: 25621660	2015
Generation of biocompatible droplets for in vivo and in vitro measurement of cell-generated mechanical stresses. Methods in cell biology\| PubMed ID: 25640439	2015
Mesenchymal condensation-dependent accumulation of collagen VI stabilizes organ-specific cell fates during embryonic tooth formation. Developmental dynamics : an official publication of the American Association of Anatomists\| PubMed ID: 25715693	2015
Biomechanical forces promote blood development through prostaglandin E2 and the cAMP-PKA signaling axis. The Journal of experimental medicine\| PubMed ID: 25870199	2015
Control of cancer formation by intrinsic genetic noise and microenvironmental cues. Nature reviews. Cancer\| PubMed ID: 26156637	2015
Programed Death is Favored by Natural Selection in Spatial Systems. Physical review letters\| PubMed ID: 26196833	2015
Matrix elasticity of void-forming hydrogels controls transplanted-stem-cell-mediated bone formation. Nature materials\| PubMed ID: 26366848	2015
Optimization of Pathogen Capture in Flowing Fluids with Magnetic Nanoparticles. Small (Weinheim an der Bergstrasse, Germany)\| PubMed ID: 26389806	2015
Shear-Activated Nanoparticle Aggregates Combined With Temporary Endovascular Bypass to Treat Large Vessel Occlusion. Stroke; a journal of cerebral circulation\| PubMed ID: 26493676	2015
Contributions of microbiome and mechanical deformation to intestinal bacterial overgrowth and inflammation in a human gut-on-a-chip. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 26668389	2016
Small airway-on-a-chip enables analysis of human lung inflammation and drug responses in vitro. Nature methods\| PubMed ID: 26689262	2016
A shear gradient-activated microfluidic device for automated monitoring of whole blood haemostasis and platelet function. Nature communications\| PubMed ID: 26733371	2016
Distinct Contributions of Astrocytes and Pericytes to Neuroinflammation Identified in a 3D Human Blood-Brain Barrier on a Chip. PloS one\| PubMed ID: 26930059	2016
Reverse Engineering Human Pathophysiology with Organs-on-Chips. Cell\| PubMed ID: 26967278	2016
Modeling Hematopoiesis and Responses to Radiation Countermeasures in a Bone Marrow-on-a-Chip. Tissue engineering. Part C, Methods\| PubMed ID: 26993746	2016
A Broad-Spectrum Infection Diagnostic that Detects Pathogen-Associated Molecular Patterns (PAMPs) in Whole Blood. EBioMedicine\| PubMed ID: 27333027	2016
Assessment of whole blood thrombosis in a microfluidic device lined by fixed human endothelium. Biomedical microdevices\| PubMed ID: 27464497	2016
Direct Bonding of Chitosan Biomaterials to Tissues Using Transglutaminase for Surgical Repair or Device Implantation. Tissue engineering. Part A\| PubMed ID: 27869543	2017
Commendation for Exposing Key Advantage of Organ Chip Approach. Cell systems\| PubMed ID: 27883885	2016
Human Gut-On-A-Chip Supports Polarized Infection of Coxsackie B1 Virus In Vitro. PloS one\| PubMed ID: 28146569	2017
Theory and associated phenomenology for intrinsic mortality arising from natural selection. PloS one\| PubMed ID: 28355288	2017
Primary Human Lung Alveolus-on-a-chip Model of Intravascular Thrombosis for Assessment of Therapeutics. Clinical pharmacology and therapeutics\| PubMed ID: 28516446	2018
New anticoagulant coatings and hemostasis assessment tools to avoid complications with pediatric left ventricular assist devices. The Journal of thoracic and cardiovascular surgery\| PubMed ID: 28526505	2017
Reproductive endocrinology: Cycling through the menstrual cycle - an out-of-body experience. Nature reviews. Endocrinology\| PubMed ID: 28549062	2017
Organs-on-chips with integrated electrodes for trans-epithelial electrical resistance (TEER) measurements of human epithelial barrier function. Lab on a chip\| PubMed ID: 28598479	2017
Organs-on-Chips with combined multi-electrode array and transepithelial electrical resistance measurement capabilities. Lab on a chip\| PubMed ID: 28608907	2017
Ultrasound-sensitive nanoparticle aggregates for targeted drug delivery. Biomaterials\| PubMed ID: 28618348	2017
Mechanical induction of dentin-like differentiation by adult mouse bone marrow stromal cells using compressive scaffolds. Stem cell research\| PubMed ID: 28841424	2017
Human Organ Chip Models Recapitulate Orthotopic Lung Cancer Growth, Therapeutic Responses, and Tumor Dormancy In Vitro. Cell reports\| PubMed ID: 29020635	2017
Mature induced-pluripotent-stem-cell-derived human podocytes reconstitute kidney glomerular-capillary-wall function on a chip. Nature biomedical engineering\| PubMed ID: 29038743	2017
Art Advancing Science: Filmmaking Leads to Molecular Insights at the Nanoscale. ACS nano\| PubMed ID: 29043776	2017
A Biologically Inspired, Functionally Graded End Effector for Soft Robotics Applications. Soft robotics\| PubMed ID: 29251563	2017
Physiologically Based Pharmacokinetic and Pharmacodynamic Analysis Enabled by Microfluidically Linked Organs-on-Chips. Annual review of pharmacology and toxicology\| PubMed ID: 29309256	2018
The Wyss institute: A new model for medical technology innovation and translation across the academic-industrial interface. Bioengineering & translational medicine\| PubMed ID: 29313034	2017
PAR1 agonists stimulate APC-like endothelial cytoprotection and confer resistance to thromboinflammatory injury. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 29343648	2018
Development of a primary human Small Intestine-on-a-Chip using biopsy-derived organoids. Scientific reports\| PubMed ID: 29440725	2018
Modeling radiation injury-induced cell death and countermeasure drug responses in a human Gut-on-a-Chip. Cell death & disease\| PubMed ID: 29445080	2018
Organ-on-Chip Recapitulates Thrombosis Induced by an anti-CD154 Monoclonal Antibody: Translational Potential of Advanced Microengineered Systems. Clinical pharmacology and therapeutics\| PubMed ID: 29484632	2018
Rapid Prototyping of Thermoplastic Microfluidic Devices. Methods in molecular biology (Clifton, N.J.)\| PubMed ID: 29633212	2018
Microfluidic Organ-on-a-Chip Models of Human Intestine. Cellular and molecular gastroenterology and hepatology\| PubMed ID: 29713674	2018
Modulation of the Cellular Uptake of DNA Origami through Control over Mass and Shape. Nano letters\| PubMed ID: 29756442	2018
Developmentally inspired human 'organs on chips'. Development (Cambridge, England)\| PubMed ID: 29776965	2018
Directed differentiation of human induced pluripotent stem cells into mature kidney podocytes and establishment of a Glomerulus Chip. Nature protocols\| PubMed ID: 29995874	2018
A linked organ-on-chip model of the human neurovascular unit reveals the metabolic coupling of endothelial and neuronal cells. Nature biotechnology\| PubMed ID: 30125269	2018
From mechanobiology to developmentally inspired engineering. Philosophical transactions of the Royal Society of London. Series B, Biological sciences\| PubMed ID: 30249774	2018
Modelling cancer in microfluidic human organs-on-chips. Nature reviews. Cancer\| PubMed ID: 30647431	2019
Platelet decoys inhibit thrombosis and prevent metastatic tumor formation in preclinical models. Science translational medicine\| PubMed ID: 30760580	2019
Species-specific enhancement of enterohemorrhagic E. coli pathogenesis mediated by microbiome metabolites. Microbiome\| PubMed ID: 30890187	2019
Seeing Your Way to New Insights in Biology. Journal of molecular biology\| PubMed ID: 31034886	2019
A complex human gut microbiome cultured in an anaerobic intestine-on-a-chip. Nature biomedical engineering\| PubMed ID: 31086325	2019
Human Intestinal Morphogenesis Controlled by Transepithelial Morphogen Gradient and Flow-Dependent Physical Cues in a Microengineered Gut-on-a-Chip. iScience\| PubMed ID: 31108394	2019
Hypoxia-enhanced Blood-Brain Barrier Chip recapitulates human barrier function and shuttling of drugs and antibodies. Nature communications\| PubMed ID: 31197168	2019
Cellular nanoscale stiffness patterns governed by intracellular forces. Nature materials\| PubMed ID: 31209386	2019
Author Correction: A complex human gut microbiome cultured in an anaerobic intestine-on-a-chip. Nature biomedical engineering\| PubMed ID: 31213704	2019
Broad-spectrum capture of clinical pathogens using engineered Fc-mannose-binding lectin enhanced by antibiotic treatment. F1000Research\| PubMed ID: 31275563	2019
Controllable Fabrication of Inhomogeneous Microcapsules for Triggered Release by Osmotic Pressure. Small (Weinheim an der Bergstrasse, Germany)\| PubMed ID: 31448553	2019
Tumor-Derived Extracellular Vesicles Breach the Intact Blood-Brain Barrier Transcytosis. ACS nano\| PubMed ID: 31479239	2019
Reproducing human and cross-species drug toxicities using a Liver-Chip. Science translational medicine\| PubMed ID: 31694927	2019
An antifouling coating that enables affinity-based electrochemical biosensing in complex biological fluids. Nature nanotechnology\| PubMed ID: 31712665	2019
Human Colon-on-a-Chip Enables Continuous In Vitro Analysis of Colon Mucus Layer Accumulation and Physiology. Cellular and molecular gastroenterology and hepatology\| PubMed ID: 31778828	2020
AAV-mediated gene therapy targeting TRPV4 mechanotransduction for inhibition of pulmonary vascular leakage. APL bioengineering\| PubMed ID: 31803860	2019
Biomimetic smoking robot for in vitro inhalation exposure compatible with microfluidic organ chips. Nature protocols\| PubMed ID: 31925401	2020
On-chip recapitulation of clinical bone marrow toxicities and patient-specific pathophysiology. Nature biomedical engineering\| PubMed ID: 31988457	2020
Robotic fluidic coupling and interrogation of multiple vascularized organ chips. Nature biomedical engineering\| PubMed ID: 31988458	2020
Quantitative prediction of human pharmacokinetic responses to drugs via fluidically coupled vascularized organ chips. Nature biomedical engineering\| PubMed ID: 31988459	2020
YAP Regulates Hematopoietic Stem Cell Formation in Response to the Biomechanical Forces of Blood Flow. Developmental cell\| PubMed ID: 32032546	2020
Author Correction: On-chip recapitulation of clinical bone marrow toxicities and patient-specific pathophysiology. Nature biomedical engineering\| PubMed ID: 32051581	2020
Biology-inspired microphysiological systems to advance patient benefit and animal welfare in drug development ALTEX\| PubMed ID: 32113184	2020
Phosphorylation of ACTN4 Leads to Podocyte Vulnerability and Proteinuric Glomerulosclerosis. Journal of the American Society of Nephrology : JASN\| PubMed ID: 32540856	2020
An Engineered Human Fc-Mannose-Binding-Lectin Captures Circulating Tumor Cells. Advanced biosystems\| PubMed ID: 32646174	2017
Human Organs-on-Chips for Virology. Trends in microbiology\| PubMed ID: 32674988	2020
Proteomic and Metabolomic Characterization of Human Neurovascular Unit Cells in Response to Methamphetamine. Advanced biosystems\| PubMed ID: 32744807	2020
Treatment of psoriasis with NFKBIZ siRNA using topical ionic liquid formulations. Science advances\| PubMed ID: 32832675	2020
Molecular mapping of transmembrane mechanotransduction through the β1 integrin-CD98hc-TRPV4 axis. Journal of cell science\| PubMed ID: 32989042	2020
Is it Time for Reviewer 3 to Request Human Organ Chip Experiments Instead of Animal Validation Studies? Advanced science (Weinheim, Baden-Wurttemberg, Germany)\| PubMed ID: 33240763	2020
Rapid Coating Process Generates Omniphobic Dentures in Minutes to Reduce Biofouling. ACS biomaterials science & engineering\| PubMed ID: 33405807	2019
Anomalous COVID-19 tests hinder researchers. Science (New York, N.Y.)\| PubMed ID: 33446547	2021
A single-cell and spatial atlas of autopsy tissues reveals pathology and cellular targets of SARS-CoV-2. bioRxiv : the preprint server for biology\| PubMed ID: 33655247	2021
Enabling out-of-body experiences for living organs. The Journal of experimental medicine\| PubMed ID: 33710255	2021
Harnessing Colon Chip Technology to Identify Commensal Bacteria That Promote Host Tolerance to Infection. Frontiers in cellular and infection microbiology\| PubMed ID: 33777849	2021
Transferrin receptor targeting by de novo sheet extension. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 33879614	2021
COVID-19 tissue atlases reveal SARS-CoV-2 pathology and cellular targets. Nature\| PubMed ID: 33915569	2021
A human-airway-on-a-chip for the rapid identification of candidate antiviral therapeutics and prophylactics. Nature biomedical engineering\| PubMed ID: 33941899	2021
Biomaterial vaccines capturing pathogen-associated molecular patterns protect against bacterial infections and septic shock. Nature biomedical engineering\| PubMed ID: 34239117	2022
Mechanosensation Mediates Long-Range Spatial Decision-Making in an Aneural Organism. Advanced materials (Deerfield Beach, Fla.)\| PubMed ID: 34263487	2021
Simulating drug concentrations in PDMS microfluidic organ chips. Lab on a chip\| PubMed ID: 34346471	2021
Evidence generation and reproducibility in cell and gene therapy research: A call to action. Molecular therapy. Methods & clinical development\| PubMed ID: 34377737	2021
Enabling Multiplexed Electrochemical Detection of Biomarkers with High Sensitivity in Complex Biological Samples. Accounts of chemical research\| PubMed ID: 34478255	2021
Establishment of a Modular Anaerobic Human Intestine Chip. Methods in molecular biology (Clifton, N.J.)\| PubMed ID: 34520007	2022
Laboratory-Generated DNA Can Cause Anomalous Pathogen Diagnostic Test Results. Microbiology spectrum\| PubMed ID: 34523989	2021
Clinically Relevant Influenza Virus Evolution Reconstituted in a Human Lung Airway-on-a-Chip. Microbiology spectrum\| PubMed ID: 34523991	2021
Bioinspired design and optimization for thin film wearable and building cooling systems. Bioinspiration & biomimetics\| PubMed ID: 34644686	2021
Enteric Coronavirus Infection and Treatment Modeled With an Immunocompetent Human Intestine-On-A-Chip. Frontiers in pharmacology\| PubMed ID: 34759819	2021
Modeling pulmonary cystic fibrosis in a human lung airway-on-a-chip. Journal of cystic fibrosis : official journal of the European Cystic Fibrosis Society\| PubMed ID: 34799298	2022
Self-assembling short immunostimulatory duplex RNAs with broad spectrum antiviral activity. bioRxiv : the preprint server for biology\| PubMed ID: 34845453	2021
Biochemical and Hematologic Reference Intervals for Anesthetized, Female, Juvenile Yorkshire Swine. Journal of the American Association for Laboratory Animal Science : JAALAS\| PubMed ID: 34903312	2022
Ultrarapid Method for Coating Electrochemical Sensors with Antifouling Conductive Nanomaterials Enables Highly Sensitive Multiplexed Detection in Whole Blood. Advanced healthcare materials\| PubMed ID: 34965031	2022
Establishment of physiologically relevant oxygen gradients in microfluidic organ chips. Lab on a chip\| PubMed ID: 35274118	2022
Ectopic Lymphoid Follicle Formation and Human Seasonal Influenza Vaccination Responses Recapitulated in an Organ-on-a-Chip. Advanced science (Weinheim, Baden-Wurttemberg, Germany)\| PubMed ID: 35289122	2022
Human organs-on-chips for disease modelling, drug development and personalized medicine. Nature reviews. Genetics\| PubMed ID: 35338360	2022
Mechanical control of innate immune responses against viral infection revealed in a human lung alveolus chip. Nature communications\| PubMed ID: 35396513	2022
Interdisciplinarity and mechanobiology. iScience\| PubMed ID: 35521523	2022
What Can an Organ-on-a-Chip Teach Us About Human Lung Pathophysiology? Physiology (Bethesda, Md.)\| PubMed ID: 35658627	2022
Biofabrication of Multiplexed Electrochemical Immunosensors for Simultaneous Detection of Clinical Biomarkers in Complex Fluids. Advanced healthcare materials\| PubMed ID: 35678244	2022
Enhancers of Host Immune Tolerance to Bacterial Infection Discovered Using Linked Computational and Experimental Approaches. Advanced science (Weinheim, Baden-Wurttemberg, Germany)\| PubMed ID: 35706367	2022
Nutritional deficiency in an intestine-on-a-chip recapitulates injury hallmarks associated with environmental enteric dysfunction. Nature biomedical engineering\| PubMed ID: 35739419	2022
A lab-on-a-chip for the concurrent electrochemical detection of SARS-CoV-2 RNA and anti-SARS-CoV-2 antibodies in saliva and plasma. Nature biomedical engineering\| PubMed ID: 35941191	2022
PIKfyve-specific inhibitors restrict replication of multiple coronaviruses in vitro but not in a murine model of COVID-19. Communications biology\| PubMed ID: 35962188	2022
Self-assembling short immunostimulatory duplex RNAs with broad-spectrum antiviral activity. Molecular therapy. Nucleic acids\| PubMed ID: 36032397	2022
Modeling mucus physiology and pathophysiology in human organs-on-chips. Advanced drug delivery reviews\| PubMed ID: 36179916	2022
Differential ABC transporter expression during hematopoiesis contributes to neutrophil-biased toxicity of Aurora kinase inhibitors. Nature communications\| PubMed ID: 36224199	2022
FcMBL magnetic bead-based MALDI-TOF MS rapidly identifies paediatric blood stream infections from positive blood cultures. PloS one\| PubMed ID: 36413530	2022
Vaginal microbiome-host interactions modeled in a human vagina-on-a-chip. Microbiome\| PubMed ID: 36434666	2022
Performance assessment and economic analysis of a human Liver-Chip for predictive toxicology. Communications medicine\| PubMed ID: 36473994	2022
Rapid quantitation of SARS-CoV-2 antibodies in clinical samples with an electrochemical sensor. Biosensors & bioelectronics\| PubMed ID: 36584477	2023
Author Correction: Performance assessment and economic analysis of a human Liver-Chip for predictive toxicology. Communications medicine\| PubMed ID: 36635369	2023
Author Correction: Performance assessment and economic analysis of a human Liver-Chip for predictive toxicology. Communications medicine\| PubMed ID: 36732600	2023
From tensegrity to human organs-on-chips: implications for mechanobiology and mechanotherapeutics. The Biochemical journal\| PubMed ID: 36821520	2023
Target-agnostic drug prediction integrated with medical record analysis uncovers differential associations of statins with increased survival in COVID-19 patients. PLoS computational biology\| PubMed ID: 37146076	2023
Report of the Assay Guidance Workshop on 3-Dimensional Tissue Models for Antiviral Drug Development. The Journal of infectious diseases\| PubMed ID: 37669225	2023
A human lung alveolus-on-a-chip model of acute radiation-induced lung injury. Nature communications\| PubMed ID: 37845224	2023
Direct therapeutic effect of sulfadoxine-pyrimethamine on nutritional deficiency-induced enteric dysfunction in a human Intestine Chip. EBioMedicine\| PubMed ID: 38101300	2024
Human organ chips for regenerative pharmacology. Pharmacology research & perspectives\| PubMed ID: 38149766	2024
DNA origami vaccine (DoriVac) nanoparticles improve both humoral and cellular immune responses to infectious diseases. bioRxiv : the preprint server for biology\| PubMed ID: 38260393	2024
Micrometer-thick and porous nanocomposite coating for electrochemical sensors with exceptional antifouling and electroconducting properties. Nature communications\| PubMed ID: 38331881	2024