Douglas K. Graham Department of Pediatrics University of Colorado Anschutz Medical Campus Biography Publications Institution JoVE Articles Douglas K. Graham has not added a biography. If you are Douglas K. Graham and would like to personalize this page please email our Author Liaison for assistance. Publications UNC569, a Novel Small Molecule Mer Inhibitor with Efficacy Against Acute Lymphoblastic Leukemia in Vitro and in Vivo Molecular Cancer Therapeutics. Aug, 2013 | Pubmed ID: 23997116 MerTK Inhibition in Tumor Leukocytes Decreases Tumor Growth and Metastasis The Journal of Clinical Investigation. Aug, 2013 | Pubmed ID: 23867499 Mer Receptor Tyrosine Kinase is a Therapeutic Target in Pre-B-cell Acute Lymphoblastic Leukemia Blood. Aug, 2013 | Pubmed ID: 23861246 Molecular Pathways: MERTK Signaling in Cancer Clinical Cancer Research : an Official Journal of the American Association for Cancer Research. Aug, 2013 | Pubmed ID: 23833304 UNC1062, a New and Potent Mer Inhibitor European Journal of Medicinal Chemistry. Jul, 2013 | Pubmed ID: 23693152 Dual ALK and MYC Rearrangements Leading to an Aggressive Variant of Anaplastic Large Cell Lymphoma Journal of Pediatric Hematology/oncology. Jul, 2013 | Pubmed ID: 23619105 MERTK Receptor Tyrosine Kinase is a Therapeutic Target in Melanoma The Journal of Clinical Investigation. May, 2013 | Pubmed ID: 23585477 Bioluminescence Imaging of Leukemia Cell Lines in Vitro and in Mouse Xenografts: Effects of Monoclonal and Polyclonal Cell Populations on Intensity and Kinetics of Photon Emission Journal of Hematology & Oncology. 2013 | Pubmed ID: 23343252 Moderate Aplastic Anemia in Children: Preliminary Outcomes for Treatment Versus Observation from a Single-institutional Experience Journal of Pediatric Hematology/oncology. Mar, 2013 | Pubmed ID: 23128338 Discovery of Novel Small Molecule Mer Kinase Inhibitors for the Treatment of Pediatric Acute Lymphoblastic Leukemia ACS Medicinal Chemistry Letters. Feb, 2012 | Pubmed ID: 22662287 Prolonged Exposure to a Mer Ligand in Leukemia: Gas6 Favors Expression of a Partial Mer Glycoform and Reveals a Novel Role for Mer in the Nucleus PloS One. 2012 | Pubmed ID: 22363695 TAM Receptors in Leukemia: Expression, Signaling, and Therapeutic Implications Critical Reviews in Oncogenesis. 2011 | Pubmed ID: 22150307 Constitutive Induction of Pro-inflammatory and Chemotactic Cytokines in Cystathionine Beta-synthase Deficient Homocystinuria Molecular Genetics and Metabolism. Aug, 2011 | Pubmed ID: 21601502 Gray Zone Lymphomas in Pediatric Patients Pediatric and Developmental Pathology : the Official Journal of the Society for Pediatric Pathology and the Paediatric Pathology Society. Jan-Feb, 2011 | Pubmed ID: 20331368 Targeting Paediatric Acute Lymphoblastic Leukaemia: Novel Therapies Currently in Development British Journal of Haematology. Nov, 2010 | Pubmed ID: 20813012 Taking Aim at Mer and Axl Receptor Tyrosine Kinases As Novel Therapeutic Targets in Solid Tumors Expert Opinion on Therapeutic Targets. Oct, 2010 | Pubmed ID: 20809868 Inhibition of Mer and Axl Receptor Tyrosine Kinases in Astrocytoma Cells Leads to Increased Apoptosis and Improved Chemosensitivity Molecular Cancer Therapeutics. May, 2010 | Pubmed ID: 20423999 Thymoma in Children: Report of 2 Cases and Review of the Literature Pediatric and Developmental Pathology : the Official Journal of the Society for Pediatric Pathology and the Paediatric Pathology Society. May-Jun, 2010 | Pubmed ID: 20055684 Mer Receptor Tyrosine Kinase is a Novel Therapeutic Target in Pediatric B-cell Acute Lymphoblastic Leukemia Blood. Sep, 2009 | Pubmed ID: 19643988 Mer Tyrosine Kinase (MerTK) Promotes Macrophage Survival Following Exposure to Oxidative Stress Journal of Leukocyte Biology. Jul, 2009 | Pubmed ID: 19386698 Tacrolimus As an Alternative to Cyclosporine in the Maintenance Phase of Immunosuppressive Therapy for Severe Aplastic Anemia in Children Pediatric Blood & Cancer. May, 2009 | Pubmed ID: 19148946 Pediatric Developmental Therapies: Interesting New Drugs Now in Early-stage Clinical Trials Current Oncology Reports. Nov, 2008 | Pubmed ID: 18928662 TAM Receptor Tyrosine Kinases: Biologic Functions, Signaling, and Potential Therapeutic Targeting in Human Cancer Advances in Cancer Research. 2008 | Pubmed ID: 18620092 BAC to the Future? Comparative Genomic Hybridization and Genotyping Pediatric Leukemia Cytogenetic Abnormalities Pediatric Blood & Cancer. Aug, 2008 | Pubmed ID: 18300321 Natural Killer Cell Neoplasms Cancer. Apr, 2008 | Pubmed ID: 18286525 Precursor Natural Killer Cell Leukemia Pediatric Blood & Cancer. Apr, 2008 | Pubmed ID: 17417789 A Soluble Form of the Mer Receptor Tyrosine Kinase Inhibits Macrophage Clearance of Apoptotic Cells and Platelet Aggregation Blood. Feb, 2007 | Pubmed ID: 17047157 Ectopic Expression of the Proto-oncogene Mer in Pediatric T-cell Acute Lymphoblastic Leukemia Clinical Cancer Research : an Official Journal of the American Association for Cancer Research. May, 2006 | Pubmed ID: 16675557 Successful Treatment of Severe Aplastic Anemia in Children Using Standardized Immunosuppressive Therapy with Antithymocyte Globulin and Cyclosporine A Pediatric Blood & Cancer. Dec, 2004 | Pubmed ID: 15390303 Disseminated Nasopharyngeal Natural Killer Cell Lymphoblastic Lymphoma in a Child Medical and Pediatric Oncology. Apr, 2003 | Pubmed ID: 12555256 Molecular Genetic Analysis of a Small Bowel Primitive Neuroectodermal Tumor Pediatric and Developmental Pathology : the Official Journal of the Society for Pediatric Pathology and the Paediatric Pathology Society. Jan-Feb, 2002 | Pubmed ID: 11815873 A avaliação pré-clínica da tirosina quinase inibidores para o tratamento de leucemia aguda Sandra Christoph1,2, Alisa B. Lee-Sherick1, Susan Sather1, Deborah DeRyckere1, Douglas K. Graham1 1Department of Pediatrics, University of Colorado Anschutz Medical Campus, 2Department of Bone Marrow Transplantation, University Hospital of Essen JoVE 50720 Medicine
A avaliação pré-clínica da tirosina quinase inibidores para o tratamento de leucemia aguda Sandra Christoph1,2, Alisa B. Lee-Sherick1, Susan Sather1, Deborah DeRyckere1, Douglas K. Graham1 1Department of Pediatrics, University of Colorado Anschutz Medical Campus, 2Department of Bone Marrow Transplantation, University Hospital of Essen JoVE 50720 Medicine