Etienne Sibille

Campbell Family Mental Health Research Institute of CAMH

Affiliated withCampbell Family Mental Health Research Institute of CAMH University of Toronto Campbell Family Mental Health Research Institute

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JoVE Journal Publications

ArticleTotal : 2	Year
Publication title Cited by 30	2021
Publication title	2023

Other Publications

Article	Year
Laminar and cellular analyses of reduced somatostatin gene expression in the subgenual anterior cingulate cortex in major depression. Neurobiology of disease\| PubMed ID: 25315685	2015
Elevated Hippocampal Cholinergic Neurostimulating Peptide precursor protein (HCNP-pp) mRNA in the amygdala in major depression. Journal of psychiatric research\| PubMed ID: 25819500	2015
Hypermethylation of BDNF and SST Genes in the Orbital Frontal Cortex of Older Individuals: A Putative Mechanism for Declining Gene Expression with Age. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology\| PubMed ID: 25881116	2015
FRAS1-related extracellular matrix 3 (FREM3) single-nucleotide polymorphism effects on gene expression, amygdala reactivity and perceptual processing speed: An accelerated aging pathway of d... Frontiers in psychology\| PubMed ID: 26441752	2015
Predisposition to treatment response in major depressive episode: A peripheral blood gene coexpression network analysis. Journal of psychiatric research\| PubMed ID: 27438688	2016
Circulating biosignatures of late-life depression (LLD): Towards a comprehensive, data-driven approach to understanding LLD pathophysiology. Journal of psychiatric research\| PubMed ID: 27447786	2016
Age-dependent increase in Kalirin-9 and Kalirin-12 transcripts in human orbitofrontal cortex. The European journal of neuroscience\| PubMed ID: 27471199	2016
Decrease in somatostatin-positive cell density in the amygdala of females with major depression. Depression and anxiety\| PubMed ID: 27557481	2017
Enhanced Molecular Aging in Late-Life Depression: the Senescent-Associated Secretory Phenotype. The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry\| PubMed ID: 27856124	2017
A Neural "Tuning Curve" for Multisensory Experience and Cognitive-Perceptual Schizotypy. Schizophrenia bulletin\| PubMed ID: 28168302	2017
Reduced Somatostatin Expression or Somatostatin-Positive Gamma-Aminobutyric Acid Neurons: A Shared Pathology Across Brain Disorders. Biological psychiatry\| PubMed ID: 28190426	2017
Somatostatin-Positive Gamma-Aminobutyric Acid Interneuron Deficits in Depression: Cortical Microcircuit and Therapeutic Perspectives. Biological psychiatry\| PubMed ID: 28697889	2017
Resilient protein co-expression network in male orbitofrontal cortex layer 2/3 during human aging. Neurobiology of aging\| PubMed ID: 28750307	2017
Characterization of GABAergic marker expression in the chronic unpredictable stress model of depression. Chronic stress (Thousand Oaks, Calif.)\| PubMed ID: 28835932	2017
Sustained Molecular Pathology Across Episodes and Remission in Major Depressive Disorder. Biological psychiatry\| PubMed ID: 28935211	2018
Fluorescence-based cell-specific detection for laser-capture microdissection in human brain. Scientific reports\| PubMed ID: 29079825	2017
Cross-Laboratory Analysis of Brain Cell Type Transcriptomes with Applications to Interpretation of Bulk Tissue Data. eNeuro\| PubMed ID: 29204516	2017
Increased Neuronal DNA/RNA Oxidation in the Frontal Cortex of Mice Subjected to Unpredictable Chronic Mild Stress. Chronic stress (Thousand Oaks, Calif.)\| PubMed ID: 29250610	2017
Identification of a novel gene regulating amygdala-mediated fear extinction. Molecular psychiatry\| PubMed ID: 29311651	2019
Shifting priorities: highly conserved behavioral and brain network adaptations to chronic stress across species. Translational psychiatry\| PubMed ID: 29353879	2018
Opposite Molecular Signatures of Depression in Men and Women. Biological psychiatry\| PubMed ID: 29548746	2018
The Relative Contributions of Cell-Dependent Cortical Microcircuit Aging to Cognition and Anxiety. Biological psychiatry\| PubMed ID: 30446205	2019
The Role of Dendritic Brain-Derived Neurotrophic Factor Transcripts on Altered Inhibitory Circuitry in Depression. Biological psychiatry\| PubMed ID: 30449530	2019
DNA methylation in the human frontal cortex reveals a putative mechanism for age-by-disease interactions. Translational psychiatry\| PubMed ID: 30696804	2019
Cell Type-Specific Gene Expression of Alpha 5 Subunit-Containing Gamma-Aminobutyric Acid Subtype A Receptors in Human and Mouse Frontal Cortex. Molecular neuropsychiatry\| PubMed ID: 30815456	2019
Residual avoidance: A new, consistent and repeatable readout of chronic stress-induced conflict anxiety reversible by antidepressant treatment. Neuropharmacology\| PubMed ID: 31075295	2019
Novel Benzodiazepine-Like Ligands with Various Anxiolytic, Antidepressant, or Pro-Cognitive Profiles. Molecular neuropsychiatry\| PubMed ID: 31192221	2019
Molecular and Cellular Evidence for Age by Disease Interactions: Updates and Path Forward. The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry\| PubMed ID: 31285153	2020
Altered GABA-mediated information processing and cognitive dysfunctions in depression and other brain disorders. Molecular psychiatry\| PubMed ID: 32346158	2021
Chronic Stress-induced Behaviors Correlate with Exacerbated Acute Stress-induced Cingulate Cortex and Ventral Hippocampus Activation. Neuroscience\| PubMed ID: 32473277	2020
Older molecular brain age in severe mental illness. Molecular psychiatry\| PubMed ID: 32632206	2020
Synthesis of chiral GABA receptor subtype selective ligands as potential agents to treat schizophrenia as well as depression. ARKIVOC : free online journal of organic chemistry\| PubMed ID: 32774192	2018
Transcriptional markers of excitation-inhibition balance in germ-free mice show region-specific dysregulation and rescue after bacterial colonization. Journal of psychiatric research\| PubMed ID: 33508544	2021
Large-Scale Transcriptomics Studies Provide Insight Into Sex Differences in Depression. Biological psychiatry\| PubMed ID: 33648716	2021
BDNF controls GABAR trafficking and related cognitive processes via autophagic regulation of p62. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology\| PubMed ID: 34341497	2021
From serendipity to rational drug design in brain disorders: in silico, in vitro, and in vivo approaches. Current opinion in pharmacology\| PubMed ID: 34461562	2021
Cortical GABA neurons and self-focus in depression: a model linking cellular, biochemical and neural network findings. Molecular psychiatry\| PubMed ID: 25237734	2014
Sex differences in mood disorders: perspectives from humans and rodent models. Biology of sex differences\| PubMed ID: 25520774	2014
VSNL1 Co-Expression Networks in Aging Include Calcium Signaling, Synaptic Plasticity, and Alzheimer's Disease Pathways. Frontiers in psychiatry\| PubMed ID: 25806004	2015
Molecular and Genetic Characterization of Depression: Overlap with other Psychiatric Disorders and Aging. Molecular neuropsychiatry\| PubMed ID: 26213687	2015
Effects of aging on circadian patterns of gene expression in the human prefrontal cortex. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 26699485	2016
α5GABAA receptor deficiency causes autism-like behaviors. Annals of clinical and translational neurology\| PubMed ID: 27231709	2016
The Role of BDNF in Age-Dependent Changes of Excitatory and Inhibitory Synaptic Markers in the Human Prefrontal Cortex. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology\| PubMed ID: 27417517	2016
Sigma-1 and N-Methyl-d-Aspartate Receptors: A Partnership with Beneficial Outcomes. Molecular neuropsychiatry\| PubMed ID: 27602356	2015
Sex-Dependent Anti-Stress Effect of an α5 Subunit Containing GABA Receptor Positive Allosteric Modulator. Frontiers in pharmacology\| PubMed ID: 27920723	2016
Norepinephrine Transporter Gene Variants and Remission From Depression With Venlafaxine Treatment in Older Adults. The American journal of psychiatry\| PubMed ID: 28068779	2017
Genetic risk for schizophrenia and psychosis in Alzheimer disease. Molecular psychiatry\| PubMed ID: 28461698	2018
Reduced GABAergic cortical inhibition in aging and depression. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology\| PubMed ID: 29849055	2018
Expression of dopamine D2 and D3 receptors in the human retina revealed by positron emission tomography and targeted mass spectrometry. Experimental eye research\| PubMed ID: 29883636	2018
Ulk2 controls cortical excitatory-inhibitory balance via autophagic regulation of p62 and GABAA receptor trafficking in pyramidal neurons. Human molecular genetics\| PubMed ID: 29893844	2018
No interaction between polygenic scores and childhood trauma in predicting suicide attempt in schizophrenia. Progress in neuro-psychopharmacology & biological psychiatry\| PubMed ID: 30149093	2019
Insight into Novel Treatment for Cognitive Dysfunctions across Disorders. ACS chemical neuroscience\| PubMed ID: 30920790	2019
Rate of brain aging and are synergistic risk factors for Alzheimer's disease. Life science alliance\| PubMed ID: 31133613	2019
Major depression and enhanced molecular senescence abnormalities in young and middle-aged adults. Translational psychiatry\| PubMed ID: 31434875	2019
Reversal of Age-Related Neuronal Atrophy by α5-GABAA Receptor Positive Allosteric Modulation. Cerebral cortex (New York, N.Y. : 1991)\| PubMed ID: 33068001	2021
Novel polygenic risk score as a translational tool linking depression-related changes in the corticolimbic transcriptome with neural face processing and anhedonic symptoms. Translational psychiatry\| PubMed ID: 33235204	2020
Differential and spatial expression meta-analysis of genes identified in genome-wide association studies of depression. Translational psychiatry\| PubMed ID: 33414381	2021
Behavioral Deficits Induced by Somatostatin-Positive GABA Neuron Silencing Are Rescued by Alpha 5 GABA-A Receptor Potentiation. The international journal of neuropsychopharmacology\| PubMed ID: 33438026	2021
Genome-wide analysis suggests the importance of vascular processes and neuroinflammation in late-life antidepressant response. Translational psychiatry\| PubMed ID: 33589590	2021
Correction: Novel polygenic risk score as a translational tool linking depression-related changes in the corticolimbic transcriptome with neural face processing and anhedonic symptoms. Translational psychiatry\| PubMed ID: 33654052	2021
Estimating and Correcting for Off-Target Cellular Contamination in Brain Cell Type Specific RNA-Seq Data. Frontiers in molecular neuroscience\| PubMed ID: 33746712	2021
Reduced anterior cingulate cortex volume induced by chronic stress correlates with increased behavioral emotionality and decreased synaptic puncta density. Neuropharmacology\| PubMed ID: 33864799	2021
Chronic Stress Alters Astrocyte Morphology in Mouse Prefrontal Cortex. The international journal of neuropsychopharmacology\| PubMed ID: 34346493	2021
Transcriptome-based polygenic score links depression-related corticolimbic gene expression changes to sex-specific brain morphology and depression risk. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology\| PubMed ID: 34588609	2021
Molecular characterization of depression trait and state. Molecular psychiatry\| PubMed ID: 34686766	2022
Chronic Stress Induces Coordinated Cortical Microcircuit Cell-Type Transcriptomic Changes Consistent With Altered Information Processing. Biological psychiatry\| PubMed ID: 34861977	2022
Reduced inhibition in depression impairs stimulus processing in human cortical microcircuits. Cell reports\| PubMed ID: 35021088	2022
Molecular origin of somatostatin-positive neuron vulnerability. Molecular psychiatry\| PubMed ID: 35145229	2022
Lower Levels of GABAergic Function Markers in Corticotropin-Releasing Hormone-Expressing Neurons in the sgACC of Human Subjects With Depression. Frontiers in psychiatry\| PubMed ID: 35280164	2022
Symptomatic and neurotrophic effects of GABAA receptor positive allosteric modulation in a mouse model of chronic stress. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology\| PubMed ID: 35701547	2022
Positive Allosteric Modulation of α5-GABAA Receptors Reverses Stress-Induced Alterations in Dopamine System Function and Prepulse Inhibition of Startle. The international journal of neuropsychopharmacology\| PubMed ID: 35732272	2022
Neurotrophic effects of potentiating gaba-mediated dendritic inhibition. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology\| PubMed ID: 35995974	2023
Hippocampal α5-GABA Receptors Modulate Dopamine Neuron Activity in the Rat Ventral Tegmental Area. Biological psychiatry global open science\| PubMed ID: 36712569	2023
Transcriptomic congruence analysis for evaluating model organisms. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 36730203	2023
Robust differences in cortical cell type proportions across healthy human aging inferred through cross-dataset transcriptome analyses. Neurobiology of aging\| PubMed ID: 36841202	2023
Prophylactic Efficacy of Riluzole against Anxiety- and Depressive-Like Behaviors in Two Rodent Stress Models. Complex psychiatry\| PubMed ID: 37101541	2023