Frédéric Chédin Department of Molecular and Cellular Biology and Genome Center University of California Biography Publications Institution JoVE Articles Frédéric Chédin has not added a biography. If you are Frédéric Chédin and would like to personalize this page please email our Author Liaison for assistance. Publications PRMT1-dependent Regulation of RNA Metabolism and DNA Damage Response Sustains Pancreatic Ductal Adenocarcinoma Nature Communications. 07, 2021 | Pubmed ID: 34330913 Defining R-loop Classes and Their Contributions to Genome Instability DNA Repair. Jul, 2021 | Pubmed ID: 34303066 Catalytically Inactive, Purified RNase H1: A Specific and Sensitive Probe for RNA-DNA Hybrid Imaging The Journal of Cell Biology. Sep, 2021 | Pubmed ID: 34232287 Recognition of RNA by the S9.6 Antibody Creates Pervasive Artifacts when Imaging RNA:DNA Hybrids The Journal of Cell Biology. Jun, 2021 | Pubmed ID: 33830170 CARM1 Inhibition Enables Immunotherapy of Resistant Tumors by Dual Action on Tumor Cells and T Cells Cancer Discovery. Aug, 2021 | Pubmed ID: 33707234 Best Practices for the Visualization, Mapping, and Manipulation of R-loops The EMBO Journal. Feb, 2021 | Pubmed ID: 33411340 Rdh54/Tid1 Inhibits Rad51-Rad54-mediated D-loop Formation and Limits D-loop Length ELife. 11, 2020 | Pubmed ID: 33185188 Bisulfite Treatment and Single-molecule Real-time Sequencing Reveal D-loop Length, Position, and Distribution ELife. 11, 2020 | Pubmed ID: 33185185 Topoisomerase 1 Prevents Replication Stress at R-loop-enriched Transcription Termination Sites Nature Communications. 08, 2020 | Pubmed ID: 32769985 SETX (senataxin), the Helicase Mutated in AOA2 and ALS4, Functions in Autophagy Regulation Autophagy. Aug, 2020 | Pubmed ID: 32686621 Characterization of R-Loop Structures Using Single-Molecule R-Loop Footprinting and Sequencing Methods in Molecular Biology (Clifton, N.J.). 2020 | Pubmed ID: 32681515 RNA-DNA Strand Exchange by the Drosophila Polycomb Complex PRC2 Nature Communications. 04, 2020 | Pubmed ID: 32286294 Emerging Roles for R-loop Structures in the Management of Topological Stress The Journal of Biological Chemistry. 04, 2020 | Pubmed ID: 32107311 Ultra-deep Coverage Single-molecule R-loop Footprinting Reveals Principles of R-loop Formation Journal of Molecular Biology. 03, 2020 | Pubmed ID: 32105733 Dimethyl Fumarate Dosing in Humans Increases Frataxin Expression: A Potential Therapy for Friedreich's Ataxia PloS One. 2019 | Pubmed ID: 31158268 The Extruded Non-template Strand Determines the Architecture of R-loops Nucleic Acids Research. 07, 2019 | Pubmed ID: 31066439 High-resolution, Strand-specific R-loop Mapping Via S9.6-based DNA-RNA Immunoprecipitation and High-throughput Sequencing Nature Protocols. 06, 2019 | Pubmed ID: 31053798 Interplay Between DNA Sequence and Negative Superhelicity Drives R-loop Structures Proceedings of the National Academy of Sciences of the United States of America. 03, 2019 | Pubmed ID: 30850542 DNA Topoisomerase I Differentially Modulates R-loops Across the Human Genome Genome Biology. 07, 2018 | Pubmed ID: 30060749 The Affinity of the S9.6 Antibody for Double-Stranded RNAs Impacts the Accurate Mapping of R-Loops in Fission Yeast Journal of Molecular Biology. 02, 2018 | Pubmed ID: 29289567 Hybrids in the Chromatin Nature Plants. 09, 2017 | Pubmed ID: 28848239 Attenuation of RNA Polymerase II Pausing Mitigates BRCA1-associated R-loop Accumulation and Tumorigenesis Nature Communications. 06, 2017 | Pubmed ID: 28649985 Telomeres in ICF Syndrome Cells Are Vulnerable to DNA Damage Due to Elevated DNA:RNA Hybrids Nature Communications. 01, 2017 | Pubmed ID: 28117327 Nascent Connections: R-Loops and Chromatin Patterning Trends in Genetics : TIG. 12, 2016 | Pubmed ID: 27793359 Co-transcriptional R-loops Are the Main Cause of Estrogen-induced DNA Damage ELife. 08, 2016 | Pubmed ID: 27552054 Prevalent, Dynamic, and Conserved R-Loop Structures Associate with Specific Epigenomic Signatures in Mammals Molecular Cell. 07, 2016 | Pubmed ID: 27373332 Comprehensive Proteomic Analysis of Mesenchymal Stem Cell Exosomes Reveals Modulation of Angiogenesis Via Nuclear Factor-KappaB Signaling Stem Cells (Dayton, Ohio). Mar, 2016 | Pubmed ID: 26782178 GC Skew is a Conserved Property of Unmethylated CpG Island Promoters Across Vertebrates Nucleic Acids Research. Nov, 2015 | Pubmed ID: 26253743 Genome-wide DNA Hypomethylation and RNA:DNA Hybrid Accumulation in Aicardi-Goutières Syndrome ELife. Jul, 2015 | Pubmed ID: 26182405 Transcription-associated R-loop Formation Across the Human FMR1 CGG-repeat Region PLoS Genetics. Apr, 2014 | Pubmed ID: 24743386 Arginine Methylation Facilitates the Recruitment of TOP3B to Chromatin to Prevent R Loop Accumulation Molecular Cell. Feb, 2014 | Pubmed ID: 24507716 An Ultrasensitive High Throughput Screen for DNA Methyltransferase 1-targeted Molecular Probes PloS One. 2013 | Pubmed ID: 24236046 R-loop Formation at Snord116 Mediates Topotecan Inhibition of Ube3a-antisense and Allele-specific Chromatin Decondensation Proceedings of the National Academy of Sciences of the United States of America. Aug, 2013 | Pubmed ID: 23918391 Inactive DNMT3B Splice Variants Modulate De Novo DNA Methylation PloS One. 2013 | Pubmed ID: 23894490 GC Skew at the 5' and 3' Ends of Human Genes Links R-loop Formation to Epigenetic Regulation and Transcription Termination Genome Research. Oct, 2013 | Pubmed ID: 23868195 R-loop Formation is a Distinctive Characteristic of Unmethylated Human CpG Island Promoters Molecular Cell. Mar, 2012 | Pubmed ID: 22387027 ICF Syndrome Mutations Cause a Broad Spectrum of Biochemical Defects in DNMT3B-mediated De Novo DNA Methylation Journal of Molecular Biology. Jun, 2011 | Pubmed ID: 21549127 The DNMT3 Family of Mammalian De Novo DNA Methyltransferases Progress in Molecular Biology and Translational Science. 2011 | Pubmed ID: 21507354 Recognition of Multivalent Histone States Associated with Heterochromatin by UHRF1 Protein The Journal of Biological Chemistry. Jul, 2011 | Pubmed ID: 21489993 UHRF1 Links the Histone Code and DNA Methylation to Ensure Faithful Epigenetic Memory Inheritance Genetics & Epigenetics. Jan, 2010 | Pubmed ID: 21643543 DNMT3L Modulates Significant and Distinct Flanking Sequence Preference for DNA Methylation by DNMT3A and DNMT3B in Vivo PLoS Genetics. Sep, 2010 | Pubmed ID: 20838592 Reconstitution and Mechanism of the Stimulation of De Novo Methylation by Human DNMT3L The Journal of Biological Chemistry. Sep, 2006 | Pubmed ID: 16829525 The AddAB Helicase/nuclease Forms a Stable Complex with Its Cognate Chi Sequence During Translocation The Journal of Biological Chemistry. Jul, 2006 | Pubmed ID: 16632468 A Novel Family of Regulated Helicases/nucleases from Gram-positive Bacteria: Insights into the Initiation of DNA Recombination Molecular Microbiology. Feb, 2002 | Pubmed ID: 11929535 Mapping R-Loops and RNA:DNA Hybrids with S9.6-Based Immunoprecipitation Methods Lionel A. Sanz1, Daisy Castillo-Guzman1, Frédéric Chédin1 1Department of Molecular and Cellular Biology and Genome Center, University of California JoVE 62455 Genetics
Mapping R-Loops and RNA:DNA Hybrids with S9.6-Based Immunoprecipitation Methods Lionel A. Sanz1, Daisy Castillo-Guzman1, Frédéric Chédin1 1Department of Molecular and Cellular Biology and Genome Center, University of California JoVE 62455 Genetics
