Frank J.T Staal

Publications

• Predicting Genotoxicity of Viral Vectors for Stem Cell Gene Therapy Using Gene Expression-based Machine Learning
  Molecular Therapy : the Journal of the American Society of Gene Therapy. Jun, 2021  |   Pubmed ID: 34174440
• A DL-4- and TNFα-based Culture System to Generate High Numbers of Nonmodified or Genetically Modified Immunotherapeutic Human T-lymphoid Progenitors
  Cellular & Molecular Immunology. Jul, 2021  |   Pubmed ID: 34117371
• Combining Mobilizing Agents with Busulfan to Reduce Chemotherapy-Based Conditioning for Hematopoietic Stem Cell Transplantation
  Cells. 04, 2021  |   Pubmed ID: 33946560
• The Route of Early T Cell Development: Crosstalk Between Epigenetic and Transcription Factors
  Cells. 04, 2021  |   Pubmed ID: 33946533
• Corrigendum: Blocking of the High-Affinity Interaction-Synapse Between SARS-CoV-2 Spike and Human ACE2 Proteins Likely Requires Multiple High-Affinity Antibodies: An Immune Perspective
  Frontiers in Immunology. 2021  |   Pubmed ID: 33936092
• Dynamic Clonal Hematopoiesis and Functional T-cell Immunity in a Supercentenarian
  Leukemia. 07, 2021  |   Pubmed ID: 33184493
• Inflammation and Wnt Signaling: Target for Immunomodulatory Therapy?
  Frontiers in Cell and Developmental Biology. 2020  |   Pubmed ID: 33614624
• A Novel Branched DNA-Based Flowcytometric Method for Single-Cell Characterization of Gene Therapy Products and Expression of Therapeutic Genes
  Frontiers in Immunology. 2020  |   Pubmed ID: 33584681
• Cell Signaling Pathway Reporters in Adult Hematopoietic Stem Cells
  Cells. 10, 2020  |   Pubmed ID: 33050292
• Blocking of the High-Affinity Interaction-Synapse Between SARS-CoV-2 Spike and Human ACE2 Proteins Likely Requires Multiple High-Affinity Antibodies: An Immune Perspective
  Frontiers in Immunology. 2020  |   Pubmed ID: 33042151
• An Adequate Human T Cell Repertoire from a Single T Cell Progenitor: Lessons from an Experiment of Nature
  EBioMedicine. Oct, 2020  |   Pubmed ID: 32977163
• Functional Definition of a Transcription Factor Hierarchy Regulating T Cell Lineage Commitment
  Science Advances. Jul, 2020  |   Pubmed ID: 32789164
• Preclinical Development of Autologous Hematopoietic Stem Cell-Based Gene Therapy for Immune Deficiencies: A Journey from Mouse Cage to Bed Side
  Pharmaceutics. Jun, 2020  |   Pubmed ID: 32545727
• Successful Preclinical Development of Gene Therapy for Recombinase-Activating Gene-1-Deficient SCID
  Molecular Therapy. Methods & Clinical Development. Jun, 2020  |   Pubmed ID: 32322605
• Single-Cell RNA Sequencing Maps Endothelial Metabolic Plasticity in Pathological Angiogenesis
  Cell Metabolism. 04, 2020  |   Pubmed ID: 32268117
• IPSC-Based Modeling of RAG2 Severe Combined Immunodeficiency Reveals Multiple T Cell Developmental Arrests
  Stem Cell Reports. 02, 2020  |   Pubmed ID: 31956083
• An Integrated Gene Expression Landscape Profiling Approach to Identify Lung Tumor Endothelial Cell Heterogeneity and Angiogenic Candidates
  Cancer Cell. 01, 2020  |   Pubmed ID: 31935371
• Autologous Stem-Cell-Based Gene Therapy for Inherited Disorders: State of the Art and Perspectives
  Frontiers in Pediatrics. 2019  |   Pubmed ID: 31737588
• ImSpectR - R Package to Quantify Immune Repertoire Diversity in Spectratype and Repertoire Sequencing Data
  Bioinformatics (Oxford, England). Oct, 2019  |   Pubmed ID: 31665245
• De Novo Generation of a Functional Human Thymus from Induced Pluripotent Stem Cells
  The Journal of Allergy and Clinical Immunology. 11, 2019  |   Pubmed ID: 31323248
• Gfi1b Regulates the Level of Wnt/β-catenin Signaling in Hematopoietic Stem Cells and Megakaryocytes
  Nature Communications. 03, 2019  |   Pubmed ID: 30894540
• Ex Vivo Expansion of Hematopoietic Stem Cells for Therapeutic Purposes: Lessons from Development and the Niche
  Cells. 02, 2019  |   Pubmed ID: 30781676
• Cell Intrinsic Regulation of External Hematopoietic Stem Cell Stress
  Stem Cell Investigation. 2018  |   Pubmed ID: 29984225
• JDP2: An Oncogenic BZIP Transcription Factor in T Cell Acute Lymphoblastic Leukemia
  The Journal of Experimental Medicine. 07, 2018  |   Pubmed ID: 29941549
• B-1 Cells and B-1 Cell Precursors Prompt Different Responses to Wnt Signaling
  PloS One. 2018  |   Pubmed ID: 29928002
• Axin2-mTurquoise2: A Novel Reporter Mouse Model for the Detection of Canonical Wnt Signalling
  Genesis (New York, N.Y. : 2000). 10, 2017  |   Pubmed ID: 28875532
• The Effects of Selective Hematopoietic Expression of Human IL-37 on Systemic Inflammation and Atherosclerosis in LDLr-Deficient Mice
  International Journal of Molecular Sciences. Aug, 2017  |   Pubmed ID: 28792474
• Activation of the Oncogene Through a Somatically Acquired Neomorphic Promoter in T-cell Acute Lymphoblastic Leukemia
  Blood. 06, 2017  |   Pubmed ID: 28270453
• Loss of CD44 Expression from Early Progenitor Cells Marks T-Cell Lineage Commitment in the Human Thymus
  Frontiers in Immunology. 2017  |   Pubmed ID: 28163708
• Wnt Signaling As Master Regulator of T-Lymphocyte Responses: Implications for Transplant Therapy
  Transplantation. Dec, 2016  |   Pubmed ID: 27861287
• Wnt Signalling Meets Epigenetics
  Stem Cell Investigation. 2016  |   Pubmed ID: 27668245
• Aberrant Wnt Signaling in Leukemia
  Cancers. Aug, 2016  |   Pubmed ID: 27571104
• Overexpression of LMO2 Causes Aberrant Human T-Cell Development In vivo by Three Potentially Distinct Cellular Mechanisms
  Experimental Hematology. 09, 2016  |   Pubmed ID: 27302866
• High Levels of Canonical Wnt Signaling Lead to Loss of Stemness and Increased Differentiation in Hematopoietic Stem Cells
  Stem Cell Reports. 05, 2016  |   Pubmed ID: 27167156
• Caught in a Wnt Storm: Complexities of Wnt Signaling in Hematopoiesis
  Experimental Hematology. 06, 2016  |   Pubmed ID: 27016274
• The Functional Relationship Between Hematopoietic Stem Cells and Developing T Lymphocytes
  Annals of the New York Academy of Sciences. 04, 2016  |   Pubmed ID: 26773328
• Visualizing Human Hematopoietic Stem Cell Trafficking In Vivo Using a Zebrafish Xenograft Model
  Stem Cells and Development. Feb, 2016  |   Pubmed ID: 26650921
• Identification of Checkpoints in Human T-cell Development Using Severe Combined Immunodeficiency Stem Cells
  The Journal of Allergy and Clinical Immunology. Feb, 2016  |   Pubmed ID: 26441229
• Development of a Diverse Human T-cell Repertoire Despite Stringent Restriction of Hematopoietic Clonality in the Thymus
  Proceedings of the National Academy of Sciences of the United States of America. Nov, 2015  |   Pubmed ID: 26483497
• The Quantity of Autocrine IL-2 Governs the Expansion Potential of CD8+ T Cells
  Journal of Immunology (Baltimore, Md. : 1950). Nov, 2015  |   Pubmed ID: 26453748
• T Cell Factor 1 Represses CD8+ Effector T Cell Formation and Function
  Journal of Immunology (Baltimore, Md. : 1950). Dec, 2014  |   Pubmed ID: 25355919
• Successful RAG1-SCID Gene Therapy Depends on the Level of RAG1 Expression
  The Journal of Allergy and Clinical Immunology. Jul, 2014  |   Pubmed ID: 25117803
• TCF-1-mediated Wnt Signaling Regulates Paneth Cell Innate Immune Defense Effectors HD-5 and -6: Implications for Crohn's Disease
  American Journal of Physiology. Gastrointestinal and Liver Physiology. Sep, 2014  |   Pubmed ID: 24994854
• Sustained Engraftment of Cryopreserved Human Bone Marrow CD34(+) Cells in Young Adult NSG Mice
  BioResearch Open Access. Jun, 2014  |   Pubmed ID: 24940562
• Somatic Mutations Found in the Healthy Blood Compartment of a 115-yr-old Woman Demonstrate Oligoclonal Hematopoiesis
  Genome Research. May, 2014  |   Pubmed ID: 24760347
• Hematopoietic MicroRNA-126 Protects Against Renal Ischemia/reperfusion Injury by Promoting Vascular Integrity
  Journal of the American Society of Nephrology : JASN. Aug, 2014  |   Pubmed ID: 24610930
• Wnt Signaling in Leukemias and Myeloma: T-cell Factors Are in Control
  Future Oncology (London, England). Nov, 2013  |   Pubmed ID: 24156335
• Alternative Splicing and Differential Expression of the Islet Autoantigen IGRP Between Pancreas and Thymus Contributes to Immunogenicity of Pancreatic Islets but Not Diabetogenicity in Humans
  Diabetologia. Dec, 2013  |   Pubmed ID: 24030068
• The Nuclear Effector of Wnt-signaling, Tcf1, Functions As a T-cell-specific Tumor Suppressor for Development of Lymphomas
  PLoS Biology. 2012  |   Pubmed ID: 23185135
• Tales of the Unexpected: Tcf1 Functions As a Tumor Suppressor for Leukemias
  Immunity. Nov, 2012  |   Pubmed ID: 23159221
• Differential Requirements for Wnt and Notch Signaling in Hematopoietic Versus Thymic Niches
  Annals of the New York Academy of Sciences. Aug, 2012  |   Pubmed ID: 22901260
• Induced Pluripotent Stem Cells and Severe Combined Immunodeficiency: Merely Disease Modeling or Potentially a Novel Cure?
  Pediatric Research. Apr, 2012  |   Pubmed ID: 22430378
• Wnt Cross-talk in the Niche
  Blood. Feb, 2012  |   Pubmed ID: 22343661
• Morbidly Obese Human Subjects Have Increased Peripheral Blood CD4+ T Cells with Skewing Toward a Treg- and Th2-dominated Phenotype
  Diabetes. Feb, 2012  |   Pubmed ID: 22228716
• Wnt Signaling Strength Regulates Normal Hematopoiesis and Its Deregulation is Involved in Leukemia Development
  Leukemia. Mar, 2012  |   Pubmed ID: 22173215
• Stem Cell Self-renewal: Lessons from Bone Marrow, Gut and IPS Toward Clinical Applications
  Leukemia. Jul, 2011  |   Pubmed ID: 21527933
• Genome-wide Expression Analysis of Paired Diagnosis-relapse Samples in ALL Indicates Involvement of Pathways Related to DNA Replication, Cell Cycle and DNA Repair, Independent of Immune Phenotype
  Leukemia. Mar, 2010  |   Pubmed ID: 20072147
• Wnt Signaling in Hematopoiesis: Crucial Factors for Self-renewal, Proliferation, and Cell Fate Decisions
  Journal of Cellular Biochemistry. Apr, 2010  |   Pubmed ID: 20069555
• Endothelial Progenitor Cell Dysfunction in Type 1 Diabetes: Another Consequence of Oxidative Stress?
  Antioxidants & Redox Signaling. Nov-Dec, 2005  |   Pubmed ID: 16356109