Frederick F. Lang

Publications

• Collision Tumor: Multinodular and Vacuolating Neuronal Tumor with Isocitrate Dehydrogenase-mutant Diffuse Astrocytoma
  Neuropathology : Official Journal of the Japanese Society of Neuropathology. Feb, 2024  |   Pubmed ID: 38414131
• The Genomic Alterations in Glioblastoma Influence the Levels of CSF Metabolites
  Acta Neuropathologica Communications. Jan, 2024  |   Pubmed ID: 38243318
• Triggering Receptor Expressed on Myeloid Cells 2 (TREM2) Regulates Phagocytosis in Glioblastoma
  Neuro-oncology. Jan, 2024  |   Pubmed ID: 38237157
• MGMT Function Determines the Differential Response of ATR Inhibitors with DNA-damaging Agents in Glioma Stem Cells for GBM Therapy
  Neuro-oncology Advances. 2024  |   Pubmed ID: 38213834
• Rapid Detection of Mutations in CSF-cfTNA with the Genexus Integrated Sequencer
  Journal of Neuro-oncology. Jan, 2024  |   Pubmed ID: 38160230
• Tumor-specific Polycistronic MiRNA Delivered by Engineered Exosomes for the Treatment of Glioblastoma
  Neuro-oncology. Feb, 2024  |   Pubmed ID: 37847405
• Myeloid-specific KDM6B Inhibition Sensitizes Glioblastoma to PD1 Blockade
  Nature Cancer. Oct, 2023  |   Pubmed ID: 37653141
• Multiomics Analyses Reveal /YBX1-controlled Posttranscriptional Circuits Promoting Glioblastoma Tumorigenesis/radioresistance
  Science Advances. Aug, 2023  |   Pubmed ID: 37540752
• Adjuvant Therapy with Oncolytic Adenovirus Delta-24-RGDOX After Intratumoral Adoptive T-cell Therapy Promotes Antigen Spread to Sustain Systemic Antitumor Immunity
  Cancer Research Communications. Jun, 2023  |   Pubmed ID: 37379361
• Oncolytic DNX-2401 Virotherapy Plus Pembrolizumab in Recurrent Glioblastoma: a Phase 1/2 Trial
  Nature Medicine. May, 2023  |   Pubmed ID: 37188783
• Comparison of Pharmacological Inhibitors of Lysine-specific Demethylase 1 in Glioblastoma Stem Cells Reveals Inhibitor-specific Efficacy Profiles
  Frontiers in Neurology. 2023  |   Pubmed ID: 37082446
• Changes in Outcomes and Factors Associated with Survival in Melanoma Patients with Brain Metastases
  Neuro-oncology. Jul, 2023  |   Pubmed ID: 36510640
• Reshaping the Tumor Microenvironment with Oncolytic Viruses, Positive Regulation of the Immune Synapse, and Blockade of the Immunosuppressive Oncometabolic Circuitry
  Journal for Immunotherapy of Cancer. Jul, 2022  |   Pubmed ID: 35902132
• An Interdisciplinary Consensus on the Management of Brain Metastases in Patients with Renal Cell Carcinoma
  CA: a Cancer Journal for Clinicians. Sep, 2022  |   Pubmed ID: 35708940
• A Window of Opportunity to Overcome Therapeutic Failure in Neuro-Oncology
  American Society of Clinical Oncology Educational Book. American Society of Clinical Oncology. Annual Meeting. Apr, 2022  |   Pubmed ID: 35580289
• Preclinical Animal Brain Tumor Models for Interventional Neuro-oncology
  Journal of Neurointerventional Surgery. May, 2022  |   Pubmed ID: 35414632
• Convection Enhanced Delivery of the Oncolytic Adenovirus Delta24-RGD in Patients with Recurrent GBM: A Phase I Clinical Trial Including Correlative Studies
  Clinical Cancer Research : an Official Journal of the American Association for Cancer Research. Apr, 2022  |   Pubmed ID: 35176144
• Single-cell Analysis of Human Glioma and Immune Cells Identifies S100A4 As an Immunotherapy Target
  Nature Communications. Feb, 2022  |   Pubmed ID: 35140215
• Long Term Outcomes Following Surgery for Pineal Region Tumors
  Journal of Neuro-oncology. Feb, 2022  |   Pubmed ID: 35083579
• Circumferential Sulcus-guided Resection Technique for Improved Outcomes of Low-grade Gliomas
  Journal of Neurosurgery. Jan, 2022  |   Pubmed ID: 34996044
• Perfusion-guided Endovascular Super-selective Intra-arterial Infusion for Treatment of Malignant Brain Tumors
  Journal of Neurointerventional Surgery. Jun, 2022  |   Pubmed ID: 34824133
• Characterization of Patient-derived Bone Marrow Human Mesenchymal Stem Cells As Oncolytic Virus Carriers for the Treatment of Glioblastoma
  Journal of Neurosurgery. Mar, 2022  |   Pubmed ID: 34450587
• Inhibition of Nicotinamide Phosphoribosyltransferase (NAMPT), the Rate-limiting Enzyme of the Nicotinamide Adenine Dinucleotide (NAD) Salvage Pathway, to Target Glioma Heterogeneity Through Mitochondrial Oxidative Stress
  Neuro-oncology. Feb, 2022  |   Pubmed ID: 34260721
• NMR Spectroscopy-Based Metabolomics of Platelets to Analyze Brain Tumors
  Reports (MDPI). Dec, 2021  |   Pubmed ID: 35937580
• Intrinsic Interferon Signaling Regulates the Cell Death and Mesenchymal Phenotype of Glioblastoma Stem Cells
  Cancers. Oct, 2021  |   Pubmed ID: 34771447
• Measuring the Metabolic Evolution of Glioblastoma Throughout Tumor Development, Regression, and Recurrence with Hyperpolarized Magnetic Resonance
  Cells. Oct, 2021  |   Pubmed ID: 34685601
• Hitchhiking to Brain Tumours: Stem Cell Delivery of Oncolytic Viruses
  The Lancet. Oncology. Aug, 2021  |   Pubmed ID: 34214494
• Targeting the αv Integrin/TGF-β Axis Improves Natural Killer Cell Function Against Glioblastoma Stem Cells
  The Journal of Clinical Investigation. Jul, 2021  |   Pubmed ID: 34138753
• An Immune-competent, Replication-permissive Syrian Hamster Glioma Model for Evaluating Delta-24-RGD Oncolytic Adenovirus
  Neuro-oncology. Nov, 2021  |   Pubmed ID: 34059921
• Medium-Chain Acyl-CoA Dehydrogenase Protects Mitochondria from Lipid Peroxidation in Glioblastoma
  Cancer Discovery. Nov, 2021  |   Pubmed ID: 34039636
• The History of Neurosurgery at Baylor College of Medicine
  Journal of Neurosurgery. Feb, 2021  |   Pubmed ID: 33607618
• Delta-24 Adenoviral Therapy for Glioblastoma: Evolution from the Bench to Bedside and Future Considerations
  Neurosurgical Focus. Feb, 2021  |   Pubmed ID: 33524949
• Intraarterial Delivery of Virotherapy for Glioblastoma
  Neurosurgical Focus. Feb, 2021  |   Pubmed ID: 33524944
• Considerations for Designing Preclinical Cancer Immune Nanomedicine Studies
  Nature Nanotechnology. Jan, 2021  |   Pubmed ID: 33349682
• Window of Opportunity Clinical Trials to Evaluate Novel Therapies for Brain Tumors
  Neurosurgery Clinics of North America. Jan, 2021  |   Pubmed ID: 33223031
• RNAi Technology Targeting the Fusion Breakpoint: an Opportunity for Precision Medicine
  Neuro-oncology Advances. 2020  |   Pubmed ID: 33241214
• Impact of Anesthesia and Analgesia Techniques on Glioblastoma Progression. A Narrative Review
  Neuro-oncology Advances. 2020  |   Pubmed ID: 33205044
• Profiling of Patients with Glioma Reveals the Dominant Immunosuppressive Axis is Refractory to Immune Function Restoration
  JCI Insight. Sep, 2020  |   Pubmed ID: 32721947
• The Role of Resting-state Functional MRI for Clinical Preoperative Language Mapping
  Cancer Imaging : the Official Publication of the International Cancer Imaging Society. Jul, 2020  |   Pubmed ID: 32653026
• A Cancer Drug Atlas Enables Synergistic Targeting of Independent Drug Vulnerabilities
  Nature Communications. Jun, 2020  |   Pubmed ID: 32523045
• Glioblastoma-mediated Immune Dysfunction Limits CMV-specific T Cells and Therapeutic Responses: Results from a Phase I/II Trial
  Clinical Cancer Research : an Official Journal of the American Association for Cancer Research. Jul, 2020  |   Pubmed ID: 32299815
• Circadian Regulator CLOCK Recruits Immune-Suppressive Microglia into the GBM Tumor Microenvironment
  Cancer Discovery. Mar, 2020  |   Pubmed ID: 31919052
• Window-of-opportunity Clinical Trial of Pembrolizumab in Patients with Recurrent Glioblastoma Reveals Predominance of Immune-suppressive Macrophages
  Neuro-oncology. Apr, 2020  |   Pubmed ID: 31755915
• Advances in Endovascular Neuro-oncology: Endovascular Selective Intra-arterial (ESIA) Infusion of Targeted Biologic Therapy for Brain Tumors
  Journal of Neurointerventional Surgery. Feb, 2020  |   Pubmed ID: 31676690
• Perilesional Resection of Glioblastoma Is Independently Associated With Improved Outcomes
  Neurosurgery. Jan, 2020  |   Pubmed ID: 30799490
• GITRL-armed Delta-24-RGD Oncolytic Adenovirus Prolongs Survival and Induces Anti-glioma Immune Memory
  Neuro-oncology Advances. 2019  |   Pubmed ID: 31608328
• Microcatheter Delivery of Neurotherapeutics: Compatibility with Mesenchymal Stem Cells
  Journal of Neurosurgery. Sep, 2019  |   Pubmed ID: 31491769
• Localized Treatment with Oncolytic Adenovirus Delta-24-RGDOX Induces Systemic Immunity Against Disseminated Subcutaneous and Intracranial Melanomas
  Clinical Cancer Research : an Official Journal of the American Association for Cancer Research. Nov, 2019  |   Pubmed ID: 31455679
• REST-DRD2 Mechanism Impacts Glioblastoma Stem Cell-mediated Tumorigenesis
  Neuro-oncology. Jun, 2019  |   Pubmed ID: 30953587
• Biological Subtypes and Survival Outcomes in Breast Cancer Patients with Brain Metastases in the Targeted Therapy Era
  Neuro-oncology Practice. Aug, 2018  |   Pubmed ID: 31386016
• Distinct Mechanisms Enable Inward or Outward Budding from Late Endosomes/multivesicular Bodies
  Experimental Cell Research. Nov, 2018  |   Pubmed ID: 30144444
• A Coclinical Radiogenomic Validation Study: Conserved Magnetic Resonance Radiomic Appearance of Periostin-Expressing Glioblastoma in Patients and Xenograft Models
  Clinical Cancer Research : an Official Journal of the American Association for Cancer Research. Dec, 2018  |   Pubmed ID: 30054278
• MRI Venous Architecture of Insula
  Journal of the Neurological Sciences. Jul, 2018  |   Pubmed ID: 29801878
• A Gene Expression Signature Predicts Recurrence-free Survival in Meningioma
  Oncotarget. Mar, 2018  |   Pubmed ID: 29662628
• Magnetic Resonance and Photoacoustic Imaging of Brain Tumor Mediated by Mesenchymal Stem Cell Labeled with Multifunctional Nanoparticle Introduced Via Carotid Artery Injection
  Nanotechnology. Apr, 2018  |   Pubmed ID: 29438105
• Phase I Study of DNX-2401 (Delta-24-RGD) Oncolytic Adenovirus: Replication and Immunotherapeutic Effects in Recurrent Malignant Glioma
  Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology. May, 2018  |   Pubmed ID: 29432077
• Dexamethasone-mediated Oncogenicity in Vitro and in an Animal Model of Glioblastoma
  Journal of Neurosurgery. Dec, 2018  |   Pubmed ID: 29328002
• Mesenchymal Stem Cells As Natural Biofactories for Exosomes Carrying MiR-124a in the Treatment of Gliomas
  Neuro-oncology. Feb, 2018  |   Pubmed ID: 29016843
• Ionizing Radiation Augments Glioma Tropism of Mesenchymal Stem Cells
  Journal of Neurosurgery. Jan, 2018  |   Pubmed ID: 28362237
• Exosomes from Glioma-Associated Mesenchymal Stem Cells Increase the Tumorigenicity of Glioma Stem-like Cells Via Transfer of MiR-1587
  Cancer Research. Nov, 2017  |   Pubmed ID: 28855213
• TIE2 Associates with Caveolae and Regulates Caveolin-1 To Promote Their Nuclear Translocation
  Molecular and Cellular Biology. Nov, 2017  |   Pubmed ID: 28760776
• Post-operative Stereotactic Radiosurgery Versus Observation for Completely Resected Brain Metastases: a Single-centre, Randomised, Controlled, Phase 3 Trial
  The Lancet. Oncology. Aug, 2017  |   Pubmed ID: 28687375
• Efficacy of Onalespib, a Long-Acting Second-Generation HSP90 Inhibitor, As a Single Agent and in Combination with Temozolomide Against Malignant Gliomas
  Clinical Cancer Research : an Official Journal of the American Association for Cancer Research. Oct, 2017  |   Pubmed ID: 28679777
• Oncolytic Adenovirus and Tumor-Targeting Immune Modulatory Therapy Improve Autologous Cancer Vaccination
  Cancer Research. Jul, 2017  |   Pubmed ID: 28566332
• Mesenchymal Stromal Cells for the Delivery of Oncolytic Viruses in Gliomas
  Cytotherapy. Apr, 2017  |   Pubmed ID: 28233640
• Preclinical Evaluation of Sequential Combination of Oncolytic Adenovirus Delta-24-RGD and Phosphatidylserine-Targeting Antibody in Pancreatic Ductal Adenocarcinoma
  Molecular Cancer Therapeutics. Apr, 2017  |   Pubmed ID: 28138026
• A Dexamethasone-regulated Gene Signature Is Prognostic for Poor Survival in Glioblastoma Patients
  Journal of Neurosurgical Anesthesiology. Jan, 2017  |   Pubmed ID: 27653222
• TIE2-mediated Tyrosine Phosphorylation of H4 Regulates DNA Damage Response by Recruiting ABL1
  Science Advances. Apr, 2016  |   Pubmed ID: 27757426
• Endoplasmic Reticulum Stress-inducing Drugs Sensitize Glioma Cells to Temozolomide Through Downregulation of MGMT, MPG, and Rad51
  Neuro-oncology. Aug, 2016  |   Pubmed ID: 26951384
• Suppression of RAF/MEK or PI3K Synergizes Cytotoxicity of Receptor Tyrosine Kinase Inhibitors in Glioma Tumor-initiating Cells
  Journal of Translational Medicine. Feb, 2016  |   Pubmed ID: 26861698
• Genetic, Epigenetic, and Molecular Landscapes of Multifocal and Multicentric Glioblastoma
  Acta Neuropathologica. Oct, 2015  |   Pubmed ID: 26323991
• Integrated Transcriptomic and Glycomic Profiling of Glioma Stem Cell Xenografts
  Journal of Proteome Research. Sep, 2015  |   Pubmed ID: 26185906
• Mesenchymal Stem Cells Isolated From Human Gliomas Increase Proliferation and Maintain Stemness of Glioma Stem Cells Through the IL-6/gp130/STAT3 Pathway
  Stem Cells (Dayton, Ohio). Aug, 2015  |   Pubmed ID: 25966666
• ESI-MS/MS and MALDI-IMS Localization Reveal Alterations in Phosphatidic Acid, Diacylglycerol, and DHA in Glioma Stem Cell Xenografts
  Journal of Proteome Research. Jun, 2015  |   Pubmed ID: 25880480
• Oncolytic Adenovirus Research Evolution: from Cell-cycle Checkpoints to Immune Checkpoints
  Current Opinion in Virology. Aug, 2015  |   Pubmed ID: 25863716
• FoxM1 Drives a Feed-Forward STAT3-Activation Signaling Loop That Promotes the Self-Renewal and Tumorigenicity of Glioblastoma Stem-like Cells
  Cancer Research. Jun, 2015  |   Pubmed ID: 25832656
• Two Mature Products of MIR-491 Coordinate to Suppress Key Cancer Hallmarks in Glioblastoma
  Oncogene. Mar, 2015  |   Pubmed ID: 24747968
• A History of the AANS/CNS Section on Tumors Biennial Satellite Symposium
  Journal of Neuro-oncology. Sep, 2014  |   Pubmed ID: 25081975
• Delta-24-RGD Oncolytic Adenovirus Elicits Anti-glioma Immunity in an Immunocompetent Mouse Model
  PloS One. 2014  |   Pubmed ID: 24827739
• Extent of Resection of Glioblastoma Revisited: Personalized Survival Modeling Facilitates More Accurate Survival Prediction and Supports a Maximum-safe-resection Approach to Surgery
  Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology. Mar, 2014  |   Pubmed ID: 24516010
• A High Notch Pathway Activation Predicts Response to γ Secretase Inhibitors in Proneural Subtype of Glioma Tumor-initiating Cells
  Stem Cells (Dayton, Ohio). Jan, 2014  |   Pubmed ID: 24038660
• MiR-124 Inhibits STAT3 Signaling to Enhance T Cell-mediated Immune Clearance of Glioma
  Cancer Research. Jul, 2013  |   Pubmed ID: 23636127
• A Prospective Randomized Trial of Perioperative Seizure Prophylaxis in Patients with Intraparenchymal Brain Tumors
  Journal of Neurosurgery. Apr, 2013  |   Pubmed ID: 23394340
• TGF-β Mediates Homing of Bone Marrow-derived Human Mesenchymal Stem Cells to Glioma Stem Cells
  Cancer Research. Apr, 2013  |   Pubmed ID: 23365134
• REST Regulates Oncogenic Properties of Glioblastoma Stem Cells
  Stem Cells (Dayton, Ohio). Mar, 2012  |   Pubmed ID: 22228704
• Genetic and Epigenetic Modifications of Sox2 Contribute to the Invasive Phenotype of Malignant Gliomas
  PloS One. 2011  |   Pubmed ID: 22069467
• High Rate of Deletion of Chromosomes 1p and 19q in Insular Oligodendroglial Tumors
  Journal of Neuro-oncology. Aug, 2010  |   Pubmed ID: 20035368
• Targeting Gelatinases with a Near-infrared Fluorescent Cyclic His-Try-Gly-Phe Peptide
  Molecular Imaging and Biology. 2009  |   Pubmed ID: 19424760
• Delta-24-RGD in Combination with RAD001 Induces Enhanced Anti-glioma Effect Via Autophagic Cell Death
  Molecular Therapy : the Journal of the American Society of Gene Therapy. Mar, 2008  |   Pubmed ID: 18253154
• Diffusely Infiltrative Low-grade Gliomas in Adults
  Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology. Mar, 2006  |   Pubmed ID: 16525178
• Delta24-hyCD Adenovirus Suppresses Glioma Growth in Vivo by Combining Oncolysis and Chemosensitization
  Cancer Gene Therapy. Mar, 2005  |   Pubmed ID: 15650766
• Prospective Clinical Trials of Brain Tumor Therapy: the Critical Role of Neurosurgeons
  Journal of Neuro-oncology. 2004  |   Pubmed ID: 15527087
• A Novel E1A-E1B Mutant Adenovirus Induces Glioma Regression in Vivo
  Oncogene. Mar, 2004  |   Pubmed ID: 15014451
• Phase I Trial of Adenovirus-mediated P53 Gene Therapy for Recurrent Glioma: Biological and Clinical Results
  Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology. Jul, 2003  |   Pubmed ID: 12839017
• Toward Better Early-phase Brain Tumor Clinical Trials: a Reappraisal of Current Methods and Proposals for Future Strategies
  Neuro-oncology. Oct, 2002  |   Pubmed ID: 12356357
• Surgical Resection of Intrinsic Insular Tumors: Complication Avoidance
  Journal of Neurosurgery. Oct, 2001  |   Pubmed ID: 11596959