Friedrich Koch-Nolte Institute of Immunology University Medical Center, Hamburg Biography Publications Institution JoVE Articles Friedrich Koch-Nolte has not added a biography. If you are Friedrich Koch-Nolte and would like to personalize this page please email our Author Liaison for assistance. Publications Tuning IL-2 Signaling by ADP-ribosylation of CD25 Scientific Reports. 2015 | Pubmed ID: 25753532 The Expression of CD39 on Regulatory T Cells is Genetically Driven and Further Upregulated at Sites of Inflammation Journal of Autoimmunity. Apr, 2015 | Pubmed ID: 25640206 Selection of Nanobodies That Block the Enzymatic and Cytotoxic Activities of the Binary Clostridium Difficile Toxin CDT Scientific Reports. 2015 | Pubmed ID: 25597743 ARTC1-mediated ADP-ribosylation of GRP78/BiP: a New Player in Endoplasmic-reticulum Stress Responses Cellular and Molecular Life Sciences : CMLS. Mar, 2015 | Pubmed ID: 25292337 ADP-ribosylation of P2X7: a Matter of Life and Death for Regulatory T Cells and Natural Killer T Cells Current Topics in Microbiology and Immunology. 2015 | Pubmed ID: 25048544 Nanobodies As Modulators of Inflammation: Potential Applications for Acute Brain Injury Frontiers in Cellular Neuroscience. 2014 | Pubmed ID: 25374510 In Vivo Near-infrared Fluorescence Targeting of T Cells: Comparison of Nanobodies and Conventional Monoclonal Antibodies Contrast Media & Molecular Imaging. Mar-Apr, 2014 | Pubmed ID: 24523058 Clostridium Difficile Toxin CDT Hijacks Microtubule Organization and Reroutes Vesicle Traffic to Increase Pathogen Adherence Proceedings of the National Academy of Sciences of the United States of America. Feb, 2014 | Pubmed ID: 24469807 Evidence of Promiscuous Endothelial Binding by Plasmodium Falciparum-infected Erythrocytes Cellular Microbiology. May, 2014 | Pubmed ID: 24444337 Mucolipidosis II-related Mutations Inhibit the Exit from the Endoplasmic Reticulum and Proteolytic Cleavage of GlcNAc-1-phosphotransferase Precursor Protein (GNPTAB) Human Mutation. Mar, 2014 | Pubmed ID: 24375680 Technical Advance: a New Cell Preparation Strategy That Greatly Improves the Yield of Vital and Functional Tregs and NKT Cells Journal of Leukocyte Biology. Mar, 2014 | Pubmed ID: 24212099 Short-term TNFα Shedding is Independent of Cytoplasmic Phosphorylation or Furin Cleavage of ADAM17 Biochimica Et Biophysica Acta. Dec, 2013 | Pubmed ID: 24135057 CD38 Controls the Innate Immune Response Against Listeria Monocytogenes Infection and Immunity. Nov, 2013 | Pubmed ID: 23980105 Physiology of ADP-ribosylation The FEBS Journal. Aug, 2013 | Pubmed ID: 23773547 The Art of Blocking ADP-ribosyltransferases (ARTs): Nanobodies As Experimental and Therapeutic Tools to Block Mammalian and Toxin ARTs The FEBS Journal. Aug, 2013 | Pubmed ID: 23627412 CD8-β ADP-ribosylation Affects CD8(+) T-cell Function European Journal of Immunology. Jul, 2013 | Pubmed ID: 23575529 Alternative Splicing of the N-terminal Cytosolic and Transmembrane Domains of P2X7 Controls Gating of the Ion Channel by ADP-ribosylation PloS One. 2012 | Pubmed ID: 22848454 Extracellular NAD(+): a Danger Signal Hindering Regulatory T Cells Microbes and Infection / Institut Pasteur. Nov, 2012 | Pubmed ID: 22634347 Melittin Modulates Keratinocyte Function Through P2 Receptor-dependent ADAM Activation The Journal of Biological Chemistry. Jul, 2012 | Pubmed ID: 22613720 Signal-peptide-peptidase-like 2a (SPPL2a) is Targeted to Lysosomes/late Endosomes by a Tyrosine Motif in Its C-terminal Tail FEBS Letters. Oct, 2011 | Pubmed ID: 21896273 Monoclonal Antibodies for the Identification and Purification of VNAR Domains and IgNAR Immunoglobulins from the Horn Shark Heterodontus Francisci Hybridoma (2005). Aug, 2011 | Pubmed ID: 21851231 Strategies for the Identification of Arginine ADP-ribosylation Sites Journal of Proteomics. Dec, 2011 | Pubmed ID: 21784185 Transgenic Overexpression of Toxin-related Ecto-ADP-ribosyltransferase ART2.2 Sensitizes T Cells but Not B Cells to NAD-induced Cell Death Molecular Immunology. Sep, 2011 | Pubmed ID: 21641039 CD38 Exacerbates Focal Cytokine Production, Postischemic Inflammation and Brain Injury After Focal Cerebral Ischemia PloS One. 2011 | Pubmed ID: 21625615 Progress in the Function and Regulation of ADP-Ribosylation Science Signaling. 2011 | Pubmed ID: 21610250 Species Specificity of ADAM10 and ADAM17 Proteins in Interleukin-6 (IL-6) Trans-signaling and Novel Role of ADAM10 in Inducible IL-6 Receptor Shedding The Journal of Biological Chemistry. Apr, 2011 | Pubmed ID: 21454673 Compartmentation of NAD+-dependent Signalling FEBS Letters. Jun, 2011 | Pubmed ID: 21443875 Single-domain Llama Antibodies As Specific Intracellular Inhibitors of SpvB, the Actin ADP-ribosylating Toxin of Salmonella Typhimurium FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology. Feb, 2011 | Pubmed ID: 20940265 ADP-ribosylation of Arginine Amino Acids. Jul, 2011 | Pubmed ID: 20652610 Extracellular NAD+ Shapes the Foxp3+ Regulatory T Cell Compartment Through the ART2-P2X7 Pathway The Journal of Experimental Medicine. Nov, 2010 | Pubmed ID: 20975043 Quantitative Magnetic Resonance Imaging of Enzyme Activity on the Cell Surface: in Vitro and in Vivo Monitoring of ADP-ribosyltransferase 2 on T Cells Molecular Imaging. Aug, 2010 | Pubmed ID: 20643024 Toward a Unified Nomenclature for Mammalian ADP-ribosyltransferases Trends in Biochemical Sciences. Apr, 2010 | Pubmed ID: 20106667 A Recombinant Heavy Chain Antibody Approach Blocks ART2 Mediated Deletion of an INKT Cell Population That Upon Activation Inhibits Autoimmune Diabetes Journal of Autoimmunity. Mar, 2010 | Pubmed ID: 19796917 Sialylated Ligands on Pathogenic Trypanosoma Cruzi Interact with Siglec-E (sialic Acid-binding Ig-like Lectin-E) Cellular Microbiology. Nov, 2009 | Pubmed ID: 19552697 Differential Regulation of P2X7 Receptor Activation by Extracellular Nicotinamide Adenine Dinucleotide and Ecto-ADP-ribosyltransferases in Murine Macrophages and T Cells Journal of Immunology (Baltimore, Md. : 1950). Jul, 2009 | Pubmed ID: 19542469 Single Domain Antibodies: Promising Experimental and Therapeutic Tools in Infection and Immunity Medical Microbiology and Immunology. Aug, 2009 | Pubmed ID: 19529959 Cloning, Expression, Purification and Crystallization As Well As X-ray Fluorescence and Preliminary X-ray Diffraction Analyses of Human ADP-ribosylhydrolase 1 Acta Crystallographica. Section F, Structural Biology and Crystallization Communications. May, 2009 | Pubmed ID: 19407395 Basal and Inducible Expression of the Thiol-sensitive ART2.1 Ecto-ADP-ribosyltransferase in Myeloid and Lymphoid Leukocytes Purinergic Signalling. Sep, 2009 | Pubmed ID: 19404775 Activation of the P2X7 Ion Channel by Soluble and Covalently Bound Ligands Purinergic Signalling. Jun, 2009 | Pubmed ID: 19255877 Characterisation of the R276A Gain-of-function Mutation in the Ectodomain of Murine P2X7 Purinergic Signalling. Jun, 2009 | Pubmed ID: 19234763 NAD+ and ATP Released from Injured Cells Induce P2X7-dependent Shedding of CD62L and Externalization of Phosphatidylserine by Murine T Cells Journal of Immunology (Baltimore, Md. : 1950). Mar, 2009 | Pubmed ID: 19234185 Emerging Roles of NAD+ and Its Metabolites in Cell Signaling Science Signaling. 2009 | Pubmed ID: 19211509 ATP Induces P2X7 Receptor-independent Cytokine and Chemokine Expression Through P2X1 and P2X3 Receptors in Murine Mast Cells Journal of Leukocyte Biology. Apr, 2009 | Pubmed ID: 19164130 Deficiency of the Tetraspanin CD63 Associated with Kidney Pathology but Normal Lysosomal Function Molecular and Cellular Biology. Feb, 2009 | Pubmed ID: 19075008 High Sensitivity of Intestinal CD8+ T Cells to Nucleotides Indicates P2X7 As a Regulator for Intestinal T Cell Responses Journal of Immunology (Baltimore, Md. : 1950). Sep, 2008 | Pubmed ID: 18768840 Mammalian ADP-ribosyltransferases and ADP-ribosylhydrolases Frontiers in Bioscience : a Journal and Virtual Library. 2008 | Pubmed ID: 18508690 Structure of Mouse ADP-ribosylhydrolase 3 (mARH3) Acta Crystallographica. Section F, Structural Biology and Crystallization Communications. Mar, 2008 | Pubmed ID: 18323597 Functional Localization of Two Poly(ADP-ribose)-degrading Enzymes to the Mitochondrial Matrix Molecular and Cellular Biology. Jan, 2008 | Pubmed ID: 17991898 ADP-ribosylation at R125 Gates the P2X7 Ion Channel by Presenting a Covalent Ligand to Its Nucleotide Binding Site FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology. Mar, 2008 | Pubmed ID: 17928361 Monitoring the Expression of Purinoceptors and Nucleotide-metabolizing Ecto-enzymes with Antibodies Directed Against Proteins in Native Conformation Purinergic Signalling. Sep, 2007 | Pubmed ID: 18404449 Extracellular NAD and ATP: Partners in Immune Cell Modulation Purinergic Signalling. Mar, 2007 | Pubmed ID: 18404420 Lipopolysaccharide, IFN-gamma, and IFN-beta Induce Expression of the Thiol-sensitive ART2.1 Ecto-ADP-ribosyltransferase in Murine Macrophages Journal of Immunology (Baltimore, Md. : 1950). Nov, 2007 | Pubmed ID: 17947697 CD83 Modulates B Cell Function in Vitro: Increased IL-10 and Reduced Ig Secretion by CD83Tg B Cells PloS One. 2007 | Pubmed ID: 17710154 NAD+ Released During Inflammation Participates in T Cell Homeostasis by Inducing ART2-mediated Death of Naive T Cells in Vivo Journal of Immunology (Baltimore, Md. : 1950). Jul, 2007 | Pubmed ID: 17579037 Single Domain Antibodies from Llama Effectively and Specifically Block T Cell Ecto-ADP-ribosyltransferase ART2.2 in Vivo FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology. Nov, 2007 | Pubmed ID: 17575259 FK778 in Experimental Xenotransplantation: a Detailed Analysis of Drug Efficacy The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation. Jan, 2007 | Pubmed ID: 17234520 Emerging Functions of Extracellular Pyridine Nucleotides Molecular Medicine (Cambridge, Mass.). Nov-Dec, 2006 | Pubmed ID: 17380199 The Structure of Human ADP-ribosylhydrolase 3 (ARH3) Provides Insights into the Reversibility of Protein ADP-ribosylation Proceedings of the National Academy of Sciences of the United States of America. Oct, 2006 | Pubmed ID: 17015823 ZBP1 Subcellular Localization and Association with Stress Granules is Controlled by Its Z-DNA Binding Domains Nucleic Acids Research. 2006 | Pubmed ID: 16990255 ADP-ribosylation of Membrane Proteins: Unveiling the Secrets of a Crucial Regulatory Mechanism in Mammalian Cells Annals of Medicine. 2006 | Pubmed ID: 16720433 Expression of Toxin-related Human Mono-ADP-ribosyltransferase 3 in Human Testes Asian Journal of Andrology. May, 2006 | Pubmed ID: 16625277 Targeted Disruption of CD38 Accelerates Autoimmune Diabetes in NOD/Lt Mice by Enhancing Autoimmunity in an ADP-ribosyltransferase 2-dependent Fashion Journal of Immunology (Baltimore, Md. : 1950). Apr, 2006 | Pubmed ID: 16585549 Sirolimus and FK778: a Comparison of Two Anti-proliferative Immunosuppressants for Prevention of Experimental Obliterative Airway Disease Transplant International : Official Journal of the European Society for Organ Transplantation. Apr, 2006 | Pubmed ID: 16573547 Cloning, Expression, Purification, Crystallization and Preliminary X-ray Diffraction Analysis of Human ARH3, the First Eukaryotic Protein-ADP-ribosylhydrolase Acta Crystallographica. Section F, Structural Biology and Crystallization Communications. Mar, 2006 | Pubmed ID: 16511307 FK778 and Tacrolimus Prevent the Development of Obliterative Airway Disease After Heterotopic Rat Tracheal Transplantation The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation. Nov, 2005 | Pubmed ID: 16297791 Use of Genetic Immunization to Raise Antibodies Recognizing Toxin-related Cell Surface ADP-ribosyltransferases in Native Conformation Cellular Immunology. Jul-Aug, 2005 | Pubmed ID: 16271711 "Agouti NOD": Identification of a CBA-derived Idd Locus on Chromosome 7 and Its Use for Chimera Production with NOD Embryonic Stem Cells Mammalian Genome : Official Journal of the International Mammalian Genome Society. Oct, 2005 | Pubmed ID: 16261419 The Phytoestrogen BiochaninA Weakens Acute Cardiac Allograft Rejection Without Affecting the Reproductive System Transplant Immunology. Oct, 2005 | Pubmed ID: 16223672 In Silico Characterization of the Family of PARP-like Poly(ADP-ribosyl)transferases (pARTs) BMC Genomics. 2005 | Pubmed ID: 16202152 Characterization of Multiple Alleles of the T-cell Differentiation Marker ART2 (RT6) in Inbred and Wild Rats Immunogenetics. Nov, 2005 | Pubmed ID: 16195877 A Panel of Monoclonal Antibodies Recognizing GPI-anchored ADP-ribosyltransferase ART4, the Carrier of the Dombrock Blood Group Antigens Cellular Immunology. Jul-Aug, 2005 | Pubmed ID: 16168396 Probing the Expression and Function of the P2X7 Purinoceptor with Antibodies Raised by Genetic Immunization Cellular Immunology. Jul-Aug, 2005 | Pubmed ID: 16165114 Expression of Insulin-like Factor 3 Protein in the Rat Testis During Fetal and Postnatal Development and in Relation to Cryptorchidism Induced by in Utero Exposure to Di (n-Butyl) Phthalate Endocrinology. Oct, 2005 | Pubmed ID: 16037377 CD38 Controls ADP-ribosyltransferase-2-catalyzed ADP-ribosylation of T Cell Surface Proteins Journal of Immunology (Baltimore, Md. : 1950). Mar, 2005 | Pubmed ID: 15749861 A PKR-like Eukaryotic Initiation Factor 2alpha Kinase from Zebrafish Contains Z-DNA Binding Domains Instead of DsRNA Binding Domains Proceedings of the National Academy of Sciences of the United States of America. Feb, 2005 | Pubmed ID: 15659550 Activity and Specificity of Toxin-related Mouse T Cell Ecto-ADP-ribosyltransferase ART2.2 Depends on Its Association with Lipid Rafts Blood. May, 2005 | Pubmed ID: 15657180 FK778 Attenuates Lymphocyte-endothelium Interaction After Cardiac Transplantation: in Vivo and in Vitro Studies Transplantation. Jul, 2004 | Pubmed ID: 15257041 Ecto-ADP-ribosyltransferases (ARTs): Emerging Actors in Cell Communication and Signaling Current Medicinal Chemistry. Apr, 2004 | Pubmed ID: 15078170 T-cell Survival Regulator LKLF is Not Involved in Inappropriate Apoptosis of Diabetes-prone BBDP Rat T Cells Annals of the New York Academy of Sciences. Dec, 2003 | Pubmed ID: 15033788 Triggering of T-cell Apoptosis by Toxin-related Ecto-ADP-ribosyltransferase ART2 Annals of the New York Academy of Sciences. Dec, 2003 | Pubmed ID: 15033737 NAD-induced T Cell Death: ADP-ribosylation of Cell Surface Proteins by ART2 Activates the Cytolytic P2X7 Purinoceptor Immunity. Oct, 2003 | Pubmed ID: 14563321 Substrate Binding and Catalysis of Ecto-ADP-ribosyltransferase 2.2 from Rat Biochemistry. Sep, 2003 | Pubmed ID: 12939142 Analysis of Subcellular Calcium Signals in T-lymphocytes Cellular Signalling. Aug, 2003 | Pubmed ID: 12781871 Flow Cytometric and Immunoblot Assays for Cell Surface ADP-ribosylation Using a Monoclonal Antibody Specific for Ethenoadenosine Analytical Biochemistry. Mar, 2003 | Pubmed ID: 12633608 T Cells of Different Developmental Stages Differ in Sensitivity to Apoptosis Induced by Extracellular NAD Developmental Immunology. Dec, 2002 | Pubmed ID: 15144016 Cutting Edge: a Natural P451L Mutation in the Cytoplasmic Domain Impairs the Function of the Mouse P2X7 Receptor Journal of Immunology (Baltimore, Md. : 1950). Oct, 2002 | Pubmed ID: 12370338 Generation and Characterization of Ecto-ADP-ribosyltransferase ART2.1/ART2.2-deficient Mice Molecular and Cellular Biology. Nov, 2002 | Pubmed ID: 12370300 Structure of the Ecto-ADP-ribosyl Transferase ART2.2 from Rat Journal of Molecular Biology. Sep, 2002 | Pubmed ID: 12270706 Independent Integration of Rodent Identifier (ID) Elements into Orthologous Sites of Some RT6 Alleles of Rattus Norvegicus and Rattus Rattus Journal of Molecular Evolution. Sep, 2002 | Pubmed ID: 12187378 Expression, Purification, Crystallization and Preliminary X-ray Analysis of Rat Ecto-ADP-ribosyltransferase 2 (ART2.2) Acta Crystallographica. Section D, Biological Crystallography. Jul, 2002 | Pubmed ID: 12077446 The Family of Toxin-related Ecto-ADP-ribosyltransferases in Humans and the Mouse Protein Science : a Publication of the Protein Society. Jul, 2002 | Pubmed ID: 12070318 Mono-ADP-ribosyltransferases in Human Monocytes: Regulation by Lipopolysaccharide The Biochemical Journal. Mar, 2002 | Pubmed ID: 11879200 Complex Regulation of the Human Gene for the Z-DNA Binding Protein DLM-1 Nucleic Acids Research. Feb, 2002 | Pubmed ID: 11842111 التحقق من Nanobody والجسم المضاد القائم Peter Bannas*1, Alexander Lenz*1,2, Valentin Kunick1,2, William Fumey1,2, Björn Rissiek2, Joanna Schmid1,2, Friedrich Haag2, Axel Leingärtner3, Martin Trepel4, Gerhard Adam1, Friedrich Koch-Nolte2 1Department of Diagnostic and Interventional Radiology, University Medical Center, Hamburg, 2Institute of Immunology, University Medical Center, Hamburg, 3University Cancer Center Hamburg, University Medical Center, Hamburg, 4Department of Oncology and Hematology, University Medical Center, Hamburg Medicine
التحقق من Nanobody والجسم المضاد القائم Peter Bannas*1, Alexander Lenz*1,2, Valentin Kunick1,2, William Fumey1,2, Björn Rissiek2, Joanna Schmid1,2, Friedrich Haag2, Axel Leingärtner3, Martin Trepel4, Gerhard Adam1, Friedrich Koch-Nolte2 1Department of Diagnostic and Interventional Radiology, University Medical Center, Hamburg, 2Institute of Immunology, University Medical Center, Hamburg, 3University Cancer Center Hamburg, University Medical Center, Hamburg, 4Department of Oncology and Hematology, University Medical Center, Hamburg Medicine