George K. Michalopoulos Department of Pathology University of Pittsburgh School of Medicine Biography Publications Institution JoVE Articles George K. Michalopoulos has not added a biography. If you are George K. Michalopoulos and would like to personalize this page please email our Author Liaison for assistance. Publications Nrf2 Deletion from Adipocytes, but Not Hepatocytes, Potentiates Systemic Metabolic Dysfunction After Long-term High-fat Diet-induced Obesity in Mice American Journal of Physiology. Endocrinology and Metabolism. Feb, 2018 | Pubmed ID: 29486138 Oct4 Is Crucial for Transdifferentiation of Hepatocytes to Biliary Epithelial Cells in an In Vitro Organoid Culture Model Gene Expression. Mar, 2018 | Pubmed ID: 29212575 Targeting Genomic Rearrangements in Tumor Cells Through Cas9-mediated Insertion of a Suicide Gene Nature Biotechnology. Jun, 2017 | Pubmed ID: 28459452 Immunohistochemical Analysis of the Stem Cell Marker LGR5 in Pediatric Liver Disease Pediatric and Developmental Pathology : the Official Journal of the Society for Pediatric Pathology and the Paediatric Pathology Society. Jan-Feb, 2017 | Pubmed ID: 28276299 MAN2A1-FER Fusion Gene Is Expressed by Human Liver and Other Tumor Types and Has Oncogenic Activity in Mice Gastroenterology. Oct, 2017 | Pubmed ID: 28245430 Bile Duct Ligation Induces ATZ Globule Clearance in a Mouse Model of α-1 Antitrypsin Deficiency Gene Expression. 02, 2017 | Pubmed ID: 27938510 Combined Systemic Elimination of MET and Epidermal Growth Factor Receptor Signaling Completely Abolishes Liver Regeneration and Leads to Liver Decompensation Hepatology (Baltimore, Md.). 11, 2016 | Pubmed ID: 27397846 Gene Expression Analysis Indicates Divergent Mechanisms in DEN-Induced Carcinogenesis in Wild Type and Bid-Deficient Livers PloS One. 2016 | Pubmed ID: 27196317 Liver-Specific Deletion of Integrin-Linked Kinase in Mice Attenuates Hepatotoxicity and Improves Liver Regeneration After Acetaminophen Overdose Gene Expression. 2016 | Pubmed ID: 27125733 Tissue-type Plasminogen Activator Suppresses Activated Stellate Cells Through Low-density Lipoprotein Receptor-related Protein 1 Laboratory Investigation; a Journal of Technical Methods and Pathology. Oct, 2015 | Pubmed ID: 26237273 Novel Fusion Transcripts Associate with Progressive Prostate Cancer The American Journal of Pathology. Oct, 2014 | Pubmed ID: 25238935 Advances in Liver Regeneration Expert Review of Gastroenterology & Hepatology. Nov, 2014 | Pubmed ID: 24964729 Development of a Chemically Defined Medium and Discovery of New Mitogenic Growth Factors for Mouse Hepatocytes: Mitogenic Effects of FGF1/2 and PDGF PloS One. 2014 | Pubmed ID: 24743506 The Liver is a Peculiar Organ when It Comes to Stem Cells The American Journal of Pathology. May, 2014 | Pubmed ID: 24681248 The Degree of Segmental Aneuploidy Measured by Total Copy Number Abnormalities Predicts Survival and Recurrence in Superficial Gastroesophageal Adenocarcinoma PloS One. 2014 | Pubmed ID: 24454681 Role of PINCH and Its Partner Tumor Suppressor Rsu-1 in Regulating Liver Size and Tumorigenesis PloS One. 2013 | Pubmed ID: 24058607 Principles of Liver Regeneration and Growth Homeostasis Comprehensive Physiology. Jan, 2013 | Pubmed ID: 23720294 Regulation of Liver Growth by Glypican 3, CD81, Hedgehog, and Hhex The American Journal of Pathology. Jul, 2013 | Pubmed ID: 23665349 Gliotoxin-induced Changes in Rat Liver Regeneration After Partial Hepatectomy Liver International : Official Journal of the International Association for the Study of the Liver. Aug, 2013 | Pubmed ID: 23552057 Expression of Hepatocyte Epidermal Growth Factor Receptor, FAS and Glypican 3 in EpCAM-positive Regenerative Clusters of Hepatocytes, Cholangiocytes, and Progenitor Cells in Human Liver Failure Human Pathology. May, 2013 | Pubmed ID: 23114924 Signals and Cells Involved in Regulating Liver Regeneration Cells. Dec, 2012 | Pubmed ID: 24710554 Gene Deletions and Amplifications in Human Hepatocellular Carcinomas: Correlation with Hepatocyte Growth Regulation The American Journal of Pathology. Apr, 2012 | Pubmed ID: 22326833 A Mouse Model of Accelerated Liver Aging Caused by a Defect in DNA Repair Hepatology (Baltimore, Md.). Feb, 2012 | Pubmed ID: 21953681 Protection Against Fas-induced Fulminant Hepatic Failure in Liver Specific Integrin Linked Kinase Knockout Mice Comparative Hepatology. Nov, 2011 | Pubmed ID: 22104495 Genes Inducing IPS Phenotype Play a Role in Hepatocyte Survival and Proliferation in Vitro and Liver Regeneration in Vivo Hepatology (Baltimore, Md.). Oct, 2011 | Pubmed ID: 21739467 Hepatocyte Proliferation and Hepatomegaly Induced by Phenobarbital and 1,4-bis [2-(3,5-dichloropyridyloxy)] Benzene is Suppressed in Hepatocyte-targeted Glypican 3 Transgenic Mice Hepatology (Baltimore, Md.). Aug, 2011 | Pubmed ID: 21574168 Excessive Hepatomegaly of Mice with Hepatocyte-targeted Elimination of Integrin Linked Kinase Following Treatment with 1,4-bis [2-(3,5-dichaloropyridyloxy)] Benzene Hepatology (Baltimore, Md.). Feb, 2011 | Pubmed ID: 21274879 Liver Regeneration: Alternative Epithelial Pathways The International Journal of Biochemistry & Cell Biology. Feb, 2011 | Pubmed ID: 19788929 Expression of Hepatocytic- and Biliary-specific Transcription Factors in Regenerating Bile Ducts During Hepatocyte-to-biliary Epithelial Cell Transdifferentiation Comparative Hepatology. Dec, 2010 | Pubmed ID: 21126359 Suppression of Liver Regeneration and Hepatocyte Proliferation in Hepatocyte-targeted Glypican 3 Transgenic Mice Hepatology (Baltimore, Md.). Sep, 2010 | Pubmed ID: 20812357 Cytosolic Phospholipase A2alpha and Peroxisome Proliferator-activated Receptor Gamma Signaling Pathway Counteracts Transforming Growth Factor Beta-mediated Inhibition of Primary and Transformed Hepatocyte Growth Hepatology (Baltimore, Md.). Aug, 2010 | Pubmed ID: 20683962 Bid Agonist Regulates Murine Hepatocyte Proliferation by Controlling Endoplasmic Reticulum Calcium Homeostasis Hepatology (Baltimore, Md.). Jul, 2010 | Pubmed ID: 20578150 Interaction of Integrin-linked Kinase and Miniature Chromosome Maintenance 7-mediating Integrin {alpha}7 Induced Cell Growth Suppression Cancer Research. Jun, 2010 | Pubmed ID: 20460506 Liver Regeneration After Partial Hepatectomy: Critical Analysis of Mechanistic Dilemmas The American Journal of Pathology. Jan, 2010 | Pubmed ID: 20019184 Hepatocyte Growth Factor (HGF) Modulates GABAergic Inhibition and Seizure Susceptibility Experimental Neurology. Jan, 2010 | Pubmed ID: 19853606 Enhanced Liver Regeneration Following Changes Induced by Hepatocyte-specific Genetic Ablation of Integrin-linked Kinase Hepatology (Baltimore, Md.). Sep, 2009 | Pubmed ID: 19575460 Investigation of the Role of Glypican 3 in Liver Regeneration and Hepatocyte Proliferation The American Journal of Pathology. Aug, 2009 | Pubmed ID: 19574424 Liver-specific Ablation of Integrin-linked Kinase in Mice Results in Abnormal Histology, Enhanced Cell Proliferation, and Hepatomegaly Hepatology (Baltimore, Md.). Dec, 2008 | Pubmed ID: 18846549 Expression of Specific Hepatocyte and Cholangiocyte Transcription Factors in Human Liver Disease and Embryonic Development Laboratory Investigation; a Journal of Technical Methods and Pathology. Aug, 2008 | Pubmed ID: 18574450 Hepatocyte Growth Factor Exerts Its Anti-inflammatory Action by Disrupting Nuclear Factor-kappaB Signaling The American Journal of Pathology. Jul, 2008 | Pubmed ID: 18502824 Mechanisms of Hepatocyte Growth Factor-mediated and Epidermal Growth Factor-mediated Signaling in Transdifferentiation of Rat Hepatocytes to Biliary Epithelium Hepatology (Baltimore, Md.). May, 2008 | Pubmed ID: 18398918 Beta-catenin Deletion in Hepatoblasts Disrupts Hepatic Morphogenesis and Survival During Mouse Development Hepatology (Baltimore, Md.). May, 2008 | Pubmed ID: 18393386 Alpha-1 Adrenergic Receptor Transactivates Signal Transducer and Activator of Transcription-3 (Stat3) Through Activation of Src and Epidermal Growth Factor Receptor (EGFR) in Hepatocytes Journal of Cellular Physiology. Aug, 2008 | Pubmed ID: 18314882 Promotion of Fas-mediated Apoptosis in Type II Cells by High Doses of Hepatocyte Growth Factor Bypasses the Mitochondrial Requirement Journal of Cellular Physiology. Nov, 2007 | Pubmed ID: 17620325 Liver Regeneration Journal of Cellular Physiology. Nov, 2007 | Pubmed ID: 17559071 Cell Cycle Effects Resulting from Inhibition of Hepatocyte Growth Factor and Its Receptor C-Met in Regenerating Rat Livers by RNA Interference Hepatology (Baltimore, Md.). Jun, 2007 | Pubmed ID: 17427161 Loss of Integrin Linked Kinase from Mouse Hepatocytes in Vitro and in Vivo Results in Apoptosis and Hepatitis Hepatology (Baltimore, Md.). Apr, 2007 | Pubmed ID: 17385211 Integrin-linked Kinase is Involved in Matrix-induced Hepatocyte Differentiation Biochemical and Biophysical Research Communications. Feb, 2007 | Pubmed ID: 17194454 Transcriptomic and Genomic Analysis of Human Hepatocellular Carcinomas and Hepatoblastomas Hepatology (Baltimore, Md.). Oct, 2006 | Pubmed ID: 17006932 Peroxisomal Localization of Hypoxia-inducible Factors and Hypoxia-inducible Factor Regulatory Hydroxylases in Primary Rat Hepatocytes Exposed to Hypoxia-reoxygenation The American Journal of Pathology. Oct, 2006 | Pubmed ID: 17003483 Flexible Lineage Specifications of Adult Hepatic Cells, Associated Molecular Pathways, and Their Relationship to Liver Cancer Cell Transplantation. 2006 | Pubmed ID: 16826797 Phenobarbital Regulates Nuclear Expression of HNF-4alpha in Mouse and Rat Hepatocytes Independent of CAR and PXR Hepatology (Baltimore, Md.). Jul, 2006 | Pubmed ID: 16799975 Hepatocyte Growth Factor Attenuates Liver Fibrosis Induced by Bile Duct Ligation The American Journal of Pathology. May, 2006 | Pubmed ID: 16651617 Distinctive Role of Stat3 and Erk-1/2 Activation in Mediating Interferon-gamma Inhibition of TGF-beta1 Action American Journal of Physiology. Renal Physiology. May, 2006 | Pubmed ID: 16332928 Prostaglandin E2 Receptor EP1 Transactivates EGFR/MET Receptor Tyrosine Kinases and Enhances Invasiveness in Human Hepatocellular Carcinoma Cells Journal of Cellular Physiology. Apr, 2006 | Pubmed ID: 16331686 Liver Regeneration Advances in Biochemical Engineering/biotechnology. 2005 | Pubmed ID: 15791946 Transdifferentiation of Rat Hepatocytes into Biliary Cells After Bile Duct Ligation and Toxic Biliary Injury Hepatology (Baltimore, Md.). Mar, 2005 | Pubmed ID: 15726663 Liver Regeneration, Growth Factors, and Amphiregulin Gastroenterology. Feb, 2005 | Pubmed ID: 15685562 Expression of Notch-1 and Its Ligand Jagged-1 in Rat Liver During Liver Regeneration Hepatology (Baltimore, Md.). Apr, 2004 | Pubmed ID: 15057910 Cyclooxygenase-2 Promotes Hepatocellular Carcinoma Cell Growth Through Akt Activation: Evidence for Akt Inhibition in Celecoxib-induced Apoptosis Hepatology (Baltimore, Md.). Sep, 2003 | Pubmed ID: 12939602 HGF-, EGF-, and Dexamethasone-induced Gene Expression Patterns During Formation of Tissue in Hepatic Organoid Cultures Gene Expression. 2003 | Pubmed ID: 12837037 PPARgamma Ligands Inhibit Cholangiocarcinoma Cell Growth Through P53-dependent GADD45 and P21 Pathway Hepatology (Baltimore, Md.). Jul, 2003 | Pubmed ID: 12829999 Gene Expression Analysis of Human Soft Tissue Leiomyosarcomas Human Pathology. Jun, 2003 | Pubmed ID: 12827608 Beta-catenin Antisense Studies in Embryonic Liver Cultures: Role in Proliferation, Apoptosis, and Lineage Specification Gastroenterology. Jan, 2003 | Pubmed ID: 12512043 Hepatocytes Undergo Phenotypic Transformation to Biliary Epithelium in Organoid Cultures Hepatology (Baltimore, Md.). Aug, 2002 | Pubmed ID: 12143035 Differential Mitogenic Effects of Single Chain Hepatocyte Growth Factor (HGF)/scatter Factor and HGF/NK1 Following Cleavage by Factor Xa The Journal of Biological Chemistry. Apr, 2002 | Pubmed ID: 11832492 Histological Organization in Hepatocyte Organoid Cultures The American Journal of Pathology. Nov, 2001 | Pubmed ID: 11696448 The Processing and Utilization of Hepatocyte Growth Factor/scatter Factor Following Partial Hepatectomy in the Rat Hepatology (Baltimore, Md.). Oct, 2001 | Pubmed ID: 11584364 Sustained Expression of Naked Plasmid DNA Encoding Hepatocyte Growth Factor in Mice Promotes Liver and Overall Body Growth Hepatology (Baltimore, Md.). Apr, 2001 | Pubmed ID: 11283849 Cationic Colloidal Silica Membrane Perturbation As a Means of Examining Changes at the Sinusoidal Surface During Liver Regeneration The American Journal of Pathology. Nov, 1999 | Pubmed ID: 10550305 Dose-dependent Biphasic Effects of Phenobarbital on Growth and Differentiation of Primary Culture Rat Hepatocytes Journal of Gastroenterology and Hepatology. Sep, 1998 | Pubmed ID: 28976694 Ligadura do colédoco parcial no Mouse: um modelo controlado da colestase obstrutiva localizada Shinichiro Yokota1,2, Yoshihiro Ono2, Toshimasa Nakao2, Peng Zhang3, George K. Michalopoulos4,5, Zahida Khan3,4,5,6 1Department of Surgery, Jichi Medical University, 2Department of Surgery, University of Pittsburgh School of Medicine, 3Department of Pediatrics, University of Pittsburgh School of Medicine, 4Department of Pathology, University of Pittsburgh School of Medicine, 5Pittsburgh Liver Research Center, University of Pittsburgh, 6McGowan Institute for Regenerative Medicine, University of Pittsburgh JoVE 56930 Biology
Ligadura do colédoco parcial no Mouse: um modelo controlado da colestase obstrutiva localizada Shinichiro Yokota1,2, Yoshihiro Ono2, Toshimasa Nakao2, Peng Zhang3, George K. Michalopoulos4,5, Zahida Khan3,4,5,6 1Department of Surgery, Jichi Medical University, 2Department of Surgery, University of Pittsburgh School of Medicine, 3Department of Pediatrics, University of Pittsburgh School of Medicine, 4Department of Pathology, University of Pittsburgh School of Medicine, 5Pittsburgh Liver Research Center, University of Pittsburgh, 6McGowan Institute for Regenerative Medicine, University of Pittsburgh JoVE 56930 Biology