Gwendalyn J. Randolph Department of Pathology and Immunology Washington University School of Medicine Biography Publications Institution JoVE Articles Gwendalyn J. Randolph has not added a biography. If you are Gwendalyn J. Randolph and would like to personalize this page please email our Author Liaison for assistance. Publications Colonic Macrophages Combat Fungal Intoxication: Metchnikoff Would Be Pleased Cell. Oct, 2020 | Pubmed ID: 33064986 YAP and TAZ Maintain PROX1 Expression in the Developing Lymphatic and Lymphovenous Valves in Response to VEGF-C Signaling Development (Cambridge, England). Oct, 2020 | Pubmed ID: 33060128 Limited Proliferation Capacity of Aortic Intima Resident Macrophages Requires Monocyte Recruitment for Atherosclerotic Plaque Progression Nature Immunology. Oct, 2020 | Pubmed ID: 32895539 Ischemia Reperfusion Injury Provokes Adverse Left Ventricular Remodeling in Dysferlin-deficient Hearts Through a Pathway That Involves TIRAP Dependent Signaling Scientific Reports. 08, 2020 | Pubmed ID: 32839504 The Lymphatic Vasculature in the 21 Century: Novel Functional Roles in Homeostasis and Disease Cell. Jul, 2020 | Pubmed ID: 32707093 Postprandial Chylomicron Output and Transport Through Intestinal Lymphatics Are Not Impaired in Active Crohn's Disease Gastroenterology. Jul, 2020 | Pubmed ID: 32681923 Peripheral Nerve Resident Macrophages Share Tissue-specific Programming and Features of Activated Microglia Nature Communications. 05, 2020 | Pubmed ID: 32439942 Kir6.1-dependent K Channels in Lymphatic Smooth Muscle and Vessel Dysfunction in Mice with Kir6.1 Gain-of-function The Journal of Physiology. May, 2020 | Pubmed ID: 32372450 Myeloid-specific Asxl2 Deletion Limits Diet-induced Obesity by Regulating Energy Expenditure The Journal of Clinical Investigation. May, 2020 | Pubmed ID: 32310225 Myocardial B Cells Are a Subset of Circulating Lymphocytes with Delayed Transit Through the Heart JCI Insight. 02, 2020 | Pubmed ID: 31945014 Cu-ATSM Positron Emission Tomography/Magnetic Resonance Imaging of Hypoxia in Human Atherosclerosis Circulation. Cardiovascular Imaging. 01, 2020 | Pubmed ID: 31910670 B Cell-Mediated Antigen Presentation Through MHC Class II Is Dispensable for Atherosclerosis Progression ImmunoHorizons. 01, 2019 | Pubmed ID: 31356175 A Stromal Niche Defined by Expression of the Transcription Factor WT1 Mediates Programming and Homeostasis of Cavity-Resident Macrophages Immunity. 07, 2019 | Pubmed ID: 31231034 Bhlhe40 Mediates Tissue-specific Control of Macrophage Proliferation in Homeostasis and Type 2 Immunity Nature Immunology. 06, 2019 | Pubmed ID: 31061528 Expression of Factor V by Resident Macrophages Boosts Host Defense in the Peritoneal Cavity The Journal of Experimental Medicine. 06, 2019 | Pubmed ID: 31048328 Cytokine Circuits in Cardiovascular Disease Immunity. 04, 2019 | Pubmed ID: 30995508 Lymphatic Network Remodeling After Small Bowel Resection Journal of Pediatric Surgery. Jun, 2019 | Pubmed ID: 30879758 Interleukin-17 Drives Interstitial Entrapment of Tissue Lipoproteins in Experimental Psoriasis Cell Metabolism. 02, 2019 | Pubmed ID: 30415924 Infection-Induced Transcriptional Changes in Hepatic Macrophage Metabolism Correlate With an Athero-Protective Phenotype Frontiers in Immunology. 2018 | Pubmed ID: 30483256 Macrophage Biology, Classification, and Phenotype in Cardiovascular Disease: JACC Macrophage in CVD Series (Part 1) Journal of the American College of Cardiology. 10, 2018 | Pubmed ID: 30360826 Transcriptome Analysis Reveals Nonfoamy Rather Than Foamy Plaque Macrophages Are Proinflammatory in Atherosclerotic Murine Models Circulation Research. 10, 2018 | Pubmed ID: 30359200 Lymph Nodes Go with the Flow The Journal of Experimental Medicine. 11, 2018 | Pubmed ID: 30355618 Kidney-resident Macrophages Promote a Proangiogenic Environment in the Normal and Chronically Ischemic Mouse Kidney Scientific Reports. 09, 2018 | Pubmed ID: 30224726 A Novel Role for C-C Motif Chemokine Receptor 2 During Infection with Hypervirulent Mycobacterium Tuberculosis Mucosal Immunology. 11, 2018 | Pubmed ID: 30115997 Interleukin-1β Has Atheroprotective Effects in Advanced Atherosclerotic Lesions of Mice Nature Medicine. Sep, 2018 | Pubmed ID: 30038218 Limited Macrophage Positional Dynamics in Progressing or Regressing Murine Atherosclerotic Plaques-Brief Report Arteriosclerosis, Thrombosis, and Vascular Biology. 08, 2018 | Pubmed ID: 29903736 Electrophilic Properties of Itaconate and Derivatives Regulate The IκBζ-ATF3 Inflammatory Axis Nature. 04, 2018 | Pubmed ID: 29670287 Contribution of Metabolic Disease to Bone Fragility in MAGP1-deficient Mice Matrix Biology : Journal of the International Society for Matrix Biology. 04, 2018 | Pubmed ID: 29519758 Editorial Overview: Innate Immunity: The Finely Tuned STING of Innate Immunity Current Opinion in Immunology. 02, 2018 | Pubmed ID: 29475574 Cardiac Lymphatic Vessels, Transport, and Healing of the Infarcted Heart JACC. Basic to Translational Science. 08, 2017 | Pubmed ID: 28989985 Thermoneutrality but Not UCP1 Deficiency Suppresses Monocyte Mobilization Into Blood Circulation Research. Sep, 2017 | Pubmed ID: 28696252 Sphingosine-1-Phosphate As the Lymphocyte's Ticket to Ride and Survive Developmental Cell. 06, 2017 | Pubmed ID: 28633013 A Polecat's View of Patrolling Monocytes Circulation Research. 05, 2017 | Pubmed ID: 28546349 Myeloid Cells Pave the Way for Lymphatic System Development and Maintenance Pflugers Archiv : European Journal of Physiology. 04, 2017 | Pubmed ID: 28220247 CD36 Deficiency Impairs the Small Intestinal Barrier and Induces Subclinical Inflammation in Mice Cellular and Molecular Gastroenterology and Hepatology. Jan, 2017 | Pubmed ID: 28066800 The Lymphatic System: Integral Roles in Immunity Annual Review of Immunology. 04, 2017 | Pubmed ID: 27860528 Defensin-chemokine Heteromeric Complexes Derived from Heterocellular Activation-a Possible Target to Inhibit CCL5 in Cardiovascular Settings Annals of Translational Medicine. Dec, 2016 | Pubmed ID: 28149859 Mafb Lineage Tracing to Distinguish Macrophages from Other Immune Lineages Reveals Dual Identity of Langerhans Cells The Journal of Experimental Medicine. 11, 2016 | Pubmed ID: 27810926 Lymphoid Aggregates Remodel Lymphatic Collecting Vessels That Serve Mesenteric Lymph Nodes in Crohn Disease The American Journal of Pathology. 12, 2016 | Pubmed ID: 27746181 Trafficking Patterns of Mononuclear Phagocytes Nature Reviews. Immunology. 11, 2016 | Pubmed ID: 27721482 Homegrown Macrophages Immunity. 09, 2016 | Pubmed ID: 27653599 MHC II+ Resident Peritoneal and Pleural Macrophages Rely on IRF4 for Development from Circulating Monocytes The Journal of Experimental Medicine. 09, 2016 | Pubmed ID: 27551152 PET/MRI of Hypoxic Atherosclerosis Using 64Cu-ATSM in a Rabbit Model Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine. Dec, 2016 | Pubmed ID: 27390157 Itaconate Links Inhibition of Succinate Dehydrogenase with Macrophage Metabolic Remodeling and Regulation of Inflammation Cell Metabolism. 07, 2016 | Pubmed ID: 27374498 Imaging of Hypoxia in Mouse Atherosclerotic Plaques with (64)Cu-ATSM Nuclear Medicine and Biology. 09, 2016 | Pubmed ID: 27372286 CCR7 and IRF4-dependent Dendritic Cells Regulate Lymphatic Collecting Vessel Permeability The Journal of Clinical Investigation. Apr, 2016 | Pubmed ID: 26999610 Homeostatic Control of Innate Lung Inflammation by Vici Syndrome Gene Epg5 and Additional Autophagy Genes Promotes Influenza Pathogenesis Cell Host & Microbe. Jan, 2016 | Pubmed ID: 26764600 CCR7: Unifying Disparate Journeys to the Lymph Node Journal of Immunology (Baltimore, Md. : 1950). Jan, 2016 | Pubmed ID: 26685312 Self-renewing Resident Arterial Macrophages Arise from Embryonic CX3CR1(+) Precursors and Circulating Monocytes Immediately After Birth Nature Immunology. Feb, 2016 | Pubmed ID: 26642357 Microbiota-Dependent Sequelae of Acute Infection Compromise Tissue-Specific Immunity Cell. Oct, 2015 | Pubmed ID: 26451485 NADPH Oxidase Controls Neutrophilic Response to Sterile Inflammation in Mice by Regulating the IL-1α/G-CSF Axis Blood. Dec, 2015 | Pubmed ID: 26443623 The Role of the Lymphatic System in Cholesterol Transport Frontiers in Pharmacology. 2015 | Pubmed ID: 26388772 Macrophage Supply and Demand at the Core of the Necrotic Granuloma Cell Host & Microbe. Jul, 2015 | Pubmed ID: 26159712 Collecting Lymphatic Vessel Permeability Facilitates Adipose Tissue Inflammation and Distribution of Antigen to Lymph Node-homing Adipose Tissue Dendritic Cells Journal of Immunology (Baltimore, Md. : 1950). Jun, 2015 | Pubmed ID: 25917096 IL-4-secreting Secondary T Follicular Helper (Tfh) Cells Arise from Memory T Cells, Not Persisting Tfh Cells, Through a B Cell-dependent Mechanism Journal of Immunology (Baltimore, Md. : 1950). Apr, 2015 | Pubmed ID: 25712216 Photoacoustic Lymphatic Imaging with High Spatial-temporal Resolution Journal of Biomedical Optics. Nov, 2014 | Pubmed ID: 25408958 Distinct Macrophage Lineages Contribute to Disparate Patterns of Cardiac Recovery and Remodeling in the Neonatal and Adult Heart Proceedings of the National Academy of Sciences of the United States of America. Nov, 2014 | Pubmed ID: 25349429 A Macrophage Revolution-and Beyond Immunological Reviews. Nov, 2014 | Pubmed ID: 25319323 Ly6Chi Monocyte Recruitment is Responsible for Th2 Associated Host-protective Macrophage Accumulation in Liver Inflammation Due to Schistosomiasis PLoS Pathogens. Aug, 2014 | Pubmed ID: 25144366 Origin and Functions of Tissue Macrophages Immunity. Jul, 2014 | Pubmed ID: 25035951 Gata6 Regulates Aspartoacylase Expression in Resident Peritoneal Macrophages and Controls Their Survival The Journal of Experimental Medicine. Jul, 2014 | Pubmed ID: 25024137 Mechanisms That Regulate Macrophage Burden in Atherosclerosis Circulation Research. May, 2014 | Pubmed ID: 24855200 Lymphatic Transport of High-density Lipoproteins and Chylomicrons The Journal of Clinical Investigation. Mar, 2014 | Pubmed ID: 24590278 Embryonic and Adult-derived Resident Cardiac Macrophages Are Maintained Through Distinct Mechanisms at Steady State and During Inflammation Immunity. Jan, 2014 | Pubmed ID: 24439267 Atherosclerosis and Transit of HDL Through the Lymphatic Vasculature Current Atherosclerosis Reports. Sep, 2013 | Pubmed ID: 23912686 Macrophages in Marseille Immunity. Apr, 2013 | Pubmed ID: 23601676 Normal Dendritic Cell Mobilization to Lymph Nodes Under Conditions of Severe Lymphatic Hypoplasia Journal of Immunology (Baltimore, Md. : 1950). May, 2013 | Pubmed ID: 23530147 Gene-expression Profiles and Transcriptional Regulatory Pathways That Underlie the Identity and Diversity of Mouse Tissue Macrophages Nature Immunology. Nov, 2012 | Pubmed ID: 23023392 Lymphatic and Blood Network Analysis During Obesity Rafael S Czepielewski*1, Alexandre Gallerand*2,3, Jérôme Gilleron2,4, Narges Khedher2,3, Gwendalyn J. Randolph1, Stoyan Ivanov2,3 1Department of Pathology and Immunology, Washington University School of Medicine, 2Université Côte d'Azur, 3Mediterranean Center of Molecular Medicine C3M, Team 13, Institut National de la Santé et de la Recherche Médicale (Inserm) UMR1065, 4Mediterranean Center of Molecular Medicine C3M, Team 7, Institut National de la Santé et de la Recherche Médicale (Inserm) UMR1065 JoVE 61814 Medicine
Lymphatic and Blood Network Analysis During Obesity Rafael S Czepielewski*1, Alexandre Gallerand*2,3, Jérôme Gilleron2,4, Narges Khedher2,3, Gwendalyn J. Randolph1, Stoyan Ivanov2,3 1Department of Pathology and Immunology, Washington University School of Medicine, 2Université Côte d'Azur, 3Mediterranean Center of Molecular Medicine C3M, Team 13, Institut National de la Santé et de la Recherche Médicale (Inserm) UMR1065, 4Mediterranean Center of Molecular Medicine C3M, Team 7, Institut National de la Santé et de la Recherche Médicale (Inserm) UMR1065 JoVE 61814 Medicine