Howard D. White

Publications

• On-grid and In-flow Mixing for Time-resolved Cryo-EM
  Acta Crystallographica. Section D, Structural Biology. Oct, 2021  |   Pubmed ID: 34605427
• Interaction of the C2 Ig-like Domain of Cardiac Myosin Binding Protein-C with F-actin
  Journal of Molecular Biology. 09, 2021  |   Pubmed ID: 34329643
• The Structure of the Native Cardiac Thin Filament at Systolic Ca Levels
  Proceedings of the National Academy of Sciences of the United States of America. 03, 2021  |   Pubmed ID: 33753506
• High-Resolution Cryo-EM Structure of the Cardiac Actomyosin Complex
  Structure (London, England : 1993). 01, 2021  |   Pubmed ID: 33065066
• Need for Speed: Examining Protein Behavior During CryoEM Grid Preparation at Different Timescales
  Structure (London, England : 1993). 11, 2020  |   Pubmed ID: 32814033
• Sample Deposition Onto Cryo-EM Grids: from Sprays to Jets and Back
  Acta Crystallographica. Section D, Structural Biology. Apr, 2020  |   Pubmed ID: 32254058
• A Cryo-EM Grid Preparation Device for Time-resolved Structural Studies
  IUCrJ. Nov, 2019  |   Pubmed ID: 31709058
• Investigation into the Mechanism of Thin Filament Regulation by Transient Kinetics and Equilibrium Binding: Is There a Conflict?
  The Journal of General Physiology. 05, 2019  |   Pubmed ID: 30824574
• N-Terminal Domains of Cardiac Myosin Binding Protein C Cooperatively Activate the Thin Filament
  Structure (London, England : 1993). 12, 2018  |   Pubmed ID: 30270174
• Distinct Sites in Tropomyosin Specify Shared and Isoform-specific Regulation of Myosins II and V
  Cytoskeleton (Hoboken, N.J.). 04, 2018  |   Pubmed ID: 29500902
• The Shaker-1 Mouse Myosin VIIa Deafness Mutation Results in a Severely Reduced Rate of the ATP Hydrolysis Step
  The Journal of Biological Chemistry. 01, 2018  |   Pubmed ID: 29167268
• Ca-induced Movement of Tropomyosin on Native Cardiac Thin Filaments Revealed by Cryoelectron Microscopy
  Proceedings of the National Academy of Sciences of the United States of America. 06, 2017  |   Pubmed ID: 28607071
• C0 and C1 N-terminal Ig Domains of Myosin Binding Protein C Exert Different Effects on Thin Filament Activation
  Proceedings of the National Academy of Sciences of the United States of America. Feb, 2016  |   Pubmed ID: 26831109
• Omecamtiv Mecarbil Modulates the Kinetic and Motile Properties of Porcine β-cardiac Myosin
  Biochemistry. Mar, 2015  |   Pubmed ID: 25680381
• Modulation of Thin Filament Activation of Myosin ATP Hydrolysis by N-terminal Domains of Cardiac Myosin Binding Protein-C
  Biochemistry. Oct, 2014  |   Pubmed ID: 25265574
• Coupling of Two Non-processive Myosin 5c Dimers Enables Processive Stepping Along Actin Filaments
  Scientific Reports. May, 2014  |   Pubmed ID: 24809456
• Regulation of Actin-myosin Interaction by Conserved Periodic Sites of Tropomyosin
  Proceedings of the National Academy of Sciences of the United States of America. Nov, 2012  |   Pubmed ID: 23091026
• Mechanism of Regulation of Native Cardiac Muscle Thin Filaments by Rigor Cardiac Myosin-S1 and Calcium
  The Journal of Biological Chemistry. Oct, 2010  |   Pubmed ID: 20696756
• The SAH Domain Extends the Functional Length of the Myosin Lever
  Proceedings of the National Academy of Sciences of the United States of America. Dec, 2009  |   Pubmed ID: 20018767
• Switch 1 Mutation S217A Converts Myosin V into a Low Duty Ratio Motor
  The Journal of Biological Chemistry. Jan, 2009  |   Pubmed ID: 19008235
• Direct Observation of the Mechanochemical Coupling in Myosin Va During Processive Movement
  Nature. Sep, 2008  |   Pubmed ID: 18668042
• Smooth Muscle Myosin Phosphorylated at Single Head Shows Sustained Mechanical Activity
  The Journal of Biological Chemistry. Jun, 2008  |   Pubmed ID: 18408003
• Kinetics of ADP Dissociation from the Trail and Lead Heads of Actomyosin V Following the Power Stroke
  The Journal of Biological Chemistry. Jan, 2008  |   Pubmed ID: 17965414
• Real-time Measurement of Myosin-nucleotide Noncovalent Complexes by Electrospray Ionization Mass Spectrometry
  Biophysical Journal. Aug, 2007  |   Pubmed ID: 17483158
• Kinetic Mechanism of MyosinV-S1 Using a New Fluorescent ATP Analogue
  Biochemistry. Oct, 2006  |   Pubmed ID: 17059220
• The Prepower Stroke Conformation of Myosin V
  The Journal of Cell Biology. Dec, 2002  |   Pubmed ID: 12499355
• Mechanism of Regulation of Phosphate Dissociation from Actomyosin-ADP-Pi by Thin Filament Proteins
  Proceedings of the National Academy of Sciences of the United States of America. Dec, 2002  |   Pubmed ID: 12486217
• Observation of Transient Disorder During Myosin Subfragment-1 Binding to Actin by Stopped-flow Fluorescence and Millisecond Time Resolution Electron Cryomicroscopy: Evidence That the Start of the Crossbridge Power Stroke in Muscle Has Variable Geometry
  Proceedings of the National Academy of Sciences of the United States of America. Jan, 1999  |   Pubmed ID: 9892656