Jacob G. Sivak School of Optometry and Vision Science University of Waterloo Biography Publications Institution JoVE Articles Jacob G. Sivak has not added a biography. If you are Jacob G. Sivak and would like to personalize this page please email our Author Liaison for assistance. Publications Neutralization of the Eye and Skin Irritant Benzalkonium Chloride Using UVC Radiation Cutaneous and Ocular Toxicology. Jun, 2021 | Pubmed ID: 33771058 Ocular Toxicology: Synergism of UV Radiation and Benzalkonium Chloride Cutaneous and Ocular Toxicology. Dec, 2020 | Pubmed ID: 33019823 Conserved Characteristics of Ocular Refractive Development - Did the Eye Evolve Once? Experimental Eye Research. 06, 2019 | Pubmed ID: 29758190 Refractive Plasticity of the Developing Chick Eye: a Summary and Update Ophthalmic & Physiological Optics : the Journal of the British College of Ophthalmic Opticians (Optometrists). Nov, 2015 | Pubmed ID: 26497292 Use of the Viability Reagent PrestoBlue in Comparison with AlamarBlue and MTT to Assess the Viability of Human Corneal Epithelial Cells Journal of Pharmacological and Toxicological Methods. Jan-Feb, 2015 | Pubmed ID: 25464019 Blood Flow Dynamics in the Snake Spectacle The Journal of Experimental Biology. Nov, 2013 | Pubmed ID: 24172887 Comparison of the Effects of Ophthalmic Solutions on Human Corneal Epithelial Cells Using Fluorescent Dyes Journal of Ocular Pharmacology and Therapeutics : the Official Journal of the Association for Ocular Pharmacology and Therapeutics. Nov, 2013 | Pubmed ID: 23905770 Application of Cyclic Biamperometry to Viability and Cytotoxicity Assessment in Human Corneal Epithelial Cells Analytical and Bioanalytical Chemistry. May, 2013 | Pubmed ID: 23443523 The Cause(s) of Myopia and the Efforts That Have Been Made to Prevent It Clinical & Experimental Optometry. Nov, 2012 | Pubmed ID: 22845416 In Vitro Ultraviolet-induced Damage in Human Corneal, Lens, and Retinal Pigment Epithelial Cells Molecular Vision. 2011 | Pubmed ID: 21270970 The Charles F. Prentice Award Lecture 2009: Crystalline Lens Research and Serendipity in Science Optometry and Vision Science : Official Publication of the American Academy of Optometry. Sep, 2010 | Pubmed ID: 20581727 Identification of Myopia-related Marker Proteins in Tilapia Retinal, RPE, and Choroidal Tissue Following Induced Form Deprivation Current Eye Research. Nov, 2009 | Pubmed ID: 19958113 Effects of 400 Nm, 420 Nm, and 435.8 Nm Radiations on Cultured Human Retinal Pigment Epithelial Cells Journal of Photochemistry and Photobiology. B, Biology. Apr, 2009 | Pubmed ID: 19201202 Contributions of Mouse Genetic Background and Age on Anterior Lens Capsule Thickness Anatomical Record (Hoboken, N.J. : 2007). Dec, 2008 | Pubmed ID: 18951502 Regional Variation in the Refractive-index of the Bovine and Human Cornea Optometry and Vision Science : Official Publication of the American Academy of Optometry. Oct, 2008 | Pubmed ID: 18832976 The Role of the Lens in Refractive Development of the Eye: Animal Models of Ametropia Experimental Eye Research. Jul, 2008 | Pubmed ID: 18405895 Effect of Age on Ocular Irritancy As Measured with in Vitro Bovine Lenses Toxicology in Vitro : an International Journal Published in Association with BIBRA. Mar, 2008 | Pubmed ID: 17977691 The Role of Hsp70 and Hsp90 in TGF-beta-induced Epithelial-to-mesenchymal Transition in Rat Lens Epithelial Explants Molecular Vision. Nov, 2007 | Pubmed ID: 18087244 Biocompatibility of Contact Lens Solutions Using Confocal Laser Scanning Microscopy and the in Vitro Bovine Cornea Eye & Contact Lens. Nov, 2007 | Pubmed ID: 17993827 Eyes of a Lower Vertebrate Are Susceptible to the Visual Environment Investigative Ophthalmology & Visual Science. Oct, 2007 | Pubmed ID: 17898310 In Vitro Assays for Evaluating the Ultraviolet B-induced Damage in Cultured Human Retinal Pigment Epithelial Cells Journal of Photochemistry and Photobiology. B, Biology. Jul, 2007 | Pubmed ID: 17566755 In Vitro Assessment of Medical Device Toxicity: Interactions of Benzalkonium Chloride with Silicone-containing and P-hema-containing Hydrogel Contact Lens Materials Eye & Contact Lens. Jan, 2007 | Pubmed ID: 17224676 Lens-specific Expression of TGF-beta Induces Anterior Subcapsular Cataract Formation in the Absence of Smad3 Investigative Ophthalmology & Visual Science. Aug, 2006 | Pubmed ID: 16877415 The Lens of the Eye As a Focusing Device and Its Response to Stress Progress in Retinal and Eye Research. Mar, 2006 | Pubmed ID: 16330238 Confocal Laser Scanning Microscopy Imaging of Dynamic TMRE Movement in the Mitochondria of Epithelial and Superficial Cortical Fiber Cells of Bovine Lenses Molecular Vision. Jul, 2005 | Pubmed ID: 16052167 Inducing Form-deprivation Myopia in Fish Investigative Ophthalmology & Visual Science. May, 2005 | Pubmed ID: 15851585 Optical Quality of the Ocular Lens of the Sea Lamprey (Petromyzon Marinus) During the Mature and Transformer Periods of Life Journal of Comparative Physiology. A, Neuroethology, Sensory, Neural, and Behavioral Physiology. Jun, 2005 | Pubmed ID: 15818479 Surfactant and UV-B-induced Damage of the Cultured Bovine Lens Toxicology in Vitro : an International Journal Published in Association with BIBRA. Dec, 2004 | Pubmed ID: 15465651 Effect of Hyperbaric Oxygen on Guinea Pig Lens Optical Quality and on the Refractive State of the Eye Experimental Eye Research. May, 2004 | Pubmed ID: 15051474 Laser Scanning Analysis of Cold Cataract in Young and Old Bovine Lenses Molecular Vision. Mar, 2004 | Pubmed ID: 15014370 Through the Lens Clearly: Phylogeny and Development: the Proctor Lecture Investigative Ophthalmology & Visual Science. Mar, 2004 | Pubmed ID: 14985284 Epithelial Activity of Hexokinase and Glucose-6-phosphate Dehydrogenase in Cultured Bovine Lenses Recovering from Pharmaceutical-induced Optical Damage Molecular Vision. Nov, 2003 | Pubmed ID: 14627957 Hsp70 in Bovine Lenses During Temperature Stress Molecular Vision. Jul, 2003 | Pubmed ID: 12867890 Mechanisms of Ocular Toxicity Using the in Vitro Bovine Lens and Sodium Dodecyl Sulfate As a Chemical Model Toxicological Sciences : an Official Journal of the Society of Toxicology. May, 2003 | Pubmed ID: 12700424 Model of Retinal Surface Area and Neuron Distribution in the Avian Eye Journal of Neuroscience Methods. Feb, 2003 | Pubmed ID: 12581844 Quantification of Chick Lens AlphaA- and Delta-crystallins in Experimentally Induced Ametropia Molecular Vision. Dec, 2002 | Pubmed ID: 12500175 Evaluation of a Porcine Lens and Fluorescence Assay Approach for in Vitro Ocular Toxicological Investigations Alternatives to Laboratory Animals : ATLA. Sep-Oct, 2002 | Pubmed ID: 12405879 Ultrasound Biomicroscopy of the Anterior Segment of the Enucleated Chicken Eye During Accommodation Ophthalmic & Physiological Optics : the Journal of the British College of Ophthalmic Opticians (Optometrists). Sep, 2002 | Pubmed ID: 12358310 A Physiological Model to Measure Effects of Age on Lenticular Accommodation and Spherical Aberration in Chickens Investigative Ophthalmology & Visual Science. Jan, 2002 | Pubmed ID: 11773018 Organ Culture System for Assessing the Toxicity of Intraocular Treatment Excipients and Pharmaceuticals Jordan Rossy1, David J. McCanna2, Bernard Fresco3, Jacob G. Sivak1 1School of Optometry and Vision Science, University of Waterloo, 2Centre for Ocular Research & Education, School of Optometry and Vision Science, University of Waterloo, 3Tonomed Inc JoVE 63176 Biology
Organ Culture System for Assessing the Toxicity of Intraocular Treatment Excipients and Pharmaceuticals Jordan Rossy1, David J. McCanna2, Bernard Fresco3, Jacob G. Sivak1 1School of Optometry and Vision Science, University of Waterloo, 2Centre for Ocular Research & Education, School of Optometry and Vision Science, University of Waterloo, 3Tonomed Inc JoVE 63176 Biology