Jens Christian Schwamborn Luxembourg Centre for Systems Biomedicine University of Luxembourg Biography Publications Institution JoVE Articles Jens Christian Schwamborn has not added a biography. If you are Jens Christian Schwamborn and would like to personalize this page please email our Author Liaison for assistance. Publications Advanced Brain Organoids for Neuroinflammation Disease Modeling Neural Regeneration Research. Jan, 2024 | Pubmed ID: 37488859 Bone Tissue and the Nervous System: What Do They Have in Common? Cells. Dec, 2022 | Pubmed ID: 36611845 Generalising from Conventional Pipelines Using Deep Learning in High-throughput Screening Workflows Scientific Reports. Jul, 2022 | Pubmed ID: 35794231 PARK7/DJ-1 Promotes Pyruvate Dehydrogenase Activity and Maintains T Homeostasis During Ageing Nature Metabolism. May, 2022 | Pubmed ID: 35618940 Generation of Isogenic Control DJ-1-delP GC13 for the Genetic Parkinson's Disease-patient Derived IPSC Line DJ-1-delP (LCSBi008-A-1) Stem Cell Research. Jul, 2022 | Pubmed ID: 35617842 Midbrain Organoids Mimic Early Embryonic Neurodevelopment and Recapitulate LRRK2-p.Gly2019Ser-associated Gene Expression American Journal of Human Genetics. Feb, 2022 | Pubmed ID: 35077669 The Parkinson's-disease-associated Mutation LRRK2-G2019S Alters Dopaminergic Differentiation Dynamics Via NR2F1 Cell Reports. Oct, 2021 | Pubmed ID: 34686322 Transition Metal Dichalcogenides to Optimize the Performance of Peptide-imprinted Conductive Polymers As Electrochemical Sensors Mikrochimica Acta. May, 2021 | Pubmed ID: 34043106 Is Serine Racemase (SRR) a Second Hit Target for LRRK2-G2019S Induced Parkinson's Disease? Neural Regeneration Research. Mar, 2021 | Pubmed ID: 32985472 Reduced Astrocytic Reactivity in Human Brains and Midbrain Organoids with PRKN Mutations NPJ Parkinson's Disease. Nov, 2020 | Pubmed ID: 33298969 Single-cell Transcriptomics Reveals Multiple Neuronal Cell Types in Human Midbrain-specific Organoids Cell and Tissue Research. Dec, 2020 | Pubmed ID: 32737576 Machine Learning-assisted Neurotoxicity Prediction in Human Midbrain Organoids Parkinsonism & Related Disorders. Jun, 2020 | Pubmed ID: 32534431 Reproducible Generation of Human Midbrain Organoids for in Vitro Modeling of Parkinson's Disease Stem Cell Research. Jul, 2020 | Pubmed ID: 32534166 Midbrain Organoids: A New Tool to Investigate Parkinson's Disease Frontiers in Cell and Developmental Biology. 2020 | Pubmed ID: 32509785 Synapse Alterations Precede Neuronal Damage and Storage Pathology in a Human Cerebral Organoid Model of CLN3-juvenile Neuronal Ceroid Lipofuscinosis Acta Neuropathologica Communications. Dec, 2019 | Pubmed ID: 31888773 Impaired Serine Metabolism Complements LRRK2-G2019S Pathogenicity in PD Patients Parkinsonism & Related Disorders. Sep, 2019 | Pubmed ID: 31621607 Automated High-throughput High-content Autophagy and Mitophagy Analysis Platform Scientific Reports. Jul, 2019 | Pubmed ID: 31263238 Neural Stem Cells of Parkinson's Disease Patients Exhibit Aberrant Mitochondrial Morphology and Functionality Stem Cell Reports. May, 2019 | Pubmed ID: 30982740 A Complex of the Ubiquitin Ligase TRIM32 and the Deubiquitinase USP7 Balances the Level of C-Myc Ubiquitination and Thereby Determines Neural Stem Cell Fate Specification Cell Death and Differentiation. Mar, 2019 | Pubmed ID: 29899379 Millifluidic Culture Improves Human Midbrain Organoid Vitality and Differentiation Lab on a Chip. Oct, 2018 | Pubmed ID: 30204191 Parkinson's Disease-Associated Mutant LRRK2-Mediated Inhibition of MiRNA Activity is Antagonized by TRIM32 Molecular Neurobiology. Apr, 2018 | Pubmed ID: 28508149 Human Induced Pluripotent Stem Cell-derived Neuronal Progenitors Are a Suitable and Effective Drug Discovery Model for Neurological MtDNA Disorders Stem Cell Investigation. 2017 | Pubmed ID: 29359140 FACS-Assisted CRISPR-Cas9 Genome Editing Facilitates Parkinson's Disease Modeling Stem Cell Reports. Nov, 2017 | Pubmed ID: 28988985 CRISPR/Cas9 and PiggyBac-mediated Footprint-free LRRK2-G2019S Knock-in Reveals Neuronal Complexity Phenotypes and α-Synuclein Modulation in Dopaminergic Neurons Stem Cell Research. Oct, 2017 | Pubmed ID: 28826027 Derivation of Human Midbrain-Specific Organoids from Neuroepithelial Stem Cells Stem Cell Reports. May, 2017 | Pubmed ID: 28416282 Nurr1:RXRα Heterodimer Activation As Monotherapy for Parkinson's Disease Proceedings of the National Academy of Sciences of the United States of America. Apr, 2017 | Pubmed ID: 28348207 Expression of the Parkinson's Disease-Associated Gene Alpha-Synuclein is Regulated by the Neuronal Cell Fate Determinant TRIM32 Molecular Neurobiology. Aug, 2017 | Pubmed ID: 27339877 Rapid and Robust Generation of Long-term Self-renewing Human Neural Stem Cells with the Ability to Generate Mature Astroglia Scientific Reports. Nov, 2015 | Pubmed ID: 26541394 TRIM32 Modulates Pluripotency Entry and Exit by Directly Regulating Oct4 Stability Scientific Reports. Aug, 2015 | Pubmed ID: 26307407 The RNA Helicase DDX6 Regulates Cell-fate Specification in Neural Stem Cells Via MiRNAs Nucleic Acids Research. Mar, 2015 | Pubmed ID: 25722370 Induced Neural Stem Cells Achieve Long-term Survival and Functional Integration in the Adult Mouse Brain Stem Cell Reports. Sep, 2014 | Pubmed ID: 25241741 A Gut-on-a-Chip Model to Study the Gut Microbiome-Nervous System Axis Catherine Sedrani1, Gemma Gomez-Giro1, Léa Grandmougin1, Jens Christian Schwamborn1, Paul Wilmes1,2 1Luxembourg Centre for Systems Biomedicine, University of Luxembourg, 2Department of Life Sciences and Medicine, Faculty of Science, Technology and Medicine, University of Luxembourg JoVE 64483 Biology
A Gut-on-a-Chip Model to Study the Gut Microbiome-Nervous System Axis Catherine Sedrani1, Gemma Gomez-Giro1, Léa Grandmougin1, Jens Christian Schwamborn1, Paul Wilmes1,2 1Luxembourg Centre for Systems Biomedicine, University of Luxembourg, 2Department of Life Sciences and Medicine, Faculty of Science, Technology and Medicine, University of Luxembourg JoVE 64483 Biology
