Jesper Tegnér Unit of Computational Medicine, Center for Molecular Medicine, Department of Medicine Solna Karolinska Institutet, Karolinska University Hospital, & Science for Life Laboratory Biography Publications Institution JoVE Articles Jesper Tegnér has not added a biography. If you are Jesper Tegnér and would like to personalize this page please email our Author Liaison for assistance. Publications Corrigendum to "Methods of Information Theory and Algorithmic Complexity for Network Biology" [Semin. Cell Dev. Biol. 51 (2016) 32-43] Seminars in Cell & Developmental Biology. Dec, 2016 | Pubmed ID: 27979328 High-specificity Bioinformatics Framework for Epigenomic Profiling of Discordant Twins Reveals Specific and Shared Markers for ACPA and ACPA-positive Rheumatoid Arthritis Genome Medicine. Nov, 2016 | Pubmed ID: 27876072 Adaptive Input Data Transformation for Improved Network Reconstruction with Information Theoretic Algorithms Statistical Applications in Genetics and Molecular Biology. Dec, 2016 | Pubmed ID: 27875324 A Perspective on Bridging Scales and Design of Models Using Low-dimensional Manifolds and Data-driven Model Inference Philosophical Transactions. Series A, Mathematical, Physical, and Engineering Sciences. Nov, 2016 | Pubmed ID: 27698038 Systems Toxicology: Systematic Approach to Predict Toxicity Current Pharmaceutical Design. Oct, 2016 | Pubmed ID: 27697024 Human Cytomegalovirus May Promote Tumour Progression by Upregulating Arginase-2 Oncotarget. Jul, 2016 | Pubmed ID: 27363017 Conditional Disease Development Extracted from Longitudinal Health Care Cohort Data Using Layered Network Construction Scientific Reports. May, 2016 | Pubmed ID: 27211115 Proposals for Enhanced Health Risk Assessment and Stratification in an Integrated Care Scenario BMJ Open. Apr, 2016 | Pubmed ID: 27084274 Human Macrophages Induce CD4(+)Foxp3(+) Regulatory T Cells Via Binding and Re-release of TGF-β Immunology and Cell Biology. Sep, 2016 | Pubmed ID: 27075967 Comparative Analysis of Protocols to Induce Human CD4+Foxp3+ Regulatory T Cells by Combinations of IL-2, TGF-beta, Retinoic Acid, Rapamycin and Butyrate PloS One. 2016 | Pubmed ID: 26886923 Evaluating Network Inference Methods in Terms of Their Ability to Preserve the Topology and Complexity of Genetic Networks Seminars in Cell & Developmental Biology. Mar, 2016 | Pubmed ID: 26851626 Methods of Information Theory and Algorithmic Complexity for Network Biology Seminars in Cell & Developmental Biology. Mar, 2016 | Pubmed ID: 26802516 From Systems Understanding to Personalized Medicine: Lessons and Recommendations Based on a Multidisciplinary and Translational Analysis of COPD Methods in Molecular Biology (Clifton, N.J.). 2016 | Pubmed ID: 26677188 Normalization of Circulating MicroRNA Expression Data Obtained by Quantitative Real-time RT-PCR Briefings in Bioinformatics. Mar, 2016 | Pubmed ID: 26238539 In Search of 'Omics'-Based Biomarkers to Predict Risk of Frailty and Its Consequences in Older Individuals: The FRAILOMIC Initiative Gerontology. 2016 | Pubmed ID: 26227153 Bioinformatics Mining and Modeling Methods for the Identification of Disease Mechanisms in Neurodegenerative Disorders International Journal of Molecular Sciences. Dec, 2015 | Pubmed ID: 26690135 The Folate-coupled Enzyme MTHFD2 is a Nuclear Protein and Promotes Cell Proliferation Scientific Reports. Oct, 2015 | Pubmed ID: 26461067 IL-1β Promotes Th17 Differentiation by Inducing Alternative Splicing of FOXP3 Scientific Reports. Oct, 2015 | Pubmed ID: 26441347 Monozygotic Twins Discordant for Common Variable Immunodeficiency Reveal Impaired DNA Demethylation During Naïve-to-memory B-cell Transition Nature Communications. Jun, 2015 | Pubmed ID: 26081581 Laboratory Biomarkers and Frailty: Presentation of the FRAILOMIC Initiative Clinical Chemistry and Laboratory Medicine. Sep, 2015 | Pubmed ID: 25993734 VEGF-B Promotes Cancer Metastasis Through a VEGF-A-independent Mechanism and Serves As a Marker of Poor Prognosis for Cancer Patients Proceedings of the National Academy of Sciences of the United States of America. Jun, 2015 | Pubmed ID: 25991856 Signaling Networks in MS: a Systems-based Approach to Developing New Pharmacological Therapies Multiple Sclerosis (Houndmills, Basingstoke, England). Feb, 2015 | Pubmed ID: 25112814 An Integrative Analysis Reveals Coordinated Reprogramming of the Epigenome and the Transcriptome in Human Skeletal Muscle After Training Epigenetics. Dec, 2014 | Pubmed ID: 25484259 Chronic Obstructive Pulmonary Disease Heterogeneity: Challenges for Health Risk Assessment, Stratification and Management Journal of Translational Medicine. Nov, 2014 | Pubmed ID: 25472887 Synergy-COPD: a Systems Approach for Understanding and Managing Chronic Diseases Journal of Translational Medicine. Nov, 2014 | Pubmed ID: 25472826 Predictive Medicine: Outcomes, Challenges and Opportunities in the Synergy-COPD Project Journal of Translational Medicine. Nov, 2014 | Pubmed ID: 25472742 Biomedical Research in a Digital Health Framework Journal of Translational Medicine. Nov, 2014 | Pubmed ID: 25472554 Systems Medicine: from Molecular Features and Models to the Clinic in COPD Journal of Translational Medicine. Nov, 2014 | Pubmed ID: 25471042 Oxygen Pathway Modeling Estimates High Reactive Oxygen Species Production Above the Highest Permanent Human Habitation PloS One. 2014 | Pubmed ID: 25375931 Accelerating Translational Research by Clinically Driven Development of an Informatics Platform--a Case Study PloS One. 2014 | Pubmed ID: 25203647 Non-HLA Genes PTPN22, CDK6 and PADI4 Are Associated with Specific Autoantibodies in HLA-defined Subgroups of Rheumatoid Arthritis Arthritis Research & Therapy. Aug, 2014 | Pubmed ID: 25138370 STATegra EMS: an Experiment Management System for Complex Next-generation Omics Experiments BMC Systems Biology. 2014 | Pubmed ID: 25033091 Data Integration in the Era of Omics: Current and Future Challenges BMC Systems Biology. 2014 | Pubmed ID: 25032990 A Vision and Strategy for the Virtual Physiological Human: 2012 Update Interface Focus. Apr, 2013 | Pubmed ID: 24427536 Implementation of the CDC Translational Informatics Platform - from Genetic Variants to the National Swedish Rheumatology Quality Register Journal of Translational Medicine. 2013 | Pubmed ID: 23548156 An Evaluation of Analysis Pipelines for DNA Methylation Profiling Using the Illumina HumanMethylation450 BeadChip Platform Epigenetics. Mar, 2013 | Pubmed ID: 23422812 Pediatric Systems Medicine: Evaluating Needs and Opportunities Using Congenital Heart Block As a Case Study Pediatric Research. Apr, 2013 | Pubmed ID: 23370412 Identification of Novel Markers in Rheumatoid Arthritis Through Integrated Analysis of DNA Methylation and MicroRNA Expression Journal of Autoimmunity. Mar, 2013 | Pubmed ID: 23306098 A Beta-mixture Quantile Normalization Method for Correcting Probe Design Bias in Illumina Infinium 450 K DNA Methylation Data Bioinformatics (Oxford, England). Jan, 2013 | Pubmed ID: 23175756 Pre-B Cell to Macrophage Transdifferentiation Without Significant Promoter DNA Methylation Changes Nucleic Acids Research. Mar, 2012 | Pubmed ID: 22086955 Workflow for Generating Competing Hypothesis from Models with Parameter Uncertainty Interface Focus. Jun, 2011 | Pubmed ID: 22670212 Decoding Complex Biological Networks - Tracing Essential and Modulatory Parameters in Complex and Simplified Models of the Cell Cycle BMC Systems Biology. Aug, 2011 | Pubmed ID: 21819620 Systems Medicine and Integrated Care to Combat Chronic Noncommunicable Diseases Genome Medicine. 2011 | Pubmed ID: 21745417 ParkDB: a Parkinson's Disease Gene Expression Database Database : the Journal of Biological Databases and Curation. 2011 | Pubmed ID: 21593080 Carotid Plaque Age is a Feature of Plaque Stability Inversely Related to Levels of Plasma Insulin PloS One. 2011 | Pubmed ID: 21490968 Blood Levels of Dual-specificity Phosphatase-1 Independently Predict Risk for Post-operative Morbidities Causing Prolonged Hospitalization After Coronary Artery Bypass Grafting International Journal of Molecular Medicine. Jun, 2011 | Pubmed ID: 21424112 A Vision and Strategy for the Virtual Physiological Human in 2010 and Beyond Philosophical Transactions. Series A, Mathematical, Physical, and Engineering Sciences. Jun, 2010 | Pubmed ID: 20439264 An Atlas of Combinatorial Transcriptional Regulation in Mouse and Man Cell. Mar, 2010 | Pubmed ID: 20211142 DGAT1 Participates in the Effect of HNF4A on Hepatic Secretion of Triglyceride-rich Lipoproteins Arteriosclerosis, Thrombosis, and Vascular Biology. May, 2010 | Pubmed ID: 20167659 Multi-organ Expression Profiling Uncovers a Gene Module in Coronary Artery Disease Involving Transendothelial Migration of Leukocytes and LIM Domain Binding 2: the Stockholm Atherosclerosis Gene Expression (STAGE) Study PLoS Genetics. Dec, 2009 | Pubmed ID: 19997623 Bridging the Gap Between Systems Biology and Medicine Genome Medicine. Sep, 2009 | Pubmed ID: 19754960 Can Modular Analysis Identify Disease-associated Candidate Genes for Therapeutics? Journal of Biology. 2009 | Pubmed ID: 19519937 Computational Disease Modeling - Fact or Fiction? BMC Systems Biology. Jun, 2009 | Pubmed ID: 19497118 The Transcriptional Network That Controls Growth Arrest and Differentiation in a Human Myeloid Leukemia Cell Line Nature Genetics. May, 2009 | Pubmed ID: 19377474 Reverse Engineering of Gene Networks with LASSO and Nonlinear Basis Functions Annals of the New York Academy of Sciences. Mar, 2009 | Pubmed ID: 19348648 Mechanism for Top-down Control of Working Memory Capacity Proceedings of the National Academy of Sciences of the United States of America. Apr, 2009 | Pubmed ID: 19339493 On Reliable Discovery of Molecular Signatures BMC Bioinformatics. Jan, 2009 | Pubmed ID: 19178740 Evidence of Highly Regulated Genes (in-Hubs) in Gene Networks of Saccharomyces Cerevisiae Bioinformatics and Biology Insights. Jul, 2008 | Pubmed ID: 19812784 ApoB100-LDL Acts As a Metabolic Signal from Liver to Peripheral Fat Causing Inhibition of Lipolysis in Adipocytes PloS One. 2008 | Pubmed ID: 19020660 Transcriptional Profiling Uncovers a Network of Cholesterol-responsive Atherosclerosis Target Genes PLoS Genetics. Mar, 2008 | Pubmed ID: 18369455 Electrotonic Signals Along Intracellular Membranes May Interconnect Dendritic Spines and Nucleus PLoS Computational Biology. Mar, 2008 | Pubmed ID: 18369427 Integrated Approaches to Uncovering Transcription Regulatory Networks in Mammalian Cells Genomics. Mar, 2008 | Pubmed ID: 18191937 Fronto-parietal Connection Asymmetry Regulates Working Memory Distractibility Journal of Integrative Neuroscience. Dec, 2007 | Pubmed ID: 18181269 [Systems Biology Makes Detailed Understanding of Complex Diseases Possible. Arteriosclerosis is an Example] Lakartidningen. Oct 17-23, 2007 | Pubmed ID: 17985711 Human C-reactive Protein Slows Atherosclerosis Development in a Mouse Model with Human-like Hypercholesterolemia Proceedings of the National Academy of Sciences of the United States of America. Aug, 2007 | Pubmed ID: 17702862 Detecting Multivariate Differentially Expressed Genes BMC Bioinformatics. May, 2007 | Pubmed ID: 17490475 Stronger Synaptic Connectivity As a Mechanism Behind Development of Working Memory-related Brain Activity During Childhood Journal of Cognitive Neuroscience. May, 2007 | Pubmed ID: 17488202 Neuronal Firing Rates Account for Distractor Effects on Mnemonic Accuracy in a Visuo-spatial Working Memory Task Biological Cybernetics. Apr, 2007 | Pubmed ID: 17260154 Thematic Review Series: Systems Biology Approaches to Metabolic and Cardiovascular Disorders. Multi-organ Whole-genome Measurements and Reverse Engineering to Uncover Gene Networks Underlying Complex Traits Journal of Lipid Research. Feb, 2007 | Pubmed ID: 17142807 Perturbations to Uncover Gene Networks Trends in Genetics : TIG. Jan, 2007 | Pubmed ID: 17098324 Brain Activity Related to Working Memory and Distraction in Children and Adults Cerebral Cortex (New York, N.Y. : 1991). May, 2007 | Pubmed ID: 16801377 Systems Biology of Innate Immunity Cellular Immunology. Dec, 2006 | Pubmed ID: 17433274 Transcriptional Network Dynamics in Macrophage Activation Genomics. Aug, 2006 | Pubmed ID: 16698233 Detection of Compound Mode of Action by Computational Integration of Whole-genome Measurements and Genetic Perturbations BMC Bioinformatics. Feb, 2006 | Pubmed ID: 16451737 Systems Biology is Taking Off Genome Research. Nov, 2003 | Pubmed ID: 14597651 Temporally Irregular Mnemonic Persistent Activity in Prefrontal Neurons of Monkeys During a Delayed Response Task Journal of Neurophysiology. Nov, 2003 | Pubmed ID: 12773500 Reverse Engineering Gene Networks: Integrating Genetic Perturbations with Dynamical Modeling Proceedings of the National Academy of Sciences of the United States of America. May, 2003 | Pubmed ID: 12730377 The Dynamical Stability of Reverberatory Neural Circuits Biological Cybernetics. Dec, 2002 | Pubmed ID: 12461636 Spike-timing-dependent Plasticity: Common Themes and Divergent Vistas Biological Cybernetics. Dec, 2002 | Pubmed ID: 12461634 Reverse Engineering Gene Networks Using Singular Value Decomposition and Robust Regression Proceedings of the National Academy of Sciences of the United States of America. Apr, 2002 | Pubmed ID: 11983907 التمايز في المختبر من خلايا CD4 الإنسان + FOXP3 + المستحثة تنظيم الخلايا التائية (iTregs) من خلايا CD4 + T السذاجة باستخدام بروتوكول تحتوي على TGF-β- Angelika Schmidt1, Szabolcs Éliás*1, Rubin N. Joshi*1, Jesper Tegnér1 1Unit of Computational Medicine, Center for Molecular Medicine, Department of Medicine Solna, Karolinska Institutet, Karolinska University Hospital, & Science for Life Laboratory JoVE 55015 Immunology and Infection
التمايز في المختبر من خلايا CD4 الإنسان + FOXP3 + المستحثة تنظيم الخلايا التائية (iTregs) من خلايا CD4 + T السذاجة باستخدام بروتوكول تحتوي على TGF-β- Angelika Schmidt1, Szabolcs Éliás*1, Rubin N. Joshi*1, Jesper Tegnér1 1Unit of Computational Medicine, Center for Molecular Medicine, Department of Medicine Solna, Karolinska Institutet, Karolinska University Hospital, & Science for Life Laboratory JoVE 55015 Immunology and Infection
