Julie K. Andersen Buck Institute for Research on Aging Biography Publications Institution JoVE Articles Julie K. Andersen has not added a biography. If you are Julie K. Andersen and would like to personalize this page please email our Author Liaison for assistance. Publications Senescence As an Amyloid Cascade: The Amyloid Senescence Hypothesis Frontiers in Cellular Neuroscience. 2020 | Pubmed ID: 32508595 Dysregulated Iron Metabolism in C. Elegans Catp-6/ATP13A2 Mutant Impairs Mitochondrial Function Neurobiology of Disease. 06, 2020 | Pubmed ID: 32032734 Targeting Kinases in Parkinson's Disease: A Mechanism Shared by LRRK2, Neurotrophins, Exenatide, Urate, Nilotinib and Lithium Journal of the Neurological Sciences. Jul, 2019 | Pubmed ID: 31129265 Gedunin Inhibits Oligomeric Aβ-Induced Microglia Activation Via Modulation of Nrf2-NF-κB Signaling Molecular Neurobiology. Nov, 2019 | Pubmed ID: 31127528 Unknown Fates of (brain) Oxidation or UFO: Close Encounters with Neuronal Senescence Free Radical Biology & Medicine. 04, 2019 | Pubmed ID: 30639615 Screening Method for Identifying Toxicants Capable of Inducing Astrocyte Senescence Toxicological Sciences : an Official Journal of the Society of Toxicology. 11, 2018 | Pubmed ID: 30010981 An Inducible MAO-B Mouse Model of Parkinson's Disease: a Tool Towards Better Understanding Basic Disease Mechanisms and Developing Novel Therapeutics Journal of Neural Transmission (Vienna, Austria : 1996). 11, 2018 | Pubmed ID: 29713806 Hsp90 Co-chaperone P23 Contributes to Dopaminergic Mitochondrial Stress Via Stabilization of PHD2: Implications for Parkinson's Disease Neurotoxicology. 03, 2018 | Pubmed ID: 29471019 Cellular Senescence Is Induced by the Environmental Neurotoxin Paraquat and Contributes to Neuropathology Linked to Parkinson's Disease Cell Reports. 01, 2018 | Pubmed ID: 29386135 MTORC1 Activation During Repeated Regeneration Impairs Somatic Stem Cell Maintenance Cell Stem Cell. Dec, 2017 | Pubmed ID: 29220665 A Novel Iron (II) Preferring Dopamine Agonist Chelator D-607 Significantly Suppresses α-syn- and MPTP-induced Toxicities In vivo Neuropharmacology. Sep, 2017 | Pubmed ID: 28533164 Anti-Inflammatory and Neuroprotective Role of Natural Product Securinine in Activated Glial Cells: Implications for Parkinson's Disease Mediators of Inflammation. 2017 | Pubmed ID: 28473732 Detrimental Effects of Oxidative Losses in Parkin Activity in a Model of Sporadic Parkinson's Disease Are Attenuated by Restoration of PGC1alpha Neurobiology of Disease. 09, 2016 | Pubmed ID: 27185595 Regulation of ATP13A2 Via PHD2-HIF1α Signaling Is Critical for Cellular Iron Homeostasis: Implications for Parkinson's Disease The Journal of Neuroscience : the Official Journal of the Society for Neuroscience. Jan, 2016 | Pubmed ID: 26818499 Mitochondrial Quality Control Via the PGC1α-TFEB Signaling Pathway Is Compromised by Parkin Q311X Mutation But Independently Restored by Rapamycin The Journal of Neuroscience : the Official Journal of the Society for Neuroscience. Sep, 2015 | Pubmed ID: 26377470 The Combination of Lithium and L-Dopa/Carbidopa Reduces MPTP-induced Abnormal Involuntary Movements (AIMs) Via Calpain-1 Inhibition in a Mouse Model: Relevance for Parkinson׳s Disease Therapy Brain Research. Oct, 2015 | Pubmed ID: 26119916 Cellular Senescence and the Aging Brain Experimental Gerontology. Aug, 2015 | Pubmed ID: 25281806 Iron Promotes Protein Insolubility and Aging in C. Elegans Aging. Nov, 2014 | Pubmed ID: 25554795 Lithium Prevents Parkinsonian Behavioral and Striatal Phenotypes in an Aged Parkin Mutant Transgenic Mouse Model Brain Research. Dec, 2014 | Pubmed ID: 25452026 Manganese Disturbs Metal and Protein Homeostasis in Caenorhabditis Elegans Metallomics : Integrated Biometal Science. Oct, 2014 | Pubmed ID: 25057947 Pharmacological Prolyl Hydroxylase Domain Inhibition As a Therapeutic Target for Parkinson's Disease CNS & Neurological Disorders Drug Targets. Feb, 2014 | Pubmed ID: 24040809 A DNA Synthesis Inhibitor is Protective Against Proteotoxic Stressors Via Modulation of Fertility Pathways in Caenorhabditis Elegans Aging. Oct, 2013 | Pubmed ID: 24123581 Reactive Oxygen and Nitrogen Species in Neurodegeneration Free Radical Biology & Medicine. Sep, 2013 | Pubmed ID: 23876468 Environmental Stress, Ageing and Glial Cell Senescence: a Novel Mechanistic Link to Parkinson's Disease? Journal of Internal Medicine. May, 2013 | Pubmed ID: 23600398 Age-related Behavioral Phenotype of an Astrocytic Monoamine Oxidase-B Transgenic Mouse Model of Parkinson's Disease PloS One. 2013 | Pubmed ID: 23326597 Anti-inflammatory Role of the Isoflavone Diadzein in Lipopolysaccharide-stimulated Microglia: Implications for Parkinson's Disease Neurotoxicity Research. Feb, 2013 | Pubmed ID: 22573480 A Possible Novel Anti-inflammatory Mechanism for the Pharmacological Prolyl Hydroxylase Inhibitor 3,4-dihydroxybenzoate: Implications for Use As a Therapeutic for Parkinson's Disease Parkinson's Disease. 2012 | Pubmed ID: 22666629 Cellular Senescence: a Link Between Cancer and Age-related Degenerative Disease? Seminars in Cancer Biology. Dec, 2011 | Pubmed ID: 21925603 Lithium Protects Against Oxidative Stress-mediated Cell Death in α-synuclein-overexpressing in Vitro and in Vivo Models of Parkinson's Disease Journal of Neuroscience Research. Oct, 2011 | Pubmed ID: 21710541 Intrinsic Bioenergetic Properties and Stress Sensitivity of Dopaminergic Synaptosomes The Journal of Neuroscience : the Official Journal of the Society for Neuroscience. Mar, 2011 | Pubmed ID: 21430153 Iron Dysregulation and Parkinson's Disease Journal of Alzheimer's Disease : JAD. Dec, 2004 | Pubmed ID: 15665414 Oxidative Stress in Neurodegeneration: Cause or Consequence? Nature Medicine. Jul, 2004 | Pubmed ID: 15298006 Paraquat and Iron Exposure As Possible Synergistic Environmental Risk Factors in Parkinson's Disease Neurotoxicity Research. 2003 | Pubmed ID: 14715449 Defects in Dynein Linked to Motor Neuron Degeneration in Mice Science of Aging Knowledge Environment : SAGE KE. May, 2003 | Pubmed ID: 12844533 The Hunt for a Cure for Parkinson's Disease Science of Aging Knowledge Environment : SAGE KE. Oct, 2001 | Pubmed ID: 14602952 Genetically Engineered Mice and Their Use in Aging Research Molecular Biotechnology. Sep, 2001 | Pubmed ID: 11697220 Quantification of Insoluble Protein Aggregation in Caenorhabditis elegans during Aging with a Novel Data-Independent Acquisition Workflow Xueshu Xie*1, Manish Chamoli*1, Dipa Bhaumik1, Renuka Sivapatham1, Suzanne Angeli1, Julie K. Andersen1, Gordon J. Lithgow1, Birgit Schilling1 1Buck Institute for Research on Aging JoVE 61366 Biology
Quantification of Insoluble Protein Aggregation in Caenorhabditis elegans during Aging with a Novel Data-Independent Acquisition Workflow Xueshu Xie*1, Manish Chamoli*1, Dipa Bhaumik1, Renuka Sivapatham1, Suzanne Angeli1, Julie K. Andersen1, Gordon J. Lithgow1, Birgit Schilling1 1Buck Institute for Research on Aging JoVE 61366 Biology