Kevin W. Plaxco

Department of Chemistry and Biochemistry, University Of California Santa Barbara

Affiliated withUniversity Of California Santa Barbara University of California at Santa Barbara

Research Area

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JoVE Journal Publications

ArticleTotal : 2	Year
Publication title Cited by 21	2011
Publication title Cited by 1	2023

Other Publications

Article	Year
Equilibrium collapse and the kinetic 'foldability' of proteins. Biochemistry\| PubMed ID: 11772031	2002
Residues participating in the protein folding nucleus do not exhibit preferential evolutionary conservation. Journal of molecular biology\| PubMed ID: 11851333	2002
How the folding rate constant of simple, single-domain proteins depends on the number of native contacts. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 11904417	2002
High-efficiency fluorescence quenching of conjugated polymers by proteins. Journal of the American Chemical Society\| PubMed ID: 12010029	2002
The backbone conformational entropy of protein folding: experimental measures from atomic force microscopy. Journal of molecular biology\| PubMed ID: 12225756	2002
Toward a taxonomy of the denatured state: small angle scattering studies of unfolded proteins. Advances in protein chemistry\| PubMed ID: 12418105	2002
The topomer search model: A simple, quantitative theory of two-state protein folding kinetics. Protein science : a publication of the Protein Society\| PubMed ID: 12493824	2003
Cooperativity, smooth energy landscapes and the origins of topology-dependent protein folding rates. Journal of molecular biology\| PubMed ID: 12547206	2003
Beyond superquenching: hyper-efficient energy transfer from conjugated polymers to gold nanoparticles. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 12750470	2003
Comparison of the folding processes of distantly related proteins. Importance of hydrophobic content in folding. Journal of molecular biology\| PubMed ID: 12842473	2003
NMR and temperature-jump measurements of de novo designed proteins demonstrate rapid folding in the absence of explicit selection for kinetics. Journal of molecular biology\| PubMed ID: 12850149	2003
Electrochemical interrogation of conformational changes as a reagentless method for the sequence-specific detection of DNA. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 12867594	2003
Contact order revisited: influence of protein size on the folding rate. Protein science : a publication of the Protein Society\| PubMed ID: 12931003	2003
Terahertz circular dichroism spectroscopy: a potential approach to the in situ detection of life's metabolic and genetic machinery. Astrobiology\| PubMed ID: 14678660	2003
Using protein folding rates to test protein folding theories. Annual review of biochemistry\| PubMed ID: 15189160	2004
Random-coil behavior and the dimensions of chemically unfolded proteins. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 15314214	2004
Apparent Debye-Huckel electrostatic effects in the folding of a simple, single domain protein. Biochemistry\| PubMed ID: 15667218	2005
Protein folding: defining a "standard" set of experimental conditions and a preliminary kinetic data set of two-state proteins. Protein science : a publication of the Protein Society\| PubMed ID: 15689503	2005
The protein folding transition state: what are Phi-values really telling us? Protein and peptide letters\| PubMed ID: 15723637	2005
Biosensors based on binding-modulated donor-acceptor distances. Trends in biotechnology\| PubMed ID: 15780710	2005
Label-free electronic detection of thrombin in blood serum by using an aptamer-based sensor. Angewandte Chemie (International ed. in English)\| PubMed ID: 16044476	2005
Engineering a signal transduction mechanism for protein-based biosensors. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 16046542	2005
Site-specific dimensions across a highly denatured protein; a single molecule study. Journal of molecular biology\| PubMed ID: 16095607	2005
Is there or isn't there? The case for (and against) residual structure in chemically denatured proteins. Critical reviews in biochemistry and molecular biology\| PubMed ID: 16126485	2005
Experimental investigation of the frequency and substitution dependence of negative phi-values in two-state proteins. Biochemistry\| PubMed ID: 16142914	2005
A reagentless signal-on architecture for electronic, aptamer-based sensors via target-induced strand displacement. Journal of the American Chemical Society\| PubMed ID: 16366535	2005
Absorption spectra of liquid water and aqueous buffers between 0.3 and 3.72 THz. The Journal of chemical physics\| PubMed ID: 16438614	2006
Differential labeling of closely spaced biosensor electrodes via electrochemical lithography. Langmuir : the ACS journal of surfaces and colloids\| PubMed ID: 16460130	2006
On the precision of experimentally determined protein folding rates and phi-values. Protein science : a publication of the Protein Society\| PubMed ID: 16501226	2006
An electronic, aptamer-based small-molecule sensor for the rapid, label-free detection of cocaine in adulterated samples and biological fluids. Journal of the American Chemical Society\| PubMed ID: 16522082	2006
Rapid, sequence-specific detection of unpurified PCR amplicons via a reusable, electrochemical sensor. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 16537478	2006
Probing the collective vibrational dynamics of a protein in liquid water by terahertz absorption spectroscopy. Protein science : a publication of the Protein Society\| PubMed ID: 16641490	2006
Cooperativity and the origins of rapid, single-exponential kinetics in protein folding. Protein science : a publication of the Protein Society\| PubMed ID: 16815915	2006
Sequence-specific, electronic detection of oligonucleotides in blood, soil, and foodstuffs with the reagentless, reusable E-DNA sensor. Analytical chemistry\| PubMed ID: 16906710	2006
Methods for the accurate estimation of confidence intervals on protein folding phi-values. Protein science : a publication of the Protein Society\| PubMed ID: 17008714	2006
Excimer-based peptide beacons: a convenient experimental approach for monitoring polypeptide-protein and polypeptide-oligonucleotide interactions. Journal of the American Chemical Society\| PubMed ID: 17061871	2006
Single-step electronic detection of femtomolar DNA by target-induced strand displacement in an electrode-bound duplex. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 17065320	2006
Collective dynamics of lysozyme in water: terahertz absorption spectroscopy and comparison with theory. The journal of physical chemistry. B\| PubMed ID: 17125398	2006
Comparison of the signaling and stability of electrochemical DNA sensors fabricated from 6- or 11-carbon self-assembled monolayers. Langmuir : the ACS journal of surfaces and colloids\| PubMed ID: 17129062	2006
Aptamer-based electrochemical detection of picomolar platelet-derived growth factor directly in blood serum. Analytical chemistry\| PubMed ID: 17194144	2007
Electrochemical detection of parts-per-billion lead via an electrode-bound DNAzyme assembly. Journal of the American Chemical Society\| PubMed ID: 17212391	2007
Increasing the resolution of single pair fluorescence resonance energy transfer measurements in solution via molecular cytometry. Analytical chemistry\| PubMed ID: 17385843	2007
Influence of local and residual structures on the scaling behavior and dimensions of unfolded proteins. Biopolymers\| PubMed ID: 17450572	2007
Peptide beacons: a new design for polypeptide-based optical biosensors. Bioconjugate chemistry\| PubMed ID: 17461545	2007
Effect of molecular crowding on the response of an electrochemical DNA sensor. Langmuir : the ACS journal of surfaces and colloids\| PubMed ID: 17488132	2007
Label-free electrochemical detection of DNA in blood serum via target-induced resolution of an electrode-bound DNA pseudoknot. Journal of the American Chemical Society\| PubMed ID: 17850085	2007
Linear, redox modified DNA probes as electrochemical DNA sensors. Chemical communications (Cambridge, England)\| PubMed ID: 17851622	2007
Preparation of electrode-immobilized, redox-modified oligonucleotides for electrochemical DNA and aptamer-based sensing. Nature protocols\| PubMed ID: 18007622	2007
Microfluidic device architecture for electrochemical patterning and detection of multiple DNA sequences. Langmuir : the ACS journal of surfaces and colloids\| PubMed ID: 18181654	2008
Chimeric peptide beacons: a direct polypeptide analog of DNA molecular beacons. Chemical communications (Cambridge, England)\| PubMed ID: 18361352	2007
Some recommendations for the practitioner to improve the precision of experimentally determined protein folding rates and phi values. Proteins\| PubMed ID: 18655053	2009
Optimization of electrochemical aptamer-based sensors via optimization of probe packing density and surface chemistry. Langmuir : the ACS journal of surfaces and colloids\| PubMed ID: 18690727	2008
Optimization of a reusable, DNA pseudoknot-based electrochemical sensor for sequence-specific DNA detection in blood serum. Analytical chemistry\| PubMed ID: 19093760	2009
Improving the stability and sensing of electrochemical biosensors by employing trithiol-anchoring groups in a six-carbon self-assembled monolayer. Analytical chemistry\| PubMed ID: 19133790	2009
Protein complexes: the evolution of symmetry. Current biology : CB\| PubMed ID: 19138586	2009
Beyond molecular beacons: optical sensors based on the binding-induced folding of proteins and polypeptides. Chemistry (Weinheim an der Bergstrasse, Germany)\| PubMed ID: 19191230	2009
Reagentless, electrochemical approach for the specific detection of double- and single-stranded DNA binding proteins. Analytical chemistry\| PubMed ID: 19199570	2009
Effects of probe length, probe geometry, and redox-tag placement on the performance of the electrochemical E-DNA sensor. Analytical chemistry\| PubMed ID: 19215066	2009
Continuous, real-time monitoring of cocaine in undiluted blood serum via a microfluidic, electrochemical aptamer-based sensor. Journal of the American Chemical Society\| PubMed ID: 19271708	2009
Surface chemistry effects on the performance of an electrochemical DNA sensor. Bioelectrochemistry (Amsterdam, Netherlands)\| PubMed ID: 19362061	2009
An electrochemical sensor for the detection of protein-small molecule interactions directly in serum and other complex matrices. Journal of the American Chemical Society\| PubMed ID: 19413316	2009
High specificity, electrochemical sandwich assays based on single aptamer sequences and suitable for the direct detection of small-molecule targets in blood and other complex matrices. Journal of the American Chemical Society\| PubMed ID: 19419171	2009
Fluorescence detection of single-nucleotide polymorphisms with a single, self-complementary, triple-stem DNA probe. Angewandte Chemie (International ed. in English)\| PubMed ID: 19431180	2009
The length and viscosity dependence of end-to-end collision rates in single-stranded DNA. Biophysical journal\| PubMed ID: 19580758	2009
Thermodynamic basis for the optimization of binding-induced biomolecular switches and structure-switching biosensors. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 19666496	2009
Measuring distances within unfolded biopolymers using fluorescence resonance energy transfer: The effect of polymer chain dynamics on the observed fluorescence resonance energy transfer effi... The Journal of chemical physics\| PubMed ID: 19725638	2009
Non-sequence-specific interactions can account for the compaction of proteins unfolded under "native" conditions. Journal of molecular biology\| PubMed ID: 19751743	2009
The rate of intramolecular loop formation in DNA and polypeptides: the absence of the diffusion-controlled limit and fractional power-law viscosity dependence. The journal of physical chemistry. B\| PubMed ID: 19780594	2009
An electrochemical sensor for single nucleotide polymorphism detection in serum based on a triple-stem DNA probe. Journal of the American Chemical Society\| PubMed ID: 19807078	2009
Comparing the properties of electrochemical-based DNA sensors employing different redox tags. Analytical chemistry\| PubMed ID: 19810694	2009
A general electrochemical method for label-free screening of protein-small molecule interactions. Chemical communications (Cambridge, England)\| PubMed ID: 19826675	2009
Exploiting binding-induced changes in probe flexibility for the optimization of electrochemical biosensors. Analytical chemistry\| PubMed ID: 20000457	2010
On the binding of cationic, water-soluble conjugated polymers to DNA: electrostatic and hydrophobic interactions. Journal of the American Chemical Society\| PubMed ID: 20058862	2010
Sensitive and selective amplified fluorescence DNA detection based on exonuclease III-aided target recycling. Journal of the American Chemical Society\| PubMed ID: 20092337	2010
Tracking a molecular motor with a nanoscale optical encoder. Nano letters\| PubMed ID: 20121107	2010
Re-engineering aptamers to support reagentless, self-reporting electrochemical sensors. The Analyst\| PubMed ID: 20174715	2010
Quantitative, reagentless, single-step electrochemical detection of anti-DNA antibodies directly in blood serum. Chemical communications (Cambridge, England)\| PubMed ID: 20177635	2010
Folding-based electrochemical biosensors: the case for responsive nucleic acid architectures. Accounts of chemical research\| PubMed ID: 20201486	2010
On the Signaling of Electrochemical Aptamer-Based Sensors: Collision- and Folding-Based Mechanisms. Electroanalysis\| PubMed ID: 20436787	2009
Engineering New Aptamer Geometries for Electrochemical Aptamer-Based Sensors. Proceedings - Society of Photo-Optical Instrumentation Engineers\| PubMed ID: 20436792	2009
Label-free, dual-analyte electrochemical biosensors: a new class of molecular-electronic logic gates. Journal of the American Chemical Society\| PubMed ID: 20527878	2010
Colorimetric detection of DNA, small molecules, proteins, and ions using unmodified gold nanoparticles and conjugated polyelectrolytes. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 20534499	2010
Structure-switching biosensors: inspired by Nature. Current opinion in structural biology\| PubMed ID: 20627702	2010
Reagentless measurement of aminoglycoside antibiotics in blood serum via an electrochemical, ribonucleic acid aptamer-based biosensor. Analytical chemistry\| PubMed ID: 20687587	2010
Investigation of an anomalously accelerating substitution in the folding of a prototypical two-state protein. Journal of molecular biology\| PubMed ID: 20816985	2010
Biomimetic glass nanopores employing aptamer gates responsive to a small molecule. Chemical communications (Cambridge, England)\| PubMed ID: 20865192	2010
An electrochemical supersandwich assay for sensitive and selective DNA detection in complex matrices. Journal of the American Chemical Society\| PubMed ID: 20873767	2010
Detection of telomerase activity in high concentration of cell lysates using primer-modified gold nanoparticles. Journal of the American Chemical Society\| PubMed ID: 20932008	2010
Using Triplex-Forming Oligonucleotide Probes for the Reagentless, Electrochemical Detection of Double-Stranded DNA. Analytical chemistry\| PubMed ID: 20936782	2010
The art of writing science. Protein science : a publication of the Protein Society\| PubMed ID: 20954234	2010
A mechanistic study of electron transfer from the distal termini of electrode-bound, single-stranded DNAs. Journal of the American Chemical Society\| PubMed ID: 20964337	2010
Switch-based biosensors: a new approach towards real-time, in vivo molecular detection. Trends in biotechnology\| PubMed ID: 21106266	2011
Universality in the timescales of internal loop formation in unfolded proteins and single-stranded oligonucleotides. Biophysical journal\| PubMed ID: 21156138	2010
Dielectric spectroscopy of proteins as a quantitative experimental test of computational models of their low-frequency harmonic motions. Journal of the American Chemical Society\| PubMed ID: 21542634	2011
Transcription factor beacons for the quantitative detection of DNA binding activity. Journal of the American Chemical Society\| PubMed ID: 21815647	2011
Probe accessibility effects on the performance of electrochemical biosensors employing DNA monolayers. Analytical and bioanalytical chemistry\| PubMed ID: 21928081	2012
CheapStat: an open-source, "do-it-yourself" potentiostat for analytical and educational applications. PloS one\| PubMed ID: 21931613	2011
Electrochemical biosensors employing an internal electrode attachment site and achieving reversible, high gain detection of specific nucleic acid sequences. Analytical chemistry\| PubMed ID: 21975121	2011
Polarity-switching electrochemical sensor for specific detection of single-nucleotide mismatches. Angewandte Chemie (International ed. in English)\| PubMed ID: 21976312	2011
High-precision, in vitro validation of the sequestration mechanism for generating ultrasensitive dose-response curves in regulatory networks. PLoS computational biology\| PubMed ID: 21998566	2011
Two-step, PCR-free telomerase detection by using exonuclease III-aided target recycling. Chembiochem : a European journal of chemical biology\| PubMed ID: 22125097	2011
Wash-free, Electrochemical Platform for the Quantitative, Multiplexed Detection of Specific Antibodies. Analytical chemistry\| PubMed ID: 22145706	2012
Entropic and electrostatic effects on the folding free energy of a surface-attached biomolecule: an experimental and theoretical study. Journal of the American Chemical Society\| PubMed ID: 22239220	2012
Engineering biosensors with extended, narrowed, or arbitrarily edited dynamic range. Journal of the American Chemical Society\| PubMed ID: 22239688	2012
Quantification of Transcription Factor Binding in Cell Extracts Using an Electrochemical, Structure-Switching Biosensor. Journal of the American Chemical Society\| PubMed ID: 22313286	2012
Effects of crowding on the stability of a surface-tethered biopolymer: an experimental study of folding in a highly crowded regime. Journal of the American Chemical Society\| PubMed ID: 24919057	2014
Exploiting the conformational-selection mechanism to control the response kinetics of a "smart" DNA hydrogel. The Analyst\| PubMed ID: 29713702	2018
An electrochemical aptamer-based sensor for the rapid and convenient measurement of L-tryptophan. Analytical and bioanalytical chemistry\| PubMed ID: 30796485	2019
Seconds-resolved pharmacokinetic measurements of the chemotherapeutic irinotecan in the living body. Chemical science\| PubMed ID: 31673321	2019
Catalytic Interruption Mitigates Edge Effects in the Characterization of Heterogeneous, Insulating Nanoparticles. Journal of the American Chemical Society\| PubMed ID: 34735140	2021
Electrochemical Aptamer-Based Sensors: A Platform Approach to High-Frequency Molecular Monitoring In Situ in the Living Body. Methods in molecular biology (Clifton, N.J.)\| PubMed ID: 34837195	2022
Improved calibration of electrochemical aptamer-based sensors. Scientific reports\| PubMed ID: 35365672	2022
On the Disinfection of Electrochemical Aptamer-Based Sensors. ECS sensors plus\| PubMed ID: 36452064	2022
Conformational-switch biosensors as novel tools to support continuous, real-time molecular monitoring in lab-on-a-chip devices. Lab on a chip\| PubMed ID: 36655710	2023
On the Rational Design of Cooperative Receptors. Annual review of biophysics\| PubMed ID: 36737603	2023
Efforts toward the continuous monitoring of molecular markers of performance. Journal of science and medicine in sport\| PubMed ID: 36841706	2023
A tight squeeze: geometric effects on the performance of three-electrode electrochemical-aptamer based sensors in constrained, placements. The Analyst\| PubMed ID: 36891771	2023