Kirill Gorshkov National Center for Advancing Translational Sciences Biography Publications Institution JoVE Articles Kirill Gorshkov has not added a biography. If you are Kirill Gorshkov and would like to personalize this page please email our Author Liaison for assistance. Publications C-Abl Activation Linked to Autophagy-Lysosomal Dysfunction Contributes to Neurological Impairment in Niemann-Pick Type A Disease Frontiers in Cell and Developmental Biology. 2022 | Pubmed ID: 35399514 A High Throughput Screening Assay for Inhibitors of SARS-CoV-2 Pseudotyped Particle Entry SLAS Discovery : Advancing Life Sciences R & D. 03, 2022 | Pubmed ID: 35086793 SARS-CoV-2 Nucleocapsid Protein TR-FRET Assay Amenable to High Throughput Screening ACS Pharmacology & Translational Science. Jan, 2022 | Pubmed ID: 35036857 Fluorescent Quantum Dots Enable SARS-CoV-2 Antiviral Drug Discovery and Development Expert Opinion on Drug Discovery. 03, 2022 | Pubmed ID: 34817309 A High Throughput Screening Assay for Inhibitors of SARS-CoV-2 Pseudotyped Particle Entry BioRxiv : the Preprint Server for Biology. Oct, 2021 | Pubmed ID: 34642691 A SARS-CoV-2 Nucleocapsid Protein TR-FRET Assay Amenable to High-throughput Screening BioRxiv : the Preprint Server for Biology. Jul, 2021 | Pubmed ID: 34268508 Generation of an Induced Pluripotent Stem Cell Line (TRNDi031-A) from a Patient with Alagille Syndrome Type 1 Carrying a Heterozygous P. C312X (c. 936 T > A) Mutation in JAGGED-1 Stem Cell Research. 07, 2021 | Pubmed ID: 34198154 Generation of an Induced Pluripotent Stem Cell Line (TRNDi030-A) from a Patient with Farber Disease Carrying a Homozygous P. Y36C (c. 107 A>G) Mutation in ASAH1 Stem Cell Research. 05, 2021 | Pubmed ID: 34088014 Enrichment of NPC1-deficient Cells with the Lipid LBPA Stimulates Autophagy, Improves Lysosomal Function, and Reduces Cholesterol Storage The Journal of Biological Chemistry. 07, 2021 | Pubmed ID: 34023384 The SARS-CoV-2 Cytopathic Effect Is Blocked by Lysosome Alkalizing Small Molecules ACS Infectious Diseases. 06, 2021 | Pubmed ID: 33346633 Zika Virus-Induced Neuronal Apoptosis Via Increased Mitochondrial Fragmentation Frontiers in Microbiology. 2020 | Pubmed ID: 33424801 CircRNA-SORE Mediates Sorafenib Resistance in Hepatocellular Carcinoma by Stabilizing YBX1 Signal Transduction and Targeted Therapy. 12, 2020 | Pubmed ID: 33361760 Development of a High-Throughput Homogeneous AlphaLISA Drug Screening Assay for the Detection of SARS-CoV-2 Nucleocapsid ACS Pharmacology & Translational Science. Dec, 2020 | Pubmed ID: 33330840 Identifying SARS-CoV-2 Entry Inhibitors Through Drug Repurposing Screens of SARS-S and MERS-S Pseudotyped Particles ACS Pharmacology & Translational Science. Dec, 2020 | Pubmed ID: 33330839 N-methyladenosine-modified CircRNA-SORE Sustains Sorafenib Resistance in Hepatocellular Carcinoma by Regulating β-catenin Signaling Molecular Cancer. 11, 2020 | Pubmed ID: 33222692 Quantum Dot-Conjugated SARS-CoV-2 Spike Pseudo-Virions Enable Tracking of Angiotensin Converting Enzyme 2 Binding and Endocytosis ACS Nano. 09, 2020 | Pubmed ID: 32845122 Development of a High-throughput Homogeneous AlphaLISA Drug Screening Assay for the Detection of SARS-CoV-2 Nucleocapsid BioRxiv : the Preprint Server for Biology. Aug, 2020 | Pubmed ID: 32839774 Drug Discovery Strategies for SARS-CoV-2 The Journal of Pharmacology and Experimental Therapeutics. 10, 2020 | Pubmed ID: 32723801 RNA-Dependent RNA Polymerase As a Target for COVID-19 Drug Discovery SLAS Discovery : Advancing Life Sciences R & D. 12, 2020 | Pubmed ID: 32660307 Cell-Based No-Wash Fluorescence Assays for Compound Screens Using a Fluorescence Cytometry Plate Reader The Journal of Pharmacology and Experimental Therapeutics. 09, 2020 | Pubmed ID: 32532853 An OpenData Portal to Share COVID-19 Drug Repurposing Data in Real Time BioRxiv : the Preprint Server for Biology. Jun, 2020 | Pubmed ID: 32511420 The SARS-CoV-2 Cytopathic Effect is Blocked with Autophagy Modulators BioRxiv : the Preprint Server for Biology. May, 2020 | Pubmed ID: 32511355 Phosphocyclocreatine is the Dominant Form of Cyclocreatine in Control and Creatine Transporter Deficiency Patient Fibroblasts Pharmacology Research & Perspectives. 12, 2019 | Pubmed ID: 31859463 Identification of Ezetimibe and Pranlukast As Pharmacological Chaperones for the Treatment of the Rare Disease Mucopolysaccharidosis Type IVA Journal of Medicinal Chemistry. 07, 2019 | Pubmed ID: 31188588 Induced Pluripotent Stem Cells for Neural Drug Discovery Drug Discovery Today. 04, 2019 | Pubmed ID: 30664937 Quantitative Chemotherapeutic Profiling of Gynecologic Cancer Cell Lines Using Approved Drugs and Bioactive Compounds Translational Oncology. Mar, 2019 | Pubmed ID: 30576957 Advancing Precision Medicine with Personalized Drug Screening Drug Discovery Today. 01, 2019 | Pubmed ID: 30125678 Zika Virus: Origins, Pathological Action, and Treatment Strategies Frontiers in Microbiology. 2018 | Pubmed ID: 30666246 Neural Stem Cells for Disease Modeling and Evaluation of Therapeutics for Tay-Sachs Disease Orphanet Journal of Rare Diseases. 09, 2018 | Pubmed ID: 30220252 Small Molecules Identified from a Quantitative Drug Combinational Screen Resensitize Cisplatin's Response in Drug-Resistant Ovarian Cancer Cells Translational Oncology. Aug, 2018 | Pubmed ID: 29982103 A Biosensor for MAPK-dependent Lin28 Signaling Molecular Biology of the Cell. 05, 2018 | Pubmed ID: 29540527 Astrocytes As Targets for Drug Discovery Drug Discovery Today. 03, 2018 | Pubmed ID: 29317338 Imágenes confocales de alto rendimiento de trímeros de púas de SARS-CoV-2 conjugados con puntos cuánticos para rastrear la unión y la endocitosis en células HEK293T Bruce Nguyen Tran1, Eunkeu Oh2, Kimihiro Susumu2,3, Mason Wolak2, Kirill Gorshkov1 1National Center for Advancing Translational Sciences, 2Optical Sciences Division, Code 5600, Naval Research Laboratory, 3Jacobs Corporation JoVE 63202 Biology
Imágenes confocales de alto rendimiento de trímeros de púas de SARS-CoV-2 conjugados con puntos cuánticos para rastrear la unión y la endocitosis en células HEK293T Bruce Nguyen Tran1, Eunkeu Oh2, Kimihiro Susumu2,3, Mason Wolak2, Kirill Gorshkov1 1National Center for Advancing Translational Sciences, 2Optical Sciences Division, Code 5600, Naval Research Laboratory, 3Jacobs Corporation JoVE 63202 Biology