Korkut Uygun

Center for Engineering in Medicine, Massachusetts General Hospital, Harvard Medical School, Shriners Hospitals for Children

Affiliated withMassachusetts General Hospital, Harvard Medical School, Shriners Hospitals for Children Massachusetts General Hospital, Harvard Medical School, and Shriners Burns Hospital Massachusetts General Hospital, Harvard Medical School

Research Area

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JoVE Journal Publications

ArticleTotal : 10	Year
Publication title Cited by 39	2011
Publication title Cited by 21	2015
Publication title Cited by 29	2015
Publication title Cited by 2	2019
Publication title Cited by 11	2021

Other Publications

Article	Year
Investigation of metabolic objectives in cultured hepatocytes. Biotechnology and bioengineering\| PubMed ID: 17058287	2007
A model for normothermic preservation of the rat liver. Tissue engineering\| PubMed ID: 17596120	2007
Tissue growth modeling in a wavy-walled bioreactor. Tissue engineering. Part A\| PubMed ID: 18847355	2009
Recovery of warm ischemic rat liver grafts by normothermic extracorporeal perfusion. Transplantation\| PubMed ID: 19155970	2009
High-throughput single cell arrays as a novel tool in biopreservation. Cryobiology\| PubMed ID: 19303403	2009
Effects of burn injury on markers of hypermetabolism in rats. Journal of burn care & research : official publication of the American Burn Association\| PubMed ID: 19898103	2009
Cell delivery: from cell transplantation to organ engineering. Cell transplantation\| PubMed ID: 20525441	2010
Organ reengineering through development of a transplantable recellularized liver graft using decellularized liver matrix. Nature medicine\| PubMed ID: 20543851	2010
Optimization-based metabolic control analysis. Biotechnology progress\| PubMed ID: 20967921	2010
In situ metabolic flux analysis to quantify the liver metabolic response to experimental burn injury. Biotechnology and bioengineering\| PubMed ID: 21077107	2010
In situ metabolic flux analysis to quantify the liver metabolic response to experimental burn injury. Biotechnology and bioengineering\| PubMed ID: 21404258	2011
Whole-organ tissue engineering: decellularization and recellularization of three-dimensional matrix scaffolds. Annual review of biomedical engineering\| PubMed ID: 21417722	2011
Subnormothermic Machine Perfusion at Both 20Â°C and 30Â°C Recovers Ischemic Rat Livers for Successful Transplantation. The Journal of surgical research\| PubMed ID: 21550058	2011
A novel 3D liver organoid system for elucidation of hepatic glucose metabolism. Biotechnology and bioengineering\| PubMed ID: 22006574	2012
A metabolic index of ischemic injury for perfusion-recovery of cadaveric rat livers. PloS one\| PubMed ID: 22194843	2011
A fitness index for transplantation of machine-perfused cadaveric rat livers. BMC research notes\| PubMed ID: 22731806	2012
Application of whole-organ tissue engineering in hepatology. Nature reviews. Gastroenterology & hepatology\| PubMed ID: 22890112	2012
A simplified subnormothermic machine perfusion system restores ischemically damaged liver grafts in a rat model of orthotopic liver transplantation. Transplantation research\| PubMed ID: 23369351	2012
Supercooling as a viable non-freezing cell preservation method of rat hepatocytes. PloS one\| PubMed ID: 23874947	2013
Strategies to rescue steatotic livers before transplantation in clinical and experimental studies. World journal of gastroenterology : WJG\| PubMed ID: 23922462	2013
Resuscitation of ischemic donor livers with normothermic machine perfusion: a metabolic flux analysis of treatment in rats. PloS one\| PubMed ID: 23922793	2013
Determination and extension of the limits to static cold storage using subnormothermic machine perfusion. The International journal of artificial organs\| PubMed ID: 24338652	2013
Injury to peribiliary glands and vascular plexus before liver transplantation predicts formation of non-anastomotic biliary strictures. Journal of hepatology\| PubMed ID: 24560661	2014
Development of Metabolic Indicators of Burn Injury: Very Low Density Lipoprotein (VLDL) and Acetoacetate Are Highly Correlated to Severity of Burn Injury in Rats. Metabolites\| PubMed ID: 24957642	2012
Supercooling enables long-term transplantation survival following 4 days of liver preservation. Nature medicine\| PubMed ID: 24973919	2014
Organomatics and organometrics: Novel platforms for long-term whole-organ culture. Technology\| PubMed ID: 25035864	2014
SIMPLE MACHINE PERFUSION SIGNIFICANTLY ENHANCES HEPATOCYTE YIELDS OF ISCHEMIC AND FRESH RAT LIVERS. Cell medicine\| PubMed ID: 25431743	2013
Supercooling preservation and transplantation of the rat liver. Nature protocols\| PubMed ID: 25692985	2015
Surgical models of Roux-en-Y gastric bypass surgery and sleeve gastrectomy in rats and mice. Nature protocols\| PubMed ID: 25719268	2015
Warm Ischemic Injury Is Reflected in the Release of Injury Markers during Cold Preservation of the Human Liver. PloS one\| PubMed ID: 25822248	2015
Systems engineering the organ preservation process for transplantation. Current opinion in biotechnology\| PubMed ID: 31280087	2019
Sequential cold storage and normothermic perfusion of the ischemic rat liver. Transplantation proceedings\| PubMed ID: 18589093	2008
Diluted blood reperfusion as a model for transplantation of ischemic rat livers: alanine aminotransferase is a direct indicator of viability. Transplantation proceedings\| PubMed ID: 20832525	2010
Perfusion defatting at subnormothermic temperatures in steatotic rat livers. Transplantation proceedings\| PubMed ID: 24182786	2013
Machine perfusion enhances hepatocyte isolation yields from ischemic livers. Cryobiology\| PubMed ID: 26188080	2015
Metabolic profiling during ex vivo machine perfusion of the human liver. Scientific reports\| PubMed ID: 26935866	2016
Nuclear receptors control pro-viral and antiviral metabolic responses to hepatitis C virus infection. Nature chemical biology\| PubMed ID: 27723751	2016
Peritransplant Energy Changes and Their Correlation to Outcome After Human Liver Transplantation. Transplantation\| PubMed ID: 28230641	2017
Liver ex situ machine perfusion preservation: A review of the methodology and results of large animal studies and clinical trials. Liver transplantation : official publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society\| PubMed ID: 28240817	2017
Subzero organ preservation: the dawn of a new ice age? Current opinion in organ transplantation\| PubMed ID: 28266941	2017
The promise of organ and tissue preservation to transform medicine. Nature biotechnology\| PubMed ID: 28591112	2017
A highly-occupied, single-cell trapping microarray for determination of cell membrane permeability. Lab on a chip\| PubMed ID: 29068447	2017
Metabolomic Modularity Analysis (MMA) to Quantify Human Liver Perfusion Dynamics. Metabolites\| PubMed ID: 29137180	2017
Improved Cuff Technique and Intraoperative Detection of Vascular Complications for Hind Limb Transplantation in Mice. Transplantation direct\| PubMed ID: 29464206	2018
Caspase Inhibition: Optimizing Grafts for Transplantation. Transplantation\| PubMed ID: 29757905	2018
Multi-omic network-based interrogation of rat liver metabolism following gastric bypass surgery featuring SWATH proteomics. Technology\| PubMed ID: 29780857	2017
Endothelial Dysfunction in Steatotic Human Donor Livers: A Pilot Study of the Underlying Mechanism During Subnormothermic Machine Perfusion. Transplantation direct\| PubMed ID: 29796416	2018
Advances in machine perfusion, organ preservation, and cryobiology: potential impact on vascularized composite allotransplantation. Current opinion in organ transplantation\| PubMed ID: 30080697	2018
Oxygenated UW Solution Decreases ATP Decay and Improves Survival After Transplantation of DCD Liver Grafts. Transplantation\| PubMed ID: 30422952	2019
Contrast-Enhanced Ultrasound to Quantifyc Perfusion in a Machine-Perfused Pig Liver. Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference\| PubMed ID: 30441057	2018
Bulk Droplet Vitrification: An Approach to Improve Large-Scale Hepatocyte Cryopreservation Outcome. Langmuir : the ACS journal of surfaces and colloids\| PubMed ID: 30514081	2019
Specific Patterns of Postoperative Temperature Elevations Predict Blood Infection in Pediatric Burn Patients. Journal of burn care & research : official publication of the American Burn Association\| PubMed ID: 30668737	2019
Increasing Donor Liver Utilization Through Machine Perfusion. Hepatology (Baltimore, Md.)\| PubMed ID: 30681724	2019
Post-hepatectomy liver regeneration in the context of bile acid homeostasis and the gut-liver signaling axis. Journal of clinical and translational research\| PubMed ID: 30761355	2018
Synthetic hemoglobin-based oxygen carriers are an acceptable alternative for packed red blood cells in normothermic kidney perfusion. American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons\| PubMed ID: 30938927	2019
A novel model for ex situ reperfusion of the human liver following subnormothermic machine perfusion. Technology\| PubMed ID: 31106253	2017
The efficacy of HBOC-201 in ex situ gradual rewarming kidney perfusion in a rat model. Artificial organs\| PubMed ID: 31368159	2020
Exploring donor demographics effects on hepatocyte yield and viability: Results of whole human liver isolation from one center. Technology\| PubMed ID: 31414037	2019
Leveraging the zebrafish to model organ transplantation. Current opinion in organ transplantation\| PubMed ID: 31483338	2019
Supercooling extends preservation time of human livers. Nature biotechnology\| PubMed ID: 31501557	2019
Effect of Ice Nucleation and Cryoprotectants during High Subzero-Preservation in Endothelialized Microchannels. ACS biomaterials science & engineering\| PubMed ID: 31544149	2018
Subnormothermic Machine Perfusion of Steatotic Livers Results in Increased Energy Charge at the Cost of Anti-Oxidant Capacity Compared to Normothermic Perfusion. Metabolites\| PubMed ID: 31652927	2019
Pumping new life into old ideas: Preservation and rehabilitation of the liver using ex situ machine perfusion. Artificial organs\| PubMed ID: 31691326	2020
Ex vivo perfusion-based engraftment of genetically engineered cell sensors into transplantable organs. PloS one\| PubMed ID: 31790444	2019
Split-Liver Ex Situ Machine Perfusion: A Novel Technique for Studying Organ Preservation and Therapeutic Interventions. Journal of clinical medicine\| PubMed ID: 31963739	2020
Metabolic and lipidomic profiling of steatotic human livers during ex situ normothermic machine perfusion guides resuscitation strategies. PloS one\| PubMed ID: 31978172	2020
Cell release during perfusion reflects cold ischemic injury in rat livers. Scientific reports\| PubMed ID: 31980677	2020
Improvement of steatotic rat liver function with a defatting cocktail during ex situ normothermic machine perfusion is not directly related to liver fat content. PloS one\| PubMed ID: 32396553	2020
Subzero non-frozen preservation of human livers in the supercooled state. Nature protocols\| PubMed ID: 32433625	2020
Tryptophan Metabolism via the Kynurenine Pathway: Implications for Graft Optimization during Machine Perfusion. Journal of clinical medicine\| PubMed ID: 32549246	2020
Viability testing of discarded livers with normothermic machine perfusion: Alleviating the organ shortage outweighs the cost. Clinical transplantation\| PubMed ID: 32860634	2020
Multiorgan Metabolomics and Lipidomics Provide New Insights Into Fat Infiltration in the Liver, Muscle Wasting, and Liver-Muscle Crosstalk Following Burn Injury. Journal of burn care & research : official publication of the American Burn Association\| PubMed ID: 32877506	2021
A portable single-sided magnetic-resonance sensor for the grading of liver steatosis and fibrosis. Nature biomedical engineering\| PubMed ID: 33257853	2021
Evolving utilization of donation after circulatory death livers in liver transplantation: The day of DCD has come. Clinical transplantation\| PubMed ID: 33368701	2021
Liver donor age affects hepatocyte function through age-dependent changes in decellularized liver matrix. Biomaterials\| PubMed ID: 33524812	2021
In Vivo Activity of Genetically Modified Cells Preseeded in Rat Vascularized Composite Allografts. Transplantation proceedings\| PubMed ID: 33985799	2021
Thrombolytic Therapy During Normothermic Machine Perfusion of Human Livers Reduces Peribiliary Vascular Plexus Injury. Frontiers in surgery\| PubMed ID: 34222314	2021
Twenty-four hour ex-vivo normothermic machine perfusion in rat livers. Technology\| PubMed ID: 34307768	2020
Optimization of Ex Vivo Machine Perfusion and Transplantation of Vascularized Composite Allografts. The Journal of surgical research\| PubMed ID: 34670191	2022
Non-invasive quantification of the mitochondrial redox state in livers during machine perfusion. PloS one\| PubMed ID: 34705828	2021
Activation of autophagy during normothermic machine perfusion of discarded livers is associated with improved hepatocellular function. American journal of physiology. Gastrointestinal and liver physiology\| PubMed ID: 34730028	2022
The effect of blood cells retained in rat livers during static cold storage on viability outcomes during normothermic machine perfusion. Scientific reports\| PubMed ID: 34848781	2021
CYP450 drug inducibility in NAFLD via an in vitro hepatic model: Understanding drug-drug interactions in the fatty liver. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie\| PubMed ID: 35062050	2022
Specific patterns of vital sign fluctuations predict infection and enable sepsis diagnosis in pediatric burn patients. PloS one\| PubMed ID: 35130306	2022
Modeling energy depletion in rat livers using Nash equilibrium metabolic pathway analysis. Scientific reports\| PubMed ID: 35241684	2022
Exceeding the Limits of Static Cold Storage in Limb Transplantation Using Subnormothermic Machine Perfusion. Journal of reconstructive microsurgery\| PubMed ID: 35764315	2022
Partial freezing of rat livers extends preservation time by 5-fold. Nature communications\| PubMed ID: 35840553	2022
A Novel Digital Algorithm for Identifying Liver Steatosis Using Smartphone-Captured Images. Transplantation direct\| PubMed ID: 35935028	2022
Pan-caspase inhibition during normothermic machine perfusion of discarded livers mitigates innate immune responses. Frontiers in immunology\| PubMed ID: 35958587	2022
Subnormothermic Ex Vivo Porcine Kidney Perfusion Improves Energy Metabolism: Analysis Using P Magnetic Resonance Spectroscopic Imaging. Transplantation direct\| PubMed ID: 36176724	2022
Microvascular assessment of fascio-cutaneous flaps by ultrasound: A large animal study. Frontiers in physiology\| PubMed ID: 36589429	2022
Development of a rat forelimb vascularized composite allograft (VCA) perfusion protocol. PloS one\| PubMed ID: 36652460	2023
Continuous versus Pulsatile Flow in 24-Hour Vascularized Composite Allograft Machine Perfusion in Swine: A Pilot Study. The Journal of surgical research\| PubMed ID: 36915006	2023
The role of antifreeze glycoprotein (AFGP) and polyvinyl alcohol/polyglycerol (X/Z-1000) as ice modulators during partial freezing of rat livers. Frontiers in physics\| PubMed ID: 37151819	2022
Gluteal Propeller Perforator Flaps: A Paradigm Shift in Abdominoperineal Amputation Reconstruction. Journal of clinical medicine\| PubMed ID: 37373707	2023
Response Regarding: Continuous Versus Pulsatile Flow in 24-h Vascularized Composite Allograft Machine Perfusion in Swine: A Pilot Study. The Journal of surgical research\| PubMed ID: 37517972	2023
Towards Optimizing Sub-Normothermic Machine Perfusion in Fasciocutaneous Flaps: A Large Animal Study. Bioengineering (Basel, Switzerland)\| PubMed ID: 38136006	2023
The Autonomization Principle in Vascularized Flaps: An Alternative Strategy for Composite Tissue Scaffold In Vivo Revascularization. Bioengineering (Basel, Switzerland)\| PubMed ID: 38136031	2023
VCA supercooling in a swine partial hindlimb model. Scientific reports\| PubMed ID: 38824189	2024
Continuous oxygen monitoring to enhance ex-vivo organ machine perfusion and reconstructive surgery. Biosensors & bioelectronics\| PubMed ID: 38971037	2024
Sub-zero non-freezing of vascularized composite allografts in a rodent partial hindlimb model. Cryobiology\| PubMed ID: 39134131	2024
Supercooling preservation of vascularized composite allografts through CPA optimization, thermal tracking, and stepwise loading techniques. Scientific reports\| PubMed ID: 39333375	2024
Optimized partial freezing protocol enables 10-day storage of rat livers. Scientific reports\| PubMed ID: 39448774	2024
Enhanced VCA Storage: A Pilot Study Demonstrating Supercooling in Orthotopic Rodent Hindlimb Transplantation. Transplantation proceedings\| PubMed ID: 39490377	2024
UW supplementation with AP39 improves liver viability following static cold storage. Scientific reports\| PubMed ID: 39789174	2025
Designer Organs: Ethical Genetic Modifications in the Era of Machine Perfusion. Annual review of biomedical engineering\| PubMed ID: 39874605	2025
Ex vivo machine perfusion as a platform for lentiviral gene delivery in rat livers. Gene therapy\| PubMed ID: 40263629	2025
Subzero kidney preservation comes to scale. American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons\| PubMed ID: 41138969	2025