Kwok-Fai Lau School of Life Sciences The Chinese University of Hong Kong Biography Publications Institution JoVE Articles Kwok-Fai Lau has not added a biography. If you are Kwok-Fai Lau and would like to personalize this page please email our Author Liaison for assistance. Publications CAG RNAs Induce DNA Damage and Apoptosis by Silencing Expression in Polyglutamine Degeneration Proceedings of the National Academy of Sciences of the United States of America. May, 2021 | Pubmed ID: 33947817 ARF6-Rac1 Signaling-mediated Neurite Outgrowth is Potentiated by the Neuronal Adaptor FE65 Through Orchestrating ARF6 and ELMO1 FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology. 12, 2020 | Pubmed ID: 33047393 Micro-RNA Clusters Integrate Evolutionary Constraints on Expression and Target Affinities: The MiR-6/5/4/286/3/309 Cluster in Drosophila Molecular Biology and Evolution. 10, 2020 | Pubmed ID: 32521021 The Roles of Atypical Protein Kinase Cs (aPKCs) in the Nervous System: Targets for Neuroregeneration? Neural Regeneration Research. Aug, 2020 | Pubmed ID: 31997808 Proximity Ligation Assay for the Investigation of the Intramolecular Interaction of ELMO1 Bio-protocol. Dec, 2019 | Pubmed ID: 33654944 Attenuation of Amyloid-β Generation by Atypical Protein Kinase C-mediated Phosphorylation of Engulfment Adaptor PTB Domain Containing 1 Threonine 35 FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology. 11, 2019 | Pubmed ID: 31373844 A Peptidylic Inhibitor for Neutralizing (GGGGCC)-Associated Neurodegeneration in C9ALS-FTD Molecular Therapy. Nucleic Acids. Jun, 2019 | Pubmed ID: 30889483 Familial Ataxia, Tremor, and Dementia in a Polish Family with a Novel Mutation in the CCDC88C Gene Movement Disorders : Official Journal of the Movement Disorder Society. 01, 2019 | Pubmed ID: 30398676 Proteolytic Cleavage of Amyloid Precursor Protein by ADAM10 Mediates Proliferation and Migration in Breast Cancer EBioMedicine. Dec, 2018 | Pubmed ID: 30470613 Exo70 Is Essential for Neurite Extension and Survival Under Thermal Stress The Journal of Neuroscience : the Official Journal of the Society for Neuroscience. 09, 2018 | Pubmed ID: 30209205 Amyloid Precursor Protein Is Associated with Aggressive Behavior in Nonluminal Breast Cancers The Oncologist. 11, 2018 | Pubmed ID: 30108157 Planar Cell Polarity Gene Triggers Apoptosis in Neurodegenerative Disease Models EMBO Reports. 09, 2018 | Pubmed ID: 30026307 Three SpoA-domain Proteins Interact in the Creation of the Flagellar Type III Secretion System in The Journal of Biological Chemistry. 09, 2018 | Pubmed ID: 29991595 Neuronal Adaptor FE65 Stimulates Rac1-mediated Neurite Outgrowth by Recruiting and Activating ELMO1 The Journal of Biological Chemistry. 05, 2018 | Pubmed ID: 29615491 A Peptidylic Inhibitor for Neutralizing Expanded RNA-induced Nucleolar Stress in Polyglutamine Diseases RNA (New York, N.Y.). 04, 2018 | Pubmed ID: 29295891 GULP1/CED-6 Ameliorates Amyloid-β Toxicity in a Drosophila Model of Alzheimer's Disease Oncotarget. Nov, 2017 | Pubmed ID: 29245900 Phosphorylation of FE65 at Threonine 579 by GSK3β Stimulates Amyloid Precursor Protein Processing Scientific Reports. 09, 2017 | Pubmed ID: 28963516 The Lysosomal Protein Cathepsin L is a Progranulin Protease Molecular Neurodegeneration. 07, 2017 | Pubmed ID: 28743268 Nucleophosmin Interacts with PIN2/TERF1-interacting Telomerase Inhibitor 1 (PinX1) and Attenuates the PinX1 Inhibition on Telomerase Activity Scientific Reports. 03, 2017 | Pubmed ID: 28255170 Assessing a Peptidylic Inhibitor-based Therapeutic Approach That Simultaneously Suppresses Polyglutamine RNA- and Protein-mediated Toxicities in Patient Cells and Drosophila Disease Models & Mechanisms. Mar, 2016 | Pubmed ID: 26839389 Phosphorylation of FE65 Ser610 by Serum- and Glucocorticoid-induced Kinase 1 Modulates Alzheimer's Disease Amyloid Precursor Protein Processing The Biochemical Journal. Sep, 2015 | Pubmed ID: 26188042 The SARS-coronavirus Membrane Protein Induces Apoptosis Via Interfering with PDK1-PKB/Akt Signalling The Biochemical Journal. Dec, 2014 | Pubmed ID: 25271362 A Novel Missense Mutation in CCDC88C Activates the JNK Pathway and Causes a Dominant Form of Spinocerebellar Ataxia Journal of Medical Genetics. Sep, 2014 | Pubmed ID: 25062847 FE65 Interacts with ADP-ribosylation Factor 6 to Promote Neurite Outgrowth FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology. Jan, 2014 | Pubmed ID: 24056087 CAG Expansion Induces Nucleolar Stress in Polyglutamine Diseases Proceedings of the National Academy of Sciences of the United States of America. Aug, 2012 | Pubmed ID: 22847428 Influenza Polymerase Activity Correlates with the Strength of Interaction Between Nucleoprotein and PB2 Through the Host-specific Residue K/E627 PloS One. 2012 | Pubmed ID: 22570712 DNA Microarray Expression Analysis of Baicalin-induced Differentiation of C17.2 Neural Stem Cells Chembiochem : a European Journal of Chemical Biology. Jun, 2012 | Pubmed ID: 22556041 Degradation of Mutant Huntingtin Via the Ubiquitin/proteasome System is Modulated by FE65 The Biochemical Journal. May, 2012 | Pubmed ID: 22352297 Promoter Characterization and Genomic Organization of the Human X11β Gene APBA2 Neuroreport. Feb, 2012 | Pubmed ID: 22222501 Genomic Organization and Promoter Cloning of the Human X11α Gene APBA1 DNA and Cell Biology. May, 2012 | Pubmed ID: 22136355 VAPB Interacts with the Mitochondrial Protein PTPIP51 to Regulate Calcium Homeostasis Human Molecular Genetics. Mar, 2012 | Pubmed ID: 22131369 Lemur Tyrosine Kinase-2 Signalling Regulates Kinesin-1 Light Chain-2 Phosphorylation and Binding of Smad2 Cargo Oncogene. May, 2012 | Pubmed ID: 21996745 Perturbation of U2AF65/NXF1-mediated RNA Nuclear Export Enhances RNA Toxicity in PolyQ Diseases Human Molecular Genetics. Oct, 2011 | Pubmed ID: 21725067 GULP1 is a Novel APP-interacting Protein That Alters APP Processing The Biochemical Journal. Jun, 2011 | Pubmed ID: 21486224 Expanded Polyglutamine Domain Possesses Nuclear Export Activity Which Modulates Subcellular Localization and Toxicity of PolyQ Disease Protein Via Exportin-1 Human Molecular Genetics. May, 2011 | Pubmed ID: 21300695 Neuronal Differentiation of C17.2 Neural Stem Cells Induced by a Natural Flavonoid, Baicalin Chembiochem : a European Journal of Chemical Biology. Feb, 2011 | Pubmed ID: 21290546 An X11alpha/FSBP Complex Represses Transcription of the GSK3beta Gene Promoter Neuroreport. Aug, 2010 | Pubmed ID: 20531236 Expression of the Neuronal Adaptor Protein X11alpha Protects Against Memory Dysfunction in a Transgenic Mouse Model of Alzheimer's Disease Journal of Alzheimer's Disease : JAD. 2010 | Pubmed ID: 20378958 Transcriptional Regulation of Human FE65, a Ligand of Alzheimer's Disease Amyloid Precursor Protein, by Sp1 Journal of Cellular Biochemistry. Mar, 2010 | Pubmed ID: 20091743 Cryptotanshinone, an Acetylcholinesterase Inhibitor from Salvia Miltiorrhiza, Ameliorates Scopolamine-induced Amnesia in Morris Water Maze Task Planta Medica. Feb, 2010 | Pubmed ID: 19774505 X11beta Rescues Memory and Long-term Potentiation Deficits in Alzheimer's Disease APPswe Tg2576 Mice Human Molecular Genetics. Dec, 2009 | Pubmed ID: 19744962 Dexras1 Interacts with FE65 to Regulate FE65-amyloid Precursor Protein-dependent Transcription The Journal of Biological Chemistry. Dec, 2008 | Pubmed ID: 18922798 Familial Amyotrophic Lateral Sclerosis-linked SOD1 Mutants Perturb Fast Axonal Transport to Reduce Axonal Mitochondria Content Human Molecular Genetics. Nov, 2007 | Pubmed ID: 17725983 Glycogen Synthase Kinase-3 Beta-mediated Tau Phosphorylation in Cultured Cell Lines Neuroreport. Feb, 2003 | Pubmed ID: 12598741 كثافة التدرج الطرد الفائق للتحقيق في إعادة تدوير الغدد الصماء في خلايا الثدييات Wai Wa Ray Chan*1, Yu Qi Zhai*1, Kwok-Fai Lau1 1School of Life Sciences, The Chinese University of Hong Kong JoVE 62621 Biochemistry فحص قائم علي بروتين الفلورية الخضراء المعززة لدراسة نمو العصب في الخلايا العصبية الاوليه Wai Wa Ray Chan*1, Wen Li*1,2, Dik Long Dennis Chau*1, Kwok-Fai Lau1 1School of Life Sciences, The Chinese University of Hong Kong, Hong Kong Special Administrative Region, 2Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen JoVE 60031 Developmental Biology
كثافة التدرج الطرد الفائق للتحقيق في إعادة تدوير الغدد الصماء في خلايا الثدييات Wai Wa Ray Chan*1, Yu Qi Zhai*1, Kwok-Fai Lau1 1School of Life Sciences, The Chinese University of Hong Kong JoVE 62621 Biochemistry
فحص قائم علي بروتين الفلورية الخضراء المعززة لدراسة نمو العصب في الخلايا العصبية الاوليه Wai Wa Ray Chan*1, Wen Li*1,2, Dik Long Dennis Chau*1, Kwok-Fai Lau1 1School of Life Sciences, The Chinese University of Hong Kong, Hong Kong Special Administrative Region, 2Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen JoVE 60031 Developmental Biology