Laura E. Niklason Department of Biomedical Engineering Yale University Biography Publications Institution JoVE Articles Laura E. Niklason has not added a biography. If you are Laura E. Niklason and would like to personalize this page please email our Author Liaison for assistance. Publications Pressure-Regulated Ventilator Splitting for Disaster Relief: Design, Testing, and Clinical Experience Anesthesia and Analgesia. Dec, 2021 | Pubmed ID: 34928890 307.8: Novel Approach in Pancreatic Islet Transplantation: Acellular Vessel Transplantation. Dec, 2021 | Pubmed ID: 34908334 A Pulmonary Vascular Model From Endothelialized Whole Organ Scaffolds Frontiers in Bioengineering and Biotechnology. 2021 | Pubmed ID: 34869270 Microvascular Fluid Flow in Ex Vivo and Engineered Lungs Journal of Applied Physiology (Bethesda, Md. : 1985). 11, 2021 | Pubmed ID: 34554016 Development of a Bioartificial Vascular Pancreas Journal of Tissue Engineering. Jan-Dec, 2021 | Pubmed ID: 34262686 An Ex Vivo Physiologic and Hyperplastic Vessel Culture Model to Study Intra-arterial Stent Therapies Biomaterials. 08, 2021 | Pubmed ID: 34087584 Integrated Single-Cell Atlas of Endothelial Cells of the Human Lung Circulation. 07, 2021 | Pubmed ID: 34030460 Single-cell Longitudinal Analysis of SARS-CoV-2 Infection in Human Airway Epithelium Identifies Target Cells, Alterations in Gene Expression, and Cell State Changes PLoS Biology. 03, 2021 | Pubmed ID: 33730024 Efficient Differentiation of Human Induced Pluripotent Stem Cells into Endothelial Cells Under Xenogeneic-free Conditions for Vascular Tissue Engineering Acta Biomaterialia. 01, 2021 | Pubmed ID: 33166710 Xenogeneic-free Generation of Vascular Smooth Muscle Cells from Human Induced Pluripotent Stem Cells for Vascular Tissue Engineering Acta Biomaterialia. 01, 2021 | Pubmed ID: 33130306 Critical Considerations for Regeneration of Vascularized Composite Tissues Tissue Engineering. Part B, Reviews. 08, 2021 | Pubmed ID: 33115331 The History of Engineered Tracheal Replacements: Interpreting the Past and Guiding the Future Tissue Engineering. Part B, Reviews. 08, 2021 | Pubmed ID: 33045942 Bioengineered Human Blood Vessels Science (New York, N.Y.). Oct, 2020 | Pubmed ID: 33033191 Challenges and Novel Therapies for Vascular Access in Haemodialysis Nature Reviews. Nephrology. 10, 2020 | Pubmed ID: 32839580 Platform Effects on Regeneration by Pulmonary Basal Cells As Evaluated by Single-Cell RNA Sequencing Cell Reports. 03, 2020 | Pubmed ID: 32209482 Bioengineering the Blood-gas Barrier Comprehensive Physiology. 03, 2020 | Pubmed ID: 32163210 Arterial Reconstruction with Human Bioengineered Acellular Blood Vessels in Patients with Peripheral Arterial Disease Journal of Vascular Surgery. 10, 2020 | Pubmed ID: 32093913 Tissue-Engineered Vascular Grafts with Advanced Mechanical Strength from Human IPSCs Cell Stem Cell. 02, 2020 | Pubmed ID: 31956039 Microvessel Network Formation and Interactions with Pancreatic Islets in Three-Dimensional Chip Cultures Tissue Engineering. Part A. 05, 2020 | Pubmed ID: 31724494 Reduced Patency in Left-sided Arteriovenous Grafts in a Porcine Model Journal of Vascular Surgery. 07, 2020 | Pubmed ID: 31699515 Single-cell Connectomic Analysis of Adult Mammalian Lungs Science Advances. 12, 2019 | Pubmed ID: 31840053 Engineering of Human Brain Organoids with a Functional Vascular-like System Nature Methods. 11, 2019 | Pubmed ID: 31591580 Utilization of Natural Detergent Potassium Laurate for Decellularization in Lung Bioengineering Tissue Engineering. Part C, Methods. 08, 2019 | Pubmed ID: 31317819 Non-invasive and Real-time Measurement of Microvascular Barrier in Intact Lungs Biomaterials. 10, 2019 | Pubmed ID: 31280072 Fas Ligand and Nitric Oxide Combination to Control Smooth Muscle Growth While Sparing Endothelium Biomaterials. 08, 2019 | Pubmed ID: 31102854 Bioengineered Human Acellular Vessels Recellularize and Evolve into Living Blood Vessels After Human Implantation Science Translational Medicine. 03, 2019 | Pubmed ID: 30918113 Epac Agonist Improves Barrier Function in IPSC-derived Endothelial Colony Forming Cells for Whole Organ Tissue Engineering Biomaterials. 04, 2019 | Pubmed ID: 30754017 Human Pluripotent Stem Cells (iPSC) Generation, Culture, and Differentiation to Lung Progenitor Cells Methods in Molecular Biology (Clifton, N.J.). 2019 | Pubmed ID: 27628133 An Ex Vivo Vessel Injury Model to Study Remodeling Cell Transplantation. 09, 2018 | Pubmed ID: 30095004 Vascularization of Natural and Synthetic Bone Scaffolds Cell Transplantation. 08, 2018 | Pubmed ID: 30008231 Extracellular Matrix in Lung Development, Homeostasis and Disease Matrix Biology : Journal of the International Society for Matrix Biology. 11, 2018 | Pubmed ID: 29524630 Flow Preservation of Umbilical Vein for Autologous Shunt and Cardiovascular Reconstruction The Annals of Thoracic Surgery. 06, 2018 | Pubmed ID: 29510094 Understanding the Extracellular Matrix to Enhance Stem Cell-Based Tissue Regeneration Cell Stem Cell. 03, 2018 | Pubmed ID: 29499149 Neuropilin-1 Mediated Arterial Differentiation of Murine Pluripotent Stem Cells Stem Cells and Development. 04, 2018 | Pubmed ID: 29415620 Susceptibility of EPTFE Vascular Grafts and Bioengineered Human Acellular Vessels to Infection The Journal of Surgical Research. 01, 2018 | Pubmed ID: 29229120 Bioengineered Lungs Generated from Human IPSCs-derived Epithelial Cells on Native Extracellular Matrix Journal of Tissue Engineering and Regenerative Medicine. 03, 2018 | Pubmed ID: 29024475 Historical Perspective and Future Direction of Blood Vessel Developments Cold Spring Harbor Perspectives in Medicine. 02, 2018 | Pubmed ID: 28348177 Controlled Gas Exchange in Whole Lung Bioreactors Journal of Tissue Engineering and Regenerative Medicine. 01, 2018 | Pubmed ID: 28083925 Efficient and Functional Endothelial Repopulation of Whole Lung Organ Scaffolds ACS Biomaterials Science & Engineering. Sep, 2017 | Pubmed ID: 33440555 A Short Discourse on Vascular Tissue Engineering NPJ Regenerative Medicine. 2017 | Pubmed ID: 29057097 Vascular Smooth Muscle Cells Derived from Inbred Swine Induced Pluripotent Stem Cells for Vascular Tissue Engineering Biomaterials. Dec, 2017 | Pubmed ID: 28942128 Engineered Microvasculature in PDMS Networks Using Endothelial Cells Derived from Human Induced Pluripotent Stem Cells Cell Transplantation. 08, 2017 | Pubmed ID: 28901188 Transplantation of Bioengineered Rat Lungs Recellularized with Endothelial and Adipose-derived Stromal Cells Scientific Reports. 08, 2017 | Pubmed ID: 28814761 Improving In vivo Outcomes of Decellularized Vascular Grafts Via Incorporation of a Novel Extracellular Matrix Biomaterials. Oct, 2017 | Pubmed ID: 28667900 Lung Regeneration: Steps Toward Clinical Implementation and Use Current Opinion in Anaesthesiology. Feb, 2017 | Pubmed ID: 27922848 Targeted Proteomics Effectively Quantifies Differences Between Native Lung and Detergent-decellularized Lung Extracellular Matrices Acta Biomaterialia. Dec, 2016 | Pubmed ID: 27693690 Engineered Tissue-Stent Biocomposites As Tracheal Replacements Tissue Engineering. Part A. Sep, 2016 | Pubmed ID: 27520928 Impaired Von Willebrand Factor Adhesion and Platelet Response in Thrombospondin-2 Knockout Mice Blood. 09, 2016 | Pubmed ID: 27471233 New Functional Tools for Antithrombogenic Activity Assessment of Live Surface Glycocalyx Arteriosclerosis, Thrombosis, and Vascular Biology. 09, 2016 | Pubmed ID: 27386939 Comparative Biology of Decellularized Lung Matrix: Implications of Species Mismatch in Regenerative Medicine Biomaterials. Sep, 2016 | Pubmed ID: 27344365 Implantable Tissue-engineered Blood Vessels from Human Induced Pluripotent Stem Cells Biomaterials. Sep, 2016 | Pubmed ID: 27336184 Bioengineered Human Acellular Vessels for Dialysis Access in Patients with End-stage Renal Disease: Two Phase 2 Single-arm Trials Lancet (London, England). May, 2016 | Pubmed ID: 27203778 Ventilation-Based Decellularization System of the Lung BioResearch Open Access. 2016 | Pubmed ID: 27186445 Biaxial Stretch Improves Elastic Fiber Maturation, Collagen Arrangement, and Mechanical Properties in Engineered Arteries Tissue Engineering. Part C, Methods. 06, 2016 | Pubmed ID: 27108525 Biomimetic Culture Reactor for Whole-Lung Engineering BioResearch Open Access. 2016 | Pubmed ID: 27088061 Netrin-1 Regulates Fibrocyte Accumulation in the Decellularized Fibrotic Sclerodermatous Lung Microenvironment and in Bleomycin-Induced Pulmonary Fibrosis Arthritis & Rheumatology (Hoboken, N.J.). May, 2016 | Pubmed ID: 26749424 Sterilization of Lung Matrices by Supercritical Carbon Dioxide Tissue Engineering. Part C, Methods. Mar, 2016 | Pubmed ID: 26697757 A Rotating Bioreactor for Scalable Culture and Differentiation of Respiratory Epithelium Cell Medicine. Oct, 2015 | Pubmed ID: 26858899 Production of Decellularized Porcine Lung Scaffolds for Use in Tissue Engineering Integrative Biology : Quantitative Biosciences from Nano to Macro. Dec, 2015 | Pubmed ID: 26426090 Tissue-Engineered Microvasculature to Reperfuse Isolated Renal Glomeruli Tissue Engineering. Part A. Nov, 2015 | Pubmed ID: 26414101 Bmk-1 Regulates Lifespan in Caenorhabditis Elegans by Activating Hsp-16 Oncotarget. Aug, 2015 | Pubmed ID: 26299918 Development of Lung Epithelium from Induced Pluripotent Stem Cells Current Transplantation Reports. Mar, 2015 | Pubmed ID: 26052480 Arterial Specification of Endothelial Cells Derived from Human Induced Pluripotent Stem Cells in a Biomimetic Flow Bioreactor Biomaterials. 2015 | Pubmed ID: 25890758 Fate of Distal Lung Epithelium Cultured in a Decellularized Lung Extracellular Matrix Tissue Engineering. Part A. Jun, 2015 | Pubmed ID: 25789725 Design and Use of a Novel Bioreactor for Regeneration of Biaxially Stretched Tissue-Engineered Vessels Tissue Engineering. Part C, Methods. Aug, 2015 | Pubmed ID: 25669988 Osteogenic Performance of Donor-matched Human Adipose and Bone Marrow Mesenchymal Cells Under Dynamic Culture Tissue Engineering. Part A. May, 2015 | Pubmed ID: 25668104 PCH-2 Regulates Caenorhabditis Elegans Lifespan Aging. Jan, 2015 | Pubmed ID: 25635513 Click-coated, Heparinized, Decellularized Vascular Grafts Acta Biomaterialia. Feb, 2015 | Pubmed ID: 25463496 Mesenchymal Stromal Cells Form Vascular Tubes when Placed in Fibrin Sealant and Accelerate Wound Healing In vivo Biomaterials. Feb, 2015 | Pubmed ID: 25433608 Efficient Intratracheal Delivery of Airway Epithelial Cells in Mice and Pigs American Journal of Physiology. Lung Cellular and Molecular Physiology. Jan, 2015 | Pubmed ID: 25416381 Extracellular Matrix As a Driver for Lung Regeneration Annals of Biomedical Engineering. Mar, 2015 | Pubmed ID: 25344351 Influence of PH on Extracellular Matrix Preservation During Lung Decellularization Tissue Engineering. Part C, Methods. Dec, 2014 | Pubmed ID: 24735501 Strategies for Whole Lung Tissue Engineering IEEE Transactions on Bio-medical Engineering. May, 2014 | Pubmed ID: 24691527 Vascular Tissue Engineering: Building Perfusable Vasculature for Implantation Current Opinion in Chemical Engineering. Feb, 2014 | Pubmed ID: 24533306 Future Prospects for Tissue Engineered Lung Transplantation: Decellularization and Recellularization-based Whole Lung Regeneration Organogenesis. Apr-Jun, 2014 | Pubmed ID: 24488093 A Call to Craft Science Translational Medicine. Jan, 2014 | Pubmed ID: 24401937 Engineering of Arteries in Vitro Cellular and Molecular Life Sciences : CMLS. Jun, 2014 | Pubmed ID: 24399290 Epithelial Cell Differentiation of Human Mesenchymal Stromal Cells in Decellularized Lung Scaffolds Tissue Engineering. Part A. Jun, 2014 | Pubmed ID: 24393055 Construction of Tissue-engineered Small-diameter Vascular Grafts in Fibrin Scaffolds in 30 Days Tissue Engineering. Part A. May, 2014 | Pubmed ID: 24320793 The Use of Optical Clearing and Multiphoton Microscopy for Investigation of Three-dimensional Tissue-engineered Constructs Tissue Engineering. Part C, Methods. Jul, 2014 | Pubmed ID: 24251630 Alveolar Epithelial Differentiation of Human Induced Pluripotent Stem Cells in a Rotating Bioreactor Biomaterials. Jan, 2014 | Pubmed ID: 24144903 Human IPS Cell-derived Alveolar Epithelium Repopulates Lung Extracellular Matrix The Journal of Clinical Investigation. Nov, 2013 | Pubmed ID: 24135142 Microfluidic Artificial "vessels" for Dynamic Mechanical Stimulation of Mesenchymal Stem Cells Integrative Biology : Quantitative Biosciences from Nano to Macro. Dec, 2012 | Pubmed ID: 23114826 Acellular Normal and Fibrotic Human Lung Matrices As a Culture System for in Vitro Investigation American Journal of Respiratory and Critical Care Medicine. Nov, 2012 | Pubmed ID: 22936357 Engineered Zinc-finger Proteins Can Compensate Genetic Haploinsufficiency by Transcriptional Activation of the Wild-type Allele: Application to Willams-Beuren Syndrome and Supravalvular Aortic Stenosis Human Gene Therapy. Nov, 2012 | Pubmed ID: 22891920 心血管再生生物学。 Cells, Tissues, Organs. 2012 | Pubmed ID: 22179179 平滑肌和人体血管工程其他细胞来源。 Cells, Tissues, Organs. 2012 | Pubmed ID: 22041291 MicroRNA 29 的抑制作用增强弹性蛋白水平在单元格 Haploinsufficient 中的弹性蛋白和生物工程的船只。 Arteriosclerosis, Thrombosis, and Vascular Biology. Nov, 2011 | Pubmed ID: 22095981 同种异体人体组织工程血管。 Journal of Vascular Surgery : Official Publication, the Society for Vascular Surgery [and] International Society for Cardiovascular Surgery, North American Chapter. Nov, 2011 | Pubmed ID: 22056286 早期研究允许组织工程血管移植物抗内膜增生的机制。 Journal of Cardiovascular Translational Research. Oct, 2011 | Pubmed ID: 21748530 脱细胞的组织工程血管动脉导管作为。 Proceedings of the National Academy of Sciences of the United States of America. May, 2011 | Pubmed ID: 21571635 建立更强的微血管。 Nature Biotechnology. May, 2011 | Pubmed ID: 21552239 基质组成及脱细胞的肺癌支架的力学。 Cells, Tissues, Organs. Apr, 2011 | Pubmed ID: 21502745 人骨髓间充质干细胞作为替代来源的平滑肌细胞在船舶工程中的使用。 Methods in Molecular Biology (Clifton, N.J.). 2011 | Pubmed ID: 21431526 现成的组织工程化血管移植。 Science Translational Medicine. Feb, 2011 | Pubmed ID: 21289273 新型可生物降解聚合物血管组织工程支架材料的发展。 Tissue Engineering. Part A. May, 2011 | Pubmed ID: 21143045 肺组织的长期培养的生物反应器。 Cell Transplantation. 2011 | Pubmed ID: 21092411 组织工程化的体内植入肺。 Science (New York, N.Y.). Jul, 2010 | Pubmed ID: 20576850 膳食限制缓解了可卡因诱导改建的嗅细胞可塑性和基因表达与行为。 Journal of Neurochemistry. Jul, 2010 | Pubmed ID: 20456017 体外黑色素瘤新型流生物反应器。 Tissue Engineering. Part C, Methods. Oct, 2010 | Pubmed ID: 20170423 猪血管内皮细胞与平滑肌细胞汗腺成为促凝血体外。 Tissue Engineering. Part A. Jun, 2010 | Pubmed ID: 20055662 使工程生物反应器、 活体成像技术与生物力学建模相结合的胶原组织的工具。 Proceedings of the National Academy of Sciences of the United States of America. Feb, 2010 | Pubmed ID: 19955446 端粒酶 Pot1 融合蛋白在血管组织工程中的实用程序。 Cell Transplantation. 2010 | Pubmed ID: 19878625 新型血清中脱细胞组织利用。 Tissue Engineering. Part C, Methods. Apr, 2010 | Pubmed ID: 19419244 使用 Bioprinting 的无支架的血管组织工程。 Biomaterials. Oct, 2009 | Pubmed ID: 19664819 体外组织工程生物相容性的内皮细胞传递系统。 Cell Transplantation. 2009 | Pubmed ID: 19500475 机械牵张对胶原和交联中影响工程血管。 Cell Transplantation. 2009 | Pubmed ID: 19500474 作为小直径血管脱细胞人类脐动脉的发展。 Tissue Engineering. Part A. Sep, 2009 | Pubmed ID: 19207043 对平滑肌细胞分化从人骨髓间充质干细胞培养基的影响。 Tissue Engineering. Part A. Feb, 2009 | Pubmed ID: 19115826 Microstructurally 动机的模型的力学行为的组织工程血管。 Annals of Biomedical Engineering. Nov, 2008 | Pubmed ID: 18720007 小直径人类血管壁工程从骨髓间充质干细胞 (人间充质干细胞)。 FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology. Jun, 2008 | Pubmed ID: 18199698 超微结构分析的胶原组织工程化动脉。 Annals of Biomedical Engineering. Oct, 2007 | Pubmed ID: 17566861 力学性能和成分的组织工程化和本机的动脉。 Annals of Biomedical Engineering. Mar, 2007 | Pubmed ID: 17206488 在蛛网膜下腔出血相关脑血管病变血管学科的作用。 Neurocritical Care. 2006 | Pubmed ID: 17290093 血管细胞工程。 Trends in Cardiovascular Medicine. Jul, 2006 | Pubmed ID: 16781948 玻璃化冷冻作为组织工程血管的存储方法的可行性。 Tissue Engineering. Feb, 2006 | Pubmed ID: 16548687 相关性和端粒酶的人体组织工程的安全。 Proceedings of the National Academy of Sciences of the United States of America. Feb, 2006 | Pubmed ID: 16477025 铜和细胞外基质的组织工程化动脉上交联的影响。 Cell Transplantation. 2005 | Pubmed ID: 16454361 铜和细胞外基质的组织工程化动脉上交联的影响。 Cell Transplantation. 2005 | Pubmed ID: 16180655 血管细胞工程。 Lancet. Jun 18-24, 2005 | Pubmed ID: 15964449 血红蛋白 Raffimer 用于术后生命威胁贫血的耶和华见证会信徒。 Canadian Journal of Anaesthesia = Journal Canadien D'anesthésie. Apr, 2005 | Pubmed ID: 15814750 后使用纯度较高的牛凝血酶的抗因子 V 抗体。 The Annals of Thoracic Surgery. Mar, 2005 | Pubmed ID: 15734434 系统的内皮细胞对血管平滑肌细胞的直接联合培养。 Biomaterials. Aug, 2005 | Pubmed ID: 15722134 工程骨骼肌成肌细胞: 三维文化和电刺激的作用。 American Journal of Physiology. Heart and Circulatory Physiology. Apr, 2005 | Pubmed ID: 15550526 免疫组化鉴定的血管内皮生长因子在猪背阔肌肌皮瓣缺血再灌注损伤后。 Annals of Plastic Surgery. Oct, 2004 | Pubmed ID: 15385779 成体干细胞无性系种群: 寿命和分化潜能。 Cell Transplantation. 2004 | Pubmed ID: 15129755 脓毒症介入放射学病人。 Journal of Vascular and Interventional Radiology : JVIR. Apr, 2004 | Pubmed ID: 15064334 血管生成治疗心血管疾病。 Current Opinion in Anaesthesiology. Feb, 2003 | Pubmed ID: 17021436 在组织工程血管的基因治疗。 Tissue Engineering. Dec, 2003 | Pubmed ID: 14670116 脱细胞本机和工程动脉支架移植。 Cell Transplantation. 2003 | Pubmed ID: 14579934 工程猪动脉: 脚手架修改的影响。 Journal of Biomedical Materials Research. Part A. Oct, 2003 | Pubmed ID: 14517890 聚羟基乙酸对猪血管平滑肌细胞生长和分化。 Journal of Biomedical Materials Research. Part A. Oct, 2003 | Pubmed ID: 14517889 人体动脉工程体外。 EMBO Reports. Jun, 2003 | Pubmed ID: 12776184 不断增长的组织工程血管模型的要求。 Cardiovascular Pathology : the Official Journal of the Society for Cardiovascular Pathology. Mar-Apr, 2003 | Pubmed ID: 12684159 血管内皮生长因子表达的猪背阔肌肌皮瓣缺血再灌注损伤后。 Plastic and Reconstructive Surgery. Feb, 2003 | Pubmed ID: 12560698 组织工程学的淋巴系统。 Annals of the New York Academy of Sciences. Dec, 2002 | Pubmed ID: 12543713 生物反应器和生物加工: 分组会议摘要。 Annals of the New York Academy of Sciences. Jun, 2002 | Pubmed ID: 12081905 生物反应器和生物加工组织工程。 Annals of the New York Academy of Sciences. Jun, 2002 | Pubmed ID: 12081903 由去细胞化肺切片制备的工程肺组织 Katherine L. Leiby1,2, Ronald Ng1, Stuart G. Campbell1,3, Laura E. Niklason1,4 1Department of Biomedical Engineering, Yale University, 2Yale School of Medicine, 3Department of Cellular and Molecular Physiology, Yale School of Medicine, 4Department of Anesthesiology, Yale School of Medicine JoVE 63151 Bioengineering 基于生物工程,人造血管使用脉动生物反应器 Angela H. Huang1, Laura E. Niklason1,2 1Department of Biomedical Engineering, Yale University, 2Department of Anesthesiology, Yale University School of Medicine JoVE 2646 Bioengineering 龙工程的程序 Elizabeth A. Calle*1, Thomas H. Petersen*2, Laura E. Niklason1,3 1Department of Biomedical Engineering, Yale University, 2Department of Biomedical Engineering, School of Medicine, Duke University, 3Department of Anesthesia, Yale University JoVE 2651 Bioengineering
由去细胞化肺切片制备的工程肺组织 Katherine L. Leiby1,2, Ronald Ng1, Stuart G. Campbell1,3, Laura E. Niklason1,4 1Department of Biomedical Engineering, Yale University, 2Yale School of Medicine, 3Department of Cellular and Molecular Physiology, Yale School of Medicine, 4Department of Anesthesiology, Yale School of Medicine JoVE 63151 Bioengineering
基于生物工程,人造血管使用脉动生物反应器 Angela H. Huang1, Laura E. Niklason1,2 1Department of Biomedical Engineering, Yale University, 2Department of Anesthesiology, Yale University School of Medicine JoVE 2646 Bioengineering
龙工程的程序 Elizabeth A. Calle*1, Thomas H. Petersen*2, Laura E. Niklason1,3 1Department of Biomedical Engineering, Yale University, 2Department of Biomedical Engineering, School of Medicine, Duke University, 3Department of Anesthesia, Yale University JoVE 2651 Bioengineering