Laurent Kremer

Dynamique des Interactions Membranaires Normales et Pathologiques, Université Montpellier

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JoVE Journal Publications

ArticleTotal : 1	Year
Publication title Cited by 57	2015

Other Publications

Article	Year
The condensing activities of the Mycobacterium tuberculosis type II fatty acid synthase are differentially regulated by phosphorylation. The Journal of biological chemistry\| PubMed ID: 16873379	2006
Re-emergence of tuberculosis: strategies and treatment. Expert opinion on investigational drugs\| PubMed ID: 11829709	2002
Immunoregulatory functions of interleukin 18 and its role in defense against bacterial pathogens. Journal of molecular medicine (Berlin, Germany)\| PubMed ID: 11894141	2002
Ppm1, a novel polyprenol monophosphomannose synthase from Mycobacterium tuberculosis. The Biochemical journal\| PubMed ID: 11931640	2002
Characterization of a putative alpha-mannosyltransferase involved in phosphatidylinositol trimannoside biosynthesis in Mycobacterium tuberculosis. The Biochemical journal\| PubMed ID: 11964144	2002
Mycolic acid biosynthesis and enzymic characterization of the beta-ketoacyl-ACP synthase A-condensing enzyme from Mycobacterium tuberculosis. The Biochemical journal\| PubMed ID: 12023885	2002
The methyl-branched fortifications of Mycobacterium tuberculosis. Chemistry & biology\| PubMed ID: 12031661	2002
Structural study of lipomannan and lipoarabinomannan from Mycobacterium chelonae. Presence of unusual components with alpha 1,3-mannopyranose side chains. The Journal of biological chemistry\| PubMed ID: 12063260	2002
Current status and future development of antitubercular chemotherapy. Expert opinion on investigational drugs\| PubMed ID: 12150700	2002
Temperature-induced changes in the cell-wall components of Mycobacterium thermoresistibile. Microbiology (Reading, England)\| PubMed ID: 12368448	2002
Overexpression of inhA, but not kasA, confers resistance to isoniazid and ethionamide in Mycobacterium smegmatis, M. bovis BCG and M. tuberculosis. Molecular microbiology\| PubMed ID: 12406221	2002
Mycobacterium bovis BCG producing interleukin-18 increases antigen-specific gamma interferon production in mice. Infection and immunity\| PubMed ID: 12438324	2002
Inhibition of InhA activity, but not KasA activity, induces formation of a KasA-containing complex in mycobacteria. The Journal of biological chemistry\| PubMed ID: 12654922	2003
Immune response induced by recombinant Mycobacterium bovis BCG producing the cholera toxin B subunit. Infection and immunity\| PubMed ID: 12704173	2003
Lipomannan and lipoarabinomannan from a clinical isolate of Mycobacterium kansasii: novel structural features and apoptosis-inducing properties. The Journal of biological chemistry\| PubMed ID: 12829695	2003
Lipomannans, but not lipoarabinomannans, purified from Mycobacterium chelonae and Mycobacterium kansasii induce TNF-alpha and IL-8 secretion by a CD14-toll-like receptor 2-dependent mechanis... Journal of immunology (Baltimore, Md. : 1950)\| PubMed ID: 12902506	2003
Protein PknE, a novel transmembrane eukaryotic-like serine/threonine kinase from Mycobacterium tuberculosis. Biochemical and biophysical research communications\| PubMed ID: 12927792	2003
Crystallization and preliminary X-ray diffraction data of Mycobacterium tuberculosis FbpC1 (Rv3803c). Acta crystallographica. Section D, Biological crystallography\| PubMed ID: 14646102	2003
The structure of Mycobacterium tuberculosis MPT51 (FbpC1) defines a new family of non-catalytic alpha/beta hydrolases. Journal of molecular biology\| PubMed ID: 14672660	2004
An FHA phosphoprotein recognition domain mediates protein EmbR phosphorylation by PknH, a Ser/Thr protein kinase from Mycobacterium tuberculosis. Biochemistry\| PubMed ID: 14690440	2003
Toll-like receptor 2 (TLR2)-dependent-positive and TLR2-independent-negative regulation of proinflammatory cytokines by mycobacterial lipomannans. Journal of immunology (Baltimore, Md. : 1950)\| PubMed ID: 15034058	2004
The use of microarray analysis to determine the gene expression profiles of Mycobacterium tuberculosis in response to anti-bacterial compounds. Tuberculosis (Edinburgh, Scotland)\| PubMed ID: 15207496	2004
Mycobacterial lipoarabinomannan and related lipoglycans: from biogenesis to modulation of the immune response. Molecular microbiology\| PubMed ID: 15228522	2004
Altered NADH/NAD+ ratio mediates coresistance to isoniazid and ethionamide in mycobacteria. Antimicrobial agents and chemotherapy\| PubMed ID: 15673755	2005
Probing the mechanism of the Mycobacterium tuberculosis beta-ketoacyl-acyl carrier protein synthase III mtFabH: factors influencing catalysis and substrate specificity. The Journal of biological chemistry\| PubMed ID: 16040614	2005
Identification and structural characterization of an unusual mycobacterial monomeromycolyl-diacylglycerol. Molecular microbiology\| PubMed ID: 16091048	2005
Mycobacterial lipomannan induces matrix metalloproteinase-9 expression in human macrophagic cells through a Toll-like receptor 1 (TLR1)/TLR2- and CD14-dependent mechanism. Infection and immunity\| PubMed ID: 16177394	2005
LosA, a key glycosyltransferase involved in the biosynthesis of a novel family of glycosylated acyltrehalose lipooligosaccharides from Mycobacterium marinum. The Journal of biological chemistry\| PubMed ID: 16257960	2005
Conditional depletion of KasA, a key enzyme of mycolic acid biosynthesis, leads to mycobacterial cell lysis. Journal of bacteriology\| PubMed ID: 16267284	2005
GroEL1: a dedicated chaperone involved in mycolic acid biosynthesis during biofilm formation in mycobacteria. Cell\| PubMed ID: 16325580	2005
Molecular structure of EmbR, a response element of Ser/Thr kinase signaling in Mycobacterium tuberculosis. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 16477027	2006
Dual inhibition of mycobacterial fatty acid biosynthesis and degradation by 2-alkynoic acids. Chemistry & biology\| PubMed ID: 16638535	2006
pH-dependent pore-forming activity of OmpATb from Mycobacterium tuberculosis and characterization of the channel by peptidic dissection. Molecular microbiology\| PubMed ID: 16803587	2006
Transfer of a point mutation in Mycobacterium tuberculosis inhA resolves the target of isoniazid. Nature medicine\| PubMed ID: 16906155	2006
X-ray crystal structure of Mycobacterium tuberculosis beta-ketoacyl acyl carrier protein synthase II (mtKasB). Journal of molecular biology\| PubMed ID: 17174327	2007
EthA, a common activator of thiocarbamide-containing drugs acting on different mycobacterial targets. Antimicrobial agents and chemotherapy\| PubMed ID: 17220416	2007
Mycobacterial lipomannan induces granuloma macrophage fusion via a TLR2-dependent, ADAM9- and beta1 integrin-mediated pathway. Journal of immunology (Baltimore, Md. : 1950)\| PubMed ID: 17312164	2007
Identification by surface plasmon resonance of the mycobacterial lipomannan and lipoarabinomannan domains involved in binding to CD14 and LPS-binding protein. FEBS letters\| PubMed ID: 17350002	2007
Deletion of kasB in Mycobacterium tuberculosis causes loss of acid-fastness and subclinical latent tuberculosis in immunocompetent mice. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 17360388	2007
Polysaccharide structural variability in mycobacteria: identification and characterization of phosphorylated mannan and arabinomannan. Glycoconjugate journal\| PubMed ID: 17510794	2007
The Mycobacterium tuberculosis FAS-II condensing enzymes: their role in mycolic acid biosynthesis, acid-fastness, pathogenesis and in future drug development. Molecular microbiology\| PubMed ID: 17555433	2007
The N-terminal domain of OmpATb is required for membrane translocation and pore-forming activity in mycobacteria. Journal of bacteriology\| PubMed ID: 17573469	2007
Structure of Mycobacterium tuberculosis mtFabD, a malonyl-CoA:acyl carrier protein transacylase (MCAT). Acta crystallographica. Section F, Structural biology and crystallization communications\| PubMed ID: 17909282	2007
Functional role of the PE domain and immunogenicity of the Mycobacterium tuberculosis triacylglycerol hydrolase LipY. Infection and immunity\| PubMed ID: 17938218	2008
EmbR2, a structural homologue of EmbR, inhibits the Mycobacterium tuberculosis kinase/substrate pair PknH/EmbR. The Biochemical journal\| PubMed ID: 17999640	2008
Antimycobacterial Activity and Mechanism of Action of NAS-91. Antimicrobial agents and chemotherapy\| PubMed ID: 18086849	2008
Thiacetazone, an antitubercular drug that inhibits cyclopropanation of cell wall mycolic acids in mycobacteria. PloS one\| PubMed ID: 18094751	2007
The Mycobacterium tuberculosis serine/threonine kinase PknL phosphorylates Rv2175c: mass spectrometric profiling of the activation loop phosphorylation sites and their role in the recruitmen... Proteomics\| PubMed ID: 18175374	2008
Mycobacterial lipomannan induces MAP kinase phosphatase-1 expression in macrophages. FEBS letters\| PubMed ID: 18201568	2008
Expression, purification and characterisation of soluble GlfT and the identification of a novel galactofuranosyltransferase Rv3782 involved in priming GlfT-mediated galactan polymerisation i... Protein expression and purification\| PubMed ID: 18248822	2008
From the characterization of the four serine/threonine protein kinases (PknA/B/G/L) of Corynebacterium glutamicum toward the role of PknA and PknB in cell division. The Journal of biological chemistry\| PubMed ID: 18442973	2008
Growth of Mycobacterium tuberculosis biofilms containing free mycolic acids and harbouring drug-tolerant bacteria. Molecular microbiology\| PubMed ID: 18466296	2008
pETPhos: a customized expression vector designed for further characterization of Ser/Thr/Tyr protein kinases and their substrates. Plasmid\| PubMed ID: 18597845	2008
TLR2-dependent eosinophil interactions with mycobacteria: role of alpha-defensins. Blood\| PubMed ID: 18978205	2009
The fatty acid biosynthesis enzyme FabI plays a key role in the development of liver-stage malarial parasites. Cell host & microbe\| PubMed ID: 19064257	2008
The Mycobacterium tuberculosis beta-ketoacyl-acyl carrier protein synthase III activity is inhibited by phosphorylation on a single threonine residue. The Journal of biological chemistry\| PubMed ID: 19074144	2009
Mycolic acid methyltransferase, MmaA4, is necessary for thiacetazone susceptibility in Mycobacterium tuberculosis. Molecular microbiology\| PubMed ID: 19183278	2009
The Mycobacterium tuberculosis GroEL1 chaperone is a substrate of Ser/Thr protein kinases. Journal of bacteriology\| PubMed ID: 19201798	2009
Dynamic and structural characterization of a bacterial FHA protein reveals a new autoinhibition mechanism. Structure (London, England : 1993)\| PubMed ID: 19368890	2009
The Mycobacterium tuberculosis Ser/Thr kinase substrate Rv2175c is a DNA-binding protein regulated by phosphorylation. The Journal of biological chemistry\| PubMed ID: 19457863	2009
Mycobacterium marinum lipooligosaccharides are unique caryophyllose-containing cell wall glycolipids that inhibit tumor necrosis factor-alpha secretion in macrophages. The Journal of biological chemistry\| PubMed ID: 19491094	2009
Oleic acid biosynthesis in Plasmodium falciparum: characterization of the stearoyl-CoA desaturase and investigation as a potential therapeutic target. PloS one\| PubMed ID: 19707292	2009
Phosphorylation of the Mycobacterium tuberculosis beta-ketoacyl-acyl carrier protein reductase MabA regulates mycolic acid biosynthesis. The Journal of biological chemistry\| PubMed ID: 20178986	2010
Enzymatic hydrolysis of trehalose dimycolate releases free mycolic acids during mycobacterial growth in biofilms. The Journal of biological chemistry\| PubMed ID: 20375425	2010
Temperature-dependent regulation of mycolic acid cyclopropanation in saprophytic mycobacteria: role of the Mycobacterium smegmatis 1351 gene (MSMEG_1351) in CIS-cyclopropanation of alpha-myc... The Journal of biological chemistry\| PubMed ID: 20457615	2010
Division and cell envelope regulation by Ser/Thr phosphorylation: Mycobacterium shows the way. Molecular microbiology\| PubMed ID: 20487298	2010
An improved method to unravel phosphoacceptors in Ser/Thr protein kinase-phosphorylated substrates. Proteomics\| PubMed ID: 20925060	2010
Structural analysis of an unusual bioactive N-acylated lipo-oligosaccharide LOS-IV in Mycobacterium marinum. Journal of the American Chemical Society\| PubMed ID: 20964371	2010
Phosphorylation of InhA inhibits mycolic acid biosynthesis and growth of Mycobacterium tuberculosis. Molecular microbiology\| PubMed ID: 21143326	2010
Synthesis and evaluation of anti-tubercular activity of new dithiocarbamate sugar derivatives. Bioorganic & medicinal chemistry letters\| PubMed ID: 21232949	2011
A Mycobacterium marinum TesA mutant defective for major cell wall-associated lipids is highly attenuated in Dictyostelium discoideum and zebrafish embryos. Molecular microbiology\| PubMed ID: 21375593	2011
Synthesis and in vitro antitubercular activity of ferrocene-based hydrazones. Bioorganic & medicinal chemistry letters\| PubMed ID: 21507641	2011
Expression of OmpATb is dependent on small membrane proteins in Mycobacterium bovis BCG. Tuberculosis (Edinburgh, Scotland)\| PubMed ID: 21802366	2011
Fatty acyl chains of Mycobacterium marinum lipooligosaccharides: structure, localization and acylation by PapA4 (MMAR_2343) protein. The Journal of biological chemistry\| PubMed ID: 21803773	2011
Negative regulation by Ser/Thr phosphorylation of HadAB and HadBC dehydratases from Mycobacterium tuberculosis type II fatty acid synthase system. Biochemical and biophysical research communications\| PubMed ID: 21819969	2011
Mycobacterium tuberculosis lipolytic enzymes as potential biomarkers for the diagnosis of active tuberculosis. PloS one\| PubMed ID: 21966416	2011
AccD6, a key carboxyltransferase essential for mycolic acid synthesis in Mycobacterium tuberculosis, is dispensable in a nonpathogenic strain. Journal of bacteriology\| PubMed ID: 21984794	2011
Exposure of mycobacteria to cell wall-inhibitory drugs decreases the production of an arabinoglycerolipid related to mycolyl-arabinogalactan-peptidoglycan metabolism. The Journal of biological chemistry\| PubMed ID: 22315220	2012
CR3-dependent negative regulation of human eosinophils by Mycobacterium bovis BCG lipoarabinomannan. Immunology letters\| PubMed ID: 22391042	2012
Synthesis and in vitro anti-tubercular evaluation of 1,2,3-triazole tethered β-lactam-ferrocene and β-lactam-ferrocenylchalcone chimeric scaffolds. Dalton transactions (Cambridge, England : 2003)\| PubMed ID: 22473422	2012
Antitubercular activity of disulfiram, an antialcoholism drug, against multidrug- and extensively drug-resistant Mycobacterium tuberculosis isolates. Antimicrobial agents and chemotherapy\| PubMed ID: 22615274	2012
Phosphorylation of mycobacterial PcaA inhibits mycolic acid cyclopropanation: consequences for intracellular survival and for phagosome maturation block. The Journal of biological chemistry\| PubMed ID: 22621931	2012
Structural determination and Toll-like receptor 2-dependent proinflammatory activity of dimycolyl-diarabino-glycerol from Mycobacterium marinum. The Journal of biological chemistry\| PubMed ID: 22798072	2012
Identification of the Mycobacterium marinum Apa antigen O-mannosylation sites reveals important glycosylation variability with the M. tuberculosis Apa homologue. Journal of proteomics\| PubMed ID: 22828516	2012
The C-terminal domain of the virulence factor MgtC is a divergent ACT domain. Journal of bacteriology\| PubMed ID: 22984256	2012
MmPPOX inhibits Mycobacterium tuberculosis lipolytic enzymes belonging to the hormone-sensitive lipase family and alters mycobacterial growth. PloS one\| PubMed ID: 23029536	2012
Azide-alkyne cycloaddition en route towards 1H-1,2,3-triazole-tethered β-lactam-ferrocene and β-lactam-ferrocenylchalcone conjugates: synthesis and in vitro anti-tubercular evaluation. Dalton transactions (Cambridge, England : 2003)\| PubMed ID: 23108229	2013
Point mutations within the fatty acid synthase type II dehydratase components HadA or HadC contribute to isoxyl resistance in Mycobacterium tuberculosis. Antimicrobial agents and chemotherapy\| PubMed ID: 23114755	2013
Exposure to a cutinase-like serine esterase triggers rapid lysis of multiple mycobacterial species. The Journal of biological chemistry\| PubMed ID: 23155047	2013
Mycobacterium tuberculosis S-adenosyl-l-homocysteine hydrolase is negatively regulated by Ser/Thr phosphorylation. Biochemical and biophysical research communications\| PubMed ID: 23178568	2013
Synthesis, antitubercular activity and mechanism of resistance of highly effective thiacetazone analogues. PloS one\| PubMed ID: 23301038	2013
Montpellier Infectious Diseases (MID), 2nd annual meeting (2012). Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases\| PubMed ID: 23416259	2013
Overexpression of the KdpF membrane peptide in Mycobacterium bovis BCG results in reduced intramacrophage growth and altered cording morphology. PloS one\| PubMed ID: 23577107	2013
Mycobacterium tuberculosis maltosyltransferase GlgE, a genetically validated antituberculosis target, is negatively regulated by Ser/Thr phosphorylation. The Journal of biological chemistry\| PubMed ID: 23609448	2013
Keto-mycolic acid-dependent pellicle formation confers tolerance to drug-sensitive Mycobacterium tuberculosis. mBio\| PubMed ID: 23653446	2013
Identification and characterisation of small-molecule inhibitors of Rv3097c-encoded lipase (LipY) of Mycobacterium tuberculosis that selectively inhibit growth of bacilli in hypoxia. International journal of antimicrobial agents\| PubMed ID: 23684389	2013
Antituberculosis thiophenes define a requirement for Pks13 in mycolic acid biosynthesis. Nature chemical biology\| PubMed ID: 23770708	2013
4-Aminoquinoline-β-lactam conjugates: synthesis, antimalarial, and antitubercular evaluation. Chemical biology & drug design\| PubMed ID: 24034147	2014
Increased phagocytosis of Mycobacterium marinum mutants defective in lipooligosaccharide production: a structure-activity relationship study. The Journal of biological chemistry\| PubMed ID: 24235141	2014
7-chloroquinoline-isatin conjugates: antimalarial, antitubercular, and cytotoxic evaluation. Chemical biology & drug design\| PubMed ID: 24341638	2014
Mycobacterium abscessus cording prevents phagocytosis and promotes abscess formation. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 24567393	2014
Acetic Acid, the active component of vinegar, is an effective tuberculocidal disinfectant. mBio\| PubMed ID: 24570366	2014
The Mycobacterium tuberculosis transcriptional repressor EthR is negatively regulated by Serine/Threonine phosphorylation. Biochemical and biophysical research communications\| PubMed ID: 24667600	2014
In vivo assessment of drug efficacy against Mycobacterium abscessus using the embryonic zebrafish test system. Antimicrobial agents and chemotherapy\| PubMed ID: 24798271	2014
Phosphorylation of KasB regulates virulence and acid-fastness in Mycobacterium tuberculosis. PLoS pathogens\| PubMed ID: 24809459	2014
[Mycobacterial cording: a new mechanism of immune evasion?]. Médecine sciences : M/S\| PubMed ID: 24939532	2014
Design, synthesis and docking studies of some novel (R)-2-(4'-chlorophenyl)-3-(4'-nitrophenyl)-1,2,3,5-tetrahydrobenzo[4,5] imidazo [1,2-c]pyrimidin-4-ol derivatives as antitubercular agents... European journal of medicinal chemistry\| PubMed ID: 24972340	2014
Overexpression of the Salmonella KdpF membrane peptide modulates expression of kdp genes and intramacrophage growth. FEMS microbiology letters\| PubMed ID: 25197761	2014
β-Lactamase inhibition by avibactam in Mycobacterium abscessus. The Journal of antimicrobial chemotherapy\| PubMed ID: 25525201	2015
Mycobacterium marinum MgtC Plays a Role in Phagocytosis but is Dispensable for Intracellular Multiplication. PloS one\| PubMed ID: 25545682	2014
Characterization of a new rat model for chronic inflammatory demyelinating polyneuropathies. Journal of neuroimmunology\| PubMed ID: 25595246	2015
Neural correlates of visual hallucinations in dementia with Lewy bodies. Alzheimer's research & therapy\| PubMed ID: 25717349	2015
A new dehydratase conferring innate resistance to thiacetazone and intra-amoebal survival of Mycobacterium smegmatis. Molecular microbiology\| PubMed ID: 25754266	2015
The Molecular Genetics of Mycolic Acid Biosynthesis. Microbiology spectrum\| PubMed ID: 26104214	2014
[Looking through zebrafish to study host-pathogen interactions]. Médecine sciences : M/S\| PubMed ID: 26152168	2015