Leonid Kruglyak

Publications

• Massively Scaled-up Testing for SARS-CoV-2 RNA Via Next-generation Sequencing of Pooled and Barcoded Nasal and Saliva Samples
  Nature Biomedical Engineering. 07, 2021  |   Pubmed ID: 34211145
• Genetics of White Color and Iridophoroma in "Lemon Frost" Leopard Geckos
  PLoS Genetics. Jun, 2021  |   Pubmed ID: 34166378
• Retrospective Detection of SARS-CoV-2 in Symptomatic Patients Prior to Widespread Diagnostic Testing in Southern California
  Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America. May, 2021  |   Pubmed ID: 33939799
• Whole-organism EQTL Mapping at Cellular Resolution with Single-cell Sequencing
  ELife. Mar, 2021  |   Pubmed ID: 33734084
• Ancient Balancing Selection Maintains Incompatible Versions of the Galactose Pathway in Yeast
  Science (New York, N.Y.). 01, 2021  |   Pubmed ID: 33479156
• Ubiquitous Selfish Toxin-Antidote Elements in Caenorhabditis Species
  Current Biology : CB. 03, 2021  |   Pubmed ID: 33417886
• Swab-Seq: A High-throughput Platform for Massively Scaled Up SARS-CoV-2 Testing
  MedRxiv : the Preprint Server for Health Sciences. Mar, 2021  |   Pubmed ID: 32909008
• Systematic Identification of -regulatory Variants That Cause Gene Expression Differences in a Yeast Cross
  ELife. 11, 2020  |   Pubmed ID: 33179598
• Toxin-Antidote Elements Across the Tree of Life
  Annual Review of Genetics. 11, 2020  |   Pubmed ID: 32886546
• Screening Human Embryos for Polygenic Traits Has Limited Utility
  Cell. 11, 2019  |   Pubmed ID: 31761530
• Rare Variants Contribute Disproportionately to Quantitative Trait Variation in Yeast
  ELife. 10, 2019  |   Pubmed ID: 31647408
• Analysis of the Genetic Basis of Height in Large Jewish Nuclear Families
  PLoS Genetics. 07, 2019  |   Pubmed ID: 31283753
• Fast Genetic Mapping of Complex Traits in C. Elegans Using Millions of Individuals in Bulk
  Nature Communications. 06, 2019  |   Pubmed ID: 31213597
• The Genetic Basis of Mutation Rate Variation in Yeast
  Genetics. 02, 2019  |   Pubmed ID: 30504363
• How Low Can You Go?
  The CRISPR Journal. 10, 2018  |   Pubmed ID: 31021269
• Genetics of -regulatory Variation in Gene Expression
  ELife. 07, 2018  |   Pubmed ID: 30014850
• Highly Parallel Genome Variant Engineering with CRISPR-Cas9
  Nature Genetics. 04, 2018  |   Pubmed ID: 29632376
• The Genetic Basis of Natural Variation in a Phoretic Behavior
  Nature Communications. 08, 2017  |   Pubmed ID: 28819099
• A Genetic Signature of the Evolution of Loss of Flight in the Galapagos Cormorant
  Science (New York, N.Y.). Jun, 2017  |   Pubmed ID: 28572335
• A Maternal-effect Selfish Genetic Element in
  Science (New York, N.Y.). 06, 2017  |   Pubmed ID: 28495877
• Accounting for Genetic Interactions Improves Modeling of Individual Quantitative Trait Phenotypes in Yeast
  Nature Genetics. Apr, 2017  |   Pubmed ID: 28250458
• The Genetic Basis of Natural Variation in Caenorhabditis Elegans Telomere Length
  Genetics. Jul, 2016  |   Pubmed ID: 27449056
• Complex Traits and Simple Systems: An Interview with Leonid Kruglyak
  Genetics. Jul, 2016  |   Pubmed ID: 27384025
• CRISPR-directed Mitotic Recombination Enables Genetic Mapping Without Crosses
  Science (New York, N.Y.). May, 2016  |   Pubmed ID: 27230379
• 2015 Curt Stern Award
  American Journal of Human Genetics. Mar, 2016  |   Pubmed ID: 26942280
• Genetic Interactions Contribute Less Than Additive Effects to Quantitative Trait Variation in Yeast
  Nature Communications. Nov, 2015  |   Pubmed ID: 26537231
• Genetics of Intraspecies Variation in Avoidance Behavior Induced by a Thermal Stimulus in Caenorhabditis Elegans
  Genetics. Aug, 2015  |   Pubmed ID: 26092720
• Remarkably Divergent Regions Punctuate the Genome Assembly of the Caenorhabditis Elegans Hawaiian Strain CB4856
  Genetics. Jul, 2015  |   Pubmed ID: 25995208
• Full-genome Evolutionary Histories of Selfing, Splitting, and Selection in Caenorhabditis
  Genome Research. May, 2015  |   Pubmed ID: 25783854
• A Powerful New Quantitative Genetics Platform, Combining Caenorhabditis Elegans High-Throughput Fitness Assays with a Large Collection of Recombinant Strains
  G3 (Bethesda, Md.). Mar, 2015  |   Pubmed ID: 25770127
• The Role of Regulatory Variation in Complex Traits and Disease
  Nature Reviews. Genetics. Apr, 2015  |   Pubmed ID: 25707927
• A Wild C. Elegans Strain Has Enhanced Epithelial Immunity to a Natural Microsporidian Parasite
  PLoS Pathogens. Feb, 2015  |   Pubmed ID: 25680197
• Genetic Mapping of MAPK-mediated Complex Traits Across S. Cerevisiae
  PLoS Genetics. Jan, 2015  |   Pubmed ID: 25569670
• Genetic Basis of Haloperidol Resistance in Saccharomyces Cerevisiae is Complex and Dose Dependent
  PLoS Genetics. Dec, 2014  |   Pubmed ID: 25521586
• Genetic Influences on Translation in Yeast
  PLoS Genetics. Oct, 2014  |   Pubmed ID: 25340754
• Genetic Influences on Brain Gene Expression in Rats Selected for Tameness and Aggression
  Genetics. Nov, 2014  |   Pubmed ID: 25189874
• Genetic Basis of Metabolome Variation in Yeast
  PLoS Genetics. Mar, 2014  |   Pubmed ID: 24603560
• A Variant in the Neuropeptide Receptor Npr-1 is a Major Determinant of Caenorhabditis Elegans Growth and Physiology
  PLoS Genetics. Feb, 2014  |   Pubmed ID: 24586193
• Genetics of Single-cell Protein Abundance Variation in Large Yeast Populations
  Nature. Feb, 2014  |   Pubmed ID: 24402228
• Genetic Basis of Ammonium Toxicity Resistance in a Sake Strain of Yeast: A Mendelian Case
  G3 (Bethesda, Md.). Mar, 2013  |   Pubmed ID: 23550140
• Finding the Sources of Missing Heritability in a Yeast Cross
  Nature. Feb, 2013  |   Pubmed ID: 23376951
• Long-range Regulatory Polymorphisms Affecting a GABA Receptor Constitute a Quantitative Trait Locus (QTL) for Social Behavior in Caenorhabditis Elegans
  PLoS Genetics. 2012  |   Pubmed ID: 23284308
• Multiparameter Behavioral Profiling Reveals Distinct Thermal Response Regimes in Caenorhabditis Elegans
  BMC Biology. Oct, 2012  |   Pubmed ID: 23114012
• More Than the Sum of Its Parts: a Complex Epistatic Network Underlies Natural Variation in Thermal Preference Behavior in Caenorhabditis Elegans
  Genetics. Dec, 2012  |   Pubmed ID: 23086219
• Absence of Detectable Arsenate in DNA from Arsenate-grown GFAJ-1 Cells
  Science (New York, N.Y.). Jul, 2012  |   Pubmed ID: 22773140
• Natural Variation in a Chloride Channel Subunit Confers Avermectin Resistance in C. Elegans
  Science (New York, N.Y.). Feb, 2012  |   Pubmed ID: 22301316
• Chromosome-scale Selective Sweeps Shape Caenorhabditis Elegans Genomic Diversity
  Nature Genetics. Jan, 2012  |   Pubmed ID: 22286215
• Accurate Proteome-wide Protein Quantification from High-resolution 15N Mass Spectra
  Genome Biology. Dec, 2011  |   Pubmed ID: 22182234
• Catecholamine Receptor Polymorphisms Affect Decision-making in C. Elegans
  Nature. Apr, 2011  |   Pubmed ID: 21412235
• Selection at Linked Sites Shapes Heritable Phenotypic Variation in C. Elegans
  Science (New York, N.Y.). Oct, 2010  |   Pubmed ID: 20947766
• Dissection of Genetically Complex Traits with Extremely Large Pools of Yeast Segregants
  Nature. Apr, 2010  |   Pubmed ID: 20393561
• Optimized Detection of Sequence Variation in Heterozygous Genomes Using DNA Microarrays with Isothermal-melting Probes
  Proceedings of the National Academy of Sciences of the United States of America. Jan, 2010  |   Pubmed ID: 20080586
• Finding the Missing Heritability of Complex Diseases
  Nature. Oct, 2009  |   Pubmed ID: 19812666
• Using Expression and Genotype to Predict Drug Response in Yeast
  PloS One. Sep, 2009  |   Pubmed ID: 19730698
• Protein Quantification Across Hundreds of Experimental Conditions
  Proceedings of the National Academy of Sciences of the United States of America. Sep, 2009  |   Pubmed ID: 19717460
• Polymorphisms in Multiple Genes Contribute to the Spontaneous Mitochondrial Genome Instability of Saccharomyces Cerevisiae S288C Strains
  Genetics. Sep, 2009  |   Pubmed ID: 19581448
• Measuring Differential Gene Expression by Short Read Sequencing: Quantitative Comparison to 2-channel Gene Expression Microarrays
  BMC Genomics. May, 2009  |   Pubmed ID: 19435513
• A Practical Algorithm for Finding Maximal Exact Matches in Large Sequence Datasets Using Sparse Suffix Arrays
  Bioinformatics (Oxford, England). Jul, 2009  |   Pubmed ID: 19389736
• Quantitative Mapping of a Digenic Behavioral Trait Implicates Globin Variation in C. Elegans Sensory Behaviors
  Neuron. Mar, 2009  |   Pubmed ID: 19285466
• Comprehensive Polymorphism Survey Elucidates Population Structure of Saccharomyces Cerevisiae
  Nature. Mar, 2009  |   Pubmed ID: 19212320
• A Polymorphism in Npr-1 is a Behavioral Determinant of Pathogen Susceptibility in C. Elegans
  Science (New York, N.Y.). Jan, 2009  |   Pubmed ID: 19150845
• Comparative Developmental Expression Profiling of Two C. Elegans Isolates
  PloS One. 2008  |   Pubmed ID: 19116648
• Genetics. It's the Sequence, Stupid!
  Science (New York, N.Y.). Oct, 2008  |   Pubmed ID: 18927376
• Genetic Basis of Individual Differences in the Response to Small-molecule Drugs in Yeast
  Nature Genetics. Apr, 2007  |   Pubmed ID: 17334364
• Revealing Complex Traits with Small Molecules and Naturally Recombinant Yeast Strains
  Chemistry & Biology. Mar, 2006  |   Pubmed ID: 16638537
• Local Regulatory Variation in Saccharomyces Cerevisiae
  PLoS Genetics. Aug, 2005  |   Pubmed ID: 16121257
• Simultaneous Genotyping, Gene-expression Measurement, and Detection of Allele-specific Expression with Oligonucleotide Arrays
  Genome Research. Feb, 2005  |   Pubmed ID: 15687292
• The Landscape of Genetic Complexity Across 5,700 Gene Expression Traits in Yeast
  Proceedings of the National Academy of Sciences of the United States of America. Feb, 2005  |   Pubmed ID: 15659551
• Extensive and Breed-specific Linkage Disequilibrium in Canis Familiaris
  Genome Research. Dec, 2004  |   Pubmed ID: 15545498
• No Bias in Linkage Analysis
  American Journal of Human Genetics. Oct, 2004  |   Pubmed ID: 15338460
• Sequence-based Linkage Analysis
  American Journal of Human Genetics. Oct, 2004  |   Pubmed ID: 15329798
• Haplotype Diversity Across 100 Candidate Genes for Inflammation, Lipid Metabolism, and Blood Pressure Regulation in Two Populations
  American Journal of Human Genetics. Apr, 2004  |   Pubmed ID: 15015130
• Selecting a Maximally Informative Set of Single-nucleotide Polymorphisms for Association Analyses Using Linkage Disequilibrium
  American Journal of Human Genetics. Jan, 2004  |   Pubmed ID: 14681826
• Trans-acting Regulatory Variation in Saccharomyces Cerevisiae and the Role of Transcription Factors
  Nature Genetics. Sep, 2003  |   Pubmed ID: 12897782
• A 3.9-centimorgan-resolution Human Single-nucleotide Polymorphism Linkage Map and Screening Set
  American Journal of Human Genetics. Aug, 2003  |   Pubmed ID: 12844283
• Genetic Dissection of Transcriptional Regulation in Budding Yeast
  Science (New York, N.Y.). Apr, 2002  |   Pubmed ID: 11923494
• A New Susceptibility Locus for Autosomal Dominant Pancreatic Cancer Maps to Chromosome 4q32-34
  American Journal of Human Genetics. Apr, 2002  |   Pubmed ID: 11870593
• Lower-than-expected Linkage Disequilibrium Between Tightly Linked Markers in Humans Suggests a Role for Gene Conversion
  American Journal of Human Genetics. Sep, 2001  |   Pubmed ID: 11473344
• Sequence Variation and Linkage Disequilibrium in the Human T-cell Receptor Beta (TCRB) Locus
  American Journal of Human Genetics. Aug, 2001  |   Pubmed ID: 11438886
• Efficient Multipoint Linkage Analysis Through Reduction of Inheritance Space
  American Journal of Human Genetics. Apr, 2001  |   Pubmed ID: 11254453