Lorne Zinman

ALS/ MN Clinic, Sunnybrook Health Science Centre

Affiliated withSunnybrook Health Science Centre University of Toronto

Research Area

Biography

Lorne Zinman has not added Biography.
If you are Lorne Zinman and would like to personalize this page please email our Author Liaison for assistance.

JoVE Journal Publications

ArticleTotal : 2	Year
Publication title Cited by 41	2011
Publication title Cited by 41	2018

Other Publications

Article	Year
Low-intensity laser therapy for painful symptoms of diabetic sensorimotor polyneuropathy: a controlled trial. Diabetes care\| PubMed ID: 15047649	2004
Cooling detection thresholds in the assessment of diabetic sensory polyneuropathy: comparison of CASE IV and Medoc instruments. Diabetes care\| PubMed ID: 15220245	2004
Sensitivity of repetitive facial-nerve stimulation in patients with myasthenia gravis. Muscle & nerve\| PubMed ID: 16421884	2006
IV immunoglobulin in patients with myasthenia gravis: a randomized controlled trial. Neurology\| PubMed ID: 17353471	2007
Genetic studies of GRN and IFT74 in amyotrophic lateral sclerosis. Neurobiology of aging\| PubMed ID: 17383054	2008
Surrogate therapeutic outcome measures in patients with myasthenia gravis. Muscle & nerve\| PubMed ID: 17918748	2008
Evidence that TDP-43 is not the major ubiquitinated target within the pathological inclusions of amyotrophic lateral sclerosis. Journal of neuropathology and experimental neurology\| PubMed ID: 18090923	2007
IVIG treatment for myasthenia gravis: effectiveness, limitations, and novel therapeutic strategies. Annals of the New York Academy of Sciences\| PubMed ID: 18567877	2008
Are statin medications safe in patients with ALS? Amyotrophic lateral sclerosis : official publication of the World Federation of Neurology Research Group on Motor Neuron Diseases\| PubMed ID: 18608105	2008
Lack of evidence of monomer/misfolded superoxide dismutase-1 in sporadic amyotrophic lateral sclerosis. Annals of neurology\| PubMed ID: 19670443	2009
Kinematics of disease progression in bulbar ALS. Journal of communication disorders\| PubMed ID: 19683250	2010
Safety of influenza vaccination in patients with myasthenia gravis: a population-based study. Muscle & nerve\| PubMed ID: 19902540	2009
Amyotrophic lateral sclerosis is a non-amyloid disease in which extensive misfolding of SOD1 is unique to the familial form. Acta neuropathologica\| PubMed ID: 20111867	2010
Non-invasive ventilation for Canadian patients with ALS: do we have consensus? The Canadian journal of neurological sciences. Le journal canadien des sciences neurologiques\| PubMed ID: 20169767	2010
Safety and efficacy of lithium in combination with riluzole for treatment of amyotrophic lateral sclerosis: a randomised, double-blind, placebo-controlled trial. Lancet neurology\| PubMed ID: 20363190	2010
Distinct biochemical signatures characterize peripherin isoform expression in both traumatic neuronal injury and motor neuron disease. Journal of neurochemistry\| PubMed ID: 20533992	2010
RNA targets of TDP-43 identified by UV-CLIP are deregulated in ALS. Molecular and cellular neurosciences\| PubMed ID: 21421050	2011
Emerging targets and treatments in amyotrophic lateral sclerosis. Lancet neurology\| PubMed ID: 21511200	2011
Pathological heterogeneity in amyotrophic lateral sclerosis with FUS mutations: two distinct patterns correlating with disease severity and mutation. Acta neuropathologica\| PubMed ID: 21604077	2011
Paraspinal myopathy with novel shard-like compact aggregates of thin filaments. Muscle & nerve\| PubMed ID: 21660984	2011
A hexanucleotide repeat expansion in C9ORF72 is the cause of chromosome 9p21-linked ALS-FTD. Neuron\| PubMed ID: 21944779	2011
Tongue movements and their acoustic consequences in amyotrophic lateral sclerosis. Folia phoniatrica et logopaedica : official organ of the International Association of Logopedics and Phoniatrics (IALP)\| PubMed ID: 22555651	2012
Investigation of C9orf72 in 4 Neurodegenerative Disorders. Archives of neurology\| PubMed ID: 22964832	2012
Enhancing clinical trials in neurodegenerative disorders: lessons from amyotrophic lateral sclerosis. Current opinion in neurology\| PubMed ID: 23160423	2012
Mortality associated with periodic limb movements during sleep in amyotrophic lateral sclerosis patients. Einstein (Sao Paulo, Brazil)\| PubMed ID: 23386081	2012
Hypermethylation of the CpG island near the G4C2 repeat in ALS with a C9orf72 expansion. American journal of human genetics\| PubMed ID: 23731538	2013
Bulbar and speech motor assessment in ALS: Challenges and future directions. Amyotrophic lateral sclerosis & frontotemporal degeneration\| PubMed ID: 23898888	2013
Mutations in the Matrin 3 gene cause familial amyotrophic lateral sclerosis. Nature neuroscience\| PubMed ID: 24686783	2014
Venous thromboembolism in amyotrophic lateral sclerosis: a prospective study. Neurology\| PubMed ID: 24727309	2014
Hypermethylation of the CpG-island near the C9orf72 G₄C₂-repeat expansion in FTLD patients. Human molecular genetics\| PubMed ID: 24908669	2014
Economic burden of amyotrophic lateral sclerosis: a Canadian study of out-of-pocket expenses. Amyotrophic lateral sclerosis & frontotemporal degeneration\| PubMed ID: 25025935	2014
Mutation analysis of patients with neurodegenerative disorders using NeuroX array. Neurobiology of aging\| PubMed ID: 25174650	2015
Identical twins with the C9orf72 repeat expansion are discordant for ALS. Neurology\| PubMed ID: 25209579	2014
Electrical impedance myography in the evaluation of the tongue musculature in amyotrophic lateral sclerosis. Muscle & nerve\| PubMed ID: 25580728	2015
The C9orf72 repeat expansion itself is methylated in ALS and FTLD patients. Acta neuropathologica\| PubMed ID: 25716178	2015
Low molecular weight species of TDP-43 generated by abnormal splicing form inclusions in amyotrophic lateral sclerosis and result in motor neuron death. Acta neuropathologica\| PubMed ID: 25788357	2015
Mutation analysis of CHCHD10 in different neurodegenerative diseases. Brain : a journal of neurology\| PubMed ID: 25833818	2015
Jump from pre-mutation to pathologic expansion in C9orf72. American journal of human genetics\| PubMed ID: 26004200	2015
Isoform-specific antibodies reveal distinct subcellular localizations of C9orf72 in amyotrophic lateral sclerosis. Annals of neurology\| PubMed ID: 26174152	2015
MTHFSD and DDX58 are novel RNA-binding proteins abnormally regulated in amyotrophic lateral sclerosis. Brain : a journal of neurology\| PubMed ID: 26525917	2016
Profiling Speech and Pausing in Amyotrophic Lateral Sclerosis (ALS) and Frontotemporal Dementia (FTD). PloS one\| PubMed ID: 26789001	2016
C9orf72 isoforms in Amyotrophic Lateral Sclerosis and Frontotemporal Lobar Degeneration. Brain research\| PubMed ID: 27134035	2016
Predicting Speech Intelligibility Decline in Amyotrophic Lateral Sclerosis Based on the Deterioration of Individual Speech Subsystems. PloS one\| PubMed ID: 27148967	2016
Genetic and epigenetic study of ALS-discordant identical twins with double mutations in SOD1 and ARHGEF28. Journal of neurology, neurosurgery, and psychiatry\| PubMed ID: 27154192	2016
Physician-assisted death: A Canada-wide survey of ALS health care providers. Neurology\| PubMed ID: 27178703	2016
Speech in ALS: Longitudinal Changes in Lips and Jaw Movements and Vowel Acoustics. Journal of medical speech-language pathology\| PubMed ID: 27453680	2013
Speech Movement Measures as Markers of Bulbar Disease in Amyotrophic Lateral Sclerosis. Journal of speech, language, and hearing research : JSLHR\| PubMed ID: 27679842	2016
DNA methylation age-acceleration is associated with disease duration and age at onset in C9orf72 patients. Acta neuropathologica\| PubMed ID: 28439722	2017
Motor Phenotype in Neurodegenerative Disorders: Gait and Balance Platform Study Design Protocol for the Ontario Neurodegenerative Research Initiative (ONDRI). Journal of Alzheimer's disease : JAD\| PubMed ID: 28671116	2017
TIA1 Mutations in Amyotrophic Lateral Sclerosis and Frontotemporal Dementia Promote Phase Separation and Alter Stress Granule Dynamics. Neuron\| PubMed ID: 28817800	2017
Dysregulation of chromatin remodelling complexes in amyotrophic lateral sclerosis. Human molecular genetics\| PubMed ID: 28973294	2017
Loss of CHCHD10-CHCHD2 complexes required for respiration underlies the pathogenicity of a CHCHD10 mutation in ALS. Human molecular genetics\| PubMed ID: 29121267	2018
Neuroleptics as therapeutic compounds stabilizing neuromuscular transmission in amyotrophic lateral sclerosis. JCI insight\| PubMed ID: 29202456	2017
Clinical and neuropathological features of ALS/FTD with TIA1 mutations. Acta neuropathologica communications\| PubMed ID: 29216908	2017
Unaffected mosaiccase: RNA foci, dipeptide proteins, but upregulated C9orf72 expression. Neurology\| PubMed ID: 29282338	2018
Motor unit number index and neurophysiological index as candidate biomarkers of presymptomatic motor neuron loss in amyotrophic lateral sclerosis. Muscle & nerve\| PubMed ID: 29381812	2018
Downregulation of exosomal miR-204-5p and miR-632 as a biomarker for FTD: a GENFI study. Journal of neurology, neurosurgery, and psychiatry\| PubMed ID: 29434051	2018
Clinical Reasoning: A 42-year-old man with unilateral leg weakness. Neurology\| PubMed ID: 29555890	2018
Genome-wide Analyses Identify KIF5A as a Novel ALS Gene. Neuron\| PubMed ID: 29566793	2018