Lucy Liaw Maine Medical Center Research Institute Biography Publications Institution JoVE Articles Lucy Liaw has not added a biography. If you are Lucy Liaw and would like to personalize this page please email our Author Liaison for assistance. Publications Characterization of Smooth Muscle Cells from Human Atherosclerotic Lesions and Their Responses to Notch Signaling Laboratory Investigation; a Journal of Technical Methods and Pathology. Mar, 2019 | Pubmed ID: 29795127 Development of a 3D Bone Marrow Adipose Tissue Model Bone. Jan, 2019 | Pubmed ID: 29366838 A Renewable Source of Human Beige Adipocytes for Development of Therapies to Treat Metabolic Syndrome Cell Reports. Dec, 2018 | Pubmed ID: 30540952 Rab27a Regulates Human Perivascular Adipose Progenitor Cell Differentiation Cardiovascular Drugs and Therapy. 10, 2018 | Pubmed ID: 30105417 Notch2 and Proteomic Signatures in Mouse Neointimal Lesion Formation Arteriosclerosis, Thrombosis, and Vascular Biology. Jul, 2018 | Pubmed ID: 29853569 Loss of Spry1 Attenuates Vascular Smooth Muscle Proliferation by Impairing Mitogen-mediated Changes in Cell Cycle Regulatory Circuits Journal of Cellular Biochemistry. 04, 2018 | Pubmed ID: 29105817 Erratum To: Suppression of Spry4 Enhances Cancer Stem Cell Properties of Human MDA-MB-231 Breast Carcinoma Cells Cancer Cell International. 2017 | Pubmed ID: 28507453 Exercise Reverses Pain-related Weight Asymmetry and Differentially Modulates Trabecular Bone Microarchitecture in a Rat Model of Osteoarthritis Life Sciences. Jul, 2017 | Pubmed ID: 28504116 Effects of Treadmill Exercise on Advanced Osteoarthritis Pain in Rats Arthritis & Rheumatology (Hoboken, N.J.). 07, 2017 | Pubmed ID: 28320059 CRISPR/Cas9-Mediated Insertion of LoxP Sites in the Mouse Dock7 Gene Provides an Effective Alternative to Use of Targeted Embryonic Stem Cells G3 (Bethesda, Md.). 07, 2016 | Pubmed ID: 27175020 Suppression of Spry1 Inhibits Triple-negative Breast Cancer Malignancy by Decreasing EGF/EGFR Mediated Mesenchymal Phenotype Scientific Reports. 03, 2016 | Pubmed ID: 26976794 Suppression of Spry4 Enhances Cancer Stem Cell Properties of Human MDA-MB-231 Breast Carcinoma Cells Cancer Cell International. 2016 | Pubmed ID: 26973433 Lipid Profiling of In Vitro Cell Models of Adipogenic Differentiation: Relationships With Mouse Adipose Tissues Journal of Cellular Biochemistry. 09, 2016 | Pubmed ID: 26910604 Methods for Analyzing Tumor Angiogenesis in the Chick Chorioallantoic Membrane Model Methods in Molecular Biology (Clifton, N.J.). 2016 | Pubmed ID: 26820962 DLL4/Notch1 and BMP9 Interdependent Signaling Induces Human Endothelial Cell Quiescence Via P27KIP1 and Thrombospondin-1 Arteriosclerosis, Thrombosis, and Vascular Biology. Dec, 2015 | Pubmed ID: 26471266 Macrophage-derived Osteopontin Induces Reactive Astrocyte Polarization and Promotes Re-establishment of the Blood Brain Barrier After Ischemic Stroke Glia. Dec, 2015 | Pubmed ID: 26148976 Cthrc1 Controls Adipose Tissue Formation, Body Composition, and Physical Activity Obesity (Silver Spring, Md.). Aug, 2015 | Pubmed ID: 26148471 BMP9 Crosstalk with the Hippo Pathway Regulates Endothelial Cell Matricellular and Chemokine Responses PloS One. 2015 | Pubmed ID: 25909848 Fibroblast Growth Factor Signaling in the Vasculature Current Atherosclerosis Reports. Jun, 2015 | Pubmed ID: 25813213 SLUG is a Direct Transcriptional Repressor of PTEN Tumor Suppressor The Prostate. Jun, 2015 | Pubmed ID: 25728608 Dynamic Interplay Between Bone and Multiple Myeloma: Emerging Roles of the Osteoblast Bone. Jun, 2015 | Pubmed ID: 25725265 Inhibition of Tumor-associated αvβ3 Integrin Regulates the Angiogenic Switch by Enhancing Expression of IGFBP-4 Leading to Reduced Melanoma Growth and Angiogenesis in Vivo Angiogenesis. Jan, 2015 | Pubmed ID: 25249331 Notch Signal Integration in the Vasculature During Remodeling Vascular Pharmacology. Nov, 2014 | Pubmed ID: 25464152 Common Features of MicroRNA Target Prediction Tools Frontiers in Genetics. 2014 | Pubmed ID: 24600468 Interactive 3D Analysis of Blood Vessel Trees and Collateral Vessel Volumes in Magnetic Resonance Angiograms in the Mouse Ischemic Hindlimb Model The Open Medical Imaging Journal. Oct, 2013 | Pubmed ID: 24563682 A Receptor-specific Function for Notch2 in Mediating Vascular Smooth Muscle Cell Growth Arrest Through Cyclin-dependent Kinase Inhibitor 1B Circulation Research. Sep, 2013 | Pubmed ID: 23965337 Spry1 and Spry4 Differentially Regulate Human Aortic Smooth Muscle Cell Phenotype Via Akt/FoxO/myocardin Signaling PloS One. 2013 | Pubmed ID: 23554919 Notch1 Activation in Embryonic VE-cadherin Populations Selectively Blocks Hematopoietic Stem Cell Generation and Fetal Liver Hematopoiesis Transgenic Research. Apr, 2013 | Pubmed ID: 22851140 Effect of Soluble Jagged1-mediated Inhibition of Notch Signaling on Proliferation and Differentiation of an Adipocyte Progenitor Cell Model Adipocyte. Jan, 2012 | Pubmed ID: 23700510 Histone Deacetylase Activity Selectively Regulates Notch-mediated Smooth Muscle Differentiation in Human Vascular Cells Journal of the American Heart Association. Jun, 2012 | Pubmed ID: 23130137 Cthrc1, a Novel Circulating Hormone Regulating Metabolism PloS One. 2012 | Pubmed ID: 23056600 BMP9 Regulates Endoglin-dependent Chemokine Responses in Endothelial Cells Blood. Nov, 2012 | Pubmed ID: 23018639 Does Treatment of Split-thickness Skin Grafts with Negative-pressure Wound Therapy Improve Tissue Markers of Wound Healing in a Porcine Experimental Model? The Journal of Trauma and Acute Care Surgery. Aug, 2012 | Pubmed ID: 22846954 Molecular Pathways of Notch Signaling in Vascular Smooth Muscle Cells Frontiers in Physiology. 2012 | Pubmed ID: 22509166 Tissue-specific Expression of Sprouty1 in Mice Protects Against High-fat Diet-induced Fat Accumulation, Bone Loss and Metabolic Dysfunction The British Journal of Nutrition. Sep, 2012 | Pubmed ID: 22142492 Mechanisms of TGF-β-induced Differentiation in Human Vascular Smooth Muscle Cells Journal of Vascular Research. 2011 | Pubmed ID: 21832838 The MiR-143/145 Cluster is a Novel Transcriptional Target of Jagged-1/Notch Signaling in Vascular Smooth Muscle Cells The Journal of Biological Chemistry. Aug, 2011 | Pubmed ID: 21685392 Characterization of Pdgfrb-Cre Transgenic Mice Reveals Reduction of ROSA26 Reporter Activity in Remodeling Arteries Genesis (New York, N.Y. : 2000). Aug, 2011 | Pubmed ID: 21557454 Regulation of Non-classical FGF1 Release and FGF-dependent Cell Transformation by CBF1-mediated Notch Signaling Journal of Cellular Physiology. Nov, 2011 | Pubmed ID: 21302306 RhoA-mediated Signaling in Notch-induced Senescence-like Growth Arrest and Endothelial Barrier Dysfunction Arteriosclerosis, Thrombosis, and Vascular Biology. Apr, 2011 | Pubmed ID: 21273559 Follistatin-like 1 Regulates Renal IL-1β Expression in Cisplatin Nephrotoxicity American Journal of Physiology. Renal Physiology. Dec, 2010 | Pubmed ID: 20861081 Human Sulfatase 2 Inhibits in Vivo Tumor Growth of MDA-MB-231 Human Breast Cancer Xenografts BMC Cancer. Aug, 2010 | Pubmed ID: 20707913 Cleavage of Osteopontin by Matrix Metalloproteinase-12 Modulates Experimental Autoimmune Encephalomyelitis Disease in C57BL/6 Mice The American Journal of Pathology. Sep, 2010 | Pubmed ID: 20651245 The Contribution of the Tie2+ Lineage to Primitive and Definitive Hematopoietic Cells Genesis (New York, N.Y. : 2000). Sep, 2010 | Pubmed ID: 20645309 Targeted Genome Modification in Mice Using Zinc-finger Nucleases Genetics. Oct, 2010 | Pubmed ID: 20628038 Sprouty1 is a Critical Regulatory Switch of Mesenchymal Stem Cell Lineage Allocation FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology. Sep, 2010 | Pubmed ID: 20410440 Notch and Transforming Growth Factor-beta (TGFbeta) Signaling Pathways Cooperatively Regulate Vascular Smooth Muscle Cell Differentiation The Journal of Biological Chemistry. Jun, 2010 | Pubmed ID: 20368328 Antigen-specific Induction of Osteopontin Contributes to the Chronification of Allergic Contact Dermatitis The American Journal of Pathology. Jan, 2010 | Pubmed ID: 20008129 Organ-specific Lymphangiectasia, Arrested Lymphatic Sprouting, and Maturation Defects Resulting from Gene-targeting of the PI3K Regulatory Isoforms P85alpha, P55alpha, and P50alpha Developmental Dynamics : an Official Publication of the American Association of Anatomists. Oct, 2009 | Pubmed ID: 19705443 Generation of IPS Cells Using Defined Factors Linked Via the Self-cleaving 2A Sequences in a Single Open Reading Frame Cell Research. Mar, 2009 | Pubmed ID: 19238173 Novel Cross-talk Between Three Cardiovascular Regulators: Thrombin Cleavage Fragment of Jagged1 Induces Fibroblast Growth Factor 1 Expression and Release Molecular Biology of the Cell. Nov, 2008 | Pubmed ID: 18784255 Soluble Forms of the Notch Ligands Delta1 and Jagged1 Promote in Vivo Tumorigenicity in NIH3T3 Fibroblasts with Distinct Phenotypes The American Journal of Pathology. Sep, 2008 | Pubmed ID: 18688026 Cardiovascular and Hematopoietic Defects Associated with Notch1 Activation in Embryonic Tie2-expressing Populations Circulation Research. Aug, 2008 | Pubmed ID: 18617694 Overexpression of Spry1 in Chondrocytes Causes Attenuated FGFR Ubiquitination and Sustained ERK Activation Resulting in Chondrodysplasia Developmental Biology. Sep, 2008 | Pubmed ID: 18582454 Hairy-related Transcription Factors Inhibit Notch-induced Smooth Muscle Alpha-actin Expression by Interfering with Notch Intracellular Domain/CBF-1 Complex Interaction with the CBF-1-binding Site Circulation Research. Mar, 2008 | Pubmed ID: 18239137 Development of Fragment-specific Osteopontin Antibodies and ELISA for Quantification in Human Metastatic Breast Cancer BMC Cancer. Jan, 2008 | Pubmed ID: 18237408 Widespread Delta-like-1 Expression in Normal Adult Mouse Tissue and Injured Endothelium is Reflected by Expression of the Dll1LacZ Locus Journal of Vascular Research. 2008 | Pubmed ID: 17898542 Notch2 Signaling Induces Apoptosis and Inhibits Human MDA-MB-231 Xenograft Growth The American Journal of Pathology. Sep, 2007 | Pubmed ID: 17675579 Inhibition of Breast Cancer Cell Adhesion and Bone Metastasis by the Extracellular Adherence Protein of Staphylococcus Aureus Biochemical and Biophysical Research Communications. May, 2007 | Pubmed ID: 17418809 A Novel Mechanism of Transcriptional Repression of P27kip1 Through Notch/HRT2 Signaling in Vascular Smooth Muscle Cells Thrombosis and Haemostasis. Sep, 2006 | Pubmed ID: 16953280 Selective Expression of an AP2/Fatty Acid Binding Protein 4-Cre Transgene in Non-adipogenic Tissues During Embryonic Development Transgenic Research. Oct, 2006 | Pubmed ID: 16952017 Variable Recombination Efficiency in Responder Transgenes Activated by Cre Recombinase in the Vasculature Transgenic Research. Feb, 2006 | Pubmed ID: 16475014 Collagen Triple Helix Repeat Containing 1, a Novel Secreted Protein in Injured and Diseased Arteries, Inhibits Collagen Expression and Promotes Cell Migration Circulation Research. Feb, 2005 | Pubmed ID: 15618538 Expression and Characterization of Recombinant Osteopontin Peptides Representing Matrix Metalloproteinase Proteolytic Fragments Matrix Biology : Journal of the International Society for Matrix Biology. Nov, 2004 | Pubmed ID: 15579312 The Non-transmembrane Form of Delta1, but Not of Jagged1, Induces Normal Migratory Behavior Accompanied by Fibroblast Growth Factor Receptor 1-dependent Transformation The Journal of Biological Chemistry. Apr, 2004 | Pubmed ID: 14769803 Improved Analysis of the Vascular Response to Arterial Ligation Using a Multivariate Approach The American Journal of Pathology. Jan, 2004 | Pubmed ID: 14695317 Alterations of Arterial Physiology in Osteopontin-null Mice Arteriosclerosis, Thrombosis, and Vascular Biology. Jun, 2003 | Pubmed ID: 12714436 Notch Activation Suppresses Fibroblast Growth Factor-dependent Cellular Transformation The Journal of Biological Chemistry. May, 2003 | Pubmed ID: 12598523 Osteopontin Inhibits Mineral Deposition and Promotes Regression of Ectopic Calcification The American Journal of Pathology. Dec, 2002 | Pubmed ID: 12466120 Inactivation of the Osteopontin Gene Enhances Vascular Calcification of Matrix Gla Protein-deficient Mice: Evidence for Osteopontin As an Inducible Inhibitor of Vascular Calcification in Vivo The Journal of Experimental Medicine. Oct, 2002 | Pubmed ID: 12391016 Members of the Jagged/Notch Gene Families Are Expressed in Injured Arteries and Regulate Cell Phenotype Via Alterations in Cell Matrix and Cell-cell Interaction The American Journal of Pathology. Sep, 2001 | Pubmed ID: 11549580 मानव aortic परिसंवहनी एडिपोज जनक कोशिकाओं की भेदभाव क्षमता S. Spencer Scott1, Xuehui Yang1, Michael Robich1, Lucy Liaw1, Joshua M. Boucher1 1Maine Medical Center Research Institute JoVE 59337 Biology
मानव aortic परिसंवहनी एडिपोज जनक कोशिकाओं की भेदभाव क्षमता S. Spencer Scott1, Xuehui Yang1, Michael Robich1, Lucy Liaw1, Joshua M. Boucher1 1Maine Medical Center Research Institute JoVE 59337 Biology