Lukasz Opalinski Department of Protein Engineering, Faculty of Biotechnology University of Wroclaw Biography Publications Institution JoVE Articles Lukasz Opalinski has not added a biography. If you are Lukasz Opalinski and would like to personalize this page please email our Author Liaison for assistance. Publications FGF2-Derived PeptibodyF2-MMAE Conjugate for Targeted Delivery of Cytotoxic Drugs into Cancer Cells Overexpressing FGFR1 Cancers. Oct, 2020 | Pubmed ID: 33076489 Stable Fibroblast Growth Factor 2 Dimers with High Pro-Survival and Mitogenic Potential International Journal of Molecular Sciences. Jun, 2020 | Pubmed ID: 32526859 FGFR1 Clustering with Engineered Tetravalent Antibody Improves the Efficiency and Modifies the Mechanism of Receptor Internalization Molecular Oncology. 09, 2020 | Pubmed ID: 32511887 FHF1 is a Bona Fide Fibroblast Growth Factor That Activates Cellular Signaling in FGFR-dependent Manner Cell Communication and Signaling : CCS. May, 2020 | Pubmed ID: 32357892 Low Stability of Integrin-Binding Deficient Mutant of FGF1 Restricts Its Biological Activity Cells. 08, 2019 | Pubmed ID: 31443196 Differential Regulation of Fibroblast Growth Factor Receptor 1 Trafficking and Function by Extracellular Galectins Cell Communication and Signaling : CCS. 06, 2019 | Pubmed ID: 31208421 Cross-Talk Between Fibroblast Growth Factor Receptors and Other Cell Surface Proteins Cells. 05, 2019 | Pubmed ID: 31091809 Crosstalk Between P38 and Erk 1/2 in Downregulation of FGF1-Induced Signaling International Journal of Molecular Sciences. Apr, 2019 | Pubmed ID: 31013829 Targeting Cellular Trafficking of Fibroblast Growth Factor Receptors As a Strategy for Selective Cancer Treatment Journal of Clinical Medicine. Dec, 2018 | Pubmed ID: 30577533 FGF2 Dual Warhead Conjugate with Monomethyl Auristatin E and α-Amanitin Displays a Cytotoxic Effect Towards Cancer Cells Overproducing FGF Receptor 1 International Journal of Molecular Sciences. Jul, 2018 | Pubmed ID: 30029518 High Affinity Promotes Internalization of Engineered Antibodies Targeting FGFR1 International Journal of Molecular Sciences. May, 2018 | Pubmed ID: 29748524 Antibody-induced Dimerization of FGFR1 Promotes Receptor Endocytosis Independently of Its Kinase Activity Scientific Reports. 08, 2017 | Pubmed ID: 28769084 The Autoinhibitory Function of D1 Domain of FGFR1 Goes Beyond the Inhibition of Ligand Binding The International Journal of Biochemistry & Cell Biology. 08, 2017 | Pubmed ID: 28652212 The Molecular Basis of RhoA Specificity in the Guanine Nucleotide Exchange Factor PDZ-RhoGEF The Journal of Biological Chemistry. Oct, 2006 | Pubmed ID: 16954208 Preparation of Site-Specific Cytotoxic Protein Conjugates via Maleimide-thiol Chemistry and Sortase A-Mediated Ligation Mateusz Adam Krzyscik1,2, Aleksandra Sokolowska-Wedzina1, Karolina Jendryczko1, Marta Pozniak1, Daria Nawrocka1, Natalia Porebska1, Malgorzata Zakrzewska1, Jacek Otlewski1, Anna Szlachcic1, Lukasz Opalinski1 1Department of Protein Engineering, Faculty of Biotechnology, University of Wroclaw, 2Department of Protein Biotechnology, Faculty of Biotechnology, University of Wroclaw JoVE 61918 Biochemistry
Preparation of Site-Specific Cytotoxic Protein Conjugates via Maleimide-thiol Chemistry and Sortase A-Mediated Ligation Mateusz Adam Krzyscik1,2, Aleksandra Sokolowska-Wedzina1, Karolina Jendryczko1, Marta Pozniak1, Daria Nawrocka1, Natalia Porebska1, Malgorzata Zakrzewska1, Jacek Otlewski1, Anna Szlachcic1, Lukasz Opalinski1 1Department of Protein Engineering, Faculty of Biotechnology, University of Wroclaw, 2Department of Protein Biotechnology, Faculty of Biotechnology, University of Wroclaw JoVE 61918 Biochemistry