M. Juliana McElrath

Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Research Center

Affiliated withFred Hutchinson Cancer Research Center

Research Area

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JoVE Journal Publications

ArticleTotal : 1	Year
Publication title Cited by 14	2012

Other Publications

Article	Year
Variable fitness impact of HIV-1 escape mutations to cytotoxic T lymphocyte (CTL) response. PLoS pathogens\| PubMed ID: 19343217	2009
Safety and immunogenicity of a high-titered canarypox vaccine in combination with rgp120 in a diverse population of HIV-1-uninfected adults: AIDS Vaccine Evaluation Group Protocol 022A. Journal of acquired immune deficiency syndromes (1999)\| PubMed ID: 11873074	2002
Progress in the development of a preventive HIV-1 vaccine. Clinics in laboratory medicine\| PubMed ID: 12489290	2002
Early induction and maintenance of Env-specific T-helper cells following human immunodeficiency virus type 1 infection. Journal of virology\| PubMed ID: 12552005	2003
Moving to human immunodeficiency virus type 1 vaccine efficacy trials: defining T cell responses as potential correlates of immunity. The Journal of infectious diseases\| PubMed ID: 12552447	2003
Persistence of extraordinarily low levels of genetically homogeneous human immunodeficiency virus type 1 in exposed seronegative individuals. Journal of virology\| PubMed ID: 12743268	2003
Comprehensive analysis of human immunodeficiency virus type 1 (HIV-1)-specific gamma interferon-secreting CD8+ T cells in primary HIV-1 infection. Journal of virology\| PubMed ID: 12768006	2003
HIV-1 vaccination administered intramuscularly can induce both systemic and mucosal T cell immunity in HIV-1-uninfected individuals. Journal of immunology (Baltimore, Md. : 1950)\| PubMed ID: 12847284	2003
Most highly exposed seronegative men lack HIV-1-specific, IFN-gamma-secreting T cells. Journal of immunology (Baltimore, Md. : 1950)\| PubMed ID: 12928421	2003
Hepatitis C virus-specific cytolytic T cell responses after antiviral therapy. Clinical immunology (Orlando, Fla.)\| PubMed ID: 14499244	2003
Evolution of CD8+ T cell immunity and viral escape following acute HIV-1 infection. Journal of immunology (Baltimore, Md. : 1950)\| PubMed ID: 14500685	2003
Broadly increased sensitivity to cytotoxic T lymphocytes resulting from Nef epitope escape mutations. Journal of immunology (Baltimore, Md. : 1950)\| PubMed ID: 14530319	2003
Incomplete immune reconstitution after initiation of highly active antiretroviral therapy in human immunodeficiency virus-infected patients with severe CD4+ cell depletion. The Journal of infectious diseases\| PubMed ID: 14673757	2003
Association of T cell proliferative responses and phenotype with virus control in chronic progressive HIV-1 disease. The Journal of infectious diseases\| PubMed ID: 14745710	2004
Comparison of systemic and mucosal delivery of 2 canarypox virus vaccines expressing either HIV-1 genes or the gene for rabies virus G protein. The Journal of infectious diseases\| PubMed ID: 15031791	2004
Statistical considerations for the design and analysis of the ELISpot assay in HIV-1 vaccine trials. Journal of immunological methods\| PubMed ID: 15183082	2004
Absence of immunodominant anti-Gag p17 (SL9) responses among Gag CTL-positive, HIV-uninfected vaccine recipients expressing the HLA-A*0201 allele. Journal of immunology (Baltimore, Md. : 1950)\| PubMed ID: 15265949	2004
Breakthrough infections during phase 1 and 2 prime-boost HIV-1 vaccine trials with canarypox vectors (ALVAC) and booster dose of recombinant gp120 or gp160. The Journal of infectious diseases\| PubMed ID: 15295694	2004
Analysis of genetic polymorphisms in CCR5, CCR2, stromal cell-derived factor-1, RANTES, and dendritic cell-specific intercellular adhesion molecule-3-grabbing nonintegrin in seronegative ind... The Journal of infectious diseases\| PubMed ID: 15319853	2004
Effect of adjunct hydroxyurea on helper T cell immunity in HIV type 1-infected patients with virological suppression. AIDS research and human retroviruses\| PubMed ID: 15320983	2004
Correlation between interferon- gamma secretion and cytotoxicity, in virus-specific memory T cells. The Journal of infectious diseases\| PubMed ID: 15478077	2004
Demographic factors that influence the neutralizing antibody response in recipients of recombinant HIV-1 gp120 vaccines. The Journal of infectious diseases\| PubMed ID: 15529261	2004
Most DC-SIGNR transcripts at mucosal HIV transmission sites are alternatively spliced isoforms. European journal of human genetics : EJHG\| PubMed ID: 15812562	2005
High-dose recombinant Canarypox vaccine expressing HIV-1 protein, in seronegative human subjects. The Journal of infectious diseases\| PubMed ID: 16136469	2005
Combined effect of CCR5-Delta32 heterozygosity and the CCR5 promoter polymorphism -2459 A/G on CCR5 expression and resistance to human immunodeficiency virus type 1 transmission. Journal of virology\| PubMed ID: 16140745	2005
CD4+ T cell receptor repertoire perturbations in HIV-1 infection: association with plasma viremia and disease progression. Clinical immunology (Orlando, Fla.)\| PubMed ID: 16403675	2006
Repeat-region polymorphisms in the gene for the dendritic cell-specific intercellular adhesion molecule-3-grabbing nonintegrin-related molecule: effects on HIV-1 susceptibility. The Journal of infectious diseases\| PubMed ID: 16453266	2006
Genetic association of the antiviral restriction factor TRIM5alpha with human immunodeficiency virus type 1 infection. Journal of virology\| PubMed ID: 16474153	2006
Abacavir hypersensitivity reaction in primary HIV infection. AIDS (London, England)\| PubMed ID: 16816555	2006
Selection on the human immunodeficiency virus type 1 proteome following primary infection. Journal of virology\| PubMed ID: 16973556	2006
Induction of human immunodeficiency virus type 1 (HIV-1)-specific T-cell responses in HIV vaccine trial participants who subsequently acquire HIV-1 infection. Journal of virology\| PubMed ID: 16973582	2006
Durable HIV-1 antibody and T-cell responses elicited by an adjuvanted multi-protein recombinant vaccine in uninfected human volunteers. Vaccine\| PubMed ID: 17049679	2007
Preservation of T cell proliferation restricted by protective HLA alleles is critical for immune control of HIV-1 infection. Journal of immunology (Baltimore, Md. : 1950)\| PubMed ID: 17082660	2006
Phase 2 study of an HIV-1 canarypox vaccine (vCP1452) alone and in combination with rgp120: negative results fail to trigger a phase 3 correlates trial. Journal of acquired immune deficiency syndromes (1999)\| PubMed ID: 17106277	2007
Comprehensive epitope analysis of cross-clade Gag-specific T-cell responses in individuals with early HIV-1 infection in the US epidemic. Vaccine\| PubMed ID: 17112643	2007
Initial events in establishing vaginal entry and infection by human immunodeficiency virus type-1. Immunity\| PubMed ID: 17306567	2007
Enhanced detection of human immunodeficiency virus type 1 (HIV-1) Nef-specific T cells recognizing multiple variants in early HIV-1 infection. Journal of virology\| PubMed ID: 17329342	2007
Defining blood processing parameters for optimal detection of cryopreserved antigen-specific responses for HIV vaccine trials. Journal of immunological methods\| PubMed ID: 17382342	2007
Macaques infected with a CCR5-tropic simian/human immunodeficiency virus (SHIV) develop broadly reactive anti-HIV neutralizing antibodies. Journal of virology\| PubMed ID: 17392364	2007
Optimization and validation of an 8-color intracellular cytokine staining (ICS) assay to quantify antigen-specific T cells induced by vaccination. Journal of immunological methods\| PubMed ID: 17451739	2007
Role of human immunodeficiency virus (HIV)-specific T-cell immunity in control of dual HIV-1 and HIV-2 infection. Journal of virology\| PubMed ID: 17582003	2007
Evolution of human immunodeficiency virus type 1 cytotoxic T-lymphocyte epitopes: fitness-balanced escape. Journal of virology\| PubMed ID: 17728222	2007
A framework for assessing immunological correlates of protection in vaccine trials. The Journal of infectious diseases\| PubMed ID: 17922394	2007
Novel cytotoxic T-lymphocyte escape mutation by a three-amino-acid insertion in the human immunodeficiency virus type 1 p6Pol and p6Gag late domain associated with drug resistance. Journal of virology\| PubMed ID: 17942528	2008
Setting the stage: host invasion by HIV. Nature reviews. Immunology\| PubMed ID: 18469831	2008
Development of an automated analysis system for data from flow cytometric intracellular cytokine staining assays from clinical vaccine trials. Cytometry. Part A : the journal of the International Society for Analytical Cytology\| PubMed ID: 18615598	2008
Safety and immunogenicity of a CTL multiepitope peptide vaccine for HIV with or without GM-CSF in a phase I trial. Vaccine\| PubMed ID: 18996425	2009
Impaired viral entry cannot explain reduced CD4+ T cell susceptibility to HIV type 1 in certain highly exposed individuals. AIDS research and human retroviruses\| PubMed ID: 19000021	2008
Efficacy assessment of a cell-mediated immunity HIV-1 vaccine (the Step Study): a double-blind, randomised, placebo-controlled, test-of-concept trial. Lancet\| PubMed ID: 19012954	2008
HIV-1 vaccine-induced immunity in the test-of-concept Step Study: a case-cohort analysis. Lancet\| PubMed ID: 19012957	2008
Post-step modifications for research on HIV vaccines. AIDS (London, England)\| PubMed ID: 19050380	2009
T cell responses generated by HIV vaccines in clinical trials. Current opinion in HIV and AIDS\| PubMed ID: 19372993	2008
Human immunodeficiency virus type 1 mediates global disruption of innate antiviral signaling and immune defenses within infected cells. Journal of virology\| PubMed ID: 19706707	2009
Preinfection human immunodeficiency virus (HIV)-specific cytotoxic T lymphocytes failed to prevent HIV type 1 infection from strains genetically unrelated to viruses in long-term exposed par... Journal of virology\| PubMed ID: 19706711	2009
Differential specificity and immunogenicity of adenovirus type 5 neutralizing antibodies elicited by natural infection or immunization. Journal of virology\| PubMed ID: 19846512	2010
Polymorphisms in toll-like receptor 4 and toll-like receptor 9 influence viral load in a seroincident cohort of HIV-1-infected individuals. AIDS (London, England)\| PubMed ID: 19855253	2009
Conserved HIV-1 epitopes continuously elicit subdominant cytotoxic T-lymphocyte responses. The Journal of infectious diseases\| PubMed ID: 19909083	2009
Ex vivo comparison of microbicide efficacies for preventing HIV-1 genomic integration in intraepithelial vaginal cells. Antimicrobial agents and chemotherapy\| PubMed ID: 19949052	2010
Virus-specific CD8+ T-cell responses better define HIV disease progression than HLA genotype. Journal of virology\| PubMed ID: 20147397	2010
In situ detection of Gag-specific CD8+ cells in the GI tract of SIV infected Rhesus macaques. Retrovirology\| PubMed ID: 20158906	2010
HIV vaccines: mosaic approach to virus diversity. Nature medicine\| PubMed ID: 20208511	2010
Innate immune signaling induces high levels of TC-specific deaminase activity in primary monocyte-derived cells through expression of APOBEC3A isoforms. The Journal of biological chemistry\| PubMed ID: 20615867	2010
Immunization with cocktail of HIV-derived peptides in montanide ISA-51 is immunogenic, but causes sterile abscesses and unacceptable reactogenicity. PloS one\| PubMed ID: 20706632	2010
Immune responses to HIV vaccines and potential impact on control of acute HIV-1 infection. The Journal of infectious diseases\| PubMed ID: 20846040	2010
Induction of immunity to human immunodeficiency virus type-1 by vaccination. Immunity\| PubMed ID: 21029964	2010
Safety and immunogenicity of a replication-defective adenovirus type 5 HIV vaccine in Ad5-seronegative persons: a randomized clinical trial (HVTN 054). PloS one\| PubMed ID: 21048953	2010
The major genetic determinants of HIV-1 control affect HLA class I peptide presentation. Science (New York, N.Y.)\| PubMed ID: 21051598	2010
Profiles of human serum antibody responses elicited by three leading HIV vaccines focusing on the induction of Env-specific antibodies. PloS one\| PubMed ID: 21085486	2010
Serological immunity to adenovirus serotype 5 is not associated with risk of HIV infection: a case-control study. AIDS (London, England)\| PubMed ID: 21150554	2011
Equivalence of ELISpot assays demonstrated between major HIV network laboratories. PloS one\| PubMed ID: 21179404	2010
A phase I trial of preventive HIV vaccination with heterologous poxviral-vectors containing matching HIV-1 inserts in healthy HIV-uninfected subjects. Vaccine\| PubMed ID: 21216311	2011
Host genetic determinants of T cell responses to the MRKAd5 HIV-1 gag/pol/nef vaccine in the step trial. The Journal of infectious diseases\| PubMed ID: 21278214	2011
Dynamics of viral evolution and CTL responses in HIV-1 infection. PloS one\| PubMed ID: 21283794	2011
Standing guard at the mucosa. Immunity\| PubMed ID: 21349427	2011
Genetic impact of vaccination on breakthrough HIV-1 sequences from the STEP trial. Nature medicine\| PubMed ID: 21358627	2011
Trivalent adenovirus type 5 HIV recombinant vaccine primes for modest cytotoxic capacity that is greatest in humans with protective HLA class I alleles. PLoS pathogens\| PubMed ID: 21383976	2011
Association between peripheral Î³Î´ T-cell profile and disease progression in individuals infected with HIV-1 or HIV-2 in West Africa. Journal of acquired immune deficiency syndromes (1999)\| PubMed ID: 21423026	2011
A trimeric, V2-deleted HIV-1 envelope glycoprotein vaccine elicits potent neutralizing antibodies but limited breadth of neutralization in human volunteers. The Journal of infectious diseases\| PubMed ID: 21451004	2011
Priming CD8+ T cells with dendritic cells matured using TLR4 and TLR7/8 ligands together enhances generation of CD8+ T cells retaining CD28. Blood\| PubMed ID: 21493800	2011
Pre-existing adenovirus immunity modifies a complex mixed Th1 and Th2 cytokine response to an Ad5/HIV-1 vaccine candidate in humans. PloS one\| PubMed ID: 21533229	2011
Demographic processes affect HIV-1 evolution in primary infection before the onset of selective processes. Journal of virology\| PubMed ID: 21593162	2011
Mapping HIV-1 vaccine induced T-cell responses: bias towards less-conserved regions and potential impact on vaccine efficacy in the Step study. PloS one\| PubMed ID: 21695251	2011
Vaccine-induced HIV-specific CD8+ T cells utilize preferential HLA alleles and target-specific regions of HIV-1. Journal of acquired immune deficiency syndromes (1999)\| PubMed ID: 21709567	2011
Host genetic polymorphisms associated with innate immune factors and HIV-1. Current opinion in HIV and AIDS\| PubMed ID: 21734565	2011
Protective HIV-specific CD8+ T cells evade Treg cell suppression. Nature medicine\| PubMed ID: 21765403	2011
HIV-DNA priming alters T cell responses to HIV-adenovirus vaccine even when responses to DNA are undetectable. Journal of immunology (Baltimore, Md. : 1950)\| PubMed ID: 21844392	2011
A phase IIA randomized clinical trial of a multiclade HIV-1 DNA prime followed by a multiclade rAd5 HIV-1 vaccine boost in healthy adults (HVTN204). PloS one\| PubMed ID: 21857901	2011
Safety and immunogenicity of an HIV adenoviral vector boost after DNA plasmid vaccine prime by route of administration: a randomized clinical trial. PloS one\| PubMed ID: 21931737	2011
Timing of plasmid cytokine (IL-2/Ig) administration affects HIV-1 vaccine immunogenicity in HIV-seronegative subjects. The Journal of infectious diseases\| PubMed ID: 21940420	2011
Vaginal langerhans cells nonproductively transporting HIV-1 mediate infection of T cells. Journal of virology\| PubMed ID: 21976645	2011
Profiling immunity to HIV vaccines with systems biology. Current opinion in HIV and AIDS\| PubMed ID: 22134340	2012
Genomewide association study for determinants of HIV-1 acquisition and viral set point in HIV-1 serodiscordant couples with quantified virus exposure. PloS one\| PubMed ID: 22174851	2011
Human adenovirus-specific T cells modulate HIV-specific T cell responses to an Ad5-vectored HIV-1 vaccine. The Journal of clinical investigation\| PubMed ID: 22201684	2012
Immune-correlates analysis of an HIV-1 vaccine efficacy trial. The New England journal of medicine\| PubMed ID: 22475592	2012
Decreased pre-existing Ad5 capsid and Ad35 neutralizing antibodies increase HIV-1 infection risk in the Step trial independent of vaccination. PloS one\| PubMed ID: 22496775	2012
Vpu Mediates Depletion of Interferon Regulatory Factor 3 during HIV Infection by a Lysosome-Dependent Mechanism. Journal of virology\| PubMed ID: 22593165	2012
Optimization and qualification of a multiplex bead array to assess cytokine and chemokine production by vaccine-specific cells. Journal of immunological methods\| PubMed ID: 22626638	2012
Vpu-Deficient HIV Strains Stimulate Innate Immune Signaling Responses in Target Cells. Journal of virology\| PubMed ID: 22647704	2012
Two new monoclonal antibodies for biochemical and flow cytometric analyses of human interferon regulatory factor-3 activation, turnover, and depletion. Methods (San Diego, Calif.)\| PubMed ID: 22705311	2012
Is an HIV vaccine possible? Journal of acquired immune deficiency syndromes (1999)\| PubMed ID: 22772390	2012
A Novel HIV Vaccine Adjuvanted by IC31 Induces Robust and Persistent Humoral and Cellular Immunity. PloS one\| PubMed ID: 22848738	2012
Quantifying Ongoing HIV-1 Exposure in HIV-1-Serodiscordant Couples to Identify Individuals With Potential Host Resistance to HIV-1. The Journal of infectious diseases\| PubMed ID: 22926009	2012
MRKAd5 HIV-1 Gag/Pol/Nef Vaccine-Induced T-Cell Responses Inadequately Predict Distance of Breakthrough HIV-1 Sequences to the Vaccine or Viral Load. PloS one\| PubMed ID: 22952672	2012