Marcelo Cypel Toronto General Hospital Research Institute University Health Network Biography Publications Institution JoVE Articles Marcelo Cypel has not added a biography. If you are Marcelo Cypel and would like to personalize this page please email our Author Liaison for assistance. Publications A Machine-learning Approach to Human Ex Vivo Lung Perfusion Predicts Transplantation Outcomes and Promotes Organ Utilization Nature Communications. Aug, 2023 | Pubmed ID: 37558674 Extending the Age Criteria of Lung Transplant Donors to 70+ Years Old Does Not Significantly Affect Recipient Survival The Journal of Thoracic and Cardiovascular Surgery. Aug, 2023 | Pubmed ID: 37541572 Identification of Regional Variation in Gene Expression and Inflammatory Proteins in Donor Lung Tissue and Ex vivo Lung Perfusate The Journal of Thoracic and Cardiovascular Surgery. Jul, 2023 | Pubmed ID: 37482240 Incidence of Post-transplant Cytomegalovirus Viremia in Patients Receiving Lungs After Ex vivo Lung Perfusion JTCVS Open. Jun, 2023 | Pubmed ID: 37425481 Time to Extubation for Lung Transplant Recipients Represents a Pragmatic End-point to Guide the Development of Prognostic Tests The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation. Jul, 2023 | Pubmed ID: 37406839 Immunomodulation of the Donor Lung with CRISPR-mediated Activation of IL-10 Expression The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation. Oct, 2023 | Pubmed ID: 37315746 Intra-subject Variability in Oscillometry Correlates with Acute Rejection and CLAD Post-lung Transplant Frontiers in Medicine. 2023 | Pubmed ID: 37305133 Outcomes of Patients with Respiratory Failure Declined for Extracorporeal Membrane Oxygenation: a Prospective Observational Study Canadian Journal of Anaesthesia = Journal Canadien D'anesthesie. Jul, 2023 | Pubmed ID: 37280459 Outcomes After Flow Cytometry Crossmatch-positive Lung Transplants Managed with Perioperative Desensitization American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons. May, 2023 | Pubmed ID: 37172694 Alpha-1-antitrypsin Safely Promotes Rapid Recovery of Pigs After Lung Transplantation American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons. Jul, 2023 | Pubmed ID: 37004914 Expanding the Lung Donor Pool: Donation After Circulatory Death, Ex-Vivo Lung Perfusion and Hepatitis C Donors Clinics in Chest Medicine. Mar, 2023 | Pubmed ID: 36774170 Triaging Donor Lungs Based on a Microaspiration Signature That Predicts Adverse Recipient Outcome The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation. Apr, 2023 | Pubmed ID: 36710092 Low-Flow Inflation Pressure-Time Curve to Identify Airway Opening Pressure in a Patient Receiving Venovenous Extracorporeal Membrane Oxygenation American Journal of Respiratory and Critical Care Medicine. Jun, 2023 | Pubmed ID: 36693031 Prevention and Management of Chronic Postsurgical Pain and Persistent Opioid Use Following Solid Organ Transplantation: Experiences From the Toronto General Hospital Transitional Pain Service Transplantation. Jun, 2023 | Pubmed ID: 36482750 Influence of Anterior Tumor Location on Survival After Resection of Lung Cancer Invading the Thoracic Inlet (Pancoast Tumors) The Journal of Thoracic and Cardiovascular Surgery. May, 2023 | Pubmed ID: 36481062 Overcoming the Limits of Lung Transplantation: 10°C Static Cold Preservation Archivos De Bronconeumologia. May, 2023 | Pubmed ID: 36473818 L-alanyl-L-glutamine Modified Perfusate Improves Human Lung Cell Functions and Extend Porcine Ex Vivo Lung Perfusion The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation. Feb, 2023 | Pubmed ID: 36411189 Determining the Impact of Ex-vivo Lung Perfusion on Hospital Costs for Lung Transplantation: A Retrospective Cohort Study The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation. Mar, 2023 | Pubmed ID: 36411188 Outcomes of Lung Transplantation from Donors with a History of Substance Abuse The Journal of Thoracic and Cardiovascular Surgery. Jan, 2023 | Pubmed ID: 36216597 Altered Purine Metabolism at Reperfusion Affects Clinical Outcome in Lung Transplantation Thorax. Mar, 2023 | Pubmed ID: 35450941 Lung Transplantation for Acute Respiratory Distress Syndrome The Journal of Thoracic and Cardiovascular Surgery. Apr, 2023 | Pubmed ID: 35379475 Testing the Delivery of Human Organ Transportation with Drones in the Real World Science Robotics. Dec, 2022 | Pubmed ID: 36542685 Evaluation of 10°C As the Optimal Storage Temperature for Aspiration-injured Donor Lungs in a Large Animal Transplant Model The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation. Dec, 2022 | Pubmed ID: 36216693 The Association Between Extravascular Lung Water and Critical Care Outcomes Following Bilateral Lung Transplantation Transplantation Direct. Oct, 2022 | Pubmed ID: 36176725 Metabolomic Fingerprinting of Porcine Lung Tissue During Pre-clinical Prolonged Lung Perfusion Using SPME Coupled with LC-HRMS Journal of Pharmaceutical Analysis. Aug, 2022 | Pubmed ID: 36105172 A Biomarker Assay to Risk-stratify Patients with Symptoms of Respiratory Tract Infection The European Respiratory Journal. Dec, 2022 | Pubmed ID: 36104292 The Metabolic Fate of Oxaliplatin in the Biological Milieu Investigated During Lung Perfusion Using a Unique Miniaturized Sampling Approach Based on Solid-phase Microextraction Coupled with Liquid Chromatography-mass Spectrometry Frontiers in Cell and Developmental Biology. 2022 | Pubmed ID: 36092704 Extracorporeal Life Support As a Bridge to Lung Transplantation: Where Are We Now? The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation. Nov, 2022 | Pubmed ID: 36089445 Transesophageal Echocardiography-Guided Extracorporeal Membrane Oxygenation Cannulation in COVID-19 Patients Journal of Cardiothoracic and Vascular Anesthesia. Dec, 2022 | Pubmed ID: 36038441 Successful Use of a Hepatitis C Viremic Donor in Pediatric Bilateral Lobar Lung Transplantation JTCVS Techniques. Aug, 2022 | Pubmed ID: 35967204 Successful 3-day Lung Preservation Using a Cyclic Normothermic Ex Vivo Lung Perfusion Strategy EBioMedicine. Sep, 2022 | Pubmed ID: 35952495 High Doses of Inhaled Nitric Oxide As an Innovative Antimicrobial Strategy for Lung Infections Biomedicines. Jun, 2022 | Pubmed ID: 35884830 Extra-Pleural Pneumonectomy (EPP) in Children and Adults with Locally Advanced Sarcoma: A CanSaRCC Study Current Oncology (Toronto, Ont.). Jun, 2022 | Pubmed ID: 35735449 Successful Sequential Transplantation of 2 Single Lungs from the Same Donor into 2 Different Recipients-use of Standard Cold Preservation and 10 °C Preservation JTCVS Techniques. Jun, 2022 | Pubmed ID: 35711178 Seminars AATS International Roundtable of Lung Transplantation for COVID-19 Seminars in Thoracic and Cardiovascular Surgery. 2022 | Pubmed ID: 35697136 Centralized Organ Recovery and Reconditioning Centers Thoracic Surgery Clinics. May, 2022 | Pubmed ID: 35512935 Donation After Circulatory Death and Lung Transplantation Jornal Brasileiro De Pneumologia : Publicacao Oficial Da Sociedade Brasileira De Pneumologia E Tisilogia. 2022 | Pubmed ID: 35475865 Outcomes of Lung Transplantation at a Canadian Center Using Donors Declined in the United States The Journal of Thoracic and Cardiovascular Surgery. Dec, 2022 | Pubmed ID: 35461711 Endobronchial Ultrasound-guided Bipolar Radiofrequency Ablation for Lung Cancer: A First-in-human Clinical Trial The Journal of Thoracic and Cardiovascular Surgery. Oct, 2022 | Pubmed ID: 35459539 The Gift of Organ Donation As a Last Wish The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation. Jun, 2022 | Pubmed ID: 35430148 Near-infrared Fluorescence Imaging During Ex vivo Lung Perfusion: Noninvasive Real-time Evaluation of Regional Lung Perfusion and Edema The Journal of Thoracic and Cardiovascular Surgery. Nov, 2022 | Pubmed ID: 35382935 Performance Measures for Lung Transplantation: Change Is Coming The Annals of Thoracic Surgery. Jul, 2022 | Pubmed ID: 35339441 Importance of Tumor Size in Resectable Stage III-N2 Non-small Cell Lung Cancer The Journal of Thoracic and Cardiovascular Surgery. Sep, 2022 | Pubmed ID: 35331553 Donation After Circulatory Death Donors in High-risk Recipients Undergoing Bilateral Lung Transplantation: An ISHLT Database Registry Analysis The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation. Jun, 2022 | Pubmed ID: 35300913 Ex Vivo Enzymatic Treatment Converts Blood Type A Donor Lungs into Universal Blood Type Lungs Science Translational Medicine. Feb, 2022 | Pubmed ID: 35171649 Outcomes of Lung Transplantation from Organ Donation After Medical Assistance in Dying: First North American Experience American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons. Jun, 2022 | Pubmed ID: 35108446 Postoperative Management of Lung Transplant Recipients in the Intensive Care Unit Anesthesiology. Mar, 2022 | Pubmed ID: 34910811 Ex Vivo Treatment of Cytomegalovirus in Human Donor Lungs Using a Novel Chemokine-based Immunotoxin The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation. Mar, 2022 | Pubmed ID: 34802874 Delivery of Regulatory T-cells for Control of Alloimmune Priming in the Donor Lung The European Respiratory Journal. Apr, 2022 | Pubmed ID: 34475226 An Ingenious Approach for Lobar Lung Transplantation The Annals of Thoracic Surgery. Jun, 2022 | Pubmed ID: 34052218 Commentary: To Die or Not to Die-rescuing Lung Cells from Ischemia-reperfusion Injury The Journal of Thoracic and Cardiovascular Surgery. Feb, 2022 | Pubmed ID: 33618878 Commentary: Bruised Donor Lungs-they May Not Be Pretty, but They Will Still Work The Journal of Thoracic and Cardiovascular Surgery. May, 2022 | Pubmed ID: 33500129 Safety of Continuous 12-hour Delivery of Antimicrobial Doses of Inhaled Nitric Oxide During Ex vivo Lung Perfusion The Journal of Thoracic and Cardiovascular Surgery. Mar, 2022 | Pubmed ID: 33478833 Lung Perfusion Journal of Thoracic Disease. Nov, 2021 | Pubmed ID: 34992839 [Not Available] CMAJ : Canadian Medical Association Journal = Journal De L'Association Medicale Canadienne. Nov, 2021 | Pubmed ID: 34810168 Engineered Mesenchymal Stromal Cell Therapy During Human Lung Lung Perfusion is Compromised by Acidic Lung Microenvironment Molecular Therapy. Methods & Clinical Development. Dec, 2021 | Pubmed ID: 34703841 A Novel Pre-clinical Strategy to Deliver Antimicrobial Doses of Inhaled Nitric Oxide PloS One. 2021 | Pubmed ID: 34644318 Lung Transplantation for Acute COVID-19: the Toronto Lung Transplant Program Experience CMAJ : Canadian Medical Association Journal = Journal De L'Association Medicale Canadienne. Sep, 2021 | Pubmed ID: 34580142 Static Lung Storage at 10°C Maintains Mitochondrial Health and Preserves Donor Organ Function Science Translational Medicine. Sep, 2021 | Pubmed ID: 34524862 Lung Transplant Recipient Attitudes and Beliefs on Accepting an Organ That is Positive for Hepatitis C Virus Transplant Infectious Disease : an Official Journal of the Transplantation Society. Aug, 2021 | Pubmed ID: 34228382 Surfactant Therapy in Lung Transplantation: A Systematic Review and Meta-analysis Transplantation Reviews (Orlando, Fla.). Dec, 2021 | Pubmed ID: 34224988 Achieving Safe Liberation During Weaning From VV-ECMO in Patients With Severe ARDS: The Role of Tidal Volume and Inspiratory Effort Chest. Nov, 2021 | Pubmed ID: 34166645 Long-term Outcomes of Sensitized Lung Transplant Recipients After Peri-operative Desensitization American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons. Oct, 2021 | Pubmed ID: 34058795 Determination of Optical Properties and Photodynamic Threshold of Lung Tissue for Treatment Planning of In Vivo Lung Perfusion Assisted Photodynamic Therapy Photodiagnosis and Photodynamic Therapy. Sep, 2021 | Pubmed ID: 34048969 Pushing the Envelope for Donor Lungs Seminars in Respiratory and Critical Care Medicine. Jun, 2021 | Pubmed ID: 34030199 Predicting Donor Lung Acceptance for Transplant During Ex Vivo Lung Perfusion: The EX Vivo Lung PerfusIon PREdiction (EXPIRE) American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons. Nov, 2021 | Pubmed ID: 33872459 Use of Metabolomics to Identify Strategies to Improve and Prolong Ex Vivo Lung Perfusion for Lung Transplants The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation. Jun, 2021 | Pubmed ID: 33849769 Prediction of Donor Related Lung Injury in Clinical Lung Transplantation Using a Validated Ex Vivo Lung Perfusion Inflammation Score The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation. Jul, 2021 | Pubmed ID: 33781664 A Call to Routinely Test Lower Respiratory Tract Samples for SARS-CoV-2 in Lung Donors American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons. Jul, 2021 | Pubmed ID: 33756058 Solid Phase Microextraction Chemical Biopsy Tool for Monitoring of Doxorubicin Residue During In vivo Lung Chemo-perfusion Journal of Pharmaceutical Analysis. Feb, 2021 | Pubmed ID: 33717610 Successful Lung Transplantation from Lungs Procured 12 Hours After Withdrawal of Life-sustaining Therapy: Changing the Paradigm of Controlled DCD Donors? The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation. Sep, 2021 | Pubmed ID: 33602628 Donor Ventilation Parameters As Predictors for Length of Mechanical Ventilation After Lung Transplantation: Results of a Prospective Multicenter Study The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation. Jan, 2021 | Pubmed ID: 33246712 Ventilation Parameters and Early Graft Function in Double Lung Transplantation The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation. Jan, 2021 | Pubmed ID: 33144029 Transcriptomic Investigation Reveals Donor-specific Gene Signatures in Human Lung Transplants The European Respiratory Journal. Apr, 2021 | Pubmed ID: 33122335 Strategies to Prolong Homeostasis of Ex vivo Perfused Lungs The Journal of Thoracic and Cardiovascular Surgery. Jun, 2021 | Pubmed ID: 32958268 Cell-free DNA in Human Ex vivo Lung Perfusate As a Potential Biomarker to Predict the Risk of Primary Graft Dysfunction in Lung Transplantation The Journal of Thoracic and Cardiovascular Surgery. Aug, 2021 | Pubmed ID: 32928548 Lung Donation After Medical Assistance in Dying at Home American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons. Jan, 2021 | Pubmed ID: 32803817 Impact of Donor Time to Cardiac Arrest in Lung Donation After Circulatory Death The Journal of Thoracic and Cardiovascular Surgery. Apr, 2021 | Pubmed ID: 32747131 Deceased-donor Lobar Lung Transplant: A Successful Strategy for Small-sized Recipients The Journal of Thoracic and Cardiovascular Surgery. May, 2021 | Pubmed ID: 32723591 A Model to Assess Acute and Delayed Lung Toxicity of Oxaliplatin During In vivo Lung Perfusion The Journal of Thoracic and Cardiovascular Surgery. May, 2021 | Pubmed ID: 32354628 Veno-venous ECMO As a Platform to Evaluate Lung Lavage and Surfactant Replacement Therapy in an Animal Model of Severe ARDS Intensive Care Medicine Experimental. Oct, 2020 | Pubmed ID: 33108583 Effect of Driving Pressure Change During Extracorporeal Membrane Oxygenation in Adults With Acute Respiratory Distress Syndrome: A Randomized Crossover Physiologic Study Critical Care Medicine. Dec, 2020 | Pubmed ID: 33044283 Ex Vivo Lung Perfusion for Donor Lung Assessment and Repair: a Review of Translational Interspecies Models American Journal of Physiology. Lung Cellular and Molecular Physiology. Dec, 2020 | Pubmed ID: 32996780 Ex-vivo Delivery of Monoclonal Antibody (Rituximab) to Treat Human Donor Lungs Prior to Transplantation EBioMedicine. Oct, 2020 | Pubmed ID: 32950000 The Impact of Concordance with a Lung Cancer Diagnosis Pathway Guideline on Treatment Access in Patients with Stage IV Lung Cancer Journal of Thoracic Disease. Aug, 2020 | Pubmed ID: 32944345 Ex Vivo Perfusion in Lung Transplantation and Removal of HCV: the Next Level Transplant International : Official Journal of the European Society for Organ Transplantation. Dec, 2020 | Pubmed ID: 32888320 When to Consider Lung Transplantation for COVID-19 The Lancet. Respiratory Medicine. Oct, 2020 | Pubmed ID: 32857989 International Society for Heart and Lung Transplantation Consensus Statement for the Standardization of Bronchoalveolar Lavage in Lung Transplantation The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation. Nov, 2020 | Pubmed ID: 32773322 Video-Assisted Thoracic Surgery As the Future of Pulmonary Metastasectomy: Reply The Annals of Thoracic Surgery. Sep, 2020 | Pubmed ID: 32693038 Immunosuppressive Therapy in Lung Transplantation Current Pharmaceutical Design. 2020 | Pubmed ID: 32600225 Short-course, Direct-acting Antivirals and Ezetimibe to Prevent HCV Infection in Recipients of Organs from HCV-infected Donors: a Phase 3, Single-centre, Open-label Study The Lancet. Gastroenterology & Hepatology. 07, 2020 | Pubmed ID: 32389183 An Extracellular Oxygen Carrier During Prolonged Pulmonary Preservation Improves Post-transplant Lung Function The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation. Jun, 2020 | Pubmed ID: 32334946 Should All Donors Be Treated by Ex Vivo Lung Perfusion?-Reply JAMA Surgery. Jun, 2020 | Pubmed ID: 32211846 Airway Oscillometry Detects Spirometric-Silent Episodes of Acute Cellular Rejection American Journal of Respiratory and Critical Care Medicine. 06, 2020 | Pubmed ID: 32135068 Increased Arginase Expression and Decreased Nitric Oxide in Pig Donor Lungs After Normothermic Ex Vivo Lung Perfusion Biomolecules. Feb, 2020 | Pubmed ID: 32075026 Initial Lung Transplantation Experience with Uncontrolled Donation After Cardiac Death in North America American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons. Jun, 2020 | Pubmed ID: 31995660 Commentary: Use of Hepatitis C Virus Viremic Donors Should Be the Standard of Care The Journal of Thoracic and Cardiovascular Surgery. May, 2020 | Pubmed ID: 31987611 Incidence of Ipsilateral Side Recurrence After Open or Video-Assisted Thoracic Surgery Resection of Colorectal Lung Metastases The Annals of Thoracic Surgery. May, 2020 | Pubmed ID: 31953045 Prevention of Viral Transmission During Lung Transplantation with Hepatitis C-viraemic Donors: an Open-label, Single-centre, Pilot Trial The Lancet. Respiratory Medicine. 02, 2020 | Pubmed ID: 31606437 Normothermic Ex vivo Lung Perfusion: Does the Indication Impact Organ Utilization and Patient Outcomes After Transplantation? The Journal of Thoracic and Cardiovascular Surgery. Jan, 2020 | Pubmed ID: 31606173 Bilateral Lobar Transplants Using One Donor for Two Small-Sized Recipients The Annals of Thoracic Surgery. May, 2020 | Pubmed ID: 31586617 Long-term Outcomes of Lung Transplant With Ex Vivo Lung Perfusion JAMA Surgery. Dec, 2019 | Pubmed ID: 31596484 Drug-resistant Cytomegalovirus Infection After Lung Transplantation: Incidence, Characteristics, and Clinical Outcomes The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation. Dec, 2019 | Pubmed ID: 31570289 Mesenchymal Stromal Cell Therapy During Ex Vivo Lung Perfusion Ameliorates Ischemia-reperfusion Injury in Lung Transplantation The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation. Nov, 2019 | Pubmed ID: 31474491 A Successful Lung Transplant from a 3-year-old Donor After Controlled Cardiac Death Followed by Ex vivo Lung Perfusion: A Case Report The Journal of Thoracic and Cardiovascular Surgery. Oct, 2019 | Pubmed ID: 31126646 Ex-vivo Lung Perfusion and Ventilation: Where to from Here? Current Opinion in Organ Transplantation. Jun, 2019 | Pubmed ID: 31090639 Veno-venous Extracorporeal Life Support for Blastomycosis-associated Acute Respiratory Distress Syndrome Perfusion. Nov, 2019 | Pubmed ID: 31027465 Donor Prone Positioning Protects Lungs from Injury During Warm Ischemia American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons. Mar, 2019 | Pubmed ID: 30887696 Phase II Clinical Trial of Adoptive Cell Therapy for Patients with Metastatic Melanoma with Autologous Tumor-infiltrating Lymphocytes and Low-dose Interleukin-2 Cancer Immunology, Immunotherapy : CII. May, 2019 | Pubmed ID: 30747243 CT-guided Microcoil Pulmonary Nodule Localization Prior to Video-assisted Thoracoscopic Surgery: Diagnostic Utility and Recurrence-Free Survival Radiology. Apr, 2019 | Pubmed ID: 30720402 Inactivating Hepatitis C Virus in Donor Lungs Using Light Therapies During Normothermic Ex Vivo Lung Perfusion Nature Communications. Jan, 2019 | Pubmed ID: 30696822 Neutrophil Extracellular Traps in Lung Perfusion Perfusate Predict the Clinical Outcome of Lung Transplant Recipients The European Respiratory Journal. Apr, 2019 | Pubmed ID: 30655281 Spectrum of Chronic Lung Allograft Pathology in a Mouse Minor-mismatched Orthotopic Lung Transplant Model American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons. Jan, 2019 | Pubmed ID: 30378739 Incidence of Primary Graft Dysfunction After Lung Transplantation is Altered by Timing of Allograft Implantation Thorax. 04, 2019 | Pubmed ID: 30301818 Pig Lung Transplant Survival Model Nature Protocols. Aug, 2018 | Pubmed ID: 30072720 Introducing the Concept of Semielective Lung Transplantation Through the Use of Ex vivo Lung Perfusion The Journal of Thoracic and Cardiovascular Surgery. Dec, 2018 | Pubmed ID: 29961586 Inhibition of Regulated Necrosis Attenuates Receptor-interacting Protein Kinase 1-mediated Ischemia-reperfusion Injury After Lung Transplantation The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation. Oct, 2018 | Pubmed ID: 29907500 Sequential Broncho-alveolar Lavages Reflect Distinct Pulmonary Compartments: Clinical and Research Implications in Lung Transplantation Respiratory Research. May, 2018 | Pubmed ID: 29801490 Comprehensive Outcomes After Lung Retransplantation: A Single-center Review Clinical Transplantation. Jun, 2018 | Pubmed ID: 29754418 Efficacy and Cost of Awake Thoracoscopy and Video-Assisted Thoracoscopic Surgery in the Undiagnosed Pleural Effusion The Annals of Thoracic Surgery. Aug, 2018 | Pubmed ID: 29577922 Equilibrium Ex Vivo Calibration of Homogenized Tissue for in Vivo SPME Quantitation of Doxorubicin in Lung Tissue Talanta. Jun, 2018 | Pubmed ID: 29567180 Pentraxin 3 Deficiency Enhances Features of Chronic Rejection in a Mouse Orthotopic Lung Transplantation Model Oncotarget. Feb, 2018 | Pubmed ID: 29492210 Effects of Warm Versus Cold Ischemic Donor Lung Preservation on the Underlying Mechanisms of Injuries During Ischemia and Reperfusion Transplantation. May, 2018 | Pubmed ID: 29470355 Lung in a Box: Ex Vivo Lung Transplantation Journal of Cardiothoracic and Vascular Anesthesia. Aug, 2018 | Pubmed ID: 29449154 Extracorporeal Life Support As a Bridge to Lung Transplantation-experience of a High-volume Transplant Center The Journal of Thoracic and Cardiovascular Surgery. Mar, 2018 | Pubmed ID: 29248282 Metabolic Profile of Ex Vivo Lung Perfusate Yields Biomarkers for Lung Transplant Outcomes Annals of Surgery. Jan, 2018 | Pubmed ID: 29240608 α-Anti-trypsin Improves Function of Porcine Donor Lungs During Ex-vivo Lung Perfusion The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation. May, 2018 | Pubmed ID: 29153638 Performance of Endobronchial Ultrasound-Guided Transbronchial Needle Aspiration for the Diagnosis of Isolated Mediastinal and Hilar Lymphadenopathy Respiration; International Review of Thoracic Diseases. 2017 | Pubmed ID: 28898881 Extracorporeal Support in Airway Surgery Journal of Thoracic Disease. Jul, 2017 | Pubmed ID: 28840012 Higher M30 and High Mobility Group Box 1 Protein Levels in Ex Vivo Lung Perfusate Are Associated with Primary Graft Dysfunction After Human Lung Transplantation The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation. Jun, 2017 | Pubmed ID: 28689646 A Novel Minimally Invasive Near-infrared Thoracoscopic Localization Technique of Small Pulmonary Nodules: A Phase I Feasibility Trial The Journal of Thoracic and Cardiovascular Surgery. Aug, 2017 | Pubmed ID: 28495056 Cost-effectiveness of Mediastinal Lymph Node Staging in Non-small Cell Lung Cancer The Journal of Thoracic and Cardiovascular Surgery. Jun, 2017 | Pubmed ID: 28283236 High Risk for Thoracotomy but Not Thoracoscopic Lobectomy The Annals of Thoracic Surgery. Jun, 2017 | Pubmed ID: 28262299 Sevoflurane Attenuates Ischemia-Reperfusion Injury in A Rat Lung Transplantation Model The Annals of Thoracic Surgery. May, 2017 | Pubmed ID: 28190546 Safety and Efficacy of Ex Vivo Donor Lung Adenoviral IL-10 Gene Therapy in a Large Animal Lung Transplant Survival Model Human Gene Therapy. Sep, 2017 | Pubmed ID: 28052693 Lung Lavage and Surfactant Replacement During Ex Vivo Lung Perfusion for Treatment of Gastric Acid Aspiration-Induced Donor Lung Injury The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation. May, 2017 | Pubmed ID: 28041954 Bilateral Pneumonectomy to Treat Uncontrolled Sepsis in a Patient Awaiting Lung Transplantation The Journal of Thoracic and Cardiovascular Surgery. Apr, 2017 | Pubmed ID: 28017368 Intensive Care Physiotherapy During Extracorporeal Membrane Oxygenation for Acute Respiratory Distress Syndrome Annals of the American Thoracic Society. Feb, 2017 | Pubmed ID: 27898220 Outcomes After Transplantation of Lungs Preserved for More Than 12 H: a Retrospective Study The Lancet. Respiratory Medicine. 02, 2017 | Pubmed ID: 27866861 Evaluation of a New Ultrasound Thoracoscope for Localization of Lung Nodules in Ex Vivo Human Lungs The Annals of Thoracic Surgery. Mar, 2017 | Pubmed ID: 27765176 Mesenchymal Stem Cell Treatment is Associated with Decreased Perfusate Concentration of Interleukin-8 During Ex Vivo Perfusion of Donor Lungs After 18-hour Preservation The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation. Oct, 2016 | Pubmed ID: 27444694 One-Year Outcomes in Caregivers of Critically Ill Patients The New England Journal of Medicine. May, 2016 | Pubmed ID: 27168433 Human α1-antitrypsin Improves Early Post-transplant Lung Function: Pre-clinical Studies in a Pig Lung Transplant Model The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation. Jul, 2016 | Pubmed ID: 27095003 The RECOVER Program: Disability Risk Groups and 1-Year Outcome After 7 or More Days of Mechanical Ventilation American Journal of Respiratory and Critical Care Medicine. Oct, 2016 | Pubmed ID: 26974173 Modified In Vivo Lung Perfusion for Local Chemotherapy: A Preclinical Study With Doxorubicin The Annals of Thoracic Surgery. Jun, 2016 | Pubmed ID: 26952295 Halofuginone Treatment Reduces Interleukin-17A and Ameliorates Features of Chronic Lung Allograft Dysfunction in a Mouse Orthotopic Lung Transplant Model The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation. Apr, 2016 | Pubmed ID: 26787621 Annexin V Homodimer Protects Against Ischemia Reperfusion-induced Acute Lung Injury in Lung Transplantation The Journal of Thoracic and Cardiovascular Surgery. Mar, 2016 | Pubmed ID: 26725713 Successful Lung Transplantation from a Donation After Cardiocirculatory Death Donor Taking More Than 120 Minutes to Cardiac Arrest After Withdrawal of Life Support Therapies The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation. Feb, 2016 | Pubmed ID: 26525404 Low-dose Computed Tomography Volumetry for Subtyping Chronic Lung Allograft Dysfunction The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation. Jan, 2016 | Pubmed ID: 26342441 Fractal Circuit Sensors Enable Rapid Quantification of Biomarkers for Donor Lung Assessment for Transplantation Science Advances. Aug, 2015 | Pubmed ID: 26601233 Using the Inherent Chemistry of the Endothelin-1 Peptide to Develop a Rapid Assay for Pre-transplant Donor Lung Assessment The Analyst. Dec, 2015 | Pubmed ID: 26548776 Cardiopulmonary Bypass and Extracorporeal Life Support for Emergent Intraoperative Thoracic Situations Thoracic Surgery Clinics. Aug, 2015 | Pubmed ID: 26210928 Retrospective Analysis of Lung Transplant Recipients Found to Have Unexpected Lung Cancer in Explanted Lungs Seminars in Thoracic and Cardiovascular Surgery. 2015 | Pubmed ID: 26074103 The Role of the Endothelin-1 Pathway As a Biomarker for Donor Lung Assessment in Clinical Ex Vivo Lung Perfusion The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation. Jun, 2015 | Pubmed ID: 25907141 Outcomes of Intraoperative Extracorporeal Membrane Oxygenation Versus Cardiopulmonary Bypass for Lung Transplantation The Journal of Thoracic and Cardiovascular Surgery. Apr, 2015 | Pubmed ID: 25583107 Neoadjuvant Chemoradiation and Surgery Improves Survival Outcomes Compared with Definitive Chemoradiation in the Treatment of Stage IIIA N2 Non-small-cell Lung Cancer European Journal of Cardio-thoracic Surgery : Official Journal of the European Association for Cardio-thoracic Surgery. Nov, 2015 | Pubmed ID: 25567960 Functional Outcomes and Quality of Life After Normothermic Ex Vivo Lung Perfusion Lung Transplantation The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation. Apr, 2015 | Pubmed ID: 25476845 Protein Expression Profiling Predicts Graft Performance in Clinical Ex Vivo Lung Perfusion Annals of Surgery. Mar, 2015 | Pubmed ID: 25371129 Ex Vivo Lung Perfusion Journal of Thoracic Disease. Aug, 2014 | Pubmed ID: 25132972 Long-term Outcome After Resection of Non-small Cell Lung Cancer Invading the Thoracic Inlet The Annals of Thoracic Surgery. Sep, 2014 | Pubmed ID: 25069687 Low Invasive in Vivo Tissue Sampling for Monitoring Biomarkers and Drugs During Surgery Laboratory Investigation; a Journal of Technical Methods and Pathology. May, 2014 | Pubmed ID: 24687119 Extracorporeal Life Support for Adults with Severe Acute Respiratory Failure The Lancet. Respiratory Medicine. Feb, 2014 | Pubmed ID: 24503270 Modified in Vivo Lung Perfusion Allows for Prolonged Perfusion Without Acute Lung Injury The Journal of Thoracic and Cardiovascular Surgery. Feb, 2014 | Pubmed ID: 24290703 Long-term Outcome After En Bloc Resection of Non-small-cell Lung Cancer Invading the Pulmonary Sulcus and Spine Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer. Dec, 2013 | Pubmed ID: 24389435 Advances in Lung Preservation The Surgical Clinics of North America. Dec, 2013 | Pubmed ID: 24206857 Bone Marrow-derived Progenitor Cells in End-stage Lung Disease Patients BMC Pulmonary Medicine. Aug, 2013 | Pubmed ID: 23915095 Physiologic Assessment of the Ex Vivo Donor Lung for Transplantation The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation. Oct, 2012 | Pubmed ID: 22975103 Experience with the First 50 Ex Vivo Lung Perfusions in Clinical Transplantation The Journal of Thoracic and Cardiovascular Surgery. Nov, 2012 | Pubmed ID: 22944089 Expansion of the Donor Lung Pool: Use of Lungs from Smokers Lancet (London, England). Aug, 2012 | Pubmed ID: 22647757 Pulmonary Bacterial Communities in Surgically Resected Noncystic Fibrosis Bronchiectasis Lungs Are Similar to Those in Cystic Fibrosis Pulmonary Medicine. 2012 | Pubmed ID: 22448327 Local Long-term Expression of Lentivirally Delivered IL-10 in the Lung Attenuates Obliteration of Intrapulmonary Allograft Airways Human Gene Therapy. Nov, 2011 | Pubmed ID: 21568692 Increased Levels of Interleukin-1β and Tumor Necrosis Factor-α in Donor Lungs Rejected for Transplantation The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation. Apr, 2011 | Pubmed ID: 21237675 Transcriptional Signatures in Donor Lungs from Donation After Cardiac Death Vs After Brain Death: a Functional Pathway Analysis The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation. Mar, 2011 | Pubmed ID: 21093300 PTX3 As a Potential Biomarker of Acute Lung Injury: Supporting Evidence from Animal Experimentation Intensive Care Medicine. Feb, 2010 | Pubmed ID: 19921147 Functional Repair of Human Donor Lungs by IL-10 Gene Therapy Science Translational Medicine. Oct, 2009 | Pubmed ID: 20368171 Activated Protein C in Ischemia-reperfusion Injury After Experimental Lung Transplantation The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation. Nov, 2009 | Pubmed ID: 19782612 Technique for Prolonged Normothermic Ex Vivo Lung Perfusion The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation. Dec, 2008 | Pubmed ID: 19059112 Anti-human Tissue Factor Antibody Ameliorated Intestinal Ischemia Reperfusion-induced Acute Lung Injury in Human Tissue Factor Knock-in Mice PloS One. Jan, 2008 | Pubmed ID: 18231608 Establishment of an Ex Vivo Lung Perfusion Rat Model for Translational Insights in Lung Transplantation Paolo Oliveira*1,3, Keiji Yamanashi*1, Aizhou Wang1, Marcelo Cypel1,2 1Toronto General Hospital Research Institute, University Health Network, 2Department of Surgery, University of Toronto, 3Departamento de Cardiopneumologia, Instituto do Coração, Faculdade de Medicina HCFMUSP, Universidade de Sao Paulo JoVE 65981 Medicine
Establishment of an Ex Vivo Lung Perfusion Rat Model for Translational Insights in Lung Transplantation Paolo Oliveira*1,3, Keiji Yamanashi*1, Aizhou Wang1, Marcelo Cypel1,2 1Toronto General Hospital Research Institute, University Health Network, 2Department of Surgery, University of Toronto, 3Departamento de Cardiopneumologia, Instituto do Coração, Faculdade de Medicina HCFMUSP, Universidade de Sao Paulo JoVE 65981 Medicine