Mariana J. Kaplan Biography Publications JoVE Articles Mariana J. Kaplan has not added a biography. If you are Mariana J. Kaplan and would like to personalize this page please email our Author Liaison for assistance. Publications Inhibition of JAK-STAT Pathway Corrects Salivary Gland Inflammation and Interferon Driven Immune Activation in Sjögren's Disease MedRxiv : the Preprint Server for Health Sciences. Aug, 2023 | Pubmed ID: 37662351 Transmission Disequilibrium Analysis of Whole Genome Data in Childhood-onset Systemic Lupus Erythematosus Genes and Immunity. Aug, 2023 | Pubmed ID: 37488248 Metabolic Alterations of the Immune System in the Pathogenesis of Autoimmune Diseases PLoS Biology. Apr, 2023 | Pubmed ID: 37098006 Apoptosis-induced Nuclear Expulsion in Tumor Cells Drives S100a4-mediated Metastatic Outgrowth Through the RAGE Pathway Nature Cancer. Mar, 2023 | Pubmed ID: 36973439 Constitutively Active Lyn Kinase Causes a Cutaneous Small Vessel Vasculitis and Liver Fibrosis Syndrome Nature Communications. Mar, 2023 | Pubmed ID: 36932076 Neutrophil Extracellular Trap-associated Carbamylation and Histones Trigger Osteoclast Formation in Rheumatoid Arthritis Annals of the Rheumatic Diseases. May, 2023 | Pubmed ID: 36737106 Spleen Tyrosine Kinase Inhibition Restores Myeloid Homeostasis in COVID-19 Science Advances. Jan, 2023 | Pubmed ID: 36598976 Low-density Granulocytes in Systemic Autoimmunity and Autoinflammation Immunological Reviews. Mar, 2023 | Pubmed ID: 36305174 Neutrophil Extracellular Traps in Systemic Autoimmune and Autoinflammatory Diseases Nature Reviews. Immunology. May, 2023 | Pubmed ID: 36257987 Coexisting Autoantibodies Against Transcription Factor Sp4 Are Associated with Decreased Cancer Risk in Patients with Dermatomyositis with Anti-TIF1γ Autoantibodies Annals of the Rheumatic Diseases. Feb, 2023 | Pubmed ID: 36008132 Neutralizing Anti‒DNase 1 and ‒DNase 1L3 Antibodies Impair Neutrophil Extracellular Traps Degradation in Hidradenitis Suppurativa The Journal of Investigative Dermatology. Jan, 2023 | Pubmed ID: 35934056 Correspondence on 'Clinical Course of Coronavirus Disease 2019 (COVID-19) in a Series of 17 Patients with Systemic Lupus Erythematosus Under Long-term Treatment with Hydroxychloroquine' Annals of the Rheumatic Diseases. Oct, 2023 | Pubmed ID: 33452005 Distinct Pathogenic Roles for Resident and Monocyte-derived Macrophages in Lupus Nephritis JCI Insight. Nov, 2022 | Pubmed ID: 36345939 Changes in Cardiorespiratory Function and Fatigue Following 12 Weeks of Exercise Training in Women with Systemic Lupus Erythematosus: a Pilot Study Lupus Science & Medicine. Oct, 2022 | Pubmed ID: 36220328 Casting a Wide NET Journal of Immunology (Baltimore, Md. : 1950). Sep, 2022 | Pubmed ID: 36130128 Quantification of Neutrophils Undergoing NET Formation and Distinguishing Mechanisms of Neutrophil Cell Death by Use of a High-Throughput Method Methods in Molecular Biology (Clifton, N.J.). 2022 | Pubmed ID: 36087264 Peroxisome Proliferator Activated Receptor-γ Agonist Pioglitazone Improves Vascular and Metabolic Dysfunction in Systemic Lupus Erythematosus Annals of the Rheumatic Diseases. Aug, 2022 | Pubmed ID: 35914929 Single-Cell Analysis Reveals the Range of Transcriptional States of Circulating Human Neutrophils Journal of Immunology (Baltimore, Md. : 1950). Aug, 2022 | Pubmed ID: 35858733 FOXM1 Network in Association with TREM1 Suppression Regulates NET Formation in Diabetic Foot Ulcers EMBO Reports. Aug, 2022 | Pubmed ID: 35856334 Neutrophil Phenotypes and Functions in Cancer: A Consensus Statement The Journal of Experimental Medicine. Jun, 2022 | Pubmed ID: 35522219 Diseases of Blood Vessels: Immune System Involvement in Vasculitis and Vasculopathy Seminars in Immunopathology. May, 2022 | Pubmed ID: 35503576 Cardiovascular Disease Risk and Pathogenesis in Systemic Lupus Erythematosus Seminars in Immunopathology. May, 2022 | Pubmed ID: 35355124 Multicenter Analysis of Neutrophil Extracellular Trap Dysregulation in Adult and Pediatric COVID-19 MedRxiv : the Preprint Server for Health Sciences. Mar, 2022 | Pubmed ID: 35262093 Autoantibodies Present in Hidradenitis Suppurativa Correlate with Disease Severity and Promote the Release of Proinflammatory Cytokines in Macrophages The Journal of Investigative Dermatology. Mar, 2022 | Pubmed ID: 34606886 Neutrophils As Drivers of Immune Dysregulation in Autoimmune Diseases with Skin Manifestations The Journal of Investigative Dermatology. Mar, 2022 | Pubmed ID: 34253374 Mitochondrial Dysfunction in the Erythroid Compartment Nature Immunology. Nov, 2021 | Pubmed ID: 34671144 Anti-Carbamylated LL37 Antibodies Promote Pathogenic Bone Resorption in Rheumatoid Arthritis Frontiers in Immunology. 2021 | Pubmed ID: 34594331 Neutrophil Dysregulation in the Pathogenesis of Systemic Lupus Erythematosus Rheumatic Diseases Clinics of North America. Aug, 2021 | Pubmed ID: 34215366 Phase 1 Double-blind Randomized Safety Trial of the Janus Kinase Inhibitor Tofacitinib in Systemic Lupus Erythematosus Nature Communications. Jun, 2021 | Pubmed ID: 34099646 Patients with COVID-19: in the Dark-NETs of Neutrophils Cell Death and Differentiation. 11, 2021 | Pubmed ID: 34031543 Cholesterol-Induced M4-Like Macrophages Recruit Neutrophils and Induce NETosis Frontiers in Immunology. 2021 | Pubmed ID: 34012454 Interferon Lambda in Inflammation and Autoimmune Rheumatic Diseases Nature Reviews. Rheumatology. Jun, 2021 | Pubmed ID: 33907323 Linking Clotting and Autoimmunity Science (New York, N.Y.). Mar, 2021 | Pubmed ID: 33707252 Neutrophils in the Pathogenesis of Rheumatic Diseases: Fueling the Fire Clinical Reviews in Allergy & Immunology. Feb, 2021 | Pubmed ID: 33155144 Proteomic, Biomechanical and Functional Analyses Define Neutrophil Heterogeneity in Systemic Lupus Erythematosus Annals of the Rheumatic Diseases. Feb, 2021 | Pubmed ID: 32988843 Lupus-like Autoimmunity and Increased Interferon Response in Patients with STAT3-deficient Hyper-IgE Syndrome The Journal of Allergy and Clinical Immunology. Feb, 2021 | Pubmed ID: 32768442 Association Between Anti-interferon-alpha Autoantibodies and COVID-19 in Systemic Lupus Erythematosus MedRxiv : the Preprint Server for Health Sciences. Nov, 2020 | Pubmed ID: 33184616 Neutrophil-mediated Carbamylation Promotes Articular Damage in Rheumatoid Arthritis Science Advances. Oct, 2020 | Pubmed ID: 33115748 Somatic Mutations in and Severe Adult-Onset Autoinflammatory Disease The New England Journal of Medicine. Dec, 2020 | Pubmed ID: 33108101 Oxidative DNA Damage Accelerates Skin Inflammation in Pristane-Induced Lupus Model Frontiers in Immunology. 2020 | Pubmed ID: 33072095 Immunometabolism in the Pathogenesis of Systemic Lupus Erythematosus: an Update Current Opinion in Rheumatology. Nov, 2020 | Pubmed ID: 32826478 Sex Differences in Neutrophil Biology Modulate Response to Type I Interferons and Immunometabolism Proceedings of the National Academy of Sciences of the United States of America. Jul, 2020 | Pubmed ID: 32601182 Macrophage Metabolic Reprogramming Presents a Therapeutic Target in Lupus Nephritis Proceedings of the National Academy of Sciences of the United States of America. Jun, 2020 | Pubmed ID: 32541026 Targeting Mitochondrial Oxidative Stress with MitoQ Reduces NET Formation and Kidney Disease in Lupus-prone MRL- Mice Lupus Science & Medicine. Apr, 2020 | Pubmed ID: 32343673 Diapedesis-Induced Integrin Signaling Via LFA-1 Facilitates Tissue Immunity by Inducing Intrinsic Complement C3 Expression in Immune Cells Immunity. Mar, 2020 | Pubmed ID: 32187519 Using the Circulating Proteome to Assess Type I Interferon Activity in Systemic Lupus Erythematosus Scientific Reports. Mar, 2020 | Pubmed ID: 32157125 Interferon Lambda Promotes Immune Dysregulation and Tissue Inflammation in TLR7-induced Lupus Proceedings of the National Academy of Sciences of the United States of America. Mar, 2020 | Pubmed ID: 32094169 Erratum for Research Article "Synovial Fibroblast-neutrophil Interactions Promote Pathogenic Adaptive Immunity in Rheumatoid Arthritis" by C. Carmona-Rivera, P. M. Carlucci, E. Moore, N. Lingampalli, H. Uchtenhagen, E. James, Y. Liu, K. L. Bicker, H. Wahamma, V. Hoffman, A. I. Catrina, P. Thompson, J. H. Buckner, W. H. Robinson, D. A. Fox, M. J. Kaplan Science Immunology. Jan, 2020 | Pubmed ID: 32005681 Technical Comment on "Synovial Fibroblast-neutrophil Interactions Promote Pathogenic Adaptive Immunity in Rheumatoid Arthritis" Science Immunology. Jan, 2020 | Pubmed ID: 32005680 Of Larks and Owls Nature Immunology. Feb, 2020 | Pubmed ID: 31932811 The Mechanics of Myeloid Cells Biology of the Cell. Apr, 2020 | Pubmed ID: 31916263 NETs Spread Ever Wider in Rheumatic Diseases Nature Reviews. Rheumatology. Feb, 2020 | Pubmed ID: 31853047 Deadliest Catch: Neutrophil Extracellular Traps in Autoimmunity Current Opinion in Rheumatology. Jan, 2020 | Pubmed ID: 31644465 Response To: 'Neutrophil Extracellular Traps and Low-density Granulocytes Are Associated with the Interferon Signature in Systemic Lupus Erythematosus, but Not in Antiphospholipid Syndrome' by Van Den Hoogen Annals of the Rheumatic Diseases. Oct, 2020 | Pubmed ID: 31272942 Transcriptomic, Epigenetic, and Functional Analyses Implicate Neutrophil Diversity in the Pathogenesis of Systemic Lupus Erythematosus Proceedings of the National Academy of Sciences of the United States of America. Dec, 2019 | Pubmed ID: 31754025 NETched in Stone Immunity. Sep, 2019 | Pubmed ID: 31533050 Neutrophil Extracellular Traps, B Cells, and Type I Interferons Contribute to Immune Dysregulation in Hidradenitis Suppurativa Science Translational Medicine. Sep, 2019 | Pubmed ID: 31484788 The Role of Neutrophils and Neutrophil Extracellular Traps in Vascular Damage in Systemic Lupus Erythematosus Journal of Clinical Medicine. Aug, 2019 | Pubmed ID: 31466329 Association of Lipoprotein Subfractions and Glycoprotein Acetylation with Coronary Plaque Burden in SLE Lupus Science & Medicine. 2019 | Pubmed ID: 31413851 Low-density Granulocytes Activate T Cells and Demonstrate a Non-suppressive Role in Systemic Lupus Erythematosus Annals of the Rheumatic Diseases. Jul, 2019 | Pubmed ID: 31040119 Deficiency of Adenosine Deaminase 2 Triggers Adenosine-mediated NETosis and TNF Production in Patients with DADA2 Blood. Jul, 2019 | Pubmed ID: 31015188 Neutrophil Subsets, Platelets, And Vascular Disease in Psoriasis JACC. Basic to Translational Science. Feb, 2019 | Pubmed ID: 30847414 Real-time Deformability Cytometry Reveals Sequential Contraction and Expansion During Neutrophil Priming Journal of Leukocyte Biology. Jun, 2019 | Pubmed ID: 30835869 Neutrophils in Rheumatoid Arthritis: Breaking Immune Tolerance and Fueling Disease Trends in Molecular Medicine. Mar, 2019 | Pubmed ID: 30709614 To NET or Not to NET:current Opinions and State of the Science Regarding the Formation of Neutrophil Extracellular Traps Cell Death and Differentiation. 03, 2019 | Pubmed ID: 30622307 Genome-wide DNA Methylation Analysis in Primary Antiphospholipid Syndrome Neutrophils Clinical Immunology (Orlando, Fla.). Nov, 2018 | Pubmed ID: 30471352 Revealing the Cellular Degradome by Mass Spectrometry Analysis of Proteasome-cleaved Peptides Nature Biotechnology. Oct, 2018 | Pubmed ID: 30346940 Myeloid-Specific Deletion of Peptidylarginine Deiminase 4 Mitigates Atherosclerosis Frontiers in Immunology. 2018 | Pubmed ID: 30140264 Dysregulated Neutrophil Responses and Neutrophil Extracellular Trap Formation and Degradation in PAPA Syndrome Annals of the Rheumatic Diseases. Dec, 2018 | Pubmed ID: 30131320 Cardiovascular Disease in Systemic Lupus Erythematosus: an Update Current Opinion in Rheumatology. Sep, 2018 | Pubmed ID: 29870498 Accelerated Model of Lupus Autoimmunity and Vasculopathy Driven by Toll-like Receptor 7/9 Imbalance Lupus Science & Medicine. 2018 | Pubmed ID: 29765617 Hepatocytes and Neutrophils Cooperatively Suppress Bacterial Infection by Differentially Regulating Lipocalin-2 and Neutrophil Extracellular Traps Hepatology (Baltimore, Md.). Oct, 2018 | Pubmed ID: 29633303 Response to Comment on "Synovial Fibroblast-neutrophil Interactions Promote Pathogenic Adaptive Immunity in Rheumatoid Arthritis" Science Immunology. Mar, 2018 | Pubmed ID: 29602804 Differential Ubiquitination in NETs Regulates Macrophage Responses in Systemic Lupus Erythematosus Annals of the Rheumatic Diseases. Jun, 2018 | Pubmed ID: 29588275 A High-Throughput Real-Time Imaging Technique To Quantify NETosis and Distinguish Mechanisms of Cell Death in Human Neutrophils Journal of Immunology (Baltimore, Md. : 1950). Jan, 2018 | Pubmed ID: 29196457 Unraveling Vascular Inflammation: From Immunology to Imaging Journal of the American College of Cardiology. Sep, 2017 | Pubmed ID: 28882238 Synovial Fibroblast-neutrophil Interactions Promote Pathogenic Adaptive Immunity in Rheumatoid Arthritis Science Immunology. Apr, 2017 | Pubmed ID: 28649674 Metabolic Abnormalities and Oxidative Stress in Lupus Current Opinion in Rheumatology. Sep, 2017 | Pubmed ID: 28639951 A Role for Muscarinic Receptors in Neutrophil Extracellular Trap Formation and Levamisole-induced Autoimmunity JCI Insight. Feb, 2017 | Pubmed ID: 28194438 Multicenter Systems Analysis of Human Blood Reveals Immature Neutrophils in Males and During Pregnancy Journal of Immunology (Baltimore, Md. : 1950). Mar, 2017 | Pubmed ID: 28179497 Disentangling the Role of Neutrophil Extracellular Traps in Rheumatic Diseases Current Opinion in Rheumatology. Jan, 2017 | Pubmed ID: 27755122 Lupus High-density Lipoprotein Induces Proinflammatory Responses in Macrophages by Binding Lectin-like Oxidised Low-density Lipoprotein Receptor 1 and Failing to Promote Activating Transcription Factor 3 Activity Annals of the Rheumatic Diseases. Mar, 2017 | Pubmed ID: 27543414 Cell Death in the Pathogenesis of Systemic Lupus Erythematosus and Lupus Nephritis Clinical Immunology (Orlando, Fla.). Dec, 2017 | Pubmed ID: 27519955 Dysfunction of Endothelial Progenitor Cells is Associated with the Type I IFN Pathway in Patients with Polymyositis and Dermatomyositis Rheumatology (Oxford, England). Nov, 2016 | Pubmed ID: 27498356 Alterations in Nuclear Structure Promote Lupus Autoimmunity in a Mouse Model Disease Models & Mechanisms. Aug, 2016 | Pubmed ID: 27483354 The Role of Neutrophils and NETosis in Autoimmune and Renal Diseases Nature Reviews. Nephrology. Jul, 2016 | Pubmed ID: 27241241 Update on Cardiovascular Disease in Lupus Current Opinion in Rheumatology. Sep, 2016 | Pubmed ID: 27227346 Placental Histology and Neutrophil Extracellular Traps in Lupus and Pre-eclampsia Pregnancies Lupus Science & Medicine. 2016 | Pubmed ID: 27158525 Neutrophil Extracellular Traps Enriched in Oxidized Mitochondrial DNA Are Interferogenic and Contribute to Lupus-like Disease Nature Medicine. Feb, 2016 | Pubmed ID: 26779811 Memory Stem T Cells in Autoimmune Disease: High Frequency of Circulating CD8+ Memory Stem Cells in Acquired Aplastic Anemia Journal of Immunology (Baltimore, Md. : 1950). Feb, 2016 | Pubmed ID: 26764034 At the Bench: Neutrophil Extracellular Traps (NETs) Highlight Novel Aspects of Innate Immune System Involvement in Autoimmune Diseases Journal of Leukocyte Biology. Feb, 2016 | Pubmed ID: 26432901 Inhibition of Neutrophil Extracellular Trap Formation After Stem Cell Transplant by Prostaglandin E2 American Journal of Respiratory and Critical Care Medicine. Jan, 2016 | Pubmed ID: 26417909 Severity of Psoriasis Associates With Aortic Vascular Inflammation Detected by FDG PET/CT and Neutrophil Activation in a Prospective Observational Study Arteriosclerosis, Thrombosis, and Vascular Biology. Dec, 2015 | Pubmed ID: 26449753 The Role of Neutrophils in the Pathogenesis of Systemic Lupus Erythematosus Current Opinion in Rheumatology. Sep, 2015 | Pubmed ID: 26125102 The Development of Depressive Symptoms During Medical Internship Stress Predicts Worsening Vascular Function Journal of Psychosomatic Research. Sep, 2015 | Pubmed ID: 26115588 A Novel Image-based Quantitative Method for the Characterization of NETosis Journal of Immunological Methods. Aug, 2015 | Pubmed ID: 26003624 Epigenome Profiling Reveals Significant DNA Demethylation of Interferon Signature Genes in Lupus Neutrophils Journal of Autoimmunity. Apr, 2015 | Pubmed ID: 25638528 Interleukin 10 Hampers Endothelial Cell Differentiation and Enhances the Effects of Interferon α on Lupus Endothelial Cell Progenitors Rheumatology (Oxford, England). Jun, 2015 | Pubmed ID: 25416712 Neutrophil Extracellular Traps Induce Endothelial Dysfunction in Systemic Lupus Erythematosus Through the Activation of Matrix Metalloproteinase-2 Annals of the Rheumatic Diseases. Jul, 2015 | Pubmed ID: 24570026 Peptidylarginine Deiminase Inhibition Disrupts NET Formation and Protects Against Kidney, Skin and Vascular Disease in Lupus-prone MRL/lpr Mice Annals of the Rheumatic Diseases. Aug, 2014 | Pubmed ID: 25104775 The Inflammasome and Lupus: Another Innate Immune Mechanism Contributing to Disease Pathogenesis? Current Opinion in Rheumatology. Sep, 2014 | Pubmed ID: 24992143 Neutrophil Extracellular Trap-derived Enzymes Oxidize High-density Lipoprotein: an Additional Proatherogenic Mechanism in Systemic Lupus Erythematosus Arthritis & Rheumatology (Hoboken, N.J.). Sep, 2014 | Pubmed ID: 24838349 Detection of SLE Antigens in Neutrophil Extracellular Traps (NETs) Methods in Molecular Biology (Clifton, N.J.). 2014 | Pubmed ID: 24497360 Peptidylarginine Deiminase Inhibition Reduces Vascular Damage and Modulates Innate Immune Responses in Murine Models of Atherosclerosis Circulation Research. Mar, 2014 | Pubmed ID: 24425713
