Matthew S. Macauley

Department of Chemical Physiology, The Scripps Research Institute

Affiliated withThe Scripps Research Institute University of Alberta

Research Area

Biography

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JoVE Journal Publications

ArticleTotal : 2	Year
Publication title Cited by 4	2016
Publication title Cited by 18	2018

Other Publications

Article	Year
Structural and dynamic independence of isopeptide-linked RanGAP1 and SUMO-1. The Journal of biological chemistry\| PubMed ID: 15355965	2004
O-GlcNAcase uses substrate-assisted catalysis: kinetic analysis and development of highly selective mechanism-inspired inhibitors. The Journal of biological chemistry\| PubMed ID: 15795231	2005
Beads-on-a-string, characterization of ETS-1 sumoylated within its flexible N-terminal sequence. The Journal of biological chemistry\| PubMed ID: 16319071	2006
O-GlcNAcase catalyzes cleavage of thioglycosides without general acid catalysis. Journal of the American Chemical Society\| PubMed ID: 16332065	2005
A highly concise preparation of O-deacetylated arylthioglycosides of N-acetyl-D-glucosamine from 2-acetamido-3,4,6-tri-O-acetyl-2-deoxy-alpha-D-glucopyranosyl chloride and aryl thiols or dis... Carbohydrate research\| PubMed ID: 16472788	2006
Identification of Asp174 and Asp175 as the key catalytic residues of human O-GlcNAcase by functional analysis of site-directed mutants. Biochemistry\| PubMed ID: 16533067	2006
Structure and mechanism of a bacterial beta-glucosaminidase having O-GlcNAcase activity. Nature structural & molecular biology\| PubMed ID: 16565725	2006
Functional analysis of a group A streptococcal glycoside hydrolase Spy1600 from family 84 reveals it is a beta-N-acetylglucosaminidase and not a hyaluronidase. The Biochemical journal\| PubMed ID: 16822234	2006
Analysis of PUGNAc and NAG-thiazoline as transition state analogues for human O-GlcNAcase: mechanistic and structural insights into inhibitor selectivity and transition state poise. Journal of the American Chemical Society\| PubMed ID: 17227027	2007
Structure of an O-GlcNAc transferase homolog provides insight into intracellular glycosylation. Nature structural & molecular biology\| PubMed ID: 18536723	2008
A potent mechanism-inspired O-GlcNAcase inhibitor that blocks phosphorylation of tau in vivo. Nature chemical biology\| PubMed ID: 18587388	2008
Elevation of global O-GlcNAc levels in 3T3-L1 adipocytes by selective inhibition of O-GlcNAcase does not induce insulin resistance. The Journal of biological chemistry\| PubMed ID: 18842583	2008
A selective inhibitor Gal-PUGNAc of human lysosomal beta-hexosaminidases modulates levels of the ganglioside GM2 in neuroblastoma cells. Angewandte Chemie (International ed. in English)\| PubMed ID: 19130519	2009
Streptococcus pneumoniae endohexosaminidase D, structural and mechanistic insight into substrate-assisted catalysis in family 85 glycoside hydrolases. The Journal of biological chemistry\| PubMed ID: 19181667	2009
Enzymatic characterization and inhibition of the nuclear variant of human O-GlcNAcase. Carbohydrate research\| PubMed ID: 19423084	2009
Increasing O-GlcNAc levels: An overview of small-molecule inhibitors of O-GlcNAcase. Biochimica et biophysica acta\| PubMed ID: 19664691	2010
Drosophila O-GlcNAc transferase (OGT) is encoded by the Polycomb group (PcG) gene, super sex combs (sxc). Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 19666537	2009
Probing synergy between two catalytic strategies in the glycoside hydrolase O-GlcNAcase using multiple linear free energy relationships. Journal of the American Chemical Society\| PubMed ID: 19715310	2009
Visualizing the reaction coordinate of an O-GlcNAc hydrolase. Journal of the American Chemical Society\| PubMed ID: 20067256	2010
Inhibition of O-GlcNAcase using a potent and cell-permeable inhibitor does not induce insulin resistance in 3T3-L1 adipocytes. Chemistry & biology\| PubMed ID: 20851343	2010
Elevation of Global O-GlcNAc in rodents using a selective O-GlcNAcase inhibitor does not cause insulin resistance or perturb glucohomeostasis. Chemistry & biology\| PubMed ID: 20851344	2010
Siglecs as sensors of self in innate and adaptive immune responses. Annals of the New York Academy of Sciences\| PubMed ID: 22288608	2012
Increasing O-GlcNAc slows neurodegeneration and stabilizes tau against aggregation. Nature chemical biology\| PubMed ID: 22366723	2012
Metabolism of vertebrate amino sugars with N-glycolyl groups: intracellular Î²-O-linked N-glycolylglucosamine (GlcNGc), UDP-GlcNGc, and the biochemical and structural rationale for the subst... The Journal of biological chemistry\| PubMed ID: 22692202	2012
Antigenic liposomes displaying CD22 ligands induce antigen-specific B cell apoptosis. The Journal of clinical investigation\| PubMed ID: 23722906	2013
Copresentation of antigen and ligands of Siglec-G induces B cell tolerance independent of CD22. Journal of immunology (Baltimore, Md. : 1950)\| PubMed ID: 23836061	2013
Immunology: glyco-engineering 'super-self'. Nature chemical biology\| PubMed ID: 24346034	2014
Disubstituted Sialic Acid Ligands Targeting Siglecs CD33 and CD22 Associated with Myeloid Leukaemias and B Cell Lymphomas. Chemical science (Royal Society of Chemistry : 2010)\| PubMed ID: 24921038	2014
Targeted delivery of mycobacterial antigens to human dendritic cells via Siglec-7 induces robust T cell activation. Journal of immunology (Baltimore, Md. : 1950)\| PubMed ID: 25000981	2014
Transcriptional programs of lymphoid tissue capillary and high endothelium reveal control mechanisms for lymphocyte homing. Nature immunology\| PubMed ID: 25173345	2014
Siglec-mediated regulation of immune cell function in disease. Nature reviews. Immunology\| PubMed ID: 25234143	2014
Siglecs induce tolerance to cell surface antigens by BIM-dependent deletion of the antigen-reactive B cells. Journal of immunology (Baltimore, Md. : 1950)\| PubMed ID: 25252961	2014
Systemic blockade of sialylation in mice with a global inhibitor of sialyltransferases. The Journal of biological chemistry\| PubMed ID: 25368325	2014
Therapeutic Targeting of Siglecs using Antibody- and Glycan-Based Approaches. Trends in pharmacological sciences\| PubMed ID: 26435210	2015
Unmasking of CD22 Co-receptor on Germinal Center B-cells Occurs by Alternative Mechanisms in Mouse and Man. The Journal of biological chemistry\| PubMed ID: 26507663	2015
Transfection of microRNA Mimics Should Be Used with Caution. Frontiers in genetics\| PubMed ID: 26697058	2015
Targeting Selectins and Their Ligands in Cancer. Frontiers in oncology\| PubMed ID: 27148485	2016
Reproducing SIVΔnef vaccine correlates of protection: trimeric gp41 antibody concentrated at mucosal front lines. AIDS (London, England)\| PubMed ID: 27428745	2016
Siglec-F is a novel intestinal M cell marker. Biochemical and biophysical research communications\| PubMed ID: 27524237	2016
Holes in the Glycan Shield of the Native HIV Envelope Are a Target of Trimer-Elicited Neutralizing Antibodies. Cell reports\| PubMed ID: 27545891	2016
Exploiting CD22 on antigen-specific B cells to prevent allergy to the major peanut allergen Ara h 2. The Journal of allergy and clinical immunology\| PubMed ID: 27554819	2016
Human CD22 Inhibits Murine B Cell Receptor Activation in a Human CD22 Transgenic Mouse Model. Journal of immunology (Baltimore, Md. : 1950)\| PubMed ID: 28972089	2017
Cell-based glycan arrays for probing glycan-glycan binding protein interactions. Nature communications\| PubMed ID: 29491407	2018
Hypersialylation in Cancer: Modulation of Inflammation and Therapeutic Opportunities. Cancers\| PubMed ID: 29912148	2018