Mercedes Gonzalez-Juarrero Mycobacteria Research Laboratories, Department of Microbiology, Immunology, and Pathology Colorado State University Biography Publications Institution JoVE Articles Mercedes Gonzalez-Juarrero has not added a biography. If you are Mercedes Gonzalez-Juarrero and would like to personalize this page please email our Author Liaison for assistance. Publications Development of a Minimalistic Physiologically Based Pharmacokinetic (mPBPK) Model for the Preclinical Development of Spectinamide Antibiotics Pharmaceutics. Jun, 2023 | Pubmed ID: 37376207 Intrapulmonary Treatment with Mycobacteriophage LysB Rapidly Reduces Mycobacterium Abscessus Burden Antimicrobial Agents and Chemotherapy. Jun, 2023 | Pubmed ID: 37154689 Characterization of Spectinamide 1599 Efficacy Against Different Mycobacterial Phenotypes Tuberculosis (Edinburgh, Scotland). May, 2023 | Pubmed ID: 37120915 Spray Dried Tigecycline Dry Powder Aerosols for the Treatment of Nontuberculous Mycobacterial Pulmonary Infections Tuberculosis (Edinburgh, Scotland). Mar, 2023 | Pubmed ID: 36716525 Microbiological Profile, Preclinical Pharmacokinetics and Efficacy of CRS0393, a Novel Antimycobacterial Agent Targeting MmpL3 Tuberculosis (Edinburgh, Scotland). Jan, 2023 | Pubmed ID: 36470124 Mucosal Exposure to Non-tuberculous Mycobacteria Elicits B Cell-mediated Immunity Against Pulmonary Tuberculosis Cell Reports. Dec, 2022 | Pubmed ID: 36516760 Development of a Mucoadhesive Liquid Crystal System for the Administration of Rifampicin Applicable in Tuberculosis Therapy Life (Basel, Switzerland). Jul, 2022 | Pubmed ID: 36013317 Mycobacterium Leprae Infection in a Wild Nine-Banded Armadillo, Nuevo León, Mexico Emerging Infectious Diseases. Mar, 2022 | Pubmed ID: 35202538 Therapeutic Efficacy of Antimalarial Drugs Targeting DosRS Signaling in Science Translational Medicine. Feb, 2022 | Pubmed ID: 35196022 Unique Features of Biofilms Formed in Synthetic Cystic Fibrosis Medium Frontiers in Microbiology. 2021 | Pubmed ID: 34777289 Lipid Nanoparticle Formulation of Niclosamide (nano NCM) Effectively Inhibits SARS-CoV-2 Replication Precision Nanomedicine. Apr, 2021 | Pubmed ID: 34676370 Preclinical Evaluation of Inhalational Spectinamide-1599 Therapy Against Tuberculosis ACS Infectious Diseases. Oct, 2021 | Pubmed ID: 34546724 Neonatal and Infant Immunity for Tuberculosis Vaccine Development: Importance of Age-matched Animal Models Disease Models & Mechanisms. Sep, 2020 | Pubmed ID: 32988990 Inhaled Tigecycline is Effective Against Mycobacterium Abscessus in Vitro and in Vivo The Journal of Antimicrobial Chemotherapy. Jul, 2020 | Pubmed ID: 32294173 Minipigs As a Neonatal Animal Model for Tuberculosis Vaccine Efficacy Testing Veterinary Immunology and Immunopathology. Sep, 2019 | Pubmed ID: 31420066 Sterilization of Mycobacterium Tuberculosis Infected Samples Using Methanol Preserves Anti-tuberculosis Drugs for Subsequent Pharmacological Testing Studies Tuberculosis (Edinburgh, Scotland). Jul, 2019 | Pubmed ID: 31378268 Development and Characterization of a Dry Powder Formulation for Anti-Tuberculosis Drug Spectinamide 1599 Pharmaceutical Research. Jul, 2019 | Pubmed ID: 31321552 Direct Inhibition of MmpL3 by Novel Antitubercular Compounds ACS Infectious Diseases. Jun, 2019 | Pubmed ID: 30882198 Comparative Pharmacokinetics of Spectinamide 1599 After Subcutaneous and Intrapulmonary Aerosol Administration in Mice Tuberculosis (Edinburgh, Scotland). Jan, 2019 | Pubmed ID: 30711150 Host Directed Therapy for Chronic Tuberculosis Via Intrapulmonary Delivery of Aerosolized Peptide Inhibitors Targeting the IL-10-STAT3 Pathway Scientific Reports. Nov, 2018 | Pubmed ID: 30413750 Optimization and Lead Selection of Benzothiazole Amide Analogs Toward a Novel Antimycobacterial Agent Frontiers in Microbiology. 2018 | Pubmed ID: 30294313 Primary Lung Dendritic Cell Cultures to Assess Efficacy of Spectinamide-1599 Against Intracellular Frontiers in Microbiology. 2018 | Pubmed ID: 30186246 Interactions of Free-living Amoebae with Rice Bacterial Pathogens Xanthomonas Oryzae Pathovars Oryzae and Oryzicola PloS One. 2018 | Pubmed ID: 30142182 Cell Mediated Immune Response in Goats After Experimental Challenge with the Virulent Brucella Melitensis Strain 16M and the Reduced Virulence Strain Rev. 1 Veterinary Immunology and Immunopathology. Aug, 2018 | Pubmed ID: 30078602 Evidence of Zoonotic Leprosy in Pará, Brazilian Amazon, and Risks Associated with Human Contact or Consumption of Armadillos PLoS Neglected Tropical Diseases. Jun, 2018 | Pubmed ID: 29953440 Yersinia Pestis Survival and Replication in Potential Ameba Reservoir Emerging Infectious Diseases. Feb, 2018 | Pubmed ID: 29350155 Evaluation of Shedding, Tissue Burdens, and Humoral Immune Response in Goats After Experimental Challenge with the Virulent Brucella Melitensis Strain 16M and the Reduced Virulence Vaccine Strain Rev. 1 PloS One. 2017 | Pubmed ID: 29028813 The Minipig As an Animal Model to Study Mycobacterium Tuberculosis Infection and Natural Transmission Tuberculosis (Edinburgh, Scotland). Sep, 2017 | Pubmed ID: 28802411 Mycobacterium Bovis Hosted by Free-living-amoebae Permits Their Long-term Persistence Survival Outside of Host Mammalian Cells and Remain Capable of Transmitting Disease to Mice Environmental Microbiology. Oct, 2017 | Pubmed ID: 28585299 Therapeutic Potential of the Mycobacterium Tuberculosis Mycolic Acid Transporter, MmpL3 Antimicrobial Agents and Chemotherapy. Sep, 2016 | Pubmed ID: 27297488 Potential and Development of Inhaled RNAi Therapeutics for the Treatment of Pulmonary Tuberculosis Advanced Drug Delivery Reviews. 07, 2016 | Pubmed ID: 27108702 Partial Saturation of Menaquinone in : Function and Essentiality of a Novel Reductase, MenJ ACS Central Science. Sep, 2015 | Pubmed ID: 26436137 Presence of Multiple Lesion Types with Vastly Different Microenvironments in C3HeB/FeJ Mice Following Aerosol Infection with Mycobacterium Tuberculosis Disease Models & Mechanisms. Jun, 2015 | Pubmed ID: 26035867 Extended Culture of Macrophages from Different Sources and Maturation Results in a Common M2 Phenotype Journal of Biomedical Materials Research. Part A. Sep, 2015 | Pubmed ID: 25684281 Long-term Survival and Virulence of Mycobacterium Leprae in Amoebal Cysts PLoS Neglected Tropical Diseases. Dec, 2014 | Pubmed ID: 25521850 Microhemorrhage is an Early Event in the Pulmonary Fibrotic Disease of PECAM-1 Deficient FVB/n Mice Experimental and Molecular Pathology. Aug, 2014 | Pubmed ID: 24972347 Spectinamides: a New Class of Semisynthetic Antituberculosis Agents That Overcome Native Drug Efflux Nature Medicine. Feb, 2014 | Pubmed ID: 24464186 GM-CSF Knockout Mice for Preclinical Testing of Agents with Antimicrobial Activity Against Mycobacterium Abscessus The Journal of Antimicrobial Chemotherapy. Apr, 2014 | Pubmed ID: 24222613 Polar Lipids of Burkholderia Pseudomallei Induce Different Host Immune Responses PloS One. 2013 | Pubmed ID: 24260378 Correlates of Immune Protection Following Cutaneous Immunization with an Attenuated Burkholderia Pseudomallei Vaccine Infection and Immunity. Dec, 2013 | Pubmed ID: 24101688 Experimental Aerosol Mycobacterium Bovis Model of Infection in Goats Tuberculosis (Edinburgh, Scotland). Sep, 2013 | Pubmed ID: 23850102 Exposition à Une Estérase Sérine Cutinase Déclenche La Lyse Rapide De Plusieurs Espèces De Mycobactéries The Journal of Biological Chemistry. Jan, 2013 | Pubmed ID: 23155047 Mouse Model for Efficacy Testing of Antituberculosis Agents Via Intrapulmonary Delivery Antimicrobial Agents and Chemotherapy. Jul, 2012 | Pubmed ID: 22547626 Immunity to TB and Targets for Immunotherapy Immunotherapy. Feb, 2012 | Pubmed ID: 22339461 Fonctions Non-glycolytiques Et Glycolytiques Du Fructose-1, 6-bisphosphate Aldolase De Mycobacterium Tuberculosis, Une Enzyme Essentielle Produite Par Réplication Et Bacilles Non Répliquées The Journal of Biological Chemistry. Nov, 2011 | Pubmed ID: 21949126 L'immunothérapie Locale Pulmonaire Avec SiARN Ciblant TGFβ1 Améliore La Capacité Antimicrobienne Chez Des Souris Infectée De Tuberculose Mycobacterium Tuberculosis (Edinburgh, Scotland). Jan, 2011 | Pubmed ID: 21195670 Optimisation Des Traitements Inhalés Pour La Tuberculose : Le Rôle Des Macrophages Et Des Cellules Dendritiques Tuberculosis (Edinburgh, Scotland). Jan, 2011 | Pubmed ID: 20888298 Plusieurs Phénotypes De La Tuberculose M. Dans Les Tissus Pulmonaires Souris Et Le Cobaye a Révélé Par Une Approche Double Coloration PloS One. 2010 | Pubmed ID: 20559431 Polarisation Différentielle Des Macrophages Alvéolaires Et Les Monocytes Moelle Osseuse Suite Chimiquement Et Inflammation Pulmonaire Chronique Induite Par L'agent Pathogène Journal of Leukocyte Biology. Jul, 2010 | Pubmed ID: 20360403 Localisée Environnement Immunosuppresseur Dans La Réaction Au Corps étranger à Implanté Des Biomatériaux The American Journal of Pathology. Jul, 2009 | Pubmed ID: 19528351 Manque D'IL-10 Altère Les Réponses Inflammatoires Et Immunitaires Au Cours D'une Infection Pulmonaire Mycobacterium Tuberculosis Tuberculosis (Edinburgh, Scotland). Mar, 2009 | Pubmed ID: 19213603 Livraison Intrapulmonaire De Ciblage XCL1 Petit ARN Interférent Dans Souris Chroniquement Infectées Par Mycobacterium Tuberculosis American Journal of Respiratory Cell and Molecular Biology. Aug, 2009 | Pubmed ID: 19097989 Réponse Immunitaire à Mycobacterium Tuberculosis Et Identification Des Marqueurs Moléculaires De La Maladie American Journal of Respiratory Cell and Molecular Biology. Apr, 2009 | Pubmed ID: 18787176 Non-équivalence Phénotypique Des Macrophages Murin (monocyte-) Des Cellules En Biomatériaux Et Modèles Inflammatoires Journal of Biomedical Materials Research. Part A. Mar, 2009 | Pubmed ID: 18357567 Interleukin-10 Favorise La Progression De La Maladie Mycobacterium Tuberculosis Chez Des Souris CBA/J Journal of Immunology (Baltimore, Md. : 1950). Oct, 2008 | Pubmed ID: 18832712 Les Niveaux Relatifs De M-CSF Et GM-CSF Influencent La Génération Spécifique Des Populations Des Macrophages Au Cours De L'infection Par Mycobacterium Tuberculosis Journal of Immunology (Baltimore, Md. : 1950). Apr, 2008 | Pubmed ID: 18354213 Modèles Animaux De M. Tuberculosis Infection Current Protocols in Microbiology. Nov, 2007 | Pubmed ID: 18770606 XCL1 Chemokine (lymphotactin) Produite Par Les Lymphocytes T CD8 Activés Pendant La Phase Chronique De L'infection Par Mycobacterium Tuberculosis Négativement Affecte La Production D'IFN-gamma Par Les Cellules T CD4 Et Participe à La Stabilité De Granulome Journal of Leukocyte Biology. Nov, 2007 | Pubmed ID: 17699612 Réaction Croisée D'anti Anticorps Monoclonaux De CD Sur Les Cellules De Cobaye : Un Résumé De La Section De Cobaye Des Données Animales Homologues HLDA8 Veterinary Immunology and Immunopathology. Sep, 2007 | Pubmed ID: 17658620 Amélioré L'activité Des Macrophages Dans Les Lésions Granulomateuses De Souris Immunisées Par Mycobacterium Tuberculosis Journal of Immunology (Baltimore, Md. : 1950). Apr, 2006 | Pubmed ID: 16585589 Les Isolats Virulents De Mycobacterium Tuberculosis Se Développent Rapidement Et Induisent Une Nécrose Cellulaire Mais Minime Apoptose Dans Les Macrophages Murins Journal of Leukocyte Biology. Jan, 2006 | Pubmed ID: 16275894 Macrophages Spumeux Dans Les Granulomes Pulmonaires Chez Des Souris Infectées Par Mycobacterium Tuberculosis Molécules Express Caractéristique Des Cellules Dendritiques Et Marqueurs D'antiapoptotiques De La Famille De Factor Receptor-associated TNF Journal of Immunology (Baltimore, Md. : 1950). Sep, 2005 | Pubmed ID: 16148133 Facteurs Associés à Des Pneumonies Sévères Granulomateuse Chez Des Souris Infectées Par La Tuberculose De Mycobacterium Vaccinés Thérapeutiquement Avec ADN Hsp65 Infection and Immunity. Aug, 2005 | Pubmed ID: 16041037 Production D'Interleukin-10 Par Les Macrophages Pulmonaires Chez Des Souris Mutantes De Xid CBA Infectées Par Mycobacterium Tuberculosis Immunology. Jun, 2005 | Pubmed ID: 15885131 Perturbation De Granulocyte-macrophage Colony Stimulant Facteur Production Dans Les Poumons Affecte Gravement La Capacité De La Souris Pour Contrôler L'infection à Mycobacterium Tuberculosis Journal of Leukocyte Biology. Jun, 2005 | Pubmed ID: 15767289 Population Stable De Lymphocytes T Exprimant Un Phénotype De Surface De Cellules Effectrices Dans Les Poumons Des Souris Chroniquement Infectées Par Mycobacterium Tuberculosis Infection and Immunity. Jan, 2004 | Pubmed ID: 14688138 Les Cellules NK Réagissent à L'infection Pulmonaire Par Le Mycobacterium Tuberculosis, Mais Jouent Un Rôle Minime Dans La Protection Journal of Immunology (Baltimore, Md. : 1950). Dec, 2003 | Pubmed ID: 14634116 Dynamique Des Populations De Cellules Macrophages Au Cours De La Tuberculose Pulmonaire Murine Journal of Immunology (Baltimore, Md. : 1950). Sep, 2003 | Pubmed ID: 12960339 Florides Réponses Inflammatoires Pulmonaires Chez Des Souris Vaccinées Avec Antigène-85 Pulsé De Cellules Dendritiques Et Contestée Par Aérosol Mycobacterium Tuberculosis Cellular Immunology. Nov, 2002 | Pubmed ID: 12718935 Production D'IL-10 in Vivo Pour Réactiver La Tuberculose Pulmonaire Chronique Chez Les Souris C57BL/6 Journal of Immunology (Baltimore, Md. : 1950). Dec, 2002 | Pubmed ID: 12444141 Temporal and Spatial Arrangement of Lymphocytes Within Lung Granulomas Induced by Aerosol Infection with Mycobacterium Tuberculosis Infection and Immunity. Mar, 2001 | Pubmed ID: 11179349 Characterization of Murine Lung Dendritic Cells Infected with Mycobacterium Tuberculosis Infection and Immunity. Feb, 2001 | Pubmed ID: 11160010 Developing a Disposable Dosator for Preclinical Testing of Dry Powder Inhalers in Small Animal Models (Video) | JoVE Sara E. Maloney1, Ian E. Stewart1, Jeffrey B. Mecham1, Mercedes Gonzalez-Juarrero2, Bernd Meibohm3, Anthony J. Hickey1 1Technology Advancement and Commercialization, RTI International, 2Mycobacteria Research Laboratories, Department of Microbiology, Immunology, and Pathology, Colorado State University, 3Department of Pharmaceutical Sciences, College of Pharmacy, University of Tennessee Health Science Center JoVE 65756 Medicine Non-chirurgicale instillation intratrachéale de souris avec analyse des poumons et les ganglions lymphatiques drainant poumon par cytométrie en flux Manira Rayamajhi1, Elizabeth F. Redente2, Tracy V. Condon1, Mercedes Gonzalez-Juarrero3, David W.H. Riches1,2,4, Laurel L. Lenz1,4 1Department of Immunology, University of Colorado School of Medicine, 2Division of Cell Biology, Department of Pediatrics, National Jewish Health, 3Department of Microbiology, Immunology, and Pathology, Colorado State University, 4Department of Immunology, National Jewish Health JoVE 2702 Immunology and Infection
Developing a Disposable Dosator for Preclinical Testing of Dry Powder Inhalers in Small Animal Models (Video) | JoVE Sara E. Maloney1, Ian E. Stewart1, Jeffrey B. Mecham1, Mercedes Gonzalez-Juarrero2, Bernd Meibohm3, Anthony J. Hickey1 1Technology Advancement and Commercialization, RTI International, 2Mycobacteria Research Laboratories, Department of Microbiology, Immunology, and Pathology, Colorado State University, 3Department of Pharmaceutical Sciences, College of Pharmacy, University of Tennessee Health Science Center JoVE 65756 Medicine
Non-chirurgicale instillation intratrachéale de souris avec analyse des poumons et les ganglions lymphatiques drainant poumon par cytométrie en flux Manira Rayamajhi1, Elizabeth F. Redente2, Tracy V. Condon1, Mercedes Gonzalez-Juarrero3, David W.H. Riches1,2,4, Laurel L. Lenz1,4 1Department of Immunology, University of Colorado School of Medicine, 2Division of Cell Biology, Department of Pediatrics, National Jewish Health, 3Department of Microbiology, Immunology, and Pathology, Colorado State University, 4Department of Immunology, National Jewish Health JoVE 2702 Immunology and Infection